|1.||Hamlyn, John M: 21 articles (03/2014 - 02/2002)|
|2.||Manunta, Paolo: 20 articles (01/2015 - 01/2005)|
|3.||Bianchi, Giuseppe: 20 articles (11/2014 - 08/2004)|
|4.||Lingrel, Jerry B: 14 articles (04/2012 - 02/2005)|
|5.||Blaustein, Mordecai P: 13 articles (03/2014 - 11/2005)|
|6.||Ferrari, Patrizia: 12 articles (11/2014 - 08/2004)|
|7.||Liu, Lijun: 11 articles (03/2015 - 04/2003)|
|8.||Quevedo, João: 10 articles (08/2015 - 12/2009)|
|9.||Valvassori, Samira S: 10 articles (08/2015 - 12/2009)|
|10.||Messaggio, Elisabetta: 10 articles (01/2015 - 09/2005)|
04/01/1976 - "The dose of ouabain necessary to produce ventricular tachycardia and death in 1-to 4-week-old rabbits was significantly greater than that required in older animals. "
03/01/1976 - "In 13 dogs the efficacy of the drug against ouabain-induced ventricular tachycardia (VT) was studied. "
09/01/2005 - "Further extract reversed ouabain-induced persistent ventricular tachycardia and restored sinus rhythm in a dose-dependent manner. "
12/01/1993 - "In contrast, this drug abolished ventricular tachycardia induced by ouabain toxicity (n = 10, 40 micrograms.kg-1 bolus followed by 0.076 microgram.kg-1.min-1 for 1 h, then 20 micrograms.kg-1 bolus, intravenously). "
07/01/1993 - "It also made the preparations develop stable ventricular tachycardia at an ouabain blood concentration of 0.246 +/- 0.007 microM, which was not significantly different from the concentration at which early arrhythmias were noted in the other series. "
|2.||Hypertension (High Blood Pressure)
01/01/1993 - "The ouabain-induced changes were significantly greater in essential hypertension than in normotensive subjects. "
09/03/1983 - "In two thirds of the untreated hypertensive and several of the normotensive subjects with a family history of hypertension the potency of the digitalis-like compound, as measured by its interference with ouabain binding, was significantly greater than in the controls. "
02/01/1996 - "Among Caucasian patients with essential hypertension, a large fraction have elevated circulating levels of endogenous ouabain, possibly caused by an inherited or acquired renal defect in clearance of this steroid. "
03/01/2014 - "This study reports the critical role of endogenous ouabain in volume-dependent hypertension. "
01/01/2014 - "This study was designed to help settle this controversy through the use of telemetric monitoring of arterial blood pressure and to elucidate the ouabain-induced alterations that could either promote or prevent hypertension. "
08/01/1988 - "In contrast, ouabain treatment resulted in a marked decrease in diastolic chamber distensibility during ischemia; this change was not completely reversible during the 10-minute reperfusion period. "
03/01/2010 - "A short (4 minutes) administration of a subinotropic dose of ouabain (100 nM) followed by an 8-minute washout before 30 minutes of global ischemia and 120 minutes of reperfusion resulted in protection against cell death, as evidenced by a significant decrease in infarct size. "
02/01/1996 - "A delayed adaptation produced a late appearing, prolonged protection against consequences of ischemia, such as early morphological changes, early and late postocclusion and reperfusion arrhythmias due to coronary artery occlusion or ouabain intoxication. "
03/01/2015 - "In Langendorff-perfused mouse hearts, OPC was initiated by 4 min of ouabain 10 μM and IPC was triggered by 4 cycles of 5 min ischemia and reperfusion prior to 40 min of global ischemia and 30 min of reperfusion. "
01/01/2013 - "OPC, induced by a 4-min exposure to 10 μM ouabain that ended 8 min before the beginning of ischemia, increased cell viability in a PKCε-dependent manner. "
|4.||Cardiac Arrhythmias (Arrythmia)
01/01/2008 - "CPA significantly increased the time of onset of arrhythmia (toxicity) induced by ouabain (1.2 muM) when it was administered 10 min before ouabain was added in organ bath. "
12/28/2006 - "In the ventricle strip, NCX(IF) ( approximately 10 U/ml) results in rapid, complete and stable inhibition of ouabain-induced arrhythmias (the inhibition of arrhythmia is not followed by revival of irregular contractions). "
02/01/2002 - "Cardiac arrhythmias in an animal model for ouabain-induced toxicity were associated with neural autonomic dysfunction. "
11/01/2000 - "To determine the effective plasma levels of CPU-86017 which could suppress the cardiac arrhythmias induced by i.v. ouabain in guinea pigs. "
11/01/2000 - "Plasma CPU-86017 concentrations regarding suppression of ouabain-induced cardiac arrhythmias and decrease of heart rate in guinea pigs."
03/01/1998 - "Ouabain was administered until ventricular fibrillation was induced. "
04/01/1996 - "Ouabain-induced ventricular fibrillation occurred at 18 +/- 5 and 12 +/- 3 min (P < 0.05) in control and AM 92016-(1 mg kg-1) treated guinea-pigs, respectively. "
03/01/1992 - "Ventricular fibrillation (VF) developed in three of the eight hearts in Group I within 10-13 mins after the addition of ouabain. "
01/01/1992 - "The threshold dose of ouabain necessary to induce ventricular fibrillation is decreased in sensitized guinea-pigs signalizing an enhanced arrhythmogenicity. "
11/01/1980 - "Although ventricular arrhythmias did occur before the increase in circulating CA, preinjection CA levels were significantly higher in animals presenting ventricular fibrillation, suggesting that a high background adrenergic tone facilitates the production of ventricular arrhythmias by ouabain. "
|1.||Adenosine Triphosphatases (ATPase)
|3.||Sodium-Potassium-Exchanging ATPase (Sodium, Potassium ATPase)