|1.||Pichichero, Michael E: 9 articles (01/2015 - 11/2008)|
|2.||Casey, Janet R: 7 articles (11/2013 - 11/2008)|
|3.||Kaur, Ravinder: 3 articles (08/2012 - 01/2011)|
|4.||Kwochka, Kenneth W: 3 articles (02/2009 - 06/2002)|
|5.||Hillier, Andrew: 3 articles (02/2009 - 06/2002)|
|6.||Cole, Lynette K: 3 articles (02/2009 - 04/2006)|
|7.||Pichichero, M E: 2 articles (12/2015 - 10/2003)|
|8.||Patel, Janak: 2 articles (07/2015 - 04/2013)|
|9.||Jesic, Snezana: 2 articles (06/2014 - 06/2006)|
|10.||Weese, J Scott: 2 articles (04/2014 - 08/2013)|
|1.||Anti-Bacterial Agents (Antibiotics)IBA
01/01/1997 - "Acupuncture enhances the efficacy of antibiotics treatment for canine otitis crises."
09/01/2009 - "Our study demonstrates that the observation option as defined by the New York Otitis Project Committee can be safely implemented in the ED and prevented the administration of antibiotics in more than 70% of the patients in our group. "
01/01/1993 - "[Pharmacokinetic study of antibiotics in otitis]."
09/01/1952 - "[Evolution of chronic otitis in a nine-month-old infant; study of the resistance of a germ to antibiotics and therapeutic conclusions]."
01/01/2015 - "Antibiotics did reduce the number of children with abnormal tympanometry findings at two to four weeks (RR 0.82, 95% CI 0.74 to 0.90; NNTB 11), at six to eight weeks (RR 0.88, 95% CI 0.78 to 1.00; NNTB 16) and the number of children with tympanic membrane perforations (RR 0.37, 95% CI 0.18 to 0.76; NNTB 33) and halved contralateral otitis episodes (RR 0.49, 95% CI 0.25 to 0.95; NNTB 11) compared with placebo. "
|2.||Ciprofloxacin (Cipro)FDA LinkGeneric
01/01/1994 - "These results suggest that, administered as an oral dose of 500 mg every 12 h, ciprofloxacin may be an effective agent for the treatment of chronic suppurative otitis. "
01/01/1994 - "This study shows ciprofloxacin to be an effective and safe agent for use in the treatment of acute exacerbations of chronic otitis treated in general practice. "
01/01/2014 - "Due to the widespread use, it seems proper research on the human population has not been taken to ensure its non-toxicity in the inner ear, therefore comparison of local ciprofloxacin ototoxicity with systemic in chronic media otitis is investigated in this study. "
01/01/1994 - "Study of the efficacy and safety of ciprofloxacin in the treatment of chronic otitis."
01/01/2014 - "Ciprofloxacin drop that is of fluoroquinolone drug class due to good treatment effect is now widely used in the treatment of chronic media otitis. "
|3.||Pneumococcal Vaccines (Pneumococcal Polysaccharide Vaccine)IBA
01/01/2002 - "The results of currently ongoing trials could provide more information whether pneumococcal vaccines are effective in specific high-risk (otitis-prone) populations."
08/14/2007 - "Vaccination is proposed to prevent otitis and several clinical trials were performed to assess the efficacy of pneumococcal vaccines. "
06/17/2002 - "Otitis prone children, while having normal IgG1 antibody levels, have low IgG2 and IgA anti-polysaccharide antibody levels and fail to respond in these subclasses upon vaccination with pneumococcal polysaccharide vaccine."
05/01/1986 - "The antibody activity of the IgM class and subclasses of IgG and IgA against pneumococcal bacteria of types 3, 6A and 19F was studied before and after administration of a pneumococcal vaccine (Pneumovax) in a group of children with recurrent acute otitis media (rAOM) and in groups of non-otitis-prone children. "
|4.||Ceftriaxone (Ceftriaxon)FDA LinkGeneric
08/01/2000 - "Ceftriaxone and otitis in children: new indication. "
01/01/1988 - "Therefore, single-dose ceftriaxone therapy cannot be suggested at present as routine therapy for acute otitis, although it may be considered a reasonable alternative in noncompliant patients."
09/01/1996 - "Pharmacokinetic study indicates that the values of the parameters in plasma after the administration of a dose of 100 mg/kg (peak level of total drug, 268 +/- 33 micrograms/ml; elimination half-life, 0.8 h; area under concentration-time curve, 488 micrograms.h.ml-1) were still suboptimal compared with the values of the parameters measured in pediatric patients after intravenous or intramuscular administration of a dose of 50 mg/kg. Our results indicate the efficacy of ceftriaxone against experimental cephalosporin-resistant pneumococcal otitis and provide a basis for the clinical use of single-dose ceftriaxone against pneumococcal otitis media."
01/01/1986 - "The efficacy of ceftriaxone, 1 g given intramuscularly once daily, was evaluated in 38 patients with pneumonia (n = 11), pulmonary empyema (n = 2), bronchitis (n = 4), tonsillitis (n = 9), sinusitis (n = 7), and otitis (n = 5). "
01/01/2010 - "To review current clinical evidence for the use of antibiotics in paediatric upper paediatric respiratory infections, repeated PubMed searches using the template algorithm -rhinosinusitis/otitis/ tonsillitis AND ()- with the settings: -Humans; English; All Child 0-18; Clinical trial; Review; Methanalysis; Guideline; Last 10 years- for the following comparators: antibiotic; amoxicillin; clavulanate; penicillin; cephalosporin; macrolide; erythromycin; rokitamycin; clindamycin; trimethoprim-sulfamethoxazole, cefopodoxime, cefdinir, cefuroxime, ceftriaxone. "
01/01/1984 - "Antibody levels against various pneumococcal capsular polysaccharides were determined in otitis-prone and healthy members of 19 families. "
03/04/2006 - "These results confirm that using the H influenzae-derived protein D as a carrier protein for pneumococcal polysaccharides not only allowed protection against pneumococcal otitis, but also against acute otitis media due to non-typable H influenzae. "
01/01/1993 - "In infants and young children up to the age of 2 years the antibody response to capsular polysaccharides is inadequate resulting in an increased incidence of diseases such as pneumonia, meningitis, otitis and other forms of bacteremic disease. "
02/01/1996 - "The presence of serum IgG to the pneumococcal capsular polysaccharides seems beneficial in the prevention of pneumococcal otitis."
01/01/1999 - "Antibody responses to the outer membrane protein P6 of non-typeable Haemophilus influenzae and pneumococcal capsular polysaccharides in otitis-prone children."
|6.||Immunoglobulin G (IgG)IBA
04/26/2012 - "Pre-vaccination, otitis-prone children had significantly higher serum IgG levels against serotypes 4, 9V and 23F and against all non-PCV7 serotypes. "
08/15/2011 - "Otitis-prone children have suboptimal circulating functional T-helper memory and reduced IgG responses to S. "
08/01/2011 - "Although non-otitis-prone children had significant increases (P < 0.001) between 6 and 24 months of age in anti-PhtD, PcpA, PhtE, and Ply IgG antibody titers as a consequence of nasopharyngeal colonization and AOM, otitis-prone children either failed to show rises or the rises were significantly less than the non-otitis-prone children. "
08/01/2011 - "At their AOM visit, anti-PhtD, -LytB, -PhtE, and -Ply IgG antibody titers in otitis-prone children were significantly lower compared with non-otitis-prone children (P < 0.05) and children with AOMTF (P < 0.05). "
01/29/2011 - "The geometric mean titers (GMTs) of IgG at their acute AOM visit against Protein D in otitis prone children were significantly lower compared to AOMTF (p value<0.01) and non-otitis prone (p value<0.03) children; otitis prone children had significantly lower IgG levels to P6 compared to AOMTF children (p value<0.02); otitis prone children had significantly lower IgG levels to OMP26 compared to AOMTF children (p value<0.04). "
|7.||Penicillins (Penicillin)FDA Link
09/01/1997 - "pneumoniae were penicillin-resistant and 4.2% intermediately resistant; 5 years earlier among otitis isolates of children only 1.7% intermediate resistance was found. "
05/01/1995 - "Eighty-five percent of the resistant otitis-related strains, including 9 of the 11 moderately penicillin-resistant strains (4 of which were multiresistant), belonged to the three most common serogroups (6, 19, and 23)."
05/01/1995 - "Low-level resistance to penicillin (MIC, 0.1-1 microgram/mL) was found in 1.7% of the otitis-related and 1.3% of the healthy-carrier strains. "
01/14/1995 - "For example, the probability of resistance to penicillin R in acute otitis has been estimated at 75% for children living in the Paris area. "
05/01/1980 - "Penicillin and acute otitis: short and long-term results."
04/01/2000 - "The aim of the present study was to ascertain whether local administration of immunoglobulin could reduce the number of episodes of otorrhoea in otitis-prone infants <2 years old who were treated with tubes, or whether it could affect the nasopharyngeal colonization and turnover of bacterial pathogens in the nasopharynx. "
01/01/2004 - "Lower immunoglobulin levels in otitis-prone children suggest a generalized decreased antibody response in otitis-prone children."
01/01/2004 - "Interestingly, the otitis-prone group of children showed significantly lower median and mean levels for all immunoglobulins compared with those children with only 2-3 previous AOM episodes. "
01/01/2004 - "Immunoglobulin levels of otitis-prone children were compared with those of children who had experienced 2-3 AOM episodes per year. "
01/01/2004 - "Immunoglobulins in otitis-prone children."
|9.||Amoxicillin (Wymox)FDA LinkGeneric
11/01/2001 - "Significantly fewer children recently treated with amoxicillin were otitis-prone than those given AMC (24% vs. 74%, P < 0.0001). "
04/01/1997 - "The proportion of subjects remaining otitis-free was 63% for the placebo group, 64% for once daily amoxicillin and 61% for twice daily amoxicillin. "
08/19/1992 - "[Amoxicillin, drug of choice in otitis]."
11/20/1993 - "Meningitis occurred in a man treated for myeloma and in an elderly woman under prolonged intermittent amoxicillin therapy for chronic otitis. "
06/01/1987 - "The epidemiology, microbiology and clinical outcome of the conjunctivitis-otitis syndrome (CJ-AOM) was investigated in a rural private practice concurrent to a double blind placebo-controlled study of orally administered amoxicillin for prevention of acute otitis media (AOM) secondary to conjunctivitis. "
08/01/1982 - "Sulphamethoxazole prophylaxis in the otitis-prone child."
08/01/1982 - "A bedtime dose of sulphamethoxazole was effective in preventing ear infections in otitis-prone young children. "
08/01/1982 - "Otitis media with effusion (secretory otitis media) was detected less often in the children who were given sulphamethoxazole; this fact suggests that prophylaxis with sulphamethoxazole may prevent persistent middle ear effusion in otitis-prone young children."
01/01/1978 - "Clinical study of sulfamethoxazole trimethoprim in ENT for suppurative otitis and rhinosinusitis."
08/01/1988 - "In case of persisting or relapsing otitis, the bacteriological examination will allow choosing the best adapted antibiotic: first generation cephalosporin, clavulanic acid and amoxicillin or trimethoprime and sulfamethoxazole."
|1.||Middle Ear Ventilation (Tympanostomy)
10/01/2005 - "The technique of subannular tube insertion is a safe and effective method for long-term middle ear ventilation in cases of adhesive otitis or severely atelectatic tympanic membrane or for patients with pathology related to dysfunction of the eustachian tube. "
07/01/2015 - "A Rare Case of Scedosporium Otitis in an Immunocompetent Child with Tympanostomy Tubes."
01/01/2003 - "Visits for otitis, frequent visits for otitis and tympanostomy tube procedures. "
06/17/2002 - "[Inserted tympanostomy tube in prolonged secretory otitis has no effect on language development]."
01/01/1997 - "Screening manometry is convenient for following up postoperative changes in the tubular function and defining duration of carrying tympanostomy in secretory otitis."
04/01/2010 - "Topical administration of RIME at 1-5 mg/ear resulted in reduction of ear inflammation in mice. "
03/07/1997 - "This biflavonoid exerted anti-inflammatory effects in animal models, with a potent inhibition of 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ear inflammation in mice after topical administration. "
02/01/2004 - "The anti-inflammatory activity of the stem extracts of Sandoricum koetjape was investigated on topical administration using the TPA (tetradecanoylphorbol acetate)-induced mouse ear inflammation model. "
05/01/2001 - "Furthermore, topical administration of HE to mice also significantly inhibited phorbol ester-induced ear inflammation. "
01/01/1994 - "Our results show that mouse ear inflammation induced by CO, AA or TPA is decreased by topical administration of CGRP, whereas that induced by CA is not affected. "
|4.||Transplantation (Transplant Recipients)
06/27/2008 - "CMV otitis: a rare presentation in an adult transplant recipient."
10/01/2015 - "In preclinical psoriasis models, AZ17 reduced IL-23-induced ear inflammation and improved psoriasis in a xenograft transplantation model where psoriasis skin is transplanted onto immune-deficient mice. "
01/01/2000 - "The epidemiology of brain abscess has changed with the increasing incidence of this infection in immunocompromised patients, particularly solid organ and bone marrow transplant recipients, and the decreasing incidence of brain abscess related to sinusitis and otitis. "
|5.||Heterologous Transplantation (Xenotransplantation)