An abnormal hardening or increased density of bone tissue.
Also Known As:
Networked: 226 relevant articles (3 outcomes, 13 trials/studies) for this Disease, Comments

Relationship Network

Disease Context: Research Results

Related Diseases

1. Neoplasm Metastasis (Metastasis)
2. Fibrosis (Cirrhosis)
3. Prostatic Neoplasms (Prostate Cancer)
4. Osteolysis
5. Plasma Cell Leukemia


1. Tefferi, Ayalew: 5 articles (01/2006 - 01/2003)
2. Vainchenker, William: 4 articles (07/2007 - 04/2003)
3. Gelb, Bruce D: 3 articles (03/2009 - 11/2002)
4. Tulliez, Micheline: 3 articles (07/2007 - 04/2003)
5. Giraudier, Stéphane: 3 articles (07/2007 - 04/2003)
6. Crosby, Andrew: 2 articles (09/2014 - 12/2013)
7. Wang, Jen C: 2 articles (12/2009 - 10/2004)
8. Hemavathy, Kirugaval: 2 articles (12/2009 - 10/2004)
9. Simpson, M A: 2 articles (03/2009 - 11/2007)
10. Patton, M A: 2 articles (03/2009 - 11/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Osteosclerosis:
1. CollagenIBA
2. Reticulin (Reticular Fiber)IBA
09/19/1981 - "At bone biopsy, various aspects of panhyperplasia, increase in the reticular fibers, myeloid fibrosis and osteosclerosis were observed. "
08/01/2011 - "CT scanning displayed femoral cortical thickening, medulla canal narrowing and lumbar spine density increasing at day 150, meanwhile, HE staining and reticular fiber staining showed the fatty degeneration or vacuolization in liver, splenomegaly with megakaryocytic proliferation, femur bone marrow fibrosis and osteosclerosis. "
01/01/2000 - "A trephine biopsy showed a hypercellular bone marrow with a proliferation of abnormal megakaryocytes, mild reticulin fibrosis, and osteosclerosis, i.e., features of an early stage of idiopathic myelofibrosis. "
12/13/1975 - "One is characterized by bone marrow hyperplasia with reticulin myelofibrosis and is usually associated with large spleen and even in some cases with polycythemia but without radiologic bone lesions; the other is characterized by bone marrow of medium or hypoplasic constitution fibrosis, with or without osteosclerosis and with radiologic bone lesions of mode-rate or important extension (respectively 16.9 p. "
01/01/1989 - "This study was firstly aimed at testing correlations between histological features (amount of haematopoiesis, cytological aspects of megakaryocytes, density of reticulin and collagen fibres and degree of osteosclerosis) and laboratory data, as well as spleen size and duration of relevant prediagnostic symptoms. "
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3. DiphosphonatesIBA
4. Parathyroid Hormone (Parathormone)IBA
5. Carbon MonoxideIBA
12/01/2012 - "The aim of this study was to determine the prevalence of idiopathic osteosclerosis (IO) and condensing osteitis (CO) in Zagreb patient population sample according to age and sex, localization in the jaw, as well as dental relationship between IO and CO lesions. "
12/01/2009 - "The objective of this study was to investigate the frequency of idiopathic osteosclerosis (IO) and condensing osteitis (CO) in a Turkish patient population, considering factors such as age and sex of the population, in addition to shape and localization, as well as the dental relationship between IO and CO lesions. "
09/01/1998 - "To document the prevalence of idiopathic osteosclerosis (IO) and condensing osteitis (CO) in a middle-age-to-older adult population and determine their long term behavior. "
01/01/2012 - "Other autoimmune rheumatic disorders (poly/dermatomyositis, polyarteritis nodosa, osteosclerosis, fibromyalgia, and so on) have been reported as potentially associated with HCV infection in patient populations from different countries, suggesting the role of genetic and/or environmental co-factors. "
07/01/1993 - "Children living in regions polluted by aluminum plant waste (sulfur dioxide, nitrogen dioxide, carbon monoxide, dust, hydrogen fluoride) developed specific abnormalities because of body poisoning with fluorides, namely, dental fluorosis, osteoporosis and osteosclerosis of the bones; periodontal diseases in these children were more incident than in controls. "
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6. Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA
7. Hexachlorobenzene (HCB)IBA
8. zoledronic acid (zoledronate)FDA Link
9. Bone Morphogenetic Protein ReceptorsIBA
10. SulfurIBA

Therapies and Procedures

1. Bone Marrow Transplantation (Transplantation, Bone Marrow)
2. Combination Drug Therapy (Combination Chemotherapy)
3. Osteotomy
4. Renal Dialysis (Hemodialysis)
5. Transplants (Transplant)

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for Osteosclerosis,
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