Osteoporosis

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11587 relevant articles (827 outcomes, 1560 trials/studies) found for this Disease

Description: Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.

Also Known As:

Age Related Osteoporosis; Age-Related Bone Loss; Age-Related Bone Losses; Age-Related Osteoporoses; Bone Loss, Age Related; Bone Losses, Age-Related; Osteoporoses; Osteoporoses, Age-Related; Osteoporoses, Senile; Osteoporosis, Age Related; Osteoporosis, Post Traumatic; Post-Traumatic Osteoporoses; Post-Traumatic Osteoporosis; Senile Osteoporoses; Age-Related Osteoporosis; Bone Loss, Age-Related; Osteoporosis, Age-Related; Osteoporosis, Post-Traumatic; Osteoporosis, Senile; Senile Osteoporosis

Relationship Network

Disease Context: Research Results

Musculoskeletal Diseases: 83

Bone Diseases: 2380

Metabolic Bone Diseases: 2312

Osteoporosis: 11587

Postmenopausal Osteoporosis: 1916

Female Athlete Triad Syndrome: 15

Related Diseases

1.	Breast Neoplasms (Breast Cancer)
2.	Metabolic Bone Diseases (Osteopenia)
3.	Bone Resorption
4.	Cardiovascular Diseases (Cardiovascular Disease)
5.	Neoplasms (Cancer)

Experts

1.	Ringe, J D: 17 articles (12/2007 - 06/2000)
2.	Iwamoto, Jun: 13 articles (02/2008 - 01/2002)
3.	Shiraki, Masataka: 13 articles (11/2007 - 03/2002)
4.	Takeda, Tsuyoshi: 12 articles (02/2008 - 01/2002)
5.	Miller, Paul D: 11 articles (03/2008 - 05/2002)
6.	Adami, S: 10 articles (01/2008 - 02/2000)
7.	Delmas, Pierre D: 9 articles (08/2008 - 08/2002)
8.	Uzawa, Mitsuyoshi: 9 articles (02/2008 - 01/2002)
9.	Rizzoli, R: 9 articles (02/2008 - 08/2000)
10.	Sato, Yoshihiro: 9 articles (02/2008 - 01/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Osteoporosis:

1.	DiphosphonatesIBA 09/01/2008 - "CONCLUSIONS: Osteoporosis treatment of high-risk women is cost-effective, with bisphosphonates providing the most benefit at lowest cost" 10/01/2001 - "Evidence from recent randomized controlled trials indicates that bisphosphonates are effective in the prevention of glucocorticoid-induced osteoporosis in men but the optimal criteria for selection of individuals for treatment requires further study." 08/01/2006 - "Bisphosphonates have proven efficacy, are widely available and currently recommended as the first-line of therapy for osteoporosis in many practice guidelines" 12/01/1994 - "The bisphosphonates show promise in this role, but the effects of the potent bisphosphonates in established osteoporosis have not yet been reported" 12/01/2006 - "The introduction of new bisphosphonates that can be taken weekly or even better monthly, has improved notably the adherence and compliance to osteoporosis treatment." Order ALL the reference details at left...
2.	Estrogens (Estrogen)FDA Link 01/01/2008 - "Because of the striking resemblance of skeletal responses in humans and rats in the state of estrogen deficiency, the ovx rat is considered to be a gold standard model for evaluating drugs for prevention and reversal of osteoporosis" 09/01/2001 - "Estrogen, especially when begun early in menopause, has been shown to be beneficial in the prevention and treatment of osteoporosis" 01/01/2000 - "Lower-dose combinations of continuous combined estrogen-progestin regimens are effective in increasing and maintaining BMD and provide a good endometrial safety profile for the long-term prevention of osteoporosis in postmenopausal women." 03/01/1988 - "Progestin supplementation also may augment the beneficial effects of estrogens in providing protection against osteoporosis, although this effect is not yet well established" 03/01/1988 - "On balance, estrogen therapy appears to be beneficial for menopausal women, as it probably reduces the risks of CAD and osteoporosis, two of the major causes of mortality and morbidity" Order ALL the reference details at left...
3.	CalciumIBA 04/01/2006 - "The "critical period model" within the life course construct is operative for calcium, a nutrient for which adequate intake is critically important during adolescence when peak bone density development, necessary for later protection against osteoporosis, is important." 03/01/1994 - "Optimal calcium intakes are desirable for prevention or treatment of osteoporosis, but the safety and efficacy of some calcium supplements used to achieve such intakes have been questioned" 11/01/1989 - "The results of this study support previous work which has indicated that supplemental calcium may be beneficial in combatting age-related bone loss." 03/01/2008 - "Modification of eating pattern by promotion of increased consumption of locally available calcium rich food may be beneficial for prevention of osteoporosis among this population." 09/01/2005 - "Our results strengthen the hypothesis that high calcium intake combined with adequate protein intake based on a high ratio of vegetable to animal protein may be protective against osteoporosis." Order ALL the reference details at left...
4.	Alendronate (Alendronate Sodium)FDA LinkGeneric 07/01/2000 - "Recent results from the first megatrial of osteoporosis with >6400 participants, the Fracture Intervention Trial (FIT), have provided important advances in our understanding of osteoporosis and the efficacy of alendronate" 01/01/2000 - "As there are no proven safe and effective treatments available for men with osteoporosis, we compared the effects of alendronate (10 mg/day) on BMD, measured using dual-energy X-ray absorptiometry, in a 12-month prospective, controlled, open label study involving (i) men with primary (n = 23) or secondary osteoporosis (n = 18), (ii) postmenopausal women with primary (n = 18) or secondary (n = 21) osteoporosis, and (iii) 29 male and 14 female untreated controls matched by age, height and weight" 07/01/2006 - "Although alendronate treatment for the prevention of osteoporotic fracture has been considered to be first line treatment, there is little knowledge whether very old osteoporosis should be treated with alendronate or not" 11/01/2003 - "Alendronate (bisphosphonate) has proven its efficacy for the treatment of osteoporosis of the lumbar spine and femoral neck" 07/01/2001 - "In summary, this is the first report indicating that treatment with alendronate was able to significantly increase BMD at the lumbar spine in GHD patients with osteoporosis receiving stable rhGH replacement for 4 yr. This increase was significantly greater in alendronate-treated patients than in patients maintained on rhGH" Order ALL the reference details at left...
5.	Calcitonin (Calcitonin, Eel)FDA Link 09/01/1994 - "Drugs that inhibit bone turnover, such as calcitonin, appear to be effective in increasing bone mass for 1.5 to 2 years, about the time it would take to replenish the remodeling space in a patient with high turnover osteoporosis" 10/01/1987 - "This type of treatment regime, with its calcitonin-like effect, might be effective in reducing net bone loss due to imbalance between bone formation and resorption at the BMU level, particularly in patients with increased numbers of BMUs ('high turnover' osteoporosis).(ABSTRACT TRUNCATED AT 250 WORDS)" 11/01/1999 - "These results suggest that the therapeutic efficacy of BPs or calcitonin in diseases such as glucocorticoid-induced osteoporosis may be due, in part, to their ability to prevent osteocyte and osteoblast apoptosis." 06/07/1992 - "Intermittent administration of low-dose calcitonin, especially together with an anabolic steroid seems to be a safe and effective therapy in established osteoporosis." 01/01/2000 - "Efficacy of calcitonin for fracture prevention in steroid-induced osteoporosis remains to be established." Order ALL the reference details at left...
6.	Vitamin D FDA LinkGeneric 06/01/2005 - "CONCLUSIONS: More than half of North American women receiving therapy to treat or prevent osteoporosis have vitamin D inadequacy, underscoring the need for improved physician and public education regarding optimization of vitamin D status in this population." 01/01/1997 - "Although vitamin D supplementation decreases bone loss and fracture risk in the frail elderly, vitamin D metabolites may prove more useful in the treatment of elderly women with vertebral osteoporosis." 04/01/2005 - "Recently, vitamin D metabolites have been internationally recognized to be effective for osteoporosis" 12/01/2004 - "Moreover, it is widely accepted that diabetes may induce osteoporosis, but the efficacy of vitamin D on diabetic osteoporosis is not clear" 02/01/2003 - "Some misunderstandings exist internationally about the efficacy of the active form of vitamin D for the treatment of osteoporosis" Order ALL the reference details at left...
7.	Raloxifene (Evista)FDA Link 07/01/2007 - "CONCLUSIONS: In postmenopausal women with osteoporosis, low-dose HRT produced significantly greater increases in BMD of the lumbar spine and total body and greater decreases in bone turnover than raloxifene at 12 months." 02/01/2006 - "The definite anti-fracture efficacy of raloxifene at the spine, its plausible effect on non-spine fracture in high-risk patients and its beneficial effect on breast and heart make this compound an interesting approach for women presenting with osteoporosis" 01/01/2006 - "In conclusion, raloxifene treatment at 60 mg/day for 1 year resulted in a significant reduction in the risk of new clinical vertebral fractures and any new clinical fracture in postmenopausal Asian women with osteoporosis." 08/01/2000 - "In randomised placebo-controlled studies involving postmenopausal women or patients with osteoporosis, raloxifene 60 to 150 mg/day was effective in increasing bone mineral density (BMD) over 12- to 36-month periods" 01/01/2004 - "Raloxifene, a selective oestrogen receptor modulator, is effective in the treatment of osteoporosis without stimulating the breast and the endometrium" Order ALL the reference details at left...
8.	HormonesIBA 01/01/2002 - "Our recent findings suggest that dried plums, a rich source of phenolic and flavonoid compounds, are highly effective in modulating bone mass in an ovarian hormone-deficient rat model of osteoporosis" 11/01/2002 - "Hormone replacement treatment (HRT) is beneficial for correction of sexual symptoms and osteoporosis in both sexes, especially in females" 10/01/2007 - "The advice that the lowest dose of hormone therapy should be given for the shortest possible time and that hormone therapy should no longer be a first-line treatment for osteoporosis has lead to a major shift in prescribing practice" 03/01/2004 - "Following American randomised controlled epidemiologic studies (HERS, WHI), regulatory authorities have advised that postmenopausal hormone therapy, using minimal effective dosages, is indicated for the first line treatment of climacteric symptoms during a limited, and problem-related period of time, and for second line prevention of osteoporosis when a non-hormonal treatment cannot be used" 05/01/2003 - "It is clear that hormone therapy is effective for postmenopausal symptoms and osteoporosis prevention" Order ALL the reference details at left...
9.	risedronic acid (risedronate)FDA LinkGeneric 06/01/2006 - "In the present study, oral administration of risedronate apparently prevented vertebral fractures by increasing lumbar BMD and caused a significant reduction in urinary NTX levels, while oral administration of placebo did not increase the lumbar BMD and prevent vertebral fractures due to osteoporosis" 06/01/2008 - "RESULTS: Monotherapy with alfacarcidol was effective for secondary osteoporosis in children, but when used in combination with risedronate it was even more effective in improving BMD" 01/01/2006 - "CONCLUSIONS: At a hypothetical threshold value of euro 40,000 per QALY gained, the results in this study indicate that risedronate is a cost-effective treatment in elderly women at the threshold of osteoporosis (i.e., a T-score of -2.5) with prevalent vertebral fractures in Sweden, Finland, Belgium, and Spain." 01/01/2006 - "Based on cost per QALY gained threshold values found in the literature, the study results indicated risedronate to be cost effective in the treatment of elderly women with established osteoporosis in all the included countries" 06/01/2002 - "Risedronate, a pyridinyl bisphosphonate, has been shown in large clinical trials to be effective in the prevention and treatment of osteoporosis" Order ALL the reference details at left...
10.	Etidronic Acid (HEDP)FDA LinkGeneric 12/15/1994 - "Etidronate may be especially beneficial in severe osteoporosis with marked loss of bone and multiple vertebral crush fractures" 06/01/1997 - "CONCLUSION: The effect of combination treatment with NaF and etidronate on the BMD of the lumbar spine in corticosteroid treated patients with established osteoporosis is superior to that of etidronate alone." 01/01/2003 - "There were fewer new fractures in group 2 than in group 1. CONCLUSION: Treatment with etidronate is effective in patients with glucocorticoid-induced osteoporosis." 08/01/2002 - "CONCLUSION: It was shown that cyclical etidronate therapy is effective for steroid induced osteoporosis." 01/01/2000 - "The findings indicated cyclical/intermittent etidronate therapy is effective in preventing corticosteroid-induced osteoporosis." Order ALL the reference details at left...

Therapies and Procedures

1.	Hormone Replacement Therapy (Therapy, Hormone Replacement) 03/28/2003 - "Therefore, when considering the reasons for prescribing hormone replacement therapy in this population, protection against osteoporosis will for most women be the prime consideration." 03/01/2002 - "New evidence suggests hormone replacement therapy (HRT) may not be the best option for the prevention and treatment of osteoporosis after all, leaving clinicians to reconsider their recommendations to patients with or at risk of the devastating disease." 11/08/1989 - "Recent advances in the techniques for measuring bone mass and the advent of hormone replacement therapy have markedly improved the outlook for patients with osteoporosis" 11/01/2000 - "Hormone replacement therapy (HRT) has been shown to be beneficial in reducing osteoporosis and alleviating climacteric symptoms" 01/01/2007 - "These drugs have been shown to be comparably effective to conventional hormone replacement therapy in animal models of osteoporosis, with potential indications for an improved safety profile" Order ALL the reference details at left...
2.	Estrogen Replacement Therapy 10/01/1999 - "BACKGROUND: Estrogen replacement therapy is increasingly used by perimenopausal and postmenopausal women for management of menopausal symptoms and for long-term protection against osteoporosis and arterial disease" 10/01/2000 - "Observational studies do not suggest any superiority of a given progestogen regarding cardiovascular risk, prevention of osteoporosis, and cognitive function in postmenopausal women on estrogen replacement therapy" 03/01/1990 - "Although clinicians and policy groups have advocated estrogen replacement therapy and other clinical measures to prevent osteoporosis, few studies have assessed whether these measures are being adopted by physicians in practice" 01/01/2007 - "Use of estrogen-replacement therapy in menopause--secondary prevention of osteoporosis]" 12/01/2006 - "Although estrogen replacement has been the main therapy to prevent and treat osteoporosis, there are concerns about its safety" Order ALL the reference details at left...
3.	Ovariectomy (Oophorectomy) 01/01/2007 - "We investigated whether treatments with beta-blockers or other administrations that have similar actions to beta-blockers, such as Chinese herbs or needling, were effective in treating osteoporosis induced by ovariectomy (OVX)" 01/01/2004 - "The flavonoid extract from Epimedium sagittatum (FES) has been found by us to be effective in preventing osteoporosis induced by ovariectomy in rats" 10/01/1999 - "OBJECTIVE: To investigate the efficacy of Chinese recipe of replenishing Kidney and activating blood circulation (RKABC) in female rats with osteoporosis induced by ovariectomy" 10/01/1999 - "Efficacy of Chinese recipes of replenishing kidney and activating blood circulation in female rats with osteoporosis induced by ovariectomy]" 06/01/2007 - "In order to study the effect of ovariectomy on the capacity of rat MSCs' differentiation into adipocytes, we established the animal models of osteoporosis by performing ovariectomy on the 3-months-old and 6-month-old female SD rats" Order ALL the reference details at left...
4.	Drug Therapy (Chemotherapy) 10/01/2007 - "The use of osteoporosis pharmacotherapy or hip protectors improved by 8.0% in the intervention group and 0.6% in the control group, but the difference was not statistically significant (P=.72)" 04/01/2002 - "OBJECTIVE: Because of the limited efficacy of available agents and to limit toxicity, there is considerable interest in combination pharmacotherapy for osteoporosis" 02/01/2001 - "The efficacy of drug therapies for osteoporosis in men requires greater attention" 01/01/2006 - "In 69.2% of the cases a new diagnosis was the reason for starting a new medication, followed by osteoporosis prophylaxis (15.0%) and improvement in pharmacotherapy (10.6%)" 12/01/2005 - "In some cases, such as idiopathic juvenile osteoporosis, the rule is spontaneous resolution, and the advisability of an aggressive drug therapy is discussed." Order ALL the reference details at left...
5.	Transplantation (Transplant Recipients) 04/01/2005 - "With the rapid increase in the number of organs transplanted worldwide and the improved survival of transplant recipients, osteoporosis has emerged as a frequent complication of the transplantation process" 08/01/2007 - "Daily bisphosphonate is effective in preventing and treating corticosteroid-induced osteoporosis in renal transplant recipients, although it frequently has gastrointestinal side effects" 03/01/2007 - "Improved survival rates have been accompanied by increased recognition of previously neglected long-term complications of transplantation such as fractures and osteoporosis" 08/01/2000 - "Osteoporosis, defined as a bone mineral density T score below -2.5, was present in 39% of patients prior to transplantation, but bone mineral density was not helpful in predicting incident fracture, whether measured before or after transplantation" 01/01/2008 - "This study was carried out to evaluate the bone health and risk factors for osteoporosis and fractures in 40 pediatric liver transplant recipients" Order ALL the reference details at left...

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