Osteonecrosis (Kienbock's Disease)

Death of a bone or part of a bone, either atraumatic or posttraumatic.
Also Known As:
Kienbock's Disease; Kienbock Disease; Kienboeck Disease; Kienboeck's Disease; Bone Aseptic Necrosis; Bone Avascular Necrosis; Kienboecks Disease; Osteonecroses; Aseptic Necrosis of Bone; Avascular Necrosis of Bone; Necrosis, Aseptic, of Bone; Necrosis, Avascular, of Bone
Networked: 3149 relevant articles (112 outcomes, 363 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Osteoarthritis
2. Pain (Aches)
3. Infection
4. Sickle Cell Anemia (Hemoglobin S Disease)
5. Joint Diseases (Joint Disease)


1. Mont, Michael A: 28 articles (10/2015 - 04/2002)
2. Yamamoto, Takuaki: 22 articles (12/2015 - 10/2004)
3. Iwamoto, Yukihide: 22 articles (12/2015 - 10/2004)
4. Otto, Sven: 19 articles (08/2015 - 03/2009)
5. Vescovi, Paolo: 18 articles (08/2015 - 12/2007)
6. Glueck, Charles J: 17 articles (12/2015 - 04/2003)
7. Motomura, Goro: 17 articles (12/2015 - 10/2004)
8. Wang, Ping: 16 articles (12/2015 - 04/2003)
9. Pautke, Christoph: 16 articles (07/2015 - 01/2010)
10. Kubo, Toshikazu: 15 articles (07/2015 - 01/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Osteonecrosis:
1. DiphosphonatesIBA
2. zoledronic acid (zoledronate)FDA Link
3. OxygenIBA
4. Alendronate (Alendronate Sodium)FDA LinkGeneric
5. Adrenal Cortex Hormones (Corticosteroids)IBA
6. Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
7. NitrogenIBA
8. pamidronate (APD)FDA LinkGeneric
9. Lovastatin (Mevacor)FDA LinkGeneric
10. TantalumIBA

Therapies and Procedures

1. Decompression
2. Arthroplasty
10/07/2015 - "Prospective, multicenter, randomized trials are needed to evaluate the efficacy of these regimens in altering the natural history of the disease.➤ Joint-preserving procedures are indicated in the treatment of precollapse disease, with several studies showing successful outcomes at mid-term and long-term follow-up.➤ Studies of total joint arthroplasty, once femoral head collapse is present, have described excellent outcomes at greater than ten years of follow-up, which is a major advance and has led to a paradigm shift in treating these patients.➤ The results of hemiresurfacing and total resurfacing arthroplasty have been suboptimal, and these procedures have restricted indications in patients with osteonecrosis of the femoral head. "
03/01/2013 - "To investigate the curative efficacy of osteonecrosis of the femoral head (ONFH) in a hip-preserving operative approach, by grafting a vascularized greater trochanter flap combined with a free iliac flap, in an attempt to seek an innovative approach for patients who suffered middle to late stage ONFH without total hip arthroplasty (THA) surgery. "
11/01/2006 - "Although the outcomes of patients who have total knee arthroplasty for the treatment of spontaneous osteonecrosis of the knee have historically been favorable, such outcomes have also shown particular improvement in the studies from more recent operative periods. "
11/01/2006 - "Total knee arthroplasty performed as treatment for either secondary osteonecrosis or spontaneous osteonecrosis and unicompartmental knee arthroplasty performed as treatment for spontaneous osteonecrosis were associated with improved outcomes in cohorts with more recent operative dates. "
01/01/2015 - "Management of osteonecrosis of the hip with resurfacing arthroplasty seems to be effective in strictly-selected patients."
3. Transplants (Transplant)
4. Osteotomy
5. Transplantation (Transplant Recipients)