Osteonecrosis (Kienbock's Disease)

Death of a bone or part of a bone, either atraumatic or posttraumatic.

Also Known As:

Kienbock's Disease; Kienbock Disease; Bone Necrosis; Kienboeck Disease; Kienboeck's Disease; Bone Aseptic Necrosis; Bone Avascular Necrosis; Bone Necroses; Kienboecks Disease; Necroses, Bone; Necrosis, Bone; Osteonecroses; Aseptic Necrosis of Bone; Avascular Necrosis of Bone; Necrosis, Aseptic, of Bone; Necrosis, Avascular, of Bone

Networked: 7150 relevant articles (300 outcomes, 980 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pain (Aches)
2.	Osteoarthritis
3.	Osteoporosis
4.	Sickle Cell Anemia (Hemoglobin S Disease)
5.	Neoplasms (Cancer)

Experts

1.	Mont, Michael A: 51 articles (06/2021 - 04/2002)
2.	Sun, Wei: 44 articles (01/2022 - 12/2004)
3.	Yamamoto, Takuaki: 43 articles (01/2022 - 06/2002)
4.	He, Wei: 37 articles (06/2022 - 10/2008)
5.	Motomura, Goro: 37 articles (01/2022 - 10/2004)
6.	Hernigou, Philippe: 34 articles (01/2022 - 12/2002)
7.	Iwamoto, Yukihide: 34 articles (01/2018 - 06/2002)
8.	Qin, Ling: 28 articles (03/2022 - 03/2008)
9.	Zhao, Dewei: 27 articles (09/2022 - 03/2011)
10.	Wang, Kunzheng: 27 articles (04/2022 - 03/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Osteonecrosis:

1.	Diphosphonates (Bisphosphonates)IBA 05/01/2015 - "Despite the widespread use of bisphosphonates and their unequivocal efficacy for the treatment of various disease states, osteonecrosis of the jaw remains one of the most feared complications associated with their use. " 01/01/2013 - "At present, there is no effective treatment for bisphosphonate induced osteonecrosis, so prevention is extremely important. " 01/01/2010 - "At present, there is no effective treatment for bisphosphonate induced osteonecrosis, so prevention is extremely important. " 10/01/2021 - "Bisphosphonates are proven to be effective in obviating the need for surgical intervention in osteonecrosis of the femoral head. " 12/01/2008 - "The use of bisphosphonates (BPs) has proven effective in the treatment of bone-related diseases, despite the potential risk of developing osteonecrosis of the jaw (ONJ). "
2.	SteroidsIBA 04/18/2023 - "Therefore, clarifying its pathogenesis and providing early and effective treatment for steroid osteonecrosis is important. " 01/01/2016 - "The product, PTA seeded with BMMSCs, was successfully produced, and was determined as high efficacy for treatment of steroid-associated osteonecrosis. " 07/01/2012 - "We investigated whether PTX could be beneficial for femoral head osteonecrosis associated with steroid through these effects. " 09/29/2011 - "Pulsed electromagnetic fields (PEMF) stimulation has been used successfully to treat nonunion fractures and femoral head osteonecrosis, but relatively little is known about its effects on preventing steroid-induced osteonecrosis. " 03/01/1995 - "Reported here is a case of steroid-induced osteonecrosis of the lateral femoral condyle that, according to preliminary results, was treated successfully with a vascularized bone and periosteal graft."
3.	GlucocorticoidsIBA 04/01/2014 - "The present study was implemented to evaluate these anti-apoptotic and tissue-protective effects in glucocorticoid-induced osteonecrosis in rats. " 12/01/2020 - "Administration of mircoRNA-135b-reinforced exosomes derived from MSCs ameliorates glucocorticoid-induced osteonecrosis of femoral head (ONFH) in rats." 06/01/2009 - "The objective of this paper was to assess the efficacy of cementation of the femoral head in stage III glucocorticoid-induced osteonecrosis. " 10/01/2023 - "This study aimed to investigate the pathogenic factors of glucocorticoids (GCs)-induced osteonecrosis of the femoral head (GONFH) and its underlying pathogenesis in vivo and in vitro. " 03/23/2023 - "Histopathologically, our in vivo study showed that DMOG not only alleviated glucocorticoid-induced osteonecrosis but also promoted angiogenesis and osteogenesis in the femoral head as detected by microcomputed tomography (Micro-CT) analysis and histological staining of OCN, TRAP, and Factor Ⅷ. "
4.	Teriparatide (Parathar)FDA Link 01/01/2016 - "Teriparatide had positive effects in preventing osteonecrosis; therefore, teriparatide could be an effective agent for MRONJ." 03/01/2020 - "Teriparatide (TPTD) treatment for Stage II-III medication-related osteonecrosis of the jaw (MRONJ) in osteoporotic patients has yielded promising results in uncontrolled studies. " 11/01/2016 - "Efficacy of Short-term Teriparatide for Hip Osteonecrosis." 10/01/2020 - "Teriparatide Promotes Bone Healing in Medication-Related Osteonecrosis of the Jaw: A Placebo-Controlled, Randomized Trial." 01/01/2016 - "Histopathological Effects of Teriparatide in Medication-Related Osteonecrosis of the Jaw: An Animal Study."
5.	Alendronate (Alendronate Sodium)FDA LinkGeneric 01/01/2015 - "Comment on "Efficacy of Alendronate for Preventing Collapse of Femoral Head in Adult Patients with Nontraumatic Osteonecrosis"." 01/01/2014 - "The purpose of the current review was to determine the efficacy of alendronate for preventing collapse of femoral head in adult patients with nontraumatic avascular osteonecrosis of femoral head (ANFH). " 01/01/2014 - "Efficacy of alendronate for preventing collapse of femoral head in adult patients with nontraumatic osteonecrosis." 12/01/2013 - "Studies concerning prognostic factors specific for alendronate-related osteonecrosis of the jaws (ONJ) are rare. " 05/01/2012 - "Alendronate in the prevention of collapse of the femoral head in nontraumatic osteonecrosis: a two-year multicenter, prospective, randomized, double-blind, placebo-controlled study."
6.	Adrenal Cortex Hormones (Corticosteroids)IBA 01/01/2008 - "Most patients had received corticosteroids, had femoral head involvement and had delayed onset of osteonecrosis. " 01/01/2018 - "This is a multicentre, randomised, double-blind, placebo-controlled clinical trial to investigate the safety and efficacy of Chinese herbal Fufang Xian Ling Gu Bao (XLGB) with antiadipogenic compounds for the prevention of corticosteroid (CS)-induced osteonecrosis of femoral head (ONFH). " 09/01/2023 - "This study has shown us that femoral head osteonecrosis can be reliably induced with LPS and corticosteroid, as described in the literature. " 09/01/2022 - "While some studies report the development of post-COVID-19 osteonecrosis after lower doses of corticosteroids and sooner after their administration than in comparable non-COVID-19 cases, our study is the first to report 2 cases with no corticosteroid administration at all. " 05/28/2020 - "Next, 12 consecutive patients with bilateral symptomatic secondary (corticosteroids) osteonecrosis without collapse were included in a clinical prospective, randomized, controlled study. "
7.	Oxygen (Dioxygen)IBA 03/01/2015 - "The authors concluded that hyperbaric oxygen treatment is effective in preserving the hip joint in stage I and II osteonecrosis of the femoral head." 07/01/1993 - "The clinical and dental records of 26 patients with the clinical diagnosis of postradiation osteonecrosis (PRON) managed with hyperbaric oxygen (HBO) were reviewed to determine the efficacy of HBO. " 04/21/2021 - "Collectively, the present study developed a novel oxygen slow-releasing composite scaffold, which can facilitate tissue engineering efficiency for treating the osteonecrosis of the femoral head by enhancing the angiogenesis and survival of grafted stem cells." 01/01/2021 - "Decrease in dysbaric osteonecrosis severity as a result of 45-minute oxygen pre-breathe." 03/01/2015 - "Hyperbaric oxygen for stage I and II femoral head osteonecrosis."
8.	Zoledronic Acid (Zometa)FDA Link 12/01/2007 - "Possible delayed onset of osteonecrosis of the jaw in association with zoledronic acid." 11/01/2023 - "This study aimed to analyze the physicochemical properties of mineralized tissues in a zoledronate (ZA)-related osteonecrosis mouse model, by a 2 × 2-factorial design, considering sex (female/male) and treatment (ZA/Saline) factors (n = 8/group). " 09/20/2023 - "The aim of the present study was to correlate the immune response with etiopathogenic factors via immunohistochemical evaluation of the maxillary tissues in zoledronic acid osteonecrosis. " 11/11/2021 - "(1) Background: The aim of this study was to test whether matrix-bound zoledronate (zol) molecules enhanced the oral biofilm colonization of a mineralized matrix, rendering the alveolar bone more susceptible to medication-related osteonecrosis of the jaw (MRONJ) following invasive dental procedures. " 01/01/2020 - "This study aims to evaluate bone repair and the development of the medication related osteonecrosis of the jaw (MRONJ) associated with the use of zoledronic acid in Wistar rats. "
9.	TantalumIBA 12/01/2021 - "Efficacy of tantalum rod insertion for preventing femoral head collapse in osteonecrosis in a paediatric population: a pilot study." 11/01/2020 - "Outcomes of conversion THA after failed porous tantalum implant for osteonecrosis of the femoral head: a comparative matched study." 07/01/2016 - "The purpose of this study was to evaluate the moderate survival data of porous tantalum rod implants for the treatment of osteonecrosis of the femoral head (ONFH). " 11/18/2015 - "To study a modified porous tantalum technique for the treatment of osteonecrosis of the femoral head. " 10/20/2014 - "This study evaluated the outcomes of using porous tantalum rods for the treatment of osteonecrosis of the femoral head (ONFH). "
10.	Therapeutic UsesIBA 01/01/2021 - "We aimed to identify the pro-angiogenic and osteogenic efficacy of adipose tissue-derived (AD) pericytes combined with Nel-like protein-1 (NELL-1) to investigate the therapeutic effects on osteonecrosis. " 01/01/2021 - "Various clinical practices have confirmed the therapeutic effect of BTP on osteonecrosis of the femoral head (ONFH), but little attention has been paid to the study of its bioactive ingredients and related mechanisms of action. " 02/01/2016 - "Thus, our study suggests that autologous bone marrow stem cells implantation has a good therapeutic effect on osteonecrosis of the femoral, resulting in beneficial clinical outcomes. " 11/01/2022 - "Therapeutic effect of human umbilical cord mesenchymal stem cells in early traumatic osteonecrosis of the femoral head." 12/01/2020 - "Exosomes were found to exert a therapeutic effect in the treatment of osteonecrosis of the femoral head (ONFH), while miR-135b was shown to play an important role in the development of ONFH. "

Therapies and Procedures

1.	Decompression 06/01/2023 - "Core decompression (CD) is beneficial in the early stage of osteonecrosis of the femoral head (ONFH). " 01/01/2018 - "While many treatment options for talar osteonecrosis exist, core decompression is suggested on young patients with good outcome results. " 10/01/2023 - "Core decompression is superior to nonoperative management for humeral head osteonecrosis: a systematic review." 01/01/2018 - "Core decompression (CD) may be effective when performed during the early stages of osteonecrosis of the femoral head (ONFH). " 05/01/2008 - "Our study confirms core decompression is a safe and effective procedure for treating early stage femoral head osteonecrosis."
2.	Therapeutics 01/01/2009 - "NMT therapy provides a safe and potentially effective treatment for jawbone osteonecrosis. " 01/01/2021 - "Thus, combinatorial therapy using AD pericytes and NELL-1 may have potential as a novel treatment for osteonecrosis." 01/01/2022 - "Surgical Therapy in Patients With Medication-Related Osteonecrosis of the Jaw Is Associated With Disease Resolution and Improved Quality of Life: A Prospective Cohort Study." 10/01/2021 - "Mesenchymal stem cell therapy improved outcome of early post-traumatic shoulder osteonecrosis: a prospective randomized clinical study of fifty patients with over ten year follow-up." 01/29/2020 - "Correlation between the efficacy of stem cell therapy for osteonecrosis of the femoral head and cell viability."
3.	Hip Replacement Arthroplasty (Total Hip Replacement) 03/01/2013 - "To investigate the curative efficacy of osteonecrosis of the femoral head (ONFH) in a hip-preserving operative approach, by grafting a vascularized greater trochanter flap combined with a free iliac flap, in an attempt to seek an innovative approach for patients who suffered middle to late stage ONFH without total hip arthroplasty (THA) surgery. " 06/12/2021 - "To determine whether multiple drilling is effective in postponing the need for total hip arthroplasty (THA) in early-stage nontraumatic osteonecrosis of the femoral head (ONFH). " 01/01/2020 - "The mainstay of treatment for traumatic pediatric osteonecrosis is hip preservation with total hip arthroplasty being reserved as a salvage procedure. " 12/01/2004 - "It may be effective in delaying the need for total hip arthroplasty in young patients with early (precollapse) stages of femoral head osteonecrosis." 02/01/2016 - "We searched the PubMed, Embase and Web of Science databases and included all case-control trials that reported on the clinical outcomes of osteonecrosis progression, incidence of total hip arthroplasty and improvement in Harris hip scores. "
4.	Transplantation 04/01/2008 - "Transplantation of BMMNCs may be a beneficial treatment for bone repair in the condition of osteonecrosis." 05/01/2022 - "Purpose The purpose is to compare the therapeutic efficacy of concentrated autologous bone marrow aspirate transplantation (CABMAT) with that of observation alone for osteonecrosis of the femoral head (ONFH). " 01/01/2020 - "Autologous peripheral blood stem cell (auto-PBSC) transplantation is an effective therapeutic for the osteonecrosis of the femoral head (ONFH) but without prognosis estimation. " 02/25/2008 - "Although our experience is limited to one patient, autologous cultured osteoblast transplantation appears to be effective for treating the osteonecrosis of femoral head." 02/01/2023 - "This study evaluated the efficacy and safety of a novel treatment for osteonecrosis, in which concentrated autologous bone marrow aspirate transplantation (CABMAT) is followed by low-intensity pulsed ultrasound (LIPUS) stimulation for 3 months. "
5.	Bone Transplantation (Bone Grafting) 01/01/2010 - "Free fibular bone grafting is an effective treatment for early osteonecrosis of the femoral head in young patients. " 02/01/2003 - "Vascularized iliac bone grafting is effective for the treatment of osteonecrosis of the femoral head in short and middle term. " 01/01/2020 - "PRP-incorporated autologous granular bone grafting is a safe and effective procedure for treatment in the precollapse stages (Association of Research Circulation Osseous stage II-III) of posttraumatic osteonecrosis of the femoral head." 01/01/1998 - "Eleven patients with stage II and IIIA Kienbock's disease treated with vascular pedicle implantation and bone grafting were reviewed to determine the long term efficacy of the procedure. " 01/01/2021 - "This study aims to investigate the long-term results of vascularized iliac bone grafting (VIBG) for osteonecrosis of the femoral head (ONFH). "