HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Osteoid Osteoma

Subscribe to New Research on Osteoid Osteoma

Benign circumscribed tumor of spongy bone occurring especially in the bones of the extremities and vertebrae, most often in young persons. (Dorland, 27th ed)

Also Known As:

Osteoma, Osteoid; Osteoid Osteomas; Osteomas, Osteoid

Networked: 148 relevant articles (15 outcomes, 14 trials/studies) for this Disease, Comments

Relationship Network

Disease Context: Research Results

Neoplasms: 421329
- Neoplasms by Histologic Type: 1
  - Connective and Soft Tissue Neoplasms
    - Connective Tissue Neoplasms: 6
      - Bone Tissue Neoplasms: 1
        Osteoma: 169
        Osteoid Osteoma: 148

Related Diseases

1.	Pain (Aches)
2.	Neoplasms (Cancer)
3.	Osteoblastoma
4.	Arthritis (Polyarthritis)
5.	Synovitis

Experts

1.	Vanderschueren, Geert M: 4 articles (04/2009 - 07/2002)
2.	Taminiau, Antoni H M: 4 articles (04/2009 - 07/2002)
3.	Obermann, Wim R: 4 articles (04/2009 - 07/2002)
4.	Bloem, Johan L: 4 articles (04/2009 - 07/2002)
5.	Laredo, Jean-Denis: 3 articles (01/2010 - 11/2008)
6.	Zouari, Leila: 2 articles (01/2010 - 11/2008)
7.	Roqueplan, François: 2 articles (01/2010 - 11/2008)
8.	Hamzé, Bassam: 2 articles (01/2010 - 11/2008)
9.	Bousson, Valérie: 2 articles (01/2010 - 11/2008)
10.	Martel, José: 2 articles (09/2009 - 12/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Osteoid Osteoma:

1.	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 05/01/1999 - "CONCLUSIONS: Occipital pain in adolescents, which is relieved by aspirin, should raise suspicion about the possibility of an osteoid osteoma of the atlas. " 01/01/1991 - "Osteoid osteoma is a tumour of bone characterised by pain which is relieved by aspirin and nonsteroidal anti-inflammatory drugs. " 02/01/1997 - "In the diagnosis of osteoid osteoma, a history of relief of pain with aspirin is important. " 09/01/1985 - "A case involving a 29-year-old female with aspirin allergy who exhibited osteoid osteoma at the distal phalanx of the hallux is presented. " 02/01/1998 - "Osteoid osteomas are benign bone-forming tumors that despite their small size (<2.0 cm) characteristically produce severe nocturnal bone pain that is relieved by aspirin. " Order ALL the reference details at left...
2.	SalicylatesIBA 01/01/2003 - "Most patients who have osteoid osteoma have a history of pain in a limb, that is characteristically worse at night and is relieved dramatically by salicylates. " 05/01/2006 - "We report a case of osteoid osteoma of the coccyx in a young man who consulted for sacrococcygeal pain partially relieved with salicylates. " 08/01/2001 - "OBJECTIVE: Osteoid osteoma mostly presents with a poorly localized pain that is worst at night and characteristically relieved by salicylates. " 03/01/2000 - "The osteoid osteoma is characterized by its nocturnal pain and relief of pain at therapy with salicylates. " 01/01/1992 - "The authors report a case of an osteoid osteoma of the femoral neck in a child, aged 3 1/2. This is a benign bone tumor, frequently painful with variable relief obtained with salicylates. " Order ALL the reference details at left...
3.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 03/01/2008 - "Remission could be achieved in both patients following treatment with nonsteroidal antiinflammatory drugs (NSAIDs).In addition to the typical sites at the long bones of the lower extremity, osteoid osteomas can also localize to other sites such as fingers. " 12/01/2002 - "CONCLUSIONS: The natural history of osteoid osteoma is self-limited so patients should be offered nonoperative treatment, reserving ablative treatment for those who are unable or unwilling to take NSAIDs until their symptoms resolve." 05/01/1993 - "Osteoid osteoma is a benign bone tumour characterized by pain which is relieved by non-steroidal anti-inflammatory drugs (NSAIDs), such as aspirin. " 02/01/1983 - "Osteoid osteoma is a benign bone tumor occurring primarily in patients under the age of 30 yr. Bone pain at night and relief by aspirin or other nonsteroidal antiinflammatory agents is a common symptom complex. " 01/01/2002 - "Since the cyclooxygenases are thought to be the source of these prostaglandins, and the central target of NSAIDs, we evaluated the expression of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) in osteoid osteoma tissues from patients following surgery. " Order ALL the reference details at left...
4.	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 12/01/2001 - "To study the mechanism and pathophysiology of the development of intramedullary high intensity areas on T2-weighted magnetic resonance images (MRI) in cases of osteoid osteoma, we examined the expression of cyclooxygenase-2 (COX-2) in the nidus and surrounding bone tissues. " 12/01/2001 - "Cyclooxygenase-2 inhibitor for pain management in osteoid osteoma." 10/01/2000 - "Intraarticular osteoid osteoma associated with synovitis: a possible role of cyclooxygenase-2 expression by osteoblasts in the nidus." 11/01/2004 - "In a prospective study, nine patients with osteoid osteoma were treated with a selective cyclooxygenase-2 inhibitor (rofecoxib). " 12/01/2001 - "Thirteen patients with osteoid osteoma were enrolled in a prospective trial to test whether rofecoxib, a selective cyclooxygenase-2 inhibitor, is as effective for pain control as acetylsalicylic acid. " Order ALL the reference details at left...
5.	rofecoxib (Vioxx)FDA Link 12/01/2001 - "Conservative medical treatment with rofecoxib for osteoid osteoma is recommended when percutaneous intervention is associated with significant morbidity." 11/01/2004 - "Effect of rofecoxib on pain caused by osteoid osteoma." 11/01/2004 - "In a prospective study, nine patients with osteoid osteoma were treated with a selective cyclooxygenase-2 inhibitor (rofecoxib). " 12/01/2001 - "Thirteen patients with osteoid osteoma were enrolled in a prospective trial to test whether rofecoxib, a selective cyclooxygenase-2 inhibitor, is as effective for pain control as acetylsalicylic acid. " 12/01/2001 - "Results of the current study suggest that pain induction in osteoid osteoma is related to cyclooxygenase-2, an enzyme that is blocked by acetylsalicylic acid and rofecoxib. " Order ALL the reference details at left...
6.	Prostaglandin Antagonists (Prostaglandin Antagonist)IBA 02/01/2000 - "BACKGROUND: Osteoid osteoma is a benign bone lesion characterized by nocturnal pain mostly, which may be relieved by non-steroidal prostaglandin inhibitors. " Order ALL the reference details at left...
7.	Dinoprostone (PGE2)FDA Link 05/01/1993 - "It is concluded that the presence of nerve fibres alone might play a more important role in mediation of pain in osteoid osteomas than some effects of osteoblast-produced PGE2 on the nerves and proliferated blood vessels." 03/01/1988 - "The increased concentrations of prostaglandin E2 found in cases of osteoid osteoma and osteoblastoma confirm studies of explants of these tumors previously recorded in the literature." 01/01/1992 - "The authors report the results of three cases of intra-articular osteoid osteoma in which it was possible to determine the levels of prostaglandin (PGE2) and prostacyclin (PGI2), which are synthesized by the tumoral tissue. " 01/01/1991 - "In nine patients with osteoid osteoma, prostaglandin E2 (PGE2) and prostacyclin (PGI2) synthesis in explants from the nidus incubated in vitro yielded 947.3 +/- 482.6 (mean +/- SD) and 340.2 +/- 178.1 pg/mg of wet tissue respectively, values 32 and 49 times higher than in fragments of normal bone. " 01/01/1991 - "In five patients with osteoid osteoma, prostaglandin E2 (PGE2) and prostacyclin (PGI2) synthesis in the nidus yielded 1155.6 +/- 496.5 (mean +/- SD) and 245.2 +/- 89.8 pg/mg respectively, values which are 33 and 26 times higher than in fragments of normal bone. " Order ALL the reference details at left...
8.	ProstaglandinsIBA 01/01/2002 - "Taken together, we conclude that the increased production of prostaglandins by osteoid osteomas implicates that COX-2 is one of the mediators of this condition. " 01/01/1991 - "Prostaglandins in osteoid osteoma." 02/01/1998 - "Prostaglandins mediate the pain of osteoid osteomas, but there have been few studies of their innervation. " 01/01/2002 - "Since the cyclooxygenases are thought to be the source of these prostaglandins, and the central target of NSAIDs, we evaluated the expression of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) in osteoid osteoma tissues from patients following surgery. " Order ALL the reference details at left...
9.	AntibodiesIBA 01/01/1989 - "The studies showed that osteonectin antibodies react reliably with benign and malignant bone-forming tumours (two cases of fibrous dysplasia, three osteoid osteomas, 13 osteosarcomas). " 05/01/1993 - "To clarify the mechanism of the pain, five osteoid osteomas were studied immunohistochemically using polyclonal antibodies against prostaglandin E2 (PGE2), S-100 protein and protein gene product 9.5 (PGP 9.5). " 02/01/1998 - "We investigated 34 osteoid osteomas using a streptavidin immunohistochemical technique and a panel of antibodies to neural and neural-associated antigens (phosphorylated neurofilament, neurofilament, and S-100 protein). " Order ALL the reference details at left...
10.	tranilast (N 5')IBA 02/01/2006 - "MATERIALS AND METHODS: Over a 5-year period, 18 patients (age range 6-17 years, mean age 11.6 years) with osteoid osteomas (femur, n=10; tibia, n=5; humerus, n=2; vertebral body, n=1) were treated with this technique. " 06/01/2001 - "MATERIALS AND METHODS: Forty-seven patients (age range, 8-41 y; mean age, 19.6 y) with osteoid osteomas (femur, n = 25; tibia, n = 15; pelvis, n = 2; humerus, n = 1; ulna, n = 1; talus, n = 1; calcaneus, n = 1; vertebral body, n = 1) were treated with CT-guided RF ablation in 15 cases after one (n = 10) or two (n = 5) unsuccessful attempts at open surgical resection. " 09/01/1998 - "From the 82 children enrolled in this study we diagnosed Coxitis fugax (n = 54), Morbus Perthes (n = 19), Epiphysiolysis capitis femoris (n = 5), rheumatic Arthritis (n = 2), septic Arthritis (n = 1) and femoral Osteoid-Osteoma (n = 1). " Order ALL the reference details at left...

Therapies and Procedures

1.	Electrocoagulation (Electrocautery) 08/05/1995 - "Percutaneous thermocoagulation appears to be effective for osteoid osteomas, and is a minimally invasive alternative to surgical resection." 07/01/2002 - "CONCLUSION: Percutaneous thermocoagulation is a safe and effective method for treatment of osteoid osteoma at any location. " 05/15/2000 - "STUDY DESIGN: Two cases are reported in which an osteoid osteoma of the lumbar spine was treated with CT-guided thermocoagulation. " 09/01/2007 - "OBJECTIVE: To compare the healing pattern of osteoid osteomas on computed tomography (CT) and magnetic resonance imaging (MRI) after successful and unsuccessful thermocoagulation. " 09/01/2007 - "The healing pattern of osteoid osteomas on computed tomography and magnetic resonance imaging after thermocoagulation." Order ALL the reference details at left...
2.	Laser Therapy (Surgery, Laser) 03/01/2008 - "CONCLUSIONS: Currently, image-guided laser ablation is a safe and effective procedure that can be proposed as the mainstay treatment of osteoid osteomas in pediatrics. " 12/01/2006 - "The purpose of this study was to analyze the costs of magnetic resonance imaging (MRI)-guided laser ablation and to compare them with the costs of surgery in the treatment of osteoid osteoma. " 10/01/2003 - "The purpose of this study was to determine the feasibility and features of low-field MR imaging in performing interstitial laser ablation of osteoid osteomas. " 01/01/2010 - "To evaluate the efficiency and complication rate of two percutaneous treatments of osteoid osteomas, percutaneous trephine resection (PR) and interstitial laser ablation (ILA). " 01/01/2010 - "Long-term results of percutaneous resection and interstitial laser ablation of osteoid osteomas." Order ALL the reference details at left...
3.	Lasers (Laser) 03/01/2009 - "Laser thermocoagualation is an effective treatment for osteoid osteoma in pediatric patients." 03/01/2006 - "After drill opening of the osteoid osteoma nidus, 12 thermal ablations were induced by laser interstitial thermal therapy (LITT) (9F Power-Laser-Set; Somatex, Germany) and 8 ablations by radiofrequency ablation (RFA) (RITA; StarBurst, USA). " 03/01/2006 - "Osteoid osteoma: experience with laser- and radiofrequency-induced ablation." 10/01/2003 - "Between September 2001 and April 2002, five consecutive patients with clinical and imaging findings suggesting osteoid osteoma and referred for removal of osteoid osteoma were treated with interstitial laser treatment. " 09/01/1998 - "[Percutaneous treatment of an osteoid osteoma of the scapula using a laser under scanner control]" Order ALL the reference details at left...
4.	Light Coagulation 11/01/2008 - "The objective of this study was to describe the technical specificities and results of computed tomography (CT)-guided percutaneous laser photocoagulation in 15 patients with osteoid osteomas of the hands and feet. " 11/01/1998 - "THE PURPOSE OF THE STUDY was to evaluate interstitial laser photocoagulation for local destruction of osteoid osteoma, with computed tomographic (CT) guidance. " 09/01/2009 - "The rate of positive biopsy results obtained in the present series with the Laurane biopsy needle is, to our knowledge, the highest rate reported in series dealing with percutaneous radiofrequency ablation and laser photocoagulation of osteoid osteomas." 09/01/2009 - "At our institution, 117 patients with a presumed diagnosis of osteoid osteoma had a trephine biopsy before a percutaneous laser photocoagulation. " 09/01/2009 - "CT-guided percutaneous radiofrequency ablation and laser photocoagulation have become the methods of choice for the treatment of all osteoid osteomas except those in contact with neural structures. " Order ALL the reference details at left...
5.	Curettage 04/01/2006 - "Percutaneous CT-guided curettage of osteoid osteoma with histological confirmation: a retrospective study and review of the literature." 01/01/2006 - "METHODS: Fourteen patients (11 males, 3 females; mean age 13 years; range 4 to 22 years) with osteoid osteoma of the long bones underwent image-guided minimal invasive intralesional extended curettage. " 05/01/2003 - "Curettage is an alternative to minimal invasive methods in cases of superficially located osteoid osteomas or in cases of unfavourable locations of the nidus (near joint or growth plate, inaccessibility)." 05/01/2003 - "Curettage is the surgical method of choice in the therapy of the osteoid osteoma, en bloc resection is justified only for recurrent lesions. " 03/01/2002 - "We treated 106 patients with a peripheral osteoid osteoma by conventional surgical methods; 81 had curettage and 25 en-bloc resection. " Order ALL the reference details at left...

blog comments powered by Disqus

TREATMENT OPTIONS
for Osteoid Osteoma,
Ranking and Evidence

*WARNING* This specific disease subtype has a relatively small number of significant evidence outcomes. You may proceed to order anyway, or go back to the search field and enter a more general type of the target illness. Once your report has been ordered, however, we can't refund the purchase.

CureHunter Patient-Physician Summary Reports collect in one document all the medications ever reported in the US National Library of Medicine—1949 to the present—to be effective against your target disease. Analytic charts allow you and your physicians to see at a glance the treatment options—including new, promising, off-label and experimental.

Free Updates for 1 Year
All 15 Outcomes
Top 200 Key Drugs and Biologics
Top 50 Key Therapies and Procedures
Detailed History Charts
Full Research Evidence References
Sample PDF Report on Psoriasis >>

Price:

$8.50 USD & Delivery via PDF download
updates for 1 year

Research Interface PRO

Rapidly retrieve clinical outcome summaries for all evidence of drug efficacy against any disease in seconds. Click "Charts" to view graphs of relative efficacy of all drugs against any known disease. CureHunter is unlike any "search engine" you have ever used. Where standard "search engines" produce lists of links, CureHunter quantifies evidence, extracts it from the literature and calculates a result you can use to immediately facilitate evidence based decision making in Real Clinical Time. Save hours of search and analysis time:

Two-clicks from Disease to Drug to Evidence: Drill down to full abstract
Enable Experts: Quickly identify key researchers and their publications
Enable FDA Link Generic: Two-clicks to FDA Products/Patents/Generics
Enable Export: All outcome statements and scores exportable to Excel/TSV for automated meta-analysis
Research Network: Explore drug and disease relationships visually
Enable Mobile Interface: Access from your cellphone, iPhone or PDA

Price:

$45.00 USD access via web interface
1 year subscription

Request Bulk Institution License Details >>