|2.||Breast Neoplasms (Breast Cancer)
|3.||Neoplasm Metastasis (Metastasis)
|1.||Goodman, Stuart B: 30 articles (12/2015 - 09/2003)|
|2.||Engh, Charles A: 27 articles (02/2012 - 01/2002)|
|3.||Fisher, J: 24 articles (04/2013 - 01/2000)|
|4.||Kim, Young-Hoo: 20 articles (11/2015 - 05/2002)|
|5.||Schwarz, Edward M: 18 articles (03/2015 - 01/2002)|
|6.||Ingham, E: 18 articles (02/2006 - 01/2000)|
|7.||Engh, C Anderson: 16 articles (05/2015 - 09/2002)|
|8.||Hopper, Robert H: 16 articles (05/2015 - 01/2002)|
|9.||Wedemeyer, Christian: 16 articles (03/2015 - 05/2005)|
|10.||Qin, An: 15 articles (01/2016 - 10/2009)|
04/01/2013 - "Despite the widespread implementation of highly cross-linked polyethylene (HXLPE) liners to reduce the clinical incidence of osteolysis, it is not known if the improved wear resistance will outweigh the inflammatory potential of HXLPE wear debris generated in vivo. "
02/01/2006 - "Periacetabular and femoral osteolysis in group 1 was significantly greater than group 2. In conclusion, the method of sterilization might have influenced the outcome of Hylamer polyethylene liners."
05/01/1996 - "The prevalence of osteolysis was also significantly greater in acetabular components with an outer diameter of fifty-five millimeters or less (a polyethylene thickness of 8.5 millimeters or less) (p = 0.03). "
10/01/1995 - "Thirteen patients in this series had radiologic osteolysis and a significantly greater femoral head displacement and polyethylene volumetric wear than those with no osteolysis. "
02/01/2013 - "The introduction of this HXLPE substantially improved the prognosis of patients after THA up to 13 years as judged by clinical scores, incidence of osteolysis, and polyethylene wear measurements. "
05/01/2005 - "Bisphosphonates have been shown to be effective against particle-induced osteolysis when administered daily. "
01/01/2000 - "It follows that pharmacological agents capable of inhibiting osteoclast activity, including bisphosphonates, are likely to be useful in the treatment of malignant osteolysis. "
09/01/2015 - "Numerous animal studies have already described the use of bisphosphonates to inhibit osteolysis induced by abrasion and secondary instability. "
01/01/2013 - "This retrospective collection of a small group of patients suggest that bisphosphonates should be clinically useful in preventing periprosthetic wear debris mediated osteolysis and claim for dedicated clinical trials. "
05/01/2009 - "Finally, we will review previous in vivo studies on the use of bisphosphonates to augment integration and to treat osteolysis surrounding failing orthopedic implants."
|3.||Alendronate (Alendronate Sodium)FDA LinkGeneric
03/15/1999 - "In a recent study it also was shown that a third generation bisphosphonate (alendronate) is effective in preventing wear debris-induced periprosthetic osteolysis. "
01/01/2002 - "A rat model was used to study the efficacy of alendronate therapy in inhibition of particle-induced periprosthetic osteolysis. "
01/01/2013 - "Low-dose alendronate (ALN) was combined with the HA coating in group III. The efficacy of the composite coating was evaluated using several parameters, including the intra-articular pressure, histology of the synovial membranes and bone-implant interfaces, bone histomorphometry and mineralization, implant stability, osteolysis-related cytokine levels, and the duration of ALN release in vitro. "
10/01/1996 - "Forty-eight percent of alendronate-treated patients showed radiologic improvement in osteolysis whereas in the placebo group only 4% improved (P = 0.02 for between-groups comparison). "
02/01/2002 - "The objective of this study was to determine whether alendronate could prevent particle-induced osteolysis or restore (reverse) bone loss in established osteolysis. "
03/01/2001 - "Rapid repair of titanium particle-induced osteolysis is dramatically reduced in aged mice."
08/01/2011 - "Protective effects of COX-2 inhibitor on titanium-particle-induced inflammatory osteolysis via the down-regulation of RANK/RANKL."
11/01/2015 - "The in vivo studies proved that AS‑IV attenuated titanium particle‑induced osteolysis in a mouse calvarial model. "
10/01/2014 - "In this study, we synthesized a compound named OA-14 (N-(3- (dodecylcarbamoyl)phenyl)-1H-indole-2-carboxamide) and examined how OA-14 affects titanium (Ti)-particle-induced osteolysis and osteoclastogenesis. "
05/01/2014 - "This study investigated the effect of titanium implant material on the ECM-degraded MMP-2 in human synovial cells and analyzed the contribution of synovial cells in osteolysis and aseptic loosening. "
|5.||zoledronic acid (zoledronate)FDA Link
06/01/2005 - "In conclusion, our observational study suggests that zoledronic acid may stimulate bone apposition locally in the process of particle-induced osteolysis."
03/01/2008 - "The bone biologic effects of zoledronate in healthy dogs and dogs with malignant osteolysis."
06/01/2005 - "We investigated the effect of a single subcutaneous dose of zoledronic acid on particle-induced osteolysis and observed excessive regional new bone formation. "
06/01/2005 - "Stimulation of bone formation by zoledronic acid in particle-induced osteolysis."
09/01/2003 - "Zoledronic acid inhibits osteoclastogenesis in vitro and in a mouse model of inflammatory osteolysis."
|6.||ultra-high molecular weight polyethylene (UHMWPE)IBA
07/01/2003 - "To prevent wear debris-induced osteolysis and aseptic loosening, cross-linked ultra-high molecular weight polyethylene's (UHMWPE) with improved wear resistance have been developed. "
10/01/2015 - "This study aims to elucidate whether dendritic cells play a role in UHMWPE particle-induced osteolysis. "
01/01/2013 - "Further a UHMWPE-induced murine calvaria erosion model study was performed to assess the effects of PQQ on wear particle-induced osteolysis in vivo. "
08/01/2006 - "Cases of osteolysis from artificial discs are extremely rare, but hip and knee studies demonstrate the osteolytic potential and clinical concern of UHMWPE wear debris. "
02/01/2006 - "In conclusion, this study provides the evidence that EM inhibits the UHMWPE particles-induced inflammatory osteolysis in a murine model, and represents a promising therapeutic candidate for the prevention and treatment of AL."
|7.||pamidronate (APD)FDA LinkGeneric
12/01/2006 - "Cyclic intravenous pamidronate treatment in children with nodulosis, arthropathy and osteolysis syndrome."
01/01/2003 - "The demonstration that drugs such as pamidronate induce specific apoptosis-related pathways in macrophages contributes data for a rational approach in the treatment and/or prevention of periprosthetic osteolysis."
10/01/2002 - "As observed in the last 17 cases, the maximum osteolysis inhibition after pamidronate occurred on the fourth day after drug infusion. "
11/01/2000 - "At skeletal X-ray examination performed after 6 and 12 cycles of pamidronate and by comparing each of consecutive imaging with previous one the progression of osteolysis was respectively found in 67% and 39% of patients. "
05/01/1990 - "APD, a bisphosphonate derivative, at a dose of 3 mg/kg to 10 mg/kg sc protected the bone by decreasing the extent of osteolysis as judged by the same criteria. "
|8.||Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
07/01/2001 - "The ability to suppress the release of TNF-alpha in patients with a total joint replacement may help to control osteolysis and to reduce the development of aseptic loosening. "
08/01/2003 - "Clinical trials are needed to define the potential benefit of biologic TNF-alpha antagonists in the treatment and prevention of malignant osteolysis."
01/01/2000 - "Here we review recent studies implicating tumor necrosis factor (TNF)-alpha in periprosthetic osteolysis and the rationale for clinical studies of anti-TNF therapy and other interventions for periprosthetic loosening."
02/01/2014 - "Elevation of serum tumor necrosis factor α in patients with periprosthetic osteolysis: a case-control study."
10/01/2013 - "During this pathological process, tumor necrosis factor-alpha (TNF-α) plays an important role in wear-particle-induced osteolysis. "
|9.||Clodronic Acid (Clodronate)IBA
08/01/1998 - "No value of oral clodronic acid in malignant osteolysis."
10/15/1997 - "The ultimate arbiter of the value of clodronate is whether it decreases the skeletal morbidity associated with osteolysis. "
01/01/1996 - "Bonefos (chlodronat, Lieras, Finland) arrests osteolysis proved by a significant increase of bone marrow density and clinical effect."
02/01/1995 - "Beneficial effects of oral clodronate in the management of malignant osteolysis and hypercalcaemia."
01/01/1995 - "Supportive clodronate therapy may even reduce hypercalcaemia mortality and the morbidity caused by osteolysis. "
|10.||Parathyroid Hormone-Related ProteinIBA
09/01/2014 - "Furthermore, miR-126-5p could control osteoclast (OC) differentiation, GCTSC proliferation and osteolysis formation in GCT through negative regulation of PTHrP. "
01/01/2011 - "Specimens with osteolysis had increased PTHrP expression and nuclear localization, compared to OSCC without osteolysis. "
11/01/2001 - "Locally accumulated PTHrP may contribute to periprosthetic osteolysis and aseptic loosening of THR through its direct effects on bone, or indirectly via the induction of inflammatory mediators."
05/01/2000 - "Using a rat model of parathyroid hormone-related peptide (PTHrP)-mediated tumor osteolysis, the aim of the present study was to define the sequential changes in, and the association between, biochemical and histomorphometric indices of bone metabolism during the early stages of developing tumor osteopathy. "
09/01/2014 - "Parathyroid hormone-related protein (PTHrP) has been identified to play a crucial role in osteolysis formation and stromal cell (GCTSC) proliferation in giant cell tumor (GCT). "
01/01/2001 - "At least with some designs, including the Oxford knee and the LCS knee, the results after a minimum follow-up of 10 years are comparable with the best results after arthroplasty with fixed-bearing designs in terms of wear, loosening, and osteolysis (Table 7). "
08/01/2007 - "Whilst the current generation of metal-on-metal resurfacing arthroplasties appear to have cured the osteolysis problems that plagued earlier resurfacing implants, fracture of the femoral head and aseptic loosening are still factors of concern in its survivorship. "
12/01/2002 - "A primary aim of research in total hip arthroplasty is to extend longevity through improved fixation and decreased wear and osteolysis. "
11/01/2001 - "The circumferential porous coating of this implant improved ingrowth and prevented distal osteolysis at a mean of ten years after the arthroplasty."
06/01/2015 - "The purpose of the present study was to evaluate factors that affect the occurrence of osteolysis through clinical and radiological comparison between a patient group in which osteolysis occurred after total knee arthroplasty (TKA) and a patient group in which osteolysis did not occur after TKA. "
|2.||Prostheses and Implants (Prosthesis)
04/01/1997 - "Tissues from loose cemented prostheses with osteolysis contained significantly greater numbers of macrophages and T lymphocytes compared with tissues from loose and well fixed cemented prostheses without osteolysis. "
12/01/2013 - "We describe the development of imaging techniques for the detection and measurement of osteolysis around THR prostheses, which enable improved clinical management of patients, provide a means of evaluating outcomes of non-surgical treatments for periprosthetic osteolysis, and assist in pre-operative planning for revision surgery. "
07/01/2008 - "For bipolar prostheses, most of the previous studies attributed the occurrence of osteolysis to wear debris generated from the bearing surface. "
11/01/2007 - "The purpose of this study was to evaluate radiographic changes reflecting or suggesting progressive osteolysis in patients with a bipolar radial head prosthesis. "
03/01/2004 - "The purpose of the present study was to evaluate a modular posterior stabilized prosthesis to determine its clinical performance as well as the rates of component loosening and osteolysis. "
|3.||Hip Replacement Arthroplasty (Total Hip Replacement)
04/01/2011 - "There have been comparatively few studies of the incidence of osteolysis and the survival of hybrid and cementless total hip replacements (THRs) in patients younger than 50 years of age. "
07/21/2010 - "Postmortem study of femoral osteolysis associated with metal-on-metal articulation in total hip replacement: an analysis of nine cases."
04/01/2002 - "Several studies have shown that certain cemented total hip replacement femoral stems have been associated with the complications of early debonding, loosening, and osteolysis. "
11/01/2014 - "Periprosthetic osteolysis in the retroacetabular region with cancellous bone loss is a recognized phenomenon in the long-term follow-up of total hip replacement. "
09/01/2014 - "Total hip replacement is indicated in late post-collapse hips but it has unsatisfactory survival because of the wear and osteolysis in young and active patients. "
03/01/2015 - "The long-term complications such as graft osteolysis are still an unsolved problem, and future research is required to understand the etiology and best treatment option. "
10/01/1997 - "Our socket is very effective in preventing osteolysis and is expected to provide more stable mechanical stability by arranging an insertion angle (35 degrees of the optimal open angle and 10 degrees of the anteversion angle) and a full bone graft in osteoarthritic patients."
05/01/2015 - "Coracoid graft osteolysis, previously reported after the Latarjet procedure, appears to be exacerbated with a risk of complete disappearance of the graft when the procedure is performed with the bioabsorbable screws used in this study."
04/01/2014 - "This study aims to investigate the hypothesis that coracoid bone graft osteolysis is more pronounced in cases without glenoid bone loss, which may be due to a diminished mechanotransduction effect at the bone healing site. "
01/01/2013 - "To our knowledge, there are no studies in literature that show the causes of coracoid bone graft osteolysis after Latarjet procedure. "
|5.||Bone Transplantation (Bone Grafting)
01/01/2013 - "This study reports the clinical outcomes for selective bone grafting in patients with osteolysis without complete revision of the TKR. "
07/01/2011 - "Clinical studies show that BPs inhibit periprosthetic bone loss due to strain-adaptive remodeling and after impaction bone grafting, although an efficacy in inhibiting inflammatory bone loss due to wear particle-induced osteolysis has not been confirmed. "
11/01/2004 - "The purpose of this study was to evaluate the 5- to 10-year clinical and radiographic results of morselized bone grafting for acetabular osteolysis during cementless acetabular revisions. "
04/01/2015 - "All of the cups were radiographically stable with no evidence of progressive radiolucencies or osteolysis regardless of bone grafting. "
04/01/2014 - "These results show that cemented liner exchange surgery can halt the progression of osteolysis and that bone grafting has the potential to restore bone."