Osteochondrodysplasias (Spondyloepiphyseal Dysplasia)

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374 relevant articles (10 outcomes, 30 trials/studies) found for this Disease

Description: Abnormal development of cartilage and bone.

Also Known As:

Spondyloepiphyseal Dysplasia; Osteochondrodysplasia; Epiphyseal Dysplasia, Multiple; Melnick Needles Syndrome; Hyperostosis Corticalis Generalisata; Dyschondroplasia; Dysplasia, Spondyloepiphyseal; Syndrome, Melnick-Needles; Syndrome, Schwartz-Jampel; Multiple Epiphyseal Dysplasia; Dysplasia, Multiple Epiphyseal; Dysplasias, Multiple Epiphyseal; Dysplasias, Spondyloepiphyseal; Epiphyseal Dysplasias, Multiple; Multiple Epiphyseal Dysplasias; Schwartz Jampel Syndrome; Spondyloepiphyseal Dysplasias; Dyschondroplasias; Melnick-Needles Syndrome; Schwartz-Jampel Syndrome

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Rickets (Rachitis)
2.	Weight Gain
3.	Osteochondritis (Osgood Schlatter Disease)
4.	Osteoarthritis
5.	Vitamin D Deficiency

Experts

1.	Ikegawa, Shiro: 5 articles (07/2005 - 01/2003)
2.	Mabuchi, Akihiko: 4 articles (07/2005 - 01/2003)
3.	Nishimura, Gen: 4 articles (11/2004 - 01/2003)
4.	Ala-Kokko, L: 4 articles (01/2004 - 01/2000)
5.	Huff, G R: 3 articles (11/2007 - 07/2005)
6.	Huff, W E: 3 articles (11/2007 - 07/2005)
7.	Rath, N C: 3 articles (11/2007 - 07/2005)
8.	Briggs, Michael D: 3 articles (12/2005 - 05/2005)
9.	Ohashi, Hirofumi: 3 articles (11/2004 - 01/2003)
10.	Haga, Nobuhiko: 3 articles (11/2004 - 01/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Osteochondrodysplasias:

1.	hydroxide ionIBA 09/01/1990 - "Two active compounds tested [1,25-(OH)2D3 and 1,24R,25-(OH)3D3] at 5 micrograms/kg of diet were effective in reducing either the incidence or severity of tibial dyschondroplasia." 02/01/1997 - "Three experiments were conducted to examine the efficacy of dietary 1,25-dihydroxycholecalciferol [(1,25-(OH)2D3)] on the development of tibial dyschondroplasia (TD) in chickens divergently selected for high (HTD) and low (LTD) incidences of TD" 07/01/2000 - "Studies indicate that dietary supplementation with 1,25-dihydroxycholecalciferol [1,25(OH)2D3] will reduce the incidence of tibial dyschondroplasia in three different strains of broilers bred to develop a high incidence of the disease" 01/01/1996 - "Studies were conducted to evaluate the level of dietary 1,25-dihydroxycholecalciferol [1,25-(OH)2D3] required to decrease the incidence of tibial dyschondroplasia (TD) in male broilers at 3 and 5 wk of age" 09/01/1995 - "Two experiments were conducted to determine whether dietary 1,25-dihydroxycholecalciferol [1,25-(OH)2D3] can prevent tibial dyschondroplasia in broiler chickens throughout the growing period when withdrawn from the grower diet" Order ALL the reference details at left...
2.	Cholecalciferol (Vitamin D3)FDA Link 07/01/2000 - "Only a few studies have been conducted on the efficacy of various vitamin D3 derivatives to prevent tibial dyschondroplasia" 01/01/2006 - "A series of experiments was conducted to investigate the effects of maternal dietary vitamin D3 supplementation at 4 different times during the laying cycle, on the performance and bone quality of broiler chicks fed a diet that induced tibial dyschondroplasia (TD) or an adequate diet" 01/01/2006 - "The effect of maternal dietary vitamin D3 supplementation on performance and tibial dyschondroplasia of broiler chicks." 02/01/1997 - "The effects of ultraviolet light and cholecalciferol and its metabolites on the development of leg abnormalities in chickens genetically selected for a high and low incidence of tibial dyschondroplasia." 01/01/1997 - "Evidence of increased cholecalciferol requirement in chicks with tibial dyschondroplasia." Order ALL the reference details at left...
3.	CalciumIBA 09/01/1995 - "When 1,25-(OH)2D3 was fed, tibial dyschondroplasia was reduced in Experiment 2 only at 3 wk. Tibial dyschondroplasia was decreased at 5 wk in Experiment 2 when .65% calcium was fed with or without 1,25-(OH)2D3 from 3 to 5 wk of age" 07/01/1995 - "4. The incidence of tibial dyschondroplasia (TD) at 3 weeks of age was highest with the basal diet containing 7.5 g calcium/kg and was markedly reduced by addition of 1,25-DHCC and/or calcium" 05/01/1993 - "Additive amelioration of tibial dyschondroplasia in broilers by supplemental calcium or feed deprivation." 05/01/1997 - "Osteochondrodysplasias, dysostoses, disorders of calcium metabolism, congenital malformations with skeletal involvement mapped on human chromosomes." 10/01/1987 - "Tibial dyschondroplasia was not eliminated by feeding a ration containing 1.5% calcium and 0.5% available phosphorus" Order ALL the reference details at left...
4.	Phosphorus (Red Phosphorus)IBA 06/01/2006 - "1. Performance, gait score (GS), tibial dyschondroplasia (TD), and tibia bone mineralisation and breaking strength were determined in 2880 male and female Ross 208 broilers fed on diets with two different concentrations of dietary metabolisable energy (ME) (11.00 or 12.00 MJ/kg) and 4 different concentrations of available phosphorus (aP) adjusted for dietary ME content (4.0, 4.5, 5.0 or 5.5 g/kg aP in starter and 3.5, 4.0, 4.5 or 5.0 g/kg aP in finisher diets containing 12.00 MJ/kg)" 09/01/1989 - "In two experiments, a high dietary level of available phosphorus (.65%) in the presence of high chloride concentrations (.36%) was associated with a significant increase in the incidence of tibial dyschondroplasia (TD) in male broiler chickens" 10/01/1987 - "Before typical dyschondroplasia developed, chickens fed a high level of phosphorus had uniformly thickened growth plates at 2 weeks of age" 10/01/1987 - "Tibial dyschondroplasia was not eliminated by feeding a ration containing 1.5% calcium and 0.5% available phosphorus" 07/01/2002 - "Role of dietary calcium and available phosphorus in the aetiology of tibial dyschondroplasia in growing turkeys." Order ALL the reference details at left...
5.	Calcitriol (Calcijex)FDA LinkGeneric 06/01/1993 - "The effects of dietary 1,25-dihydroxycholecalciferol on the incidence and severity of tibial dyschondroplasia (TD) were assessed in broiler fowl selected for TD (high-TD line) and against TD (low-TD line)" 06/01/1993 - "Avian tibial dyschondroplasia: the interaction of genetic selection and dietary 1,25-dihydroxycholecalciferol." 02/01/1997 - "Three experiments were conducted to examine the efficacy of dietary 1,25-dihydroxycholecalciferol [(1,25-(OH)2D3)] on the development of tibial dyschondroplasia (TD) in chickens divergently selected for high (HTD) and low (LTD) incidences of TD" 07/01/2000 - "Studies indicate that dietary supplementation with 1,25-dihydroxycholecalciferol [1,25(OH)2D3] will reduce the incidence of tibial dyschondroplasia in three different strains of broilers bred to develop a high incidence of the disease" 01/01/1996 - "Studies were conducted to evaluate the level of dietary 1,25-dihydroxycholecalciferol [1,25-(OH)2D3] required to decrease the incidence of tibial dyschondroplasia (TD) in male broilers at 3 and 5 wk of age" Order ALL the reference details at left...
6.	CollagenIBA 06/01/1976 - "The present study does not exclude possible abnormalities of collagen at a higher lever of supramolecular organization in osteochondrodysplasias." 12/15/2007 - "WISP3 is essential for maintaining cartilage integrity mainly by regulating the expression of collagen II, and mutations of WISP3 linked to spondyloepiphyseal dysplasia tarda with progressive arthropathy (SEDT-PA) can compromise this function and lead to cartilage loss" 01/01/2002 - "Y-position collagen II mutation disrupts cartilage formation and skeletal development in a transgenic mouse model of spondyloepiphyseal dysplasia." 11/01/2001 - "There was no apparent evidence of spondyloepiphyseal dysplasia or other dysplasias usually associated with mutations in collagen genes" 05/01/2000 - "55, 678-684) in a large English family with multiple epiphyseal dysplasia established the EDM2 locus, a region of chromosome 1 containing the COL9A2 collagen gene" Order ALL the reference details at left...
7.	ThiramIBA 12/01/2007 - "1. An experiment was conducted to study the effect of thiram on liver antioxidant capacity and incidence of tibial dyschondroplasia in broilers" 12/01/2007 - "Effect of diet with thiram on liver antioxidant capacity and tibial dyschondroplasia in broilers." 11/01/2007 - "Thiram-induced changes in the expression of genes relating to vascularization and tibial dyschondroplasia." 08/01/2007 - "Induction of tibial dyschondroplasia in turkeys by tetramethylthiuram disulfide (thiram)." 07/01/2005 - "Changes in the tibial growth plates of chickens with thiram-induced dyschondroplasia." Order ALL the reference details at left...
8.	Vitamin D FDA LinkGeneric 09/01/1990 - "Efficacy of several vitamin D compounds in the prevention of tibial dyschondroplasia in broiler chickens." 07/01/2000 - "These studies indicate that these high tibial dyschondroplasia strains have a defect(s) in vitamin D metabolism" 01/01/1997 - "A series of experiments was conducted to test the hypothesis that vitamin D utilization may not be as efficient in chicks with tibial dyschondroplasia (TD)" 02/01/1997 - "Four experiments were conducted to investigate the effects of ultraviolet (UV) light exposure and several cholecalciferol metabolites on the development of tibial dyschondroplasia (TD) and other parameters associated with vitamin D metabolism in chickens selected for high (HTD) and low (LTD) incidence of TD" 02/01/1997 - "Dietary 1,25-dihydroxycholecalciferol has variable effects on the incidences of leg abnormalities, plasma vitamin D metabolites, and vitamin D receptors in chickens divergently selected for tibial dyschondroplasia." Order ALL the reference details at left...
9.	Calcifediol (Calcidiol)FDA Link 07/01/2002 - "We hypothesised that as OC has some similarities to dyschondroplasia, which involves a failure of growth plate chondrocytes to fully differentiate and hypertrophy, treatment with 25-hydroxyvitamin D3 (25-D) might reduce the incidence and/or severity of lesions in pigs, as it does in chickens with dyschondroplasia" 12/01/2004 - "Effect of casein phosphopeptide and 25-hydroxycholecalciferol on tibial dyschondroplasia in growing broiler chickens." 12/01/2004 - "1. An experiment was conducted to investigate the influence of dietary casein phosphopeptides and 25-hydroxycholecalciferol on the incidence of tibial dyschondroplasia (TD) in 14-d-old commercial broiler chickens" 07/01/2000 - "Ascorbic acid may play a role in stimulating 1-hydroxylation of 25-hydroxycholecalciferol [25-(OH)D3], but the evidence is not clear under exactly what conditions this relationship is important in practical prevention of tibial dyschondroplasia" 04/01/1994 - "Effect of genetic strain, calcium, and feed withdrawal on growth, tibial dyschondroplasia, plasma 1,25-dihydroxycholecalciferol, and plasma 25-hydroxycholecalciferol in sixteen-day-old chickens." Order ALL the reference details at left...
10.	6-Phytase (Phytase)IBA 01/01/1996 - "The addition of 1,25-(OH)2D3, but not phytase, reduced Ca requirements and decreased the incidence of tibial dyschondroplasia" 06/01/2001 - "A study was conducted to determine the effect of dietary supplementation of phytase on the incidence and severity of tibial dyschondroplasia (TD) in chickens selected for high (HTD) and low (LTD) incidences of TD for 11 generations" 06/01/2001 - "Influence of dietary phytase supplementation on incidence and severity in broilers divergently selected for tibial dyschondroplasia." Order ALL the reference details at left...

Therapies and Procedures

1.	Mechanical Ventilators (Ventilator) 06/01/2001 - "Improvement in daily activities using a portable ventilator in a patient with spondyloepiphyseal dysplasia congenita." 11/01/1996 - "Spondyloepiphyseal dysplasia congenita with ventilator dependence: two case reports." Order ALL the reference details at left...
2.	Osteotomy 01/01/2003 - "PURPOSE OF THE STUDY: The presentation of our results of surgical treatment of the hip joints affected by multiple epiphyseal dysplasia, using the Steel technique of triple osteotomy of the innominate bone in children" 01/01/2003 - "CONCLUSIONS: The Steel triple osteotomy of the innominate bone permits correction of abnormal anatomical conditions of hip joints in severe multiple epiphyseal dysplasia" 01/01/2003 - "DISCUSSION: A comparison of our results with those of other authors was not possible since no literature data were available on the Steel osteotomy in patients with multiple epiphyseal dysplasia" 07/01/1999 - "Transtrochanteric curved varus femoral osteotomy for spondyloepiphyseal dysplasia tarda" 01/01/2008 - "Bilateral valgus-extension osteotomy of hip using hybrid external fixator in spondyloepiphyseal dysplasia: early results of a salvage procedure." Order ALL the reference details at left...
3.	Arthroplasty 02/01/2004 - "In this study, we evaluated the long-term clinical and radiographic outcomes of total hip arthroplasty in patients with osteochondrodysplasia" 02/01/2004 - "CONCLUSIONS: There was a high prevalence of complications, periprosthetic fractures, and mechanical failure in these patients with osteochondrodysplasia who underwent total hip arthroplasty" 01/01/1988 - "Spondyloepiphyseal dysplasia tarda: bilateral total arthroplasty of the hip]" 02/01/2004 - "METHODS: Between 1971 and 1997, sixty-two total hip arthroplasties were performed at our institution in thirty-seven patients with severe osteoarthritis secondary to osteochondrodysplasia" 02/01/2004 - "BACKGROUND: Patients with short stature and osseous deformities resulting from osteochondrodysplasia frequently have premature development of advanced degenerative disease of the hip and thus may require total hip arthroplasty" Order ALL the reference details at left...
4.	Tracheostomy 07/01/1993 - "Emergency tracheostomy in a patient with Melnick-Needles syndrome and sleep apnoea." 01/01/2008 - "To our knowledge, this is the first reported case of mandibular distraction osteogenesis used to cure obstructive sleep apnea and eliminate the need for tracheostomy in a patient with Melnick-Needles syndrome" 01/01/2008 - "This is a report of a patient with Melnick-Needles syndrome who presented to our unit after multiple bouts of respiratory failure and with a tracheostomy in whom mandibular distraction osteogenesis was used to retire her tracheostomy and to cure her sleep apnea" Order ALL the reference details at left...
5.	Arthrodesis 03/15/2006 - "MATERIALS AND METHODS: The charts of 25 patients with skeletal dysplasia (spondyloepiphyseal dysplasia, spondyloepimetaphyseal dysplasia, pseudoachondroplasia, Morquio, or Kniest) who had undergone cervical arthrodesis to treat instability were reviewed for evidence of fusion, neurologic improvement, and complications" 10/01/2008 - "The indications for atlantoaxial arthrodesis were: (a) absent odontoid process, dystopic os odontoideum, absent posterior arch of C1; (b) Morquio's syndrome, Goldenhar's syndrome, Conradi's syndrome, and spondyloepiphyseal dysplasia" Order ALL the reference details at left...

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