|1.||Yanagita, Teruyoshi: 6 articles (01/2012 - 08/2004)|
|2.||Wang, Yu-Ming: 6 articles (05/2011 - 08/2004)|
|3.||Xue, Chang-Hu: 4 articles (05/2011 - 01/2010)|
|4.||Nagao, Koji: 4 articles (01/2010 - 08/2004)|
|5.||Lee, Byung-Hoon: 3 articles (04/2015 - 09/2011)|
|6.||Zhang, Bei: 3 articles (01/2012 - 09/2010)|
|7.||Xue, Yong: 3 articles (01/2012 - 01/2010)|
|8.||Xu, Jie: 3 articles (01/2012 - 09/2010)|
|9.||Cha, Jae-Young: 3 articles (12/2011 - 08/2004)|
|10.||Hu, Xiao-Qian: 3 articles (05/2011 - 01/2010)|
05/01/2011 - "The aim of this study was to investigate the possible mechanism of orotic acid-induced fatty liver in rats. "
05/01/2011 - "Study on possible mechanism of orotic acid-induced fatty liver in rats."
03/01/1988 - "In rats, dietary orotic acid exerts several effects on lipid metabolism; its overall consequence is that excessively high hepatic fat concentrations are built up over a short period of time, thus making this an ideal model to study the ultrasonic propagation properties as a function of sequential development of fatty liver. "
03/01/1986 - "Ultrastructural and enzyme histochemical studies in orotic acid-induced fatty liver."
05/01/1969 - "Studies on orotic acid fatty liver in rats: factors influencing the induction of fatty liver."
01/01/2013 - "Tri- and diorganotin(IV) complexes of biologically important orotic acid: synthesis, spectroscopic studies, in vitro anti-cancer, DNA fragmentation, enzyme assays and in vivo anti-inflammatory activities."
09/01/1993 - "The present study was designed to determine the long-term effects of orotic acid (OA), a multi-organ tumor promoter, in rats not exposed to any carcinogen. "
09/01/1993 - "Studies on liver tumor promotion in the rat by orotic acid: dose and minimum exposure time required for dietary orotic acid to promote hepatocarcinogenesis."
06/01/1992 - "Because our earlier studies have demonstrated that orotic acid is a liver tumor promoter in the rat, it was of interest to determine whether this genetic disorder also increases the risk of tumor promotion. "
01/01/1990 - "The present study was designed to determine whether orotic acid, a liver tumor promoter in the rat, also promotes liver carcinogenesis in the mouse. "
|3.||Hepatocellular Carcinoma (Hepatoma)
08/01/1993 - "The present study was designed to determine whether a delay in the start of the promoting regimen after the administration of a carcinogen would influence the promoting efficacy of orotic acid on the development of hepatocellular carcinoma in rats. "
05/01/1984 - "The present study was designed to determine whether prolonged feeding of orotic acid will result in hepatocellular carcinoma in initiated rats. "
01/01/2012 - "Proliferating effect of orotic acid through mTORC1 activation mediated by negative regulation of AMPK in SK-Hep1 hepatocellular carcinoma cells."
07/15/1994 - "Hepatocyte nodules developed in 56% of the rats after 20 weeks of promotion, while the first hepatocellular carcinoma was observed in one rat sacrificed after 29 weeks of orotic acid promotion. "
09/01/1993 - "However, the incidence of hepatocellular carcinoma was greatly increased in animals exposed to the orotic acid diet, with 42% incidence in initiated rats given orotic acid diet for 10 weeks and up to 75% in those exposed to this diet for 40 weeks. "
02/01/1979 - "The effect of orotic acid on the development of compensatory pulmonary hypertrophy has been studied in the clinic and in the experiments (71 patients, and 349 rats) carried out with the use of morphologic, biochemical cytochemical, immunologic and clinical methods, and also through autoradiography. "
12/01/1974 - "The action of orotic acid as a positive inotropic agent during the acute phase of myocardial hypertrophy."
07/01/1969 - "[Orotic acid and purinor effect on protein biosynthesis in compensatory hyperfunction and hypertrophy of the heart]."
07/01/1975 - "[Effect of potassium orotate on compensatory hypertrophy of the remaining lung after left-side pneumonectomy]."
08/01/1994 - "Orotic acid accelerates compensatory myocardial hypertrophy after regional ischemia and improves left ventricular function acutely after global ischemia. "
11/01/1999 - "Plasma concentrations and renal clearance of orotic acid in argininosuccinic acid synthetase deficiency."
02/01/2014 - "Urinary orotic acid was elevated, consistent with the urea cycle disorder type 1 citrullinemia. "
03/01/2014 - "Argininosuccinate synthetase deficiency (citrullinemia type 1) is a rare autosomal recessive disorder of the urea cycle characterized by elevated concentrations of citrulline, ammonia, and orotic acid, manifesting with acute hyperammonemic crises, usually early in life, with concurrent neurologic deterioration. "
08/01/1980 - "Orotic acid excretion in urine in increased in ornithine transcarbamylase deficiency, citrullinemia and argininemia; it is barely increased in argininosuccinic aciduria and normal in carbamylphosphate synthetase deficiency and in hyperammonemia due to organic aciduria. "
|3.||Deoxycholic Acid (Sodium Deoxycholate)
|4.||Linoleic Acid (Linoleate)
|5.||alpha-Linolenic Acid (Linolenic Acid)
|8.||RNA (Ribonucleic Acid)
|1.||Induced Heart Arrest (Cardioplegia)
|3.||Transplantation (Transplant Recipients)
|4.||Pneumonectomy (Lung Volume Reduction)