|1.||Fukushima, Masakazu: 10 articles (12/2008 - 02/2004)|
|2.||Komori, Yoshiyuki: 8 articles (08/2008 - 07/2005)|
|3.||Inaba, Kazuki: 8 articles (08/2008 - 07/2005)|
|4.||Sakurai, Yoichi: 8 articles (08/2008 - 07/2005)|
|5.||Uyama, Ichiro: 8 articles (08/2008 - 07/2005)|
|6.||Sanada, Yuichi: 6 articles (11/2010 - 12/2006)|
|7.||Yoshida, Kazuhiro: 6 articles (11/2010 - 12/2006)|
|8.||Tsutsumi, Yutaka: 6 articles (08/2008 - 04/2006)|
|9.||Kamoshida, Shingo: 6 articles (08/2008 - 04/2006)|
|10.||Krungkrai, Sudaratana R: 5 articles (03/2014 - 04/2004)|
08/01/2005 - "Preparation of anti-orotate phosphoribosyltransferase antibody and its application to immunochemical detection in human tumor cells."
02/01/1982 - "OMPase activity has also been detected in various mammalian tissues including normal human tissues, human tumor xenografts, lymphocytes, and rat liver. "
11/09/2007 - "Orotate phosphoribosyltransferase expression level in tumors is a potential determinant of the efficacy of 5-fluorouracil."
08/01/2005 - "Orotate phosphoribosyltransferase (OPRT) is a key enzyme in the anabolism of 5-fluorouracil (5-FU), and its expression in tumors is thought to increase the efficacy of 5-FU against the tumor. "
01/01/2015 - "Orotate phosphoribosyltransferase localizes to the Golgi complex and its expression levels affect the sensitivity to anti-cancer drug 5-fluorouracil."
|2.||Colorectal Neoplasms (Colorectal Cancer)
11/01/2008 - "The purpose of this study was to evaluate the pattern of the expression of orotate phosphoribosyltransferase (OPRT) in several components of colorectal carcinoma (CRC). "
11/01/2008 - "Expression of orotate phosphoribosyltransferase in colorectal carcinoma: an immunohistochemical analysis in several components of neoplastic lesions."
08/01/2012 - "To investigate the expression of orotate phosphoribosyltransferase (OPRT) in colorectal carcinoma and analyze its correlations with the toxicities of chemotherapy. "
08/01/2012 - "[Expressions of orotate phosphoribosyltransferase in colorectal carcinoma and its correlations with toxicities of chemotherapy]."
08/01/2000 - "In conclusion, F3(d)Thd, an antimetabolite that inhibits TS activity, may be effective against 5-FU and/or FdUrd-resistance in colorectal cancer cells caused by amplification of TS and/or deletion of orotate phosphoribosyltransferase."
|3.||Stomach Neoplasms (Stomach Cancer)
12/01/2008 - "Decreased orotate phosphoribosyltransferase activity produces 5-fluorouracil resistance in a human gastric cancer cell line."
12/01/2006 - "The expression profiles of orotate phosphoribosyltransferase and dihydropyrimidine dehydrogenase in gastric cancer and their clinical significance."
12/01/2011 - "Biomarker analysis in patients with advanced gastric cancer treated with S-1 plus cisplatin chemotherapy: orotate phosphoribosyltransferase expression is associated with treatment outcomes."
09/28/2010 - "We measured the protein expression levels of thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), and orotate phosphoribosyltransferase (OPRT) in advanced gastric cancer. "
12/08/2007 - "Using this method, the 17 gastric cancer biopsy specimens, before undergoing S-1 based neoadjuvant chemotherapy, were assessed in order to determine the expression levels of the thymidylate synthase (TS), orotate phosphoribosyltransferase (OPRT) and dihydropyrimidine dehydrogenase (DPD) which determines S-1 efficacy. "
|4.||Gastrointestinal Neoplasms (Gastrointestinal Cancer)
01/01/2008 - "Thymidylate synthase, dihydropyrimidine dehydrogenase, thymidine phosphorylase, and orotate phosphoribosyltransferase gene expressions are reported to be valid predictive markers for 5-fluorouracil sensitivity to gastrointestinal cancer. "
07/01/2015 - "The efficacy of 5-fluorouracil (5FU)-based therapy, which remains the cornerstone of gastrointestinal cancer treatment, depends upon the expression of enzymes involved in pyrimidine metabolism, including thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), thymidine phosphorylase (TP), and orotate phosphoribosyltransferase (OPRT). "
01/01/2007 - "The purpose of this study was to clarify the role of orotate phosphoribosyltransferase (OPRT) in the progression of hepatobiliary and pancreatic carcinomas. "
01/01/2007 - "Levels and expressions of orotate phosphoribosyltransferase in gastric carcinoma and normal gastric mucosa tissues."
01/01/2007 - "Expression of orotate phosphoribosyltransferase (OPRT) in hepatobiliary and pancreatic carcinoma."
08/01/2006 - "[Clinical and prognostic significance of protein and gene expression of orotate phosphoribosyltransferase in gastric carcinoma]."
06/01/2006 - "Orotate phosphoribosyltransferase levels measured by a newly established enzyme-linked immunosorbent assay in gastric carcinoma."
|2.||Dihydrouracil Dehydrogenase (NADP) (Dihydropyrimidine Dehydrogenase)
|6.||Messenger RNA (mRNA)
|8.||Orotidine-5'-Phosphate Decarboxylase (Orotidine 5 Phosphate Decarboxylase)
|9.||Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
|10.||Uridine Monophosphate (UMP)
|1.||Drug Therapy (Chemotherapy)
|3.||Heterologous Transplantation (Xenotransplantation)