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Orotate Phosphoribosyltransferase

The enzyme catalyzing the formation of orotidine-5'-phosphoric acid (orotidylic acid) from orotic acid and 5-phosphoribosyl-1-pyrophosphate in the course of pyrimidine nucleotide biosynthesis. EC 2.4.2.10.
Also Known As:
OMPase; Orotidine-5'-Monophosphate Phosphohydrolase; Orotidine 5' Monophosphate Phosphohydrolase; Orotidine 5' Phosphate Pyrophosphorylase; Phosphohydrolase, Orotidine-5'-Monophosphate; Phosphoribosyltransferase, Orotate; Phosphorylase, Orotidylic Acid; Pyrophosphorylase, Orotidine-5'-Phosphate; Orotidine-5'-Phosphate Pyrophosphorylase; Orotidylic Acid Phosphorylase; Orotidine-5'-phosphate:pyrophosphate phospho-alpha-D-ribosyltransferase
Networked: 82 relevant articles (7 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Fukushima, Masakazu: 10 articles (12/2008 - 02/2004)
2. Komori, Yoshiyuki: 8 articles (08/2008 - 07/2005)
3. Inaba, Kazuki: 8 articles (08/2008 - 07/2005)
4. Sakurai, Yoichi: 8 articles (08/2008 - 07/2005)
5. Uyama, Ichiro: 8 articles (08/2008 - 07/2005)
6. Sanada, Yuichi: 6 articles (11/2010 - 12/2006)
7. Yoshida, Kazuhiro: 6 articles (11/2010 - 12/2006)
8. Tsutsumi, Yutaka: 6 articles (08/2008 - 04/2006)
9. Kamoshida, Shingo: 6 articles (08/2008 - 04/2006)
10. Krungkrai, Sudaratana R: 5 articles (03/2014 - 04/2004)

Related Diseases

1. Neoplasms (Cancer)
2. Colorectal Neoplasms (Colorectal Cancer)
3. Stomach Neoplasms (Stomach Cancer)
4. Gastrointestinal Neoplasms (Gastrointestinal Cancer)
5. Carcinoma (Carcinomatosis)

Related Drugs and Biologics

1. Fluorouracil (Carac)
2. Dihydrouracil Dehydrogenase (NADP) (Dihydropyrimidine Dehydrogenase)
3. Thymidylate Synthase
4. Thymidine Phosphorylase
5. Enzymes
6. Messenger RNA (mRNA)
7. pyrimidine
8. Orotidine-5'-Phosphate Decarboxylase (Orotidine 5 Phosphate Decarboxylase)
9. Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
10. Uridine Monophosphate (UMP)

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Adjuvant Chemotherapy
3. Heterologous Transplantation (Xenotransplantation)
4. Lasers (Laser)