Ornithine Decarboxylase (Decarboxylase, Ornithine)

A pyridoxal-phosphate protein, believed to be the rate-limiting compound in the biosynthesis of polyamines. It catalyzes the decarboxylation of ornithine to form putrescine, which is then linked to a propylamine moiety of decarboxylated S-adenosylmethionine to form spermidine.

Also Known As:

Networked: 1741 relevant articles (27 outcomes, 154 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Sultana, Sarwat: 19 articles (09/2016 - 01/2003)
2.	Casero, Robert A: 12 articles (11/2021 - 12/2003)
3.	O'Brien, Thomas G: 12 articles (04/2009 - 04/2002)
4.	Bachmann, André S: 10 articles (01/2021 - 12/2008)
5.	Gerner, Eugene W: 10 articles (01/2014 - 05/2002)
6.	Gilmour, Susan K: 9 articles (03/2014 - 01/2005)
7.	Afaq, Farrukh: 8 articles (08/2014 - 01/2003)
8.	Hayes, Candace S: 8 articles (03/2014 - 01/2005)
9.	Liu, Xian-Xi: 8 articles (11/2013 - 04/2003)
10.	Shantz, Lisa M: 8 articles (07/2012 - 04/2002)

Related Diseases

1.	Neoplasms (Cancer) 12/01/1994 - "However, the ornithine decarboxylase (ODC) activity in the neoplasms was significantly greater than that of the non-neoplastic and control mucosae (P < 0.001). " 01/01/2005 - "To study the mechanism of this selective effect, we used the ornithine decarboxylase (ODC)/Ras double transgenic mouse model that develops spontaneous skin tumors due to over-expression of ODC and a v-Ha-ras transgene. " 11/01/2004 - "The aim of this study is to analyze MTAP and ornithine decarboxylase (ODC) expression in primary pancreatic tumor specimens. " 06/01/1999 - "In this study, we investigated the effect of InsP6 on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity, an essential event in tumor promotion in HEL-30 cells, a murine keratinocyte cell line and SENCAR mouse skin. " 05/01/1994 - "In the present study, the role of this reactive intermediate in the induction of ornithine decarboxylase (ODC), a gene strongly associated with tumor promotion, was investigated in cultured keratinocytes. "
2.	Carcinogenesis 02/15/2005 - "Numerous studies have linked overexpression of ornithine decarboxylase (Odc) gene with enhanced susceptibility to mouse skin tumorigenesis. " 11/03/1995 - "We have now subjected the animals to a long-term survival study in order to assess whether constitutively over-expressed ornithine decarboxylase would predispose them to enhanced tumorigenesis and neuronal degeneration. " 06/01/1989 - "Ornithine decarboxylase (ODC) activity was determined in order to study the role of promoters in the process of colorectal carcinogenesis. " 02/14/2022 - "Ornithine decarboxylase (ODC), which is involved into multiple pathways, is closely related to carcinogenesis and development. " 12/01/2020 - "Chronic stress decreases ornithine decarboxylase expression and protects against 1,2-dimethylhydrazine-induced colon carcinogenesis."
3.	Skin Neoplasms (Skin Cancer) 01/01/2010 - "Targeting ornithine decarboxylase for the prevention of nonmelanoma skin cancer in humans." 01/01/2003 - "In a second experiment, two groups each consisting of three CD(1) mice were used to assess the effect of pomegranate seed oil on TPA-stimulated ornithine decarboxylase (ODC) activity, an important event in skin cancer promotion. " 07/03/2023 - "Here we report clinical risk factors and event rates for the development of new non-melanoma skin cancer (NMSC) in a randomized, double-blind, placebo-controlled trial of the irreversible ornithine decarboxylase (ODC) inhibitor, difluromethylornithine (DFMO), over a 3-5-year follow-up. " 09/01/2012 - "A significant reduction in the expression of ornithine decarboxylase, a key enzyme in the promotion stage of 2-stage skin cancer, in the plant-treated group was also observed. " 10/08/2010 - "Cytoplasmic accumulation of the RNA-binding protein HuR stabilizes the ornithine decarboxylase transcript in a murine nonmelanoma skin cancer model."
4.	Starvation 04/16/1987 - "Substrate specificity in the stimulation of intestinal ornithine decarboxylase activity by refeeding after starvation." 01/01/1987 - "Increasing the duration of maternal starvation resulted in a progressive increase in fetal brain ornithine decarboxylase. " 11/15/1980 - "In conclusion, these findings indicate that the regulation of ornithine decarboxylase in many tissues is grossly impaired in diabetes and starvation. " 11/15/1980 - "Starvation for 48h decreased ornithine decarboxylase activity to very low values in tissues of both normal and diabetic rats. " 06/01/1978 - "Induction of ornithine decarboxylase in synchronized BHK cells by calf serum after a short period of serum-starvation."
5.	Hyperplasia 04/20/2002 - "In the present study, we found that BQ and LPA at concentrations of 25,50,75 mg/ml caused significant induction of hyperplasia, but only LPA caused an increase of epidermal ornithine decarboxylase (ODC). " 01/01/1994 - "Results from several studies have demonstrated that both ornithine decarboxylase (ODC) and DAO activity rise during adaptive hyperplasia seen after small bowel resection. " 09/01/1999 - "Type I diabetes is associated with jejunal mucosal hyperplasia, and administration of diflouromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase (ODC), causes hypoplasia. " 12/01/1994 - "Inhibition of ornithine decarboxylase does not prevent intestinal smooth muscle hyperplasia in the rat." 06/01/1991 - "Intimal hyperplasia is reduced by ornithine decarboxylase inhibition."

Related Drugs and Biologics

1.	Eflornithine (Ornidyl)
2.	Enzymes
3.	Polyamines
4.	Putrescine
5.	anthracene
6.	DNA (Deoxyribonucleic Acid)
7.	Spermidine
8.	Adenosylmethionine Decarboxylase
9.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)
10.	Piroxicam (Feldene)

Related Therapies and Procedures

1.	Therapeutics
2.	Chemoprevention
3.	Oral Administration
4.	Drug Therapy (Chemotherapy)
5.	Ovariectomy (Oophorectomy)