Orbital Diseases

01/01/2015 - "To review the clinical efficacy and safety of rituximab for treatment of IgG4-related orbital disease (IgG4-ROD). "
01/01/2015 - "Rituximab for the treatment of IgG4-related orbital disease: experience from five cases."
12/01/2019 - "We examined the clinical outcomes, imaging results, and histopathological findings of all patients from September 1, 1994, through July 1, 2017, with a diagnosis of orbital GPA who, after treatment with rituximab, required an orbital excisional biopsy for refractory orbital disease. "
05/01/2014 - "Of 10 enrolled patients, 7 demonstrated improvement on the orbital disease grading scale at the 24-week end point with rituximab therapy. "
05/01/2014 - "Rituximab was safe and effective in 7 of 10 patients with noninfectious orbital disease, although 4 required reinfusion with rituximab to maintain control of orbital inflammation. "

10/20/2022 - "Non-specific orbital inflammation (NSOI) and IgG4-related orbital disease (IgG4-ROD) are currently treated with non-specific immunosuppressive agents based on non-randomized, uncontrolled studies. "
05/01/2015 - "We present here two children with IgG4-related orbital disease, one of whom responded well to prednisolone treatment while the other one was refractory to most immunosuppressive agents. "

12/06/2018 - "Although orbital MRI remains the gold standard for imaging orbital disease, many orbital lesions are now detected on somatostatin-receptor (SSTR) based imaging such as 68Ga-DOTATATE PET-CT. "
12/01/2019 - "The basis of using 68Ga-DOTANOC PET/CT in IgG4 orbital disease is the known expression of somatostatin receptors in chronic inflammatory cells (Cuccurullo et al. Indian J Radiol Imaging 27:509-16, 2017) and also avidity shown previously in other IgG4-related diseases (Cheng et al. Clin Nucl Med 43:773-6, 2018)."

05/01/2015 - "We present here two children with IgG4-related orbital disease, one of whom responded well to prednisolone treatment while the other one was refractory to most immunosuppressive agents. "
05/04/2021 - "Debulking Surgery Combined with Low-Dose Oral Prednisolone and Azathioprine for Intractable IgG4-Related Orbital Disease: A Case Report."
05/04/2021 - "A case of intractable IgG4-related orbital disease (IgG4-ROD) was successfully treated by debulking surgery combined with low-dose prednisolone and azathioprine as maintenance therapy. "

04/01/2022 - "Treatment with cisplatin and 5-Fluorouracil proved efficacious with a significant reduction of orbital and post-orbital disease on interval scanning."

04/01/2022 - "Treatment with cisplatin and 5-Fluorouracil proved efficacious with a significant reduction of orbital and post-orbital disease on interval scanning."

12/06/2018 - "Although orbital MRI remains the gold standard for imaging orbital disease, many orbital lesions are now detected on somatostatin-receptor (SSTR) based imaging such as 68Ga-DOTATATE PET-CT. "

01/01/2019 - "The aim of the present study was to observe the histopathological changes of immunoglobulin G4-related orbital diseases (IgG4-RODs), summarize the clinical manifestations and imaging features of the IgG4-RODs of the eyelids and explore the early diagnosis of IgG4-RODs. "
01/01/2022 - "Immunoglobulin G4-related orbital disease in an 8-year-old girl."
12/01/2020 - "Immunoglobulin G4-Related Orbital Disease with Bilateral Optic Perineuritis and Maxillary Nerves Involvement: A Case Report."
07/01/2017 - "Immunoglobulin G4-related orbital disease: An important differential diagnosis for orbital swellings with lymphoplasmacytic infiltration."
05/01/2015 - "Immunoglobulin G4-related orbital disease: report of two pediatric cases."

09/11/2022 - "To improve the standardized diagnosis and treatment of TAO in China, the Oculoplastic and Orbital Disease Group of Chinese Ophthalmological Society of Chinese Medical Association and the Thyroid Group of Chinese Society of Endocrinology of Chinese Medical Association have jointly drawn up this first clinical guideline in China for TAO by complying with the principles, methods and steps of guideline formation. "
05/01/2021 - "The data of 2170 TAO patients who were seen at the Orbital Disease Clinic, West China Hospital, Sichuan University from September, 2009 to January, 2020 were collected retrospectively. "
01/01/2019 - "Thyroid-associated ophthalmoapthy (TAO) is the most common orbital disease. "
06/11/2017 - "TAO is a common autoimmune orbital disease. "
07/01/2012 - "A case-control gene expression study was conducted using test samples of orbital fat from TAO patients and control orbital fat specimens; apart from drugs to control thyrotoxicosis, the TAO patients had received no treatment for orbital disease. "

04/01/2004 - "In eyes with retinal or orbital diseases, the correlation coefficients were lower than in the control study group. "
04/01/2004 - "Depending on coexisting retinal or orbital diseases, ophthalmodynamometric estimation of the central retinal artery collapse pressure, performed during a routine Goldmann contact lens ophthalmoscopy, correlates with systemic blood pressure measurements."
11/01/2016 - "Venous pulsation properties also have significant prognostic value in predicting long-term outcomes for both glaucoma and central retinal vein occlusion, as well as utility in other retinal vasculopathies and orbital disease. "
12/01/2009 - "The most frequent ophthalmic lesions are inflammatory orbital disease, (necrotising) scleritis with or without keratopathy, episcleritis, conjunctivitis and even conjunctival ulcer, nasolacrimal ducts obstruction, uveitis, retinal vasculitis and even central retinal vascular occlusion, optic neuritis. "
01/01/2017 - "To apply this technique to quantitatively assess retinal nerve fiber layer (RNFL) and macular ring thicknesses in healthy subjects and in patients with TAO to determine their relationship to the severity of the orbital disease. "

05/01/1996 - "Patients with extraocular orbital disease and had a good outcome with this therapy. "
11/01/2018 - "During the past decade, improved understanding of the pathology and pathophysiology of particular orbital diseases, advancements in clinical endoscopy and microscopy, the introduction of modern imaging techniques for preoperative visualization of pathologic findings, modern approaches to orbital reconstruction, as well as developments in adjuvant therapy have led to a reduction in invasiveness and development of the modern minimally invasive surgical approaches to the orbit usually used today. "
10/17/2023 - "To evaluate retrobulbar injection of PA as a potential therapy for orbital diseases with fat proliferation, in vivo studies in different animal models, higher concentrations of PA, or longer follow-up duration are required."
09/11/2023 - "Analysis of big data may improve our overall understanding of orbital disease and role of adjuvant therapies. "
05/09/2022 - "New medical therapies have been developed for the management of lymphatic orbital disease. "

05/01/2012 - "In contrast, 48% (10 of 21) with orbital disease completed chemotherapy and only 50% (5 of 10) achieved remission. "
07/01/2023 - "Treatment includes chemotherapy and radiation, which may improve orbital disease; however, the overall prognosis remains poor."
10/01/2016 - "In patients with residual orbital disease after chemotherapy, low dose radiation can be used to improve local disease control and improve quality of life. "
01/01/2016 - "There is currently little evidence that unifocal orbital disease increases the risk for CNS-LCH and therefore warrants prophylactic systemic chemotherapy in all patients."
05/01/2012 - "Those with ocular and orbital disease received chemotherapy. "

08/01/2022 - "All nine patients with limited orbital disease had good improvement with fewer injections (median = 4). "
03/01/2016 - "The exclusion criteria were patients with any previous ocular surgery 6 months before filler injection, patients with orbital diseases, and patients who had HAG injections for functional purposes. "
01/01/2022 - "In patients with minimal orbital disease and especially with preserved vision, retrobulbar injections of amphotericin B can be of great help in controlling the disease. "
05/01/2014 - "Systemic corticosteroids and cyclosporine were initiated unsuccessfully; therefore intra-lesional injections of triamcinolone were started, which controlled the orbital disease. "

07/01/2017 - "As of this writing, 2 patients have completed therapy and remain disease free at least 1 year after treatment completion; the other patient is still receiving treatment, and his orbital disease is responding. "
12/01/2019 - "We examined the clinical outcomes, imaging results, and histopathological findings of all patients from September 1, 1994, through July 1, 2017, with a diagnosis of orbital GPA who, after treatment with rituximab, required an orbital excisional biopsy for refractory orbital disease. "

01/01/2022 - "Radiotherapy was used as the last resort in one patient with severe orbital disease. "
01/01/2008 - "In addition, we demonstrate clinico-pathological correlation with an identical chronic B-cell lymphocytic infiltrate in both orbit and bone marrow, with good response of the orbital disease to local radiotherapy."
12/01/2004 - "[The applications of the radiotherapy in the orbital disease]."
08/04/1989 - "[Radiotherapy of endocrine orbital disease]."
04/01/1988 - "Radiotherapy in benign orbital disease. "