Opisthorchiasis

Infection with flukes of the genus Opisthorchis.

Also Known As:

Opisthorchis Infection; Opisthorchis felineus Infection; Opisthorchis viverrini Infection; Infection, Opisthorchis; Infection, Opisthorchis felineus; Infection, Opisthorchis viverrini; Infections, Opisthorchis; Infections, Opisthorchis felineus; Infections, Opisthorchis viverrini; Opisthorchiases; Opisthorchis Infections; Opisthorchis felineus Infections; Opisthorchis viverrini Infections

Networked: 427 relevant articles (21 outcomes, 52 trials/studies)

Relationship Network

Disease Context: Research Results

Infections: 526564
- Parasitic Diseases: 4870
  - Helminthiasis: 527
    - Trematode Infections: 111
      - Opisthorchiasis: 427

Related Diseases

1.	Opisthorchiasis
2.	Infections
3.	Cholangiocarcinoma
4.	Inflammation (Inflammations)
5.	Clonorchiasis

Experts

1.	Sithithaworn, Paiboon: 34 articles (06/2022 - 11/2008)
2.	Sripa, Banchob: 31 articles (08/2022 - 05/2003)
3.	Brindley, Paul J: 30 articles (03/2022 - 11/2008)
4.	Yongvanit, Puangrat: 25 articles (01/2019 - 07/2008)
5.	Pinlaor, Somchai: 23 articles (01/2022 - 07/2008)
6.	Boonmars, Thidarut: 22 articles (12/2021 - 08/2009)
7.	Laha, Thewarach: 20 articles (07/2021 - 11/2008)
8.	Mairiang, Eimorn: 18 articles (08/2022 - 10/2009)
9.	Loilome, Watcharin: 16 articles (06/2022 - 03/2012)
10.	Pairojkul, Chawalit: 16 articles (01/2021 - 01/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Opisthorchiasis:

1.	Praziquantel (Biltricide)FDA Link 09/01/1981 - "High efficacy of praziquantel in the treatment of 22 patients with Clonorchis/Opisthorchis infections." 11/01/2007 - "In the present study, conducted in December 2005 during a mass treatment campaign for the control of opisthorchiasis in 232 individuals in Nala village, Keo Udom district, Lao PDR, performance of the dose pole in estimating dosages of praziquantel was compared with a bathroom scale; a digital scale was used as the gold standard. " 07/01/1994 - "There are no either basic differences in the efficacy of praziquantel doses of 30, 40, and 60 mg used in the treatment of patients with Opisthorchis infection in whom 1 to 1.00 eggs per g feces are found. " 07/01/1990 - "[A comparative study of the efficacy of praziquantel and its liposomal form in experimental opisthorchiasis]." 09/01/1981 - "In a prospective clinical study, the efficacy of praziquantel in the treatment of 22 patients with Clonorchis/Opisthorchis infections was investigated. "
2.	AntigensIBA 06/02/2023 - "The gold standard for diagnosing opisthorchiasis is still via stool microscopy, but the advent of novel serological, antigen, and molecular tests shows promise as more convenient, alternative diagnostic methods. " 11/21/2023 - "A field trial in the application of urinary OV-RDT was compared with urinary antigen ELISA at baseline screening and assessment of drug treatment outcomes in opisthorchiasis (n = 1629). " 01/01/2023 - "In this study, we prospectively monitored Opisthorchis viverrini antigen concentrations for 30 consecutive days and at subsequent monthly intervals in a cohort of opisthorchiasis-positive individuals. " 03/28/2022 - "This study demonstrated a direct link of urine and copro antigen tests with worms infecting the liver thereby reaffirming the reliability of urine and copro antigen assay in opisthorchiasis diagnosis." 04/01/2001 - "This study has indicated that long-term preservation of complaints in patients with prior chronic opisthorchiasis may be due not only to morphological changes in the organ, but by the persistence of functional Opisthorchias antigens, which determines preserved sensitization that plays a leading role in the pathogenesis of chronic opisthorchiasis. "
3.	EnzymesIBA 11/01/2008 - "Immunoblotting was used to assess the potential of this enzyme for immunodiagnosis of human opisthorchiasis. " 01/01/2004 - "[Enzyme immunoassay of opisthorchiasis in the population of the Shuryshkarsk district, Iamalo-Nenets autonomous region]." 10/01/1999 - "Communication 2. Enzyme immunoassay test system for diagnosis of acute opisthorchiasis]." 10/01/1999 - "[Enzyme immunoassay in diagnosis of opisthorchiasis. " 01/01/1971 - "[Content of some enzymes in children with opisthorchiasis]."
4.	Monoclonal AntibodiesIBA 11/01/2020 - "The 1A2 monoclonal antibody may be of value in the diagnosis of opisthorchiasis by coproantigen detection." 12/01/2013 - "Improved performance and quantitative detection of copro-antigens by a monoclonal antibody based ELISA to diagnose human opisthorchiasis." 07/05/2021 - "To address the role of anti-Ov-TSP-2 antibodies in protection, we assessed the protective capacity of anti-Ov-TSP-2 monoclonal antibodies (mAbs) against opisthorchiasis. " 06/01/1995 - "Evaluation of a monoclonal antibody-based enzyme linked immunosorbent assay for the diagnosis of Opisthorchis viverrini infection in an endemic area." 06/01/1995 - "A monoclonal antibody-based enzyme-linked immunosorbent assay (MAb-ELISA) was evaluated for its potential in the diagnosis of opisthorchiasis in an area endemic for Opisthorchis viverrini infection. "
5.	Biomarkers (Surrogate Marker)IBA 07/01/2008 - "Urinary epsilondA and epsilondC levels should be explored (a) as noninvasive risk markers for developing opisthorchiasis-related CCA and (b) as promising biomarkers to assess the efficacy of preventive and therapeutic interventions." 05/01/2010 - "This study provides basic information for Prdx6 as a potential biomarker and therapeutic target for opisthorchiasis." 01/01/2015 - "A candidate biomarker was confirmed by immunoprecipitation and western blot, and was further analyzed using ELISA and sera from normal control hamsters, hamsters with opisthorchiasis and hamsters with various stages of CCA, as well as from CCA patients and healthy individuals. " 05/01/2014 - "These multiple risk biomarkers could now be explored for screening including chemopreventive intervention of subjects living in endemic areas where the prevalence of opisthorchiasis remains high. " 03/01/2014 - "Our results strongly suggested that MFG-E8 is a promising biomarker for the diagnosis, prognosis, and therapy target of opisthorchiasis-associated CCA."
6.	Proteins (Proteins, Gene)FDA Link 04/01/2003 - "Cytochemistry was used to study the level of lysosomal cationic proteins of polymorphonuclear peripheral leukocytes in 25 and 20 patients with acute and chronic opisthorchiasis, respectively, before treatment. " 03/01/2016 - "This protein was also observed in parasite organs, especially during the chronic phase of opisthorchiasis. " 03/01/2016 - "Liver tissues derived from normal hamsters and those with chronic/advanced opisthorchiasis (n = 5 per group) were subjected to 2DE and LC-MS/MS. Candidate protein expression was confirmed in hamster models and human CCA tissue microarray (TMA) using immunohistochemistry and Western blot. " 03/01/2010 - "viverrini proteins identified here provide an extensive catalogue of novel leads for research on the pathogenesis of opisthorchiasis and the development of novel interventions for this disease and CCA, as well as providing a scaffold for sequencing the genome of this fluke." 04/01/2003 - "That the ratios of an increase in the intracellular content of lysosomal cationic proteins to that in the control individuals were found to be 13.86 and 4.50 for acute and chronic opisthorchiasis, respectively. "
7.	AnthelminticsIBA 03/01/1988 - "The purpose of this study was to explore alternative method(s) to monitor the efficacy of anthelmintic treatment of patients with opisthorchiasis. " 06/01/2021 - "Compared with previously published data on the effectiveness of various drugs in experimental opisthorchiasis felinea, PZQ-Na2GA × 3 exerts the most potent anthelmintic effect. " 05/01/2021 - "We conducted a prospective case-control study to evaluate the gut microbiota in children with Opisthorchis felineus infection (n=50) before and after anthelmintic treatment and in uninfected children (n=49) in the endemic region. " 06/01/2019 - "A Syrian golden hamster model of opisthorchiasis revealed a considerable anthelmintic effect at all tested PrzQ:GA doses (50, 100, 200, 400, and 1100 mg/kg) with the best performance at 400 and 1100 mg/kg. Further comparison of the effects of PrzQ (400 mg/kg) and PrzQ:GA (400 mg/kg) regarding the state of the host indicated significant advantages of the latter. " 01/01/1990 - "[Clinico-immunologic indicators in children with opisthorchiasis in relation to the use of various anthelmintics]."
8.	ImmunosorbentsIBA 01/01/2017 - "Fecal analysis and enzyme-linked immunosorbent assay tests can be used to diagnose opisthorchiasis. " 08/01/1995 - "We evaluated an enzyme-linked immunosorbent assay using crude parasite homogenates as a diagnostic test for Opisthorchis viverrini infection in humans. " 07/01/1994 - "viverrini adult worm homogenate and metacercaria homogenate (MH) were studied using enzyme-linked immunosorbent and immunoblot assays in 65 infected residents of an opisthorchiasis-endemic area in Thailand. " 03/01/1988 - "The humoral immune response in patients with opisthorchiasis was investigated using an enzyme-linked immunosorbent assay. " 06/01/1985 - "Enzyme-linked immunosorbent assay for detection of Opisthorchis viverrini infection."
9.	CytokinesIBA 08/23/2018 - "This study aimed to investigate risk factors for ICC with a focus on opisthorchiasis and polymorphisms of proinflammatory cytokines (IL-1β and TNF-α). " 10/01/2011 - "[The value of cytokines in immunity in case of opisthorchiasis]." 04/01/2010 - "The production of these cytokines in opisthorchiasis patients with a high infestation rate (Group 2) was significantly higher than that in those with a low infestation rate (Group 1). " 04/01/2010 - "[Cytokine production in relation to the rate of infestation in patients with chronic opisthorchiasis]." 07/01/2008 - "There was an increase in the number of receptor structures to eosinophil-specific cytokines (IL-5R-, IL-3R-, and CCR3-positive cells) in patients with opisthorchiasis. "
10.	Formaldehyde (Formol)FDA Link 06/27/2022 - "Performance of Mini Parasep® SF stool concentrator kit, Kato-Katz, and formalin-ethyl acetate concentration methods for diagnosis of opisthorchiasis in Northeast Thailand." 03/01/2012 - "All were stool-examined for Opisthorchis viverrini infection by standard quantitative formalin/ethyl acetate concentration technique. " 01/01/1990 - "Three series of investigations of the sensitivities of the modified chemical sedimentation method, microscopy of the native smear, Kato's, Hein's, Kalantaryan's, Stoll's methods, and ether-formalin sedimentation of helminthic eggs were carried out with the material from opisthorchiasis patients with invasion of low intensity. " 11/21/2023 - "Screening for opisthorchiasis, a parasitic worm infection affecting many millions of people in Southeast Asia, has traditionally relied on faecal egg examination such as the formalin-ethyl acetate concentration technique (FECT) and Kato-Katz method. " 03/01/2012 - "In cooperation with the other human opisthorchiasis control programs in an endemic area of 29 villages in Ban Haet, Ban Phai, Chonnabot and Muncha Khiri Districts, Khon Kaen, this study investigated the prevalence of Opisthorchis viverrini infection using a formalin-ether sedimentation method as the gold standard, and hematology and blood chemistry of the reservoir hosts in this endemic area. "

Therapies and Procedures

1.	Therapeutics 01/01/2010 - "[Principles of therapy of hepatobiliary and pancreatic pathology in elderly people with chronic opisthorchiasis]." 01/01/2009 - "[Diastolic dysfunction of left ventricle in psoriatic patients with concomitant opisthorchiasis before and after antihelminthic therapy]." 01/01/2008 - "[Combined therapy of patients with chronic opisthorchiasis including background resonance radiation]." 10/01/2007 - "[Systemic responsiveness and the efficiency of antihomotoxic therapy for chronic opisthorchiasis. " 04/01/2007 - "The authors propose a new treatment policy for opisthorchiasis, which is intended for the body's self-regulation and based on the use of antihomotoxic therapy. "
2.	Aftercare (After-Treatment) 03/01/1985 - "[Immune system in children with opisthorchiasis before and after treatment]." 04/01/2003 - "Antihelminthic therapy improved the results of hepatic tests in different periods after treatment for acute or chronic opisthorchiasis in relation to the rate of compensation of structural lesions. " 03/01/1989 - "Ultrasonographic study of the biliary system in opisthorchiasis patients after treatment with praziquantel." 01/01/1984 - "In a study, gallbladder lesions due to Opisthorchis viverrini infection were controlled roentgenographically after treatment with praziquantel (2-cyclohexylcarbonyl-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a] isoquinolin- 4-one, EMBAY 8440, Biltricide). " 01/01/2002 - "The lymphocytic populations of the immune system were studied in patients diagnosed as having acute opisthorchiasis before and 1-3 days after treatment with biltricide in a dose of 60 mg/kg body weight. "
3.	Duration of Therapy 03/01/1984 - "Albendazole was shown to be effective against Opisthorchis viverrini infection as well as other concomitant intestinal helminthic infections; but the optimal dosage and duration of treatment have not yet been achieved."
4.	Drug Therapy (Chemotherapy) 01/01/2012 - "viverrini, and hence it will be interesting to monitor potential ancillary benefits of a preventive chemotherapy strategy that targets STHs in areas where opisthorchiasis is co-endemic. " 01/01/2003 - "Chronic opisthorchiasis is treated in three stages: preparation measures, specific chemotherapy, rehabilitation." 03/01/1981 - "[Factors affecting the effectiveness of chemotherapy in opisthorchiasis. " 09/01/1980 - "[Factors affecting the effectiveness of opisthorchiasis chemotherapy. " 09/01/1994 - "However, it is also evident that drug therapy alone will not solve the opisthorchiasis problem, as indicated by the reinfection rate of almost 10% at the end of the study."
5.	Punctures 11/01/1965 - "[Opisthorchiasis--contraindication to diagnostic puncture of the liver (pathomorphologic study)]."