|3.||Filarial Elephantiasis (Lymphatic Filariasis)
|5.||Ocular Onchocerciasis (River Blindness)
|1.||Hoerauf, Achim: 30 articles (12/2015 - 01/2002)|
|2.||Boussinesq, Michel: 20 articles (05/2015 - 07/2002)|
|3.||Kamgno, Joseph: 19 articles (05/2015 - 07/2002)|
|4.||Wanji, Samuel: 19 articles (01/2015 - 02/2007)|
|5.||Basáñez, María-Gloria: 17 articles (07/2015 - 01/2003)|
|6.||Prichard, Roger K: 15 articles (10/2014 - 01/2006)|
|7.||Boussinesq, M: 15 articles (07/2011 - 01/2000)|
|8.||Büttner, Dietrich W: 15 articles (07/2010 - 04/2002)|
|9.||Specht, Sabine: 13 articles (12/2015 - 09/2008)|
|10.||Adjei, Ohene: 13 articles (08/2015 - 04/2002)|
|1.||Ivermectin (Mectizan)FDA Link
01/01/2008 - "We have helped administer nearly 20% of the 530 million Mectizan (ivermectin) doses for onchocerciasis, which is now being controlled throughout most of Africa, and is progressing toward elimination in the Americas. "
04/01/2004 - "Through the extensive clinical testing protocols implemented in a variety of countries in Aftica, ivermectin has been proven to be a safe and highly effective treatment for onchocerciasis. "
05/01/1994 - "Ivermectin is highly effective against animal intestinal nematodes and is used in the treatment of onchocerciasis in humans. "
10/01/2004 - "This shows that Community Directed Treatment with Ivermectin (CDTI) campaign is successful and should be sustained until onchocerciasis is eliminated as a public health problem in the area."
04/01/2004 - "If ivermectin-based programmes for the control of human onchocerciasis are to be successful, the drug must remain effective for as long as necessary. "
|2.||Doxycycline (Vibramycin)FDA LinkGeneric
01/01/2009 - "Doxycycline has been shown to be effective in the treatment of onchocerciasis and has the added advantages of killing adult Onchocerca volvulus but neither adult Loa loa nor their microfilariae. "
05/01/2006 - "Recent research using a chemotherapeutic approach that targets filarial Wolbachia symbionts in the treatment and control of onchocerciasis, however, suggests that 100 mg/d of doxycycline for 6 weeks might be effective in reducing the filarial load and preventing ocular symptoms."
09/01/2008 - "Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study."
12/01/2001 - "In the first trial on human onchocerciasis depletion of bacteria following treatment with doxycycline resulted in a complete and long-term block of embryogenesis. "
04/15/2015 - "The efficacy parameters are pertinent to the prospects of using doxycycline on a "test and treat" basis for onchocerciasis control and confirm doxycycline as a potent macrofilaricidal therapy. "
|3.||Diethylcarbamazine (Hetrazan)FDA Link
09/01/1980 - "A double-masked, controlled clinical trial was conducted in Guatemala to assess the safety and efficacy of diethylcarbamazine (DEC) lotion as compared to placebo lotion in the treatment of onchocerciasis. "
05/03/1980 - "In a double-blind controlled clinical trial comparing the safety and efficacy of oral diethylcarbamazine citrate (DEC) with topical DEC for the treatment of onchocerciasis twenty men with moderate skin-snip microfilarial counts received daily therapy for 1 week, then weekly therapy for the rest of 6 months. "
12/01/1987 - "Analyses are made of a pooled set of data from ten separate studies of diethylcarbamazine (DEC) conducted at the Onchocerciasis Chemotherapeutic Research Centre, Tamale, between 1978 and 1983. "
05/10/1952 - "A histological study of onchocerciasis treated with hetrazan."
01/01/2007 - "As part of a baseline data collection for assessing the impact of the African Programme for Onchocerciasis Control, to evaluate the diethylcarbamazine (DEC) patch test in determining the endemicity of onchocerciasis. "
11/01/1990 - "These antigens may be useful as targets for improved diagnostic tests for onchocerciasis based on parasite antigen detection."
06/30/2005 - "In the search for Onchocerca volvulus antigens possibly involved in protection against human onchocerciasis, partial amino acid sequence analysis of one of the O. "
09/01/1993 - "Thus, although this study has provided new information on parasite antigens in sera from onchocerciasis patients, additional work will be needed to achieve the goal of producing a sensitive and specific antigen diagnostic test for onchocerciasis."
09/01/1989 - "In order to assess the possible suppression of immune responses to non-specific antigens in patients with generalized onchocerciasis, a vaccination study was conducted among the population of eight Liberian villages. "
06/01/1986 - "A study on antigen recognition by onchocerciasis patients with different clinical forms of disease."
12/01/2011 - "The study was aimed at determining the pattern of co-occurrence of species of microfilaraemia between onchocerciasis endemic and sporadic populations. "
01/01/2015 - "Adherence to IVM repeated treatment has recently been shown to be a confounding factor for onchocerciasis elimination precisely in rain forest areas where transmission continues and Loa loa co-exists with Onchocerca volvulus. "
09/01/2008 - "The NGDO Co-ordination Group for Onchocerciasis Control."
09/01/2008 - "The protocol, criteria and deadline for stopping all onchocerciasis treatment in the region should soon be addressed by OEPA's Program Co-ordinating Committee (PCC), in co-ordination with the PAHO."
09/01/2008 - "In 1992, the Onchocerciasis Elimination Program for the Americas (OEPA) was launched, with its headquarters in Guatemala, to act as a technical and co-ordinating body of a multinational, multi-agency coalition that includes the endemic countries, PAHO, The Carter Center, Lions Clubs, the United States Centers for Disease Control and Prevention, The Bill and Melinda Gates Foundation, Merck & Co., Inc., and other partners. "
|6.||Suramin (Suramin Sodium)IBA
12/01/1985 - "Suramin in the treatment of onchocerciasis: the efficacy of low doses on the parasite in an area with vector control."
05/01/1998 - "Ten male patients with onchocerciasis received six weekly infusions of suramin according to the WHO-recommended regimen. "
05/01/1998 - "Clinical pharmacokinetics of suramin in patients with onchocerciasis."
05/01/1992 - "Suramin and therapy of onchocerciasis."
06/13/1987 - "Suramin and eosinophil degranulation and vacuolation in onchocerciasis."
01/01/1981 - "Studies of metrifonate in onchocerciasis."
06/01/1978 - "Further studies on the treatment of onchocerciasis with metrifonate."
03/01/1979 - "Skin snips of six patients with manifest onchocerciasis treated with a single dose of metrifonate (10 mg/kg) were examined by electron microscopy one, three, five and ten days after application of the drug. "
09/01/1968 - "[Treatment of onchocerciasis with trichlorofon (Neguvon). "
06/01/1980 - "The chemotherapy of onchocerciasis IV. Further trials with metrifonate."
06/01/2014 - "Provided its results confirm those from this study, availability of moxidectin to control programmes could help them achieve onchocerciasis elimination objectives. "
08/01/2011 - "Moxidectin, a macrocyclic lactone, is currently in clinical trials for onchocerciasis. "
01/01/2015 - "Moxidectin is a promising new drug for the control and elimination of onchocerciasis. "
01/01/2015 - "The potential impact of moxidectin on onchocerciasis elimination in Africa: an economic evaluation based on the Phase II clinical trial data."
11/01/2011 - "Moxidectin, registered worldwide as a veterinary antiparasitic agent, is currently under development for humans for the treatment of onchocerciasis in collaboration with the World Health Organization. "
|9.||Immunoglobulin E (IgE)IBA
12/01/1982 - "The present study reports the presence of Onchocerca volvulus specific IgE in the sera obtained from onchocerciasis patients. "
01/01/2002 - "Sowda patients had higher IgE levels than those with generalized onchocerciasis. "
03/15/1999 - "Statistical differences between both sections were found for the absolute eosinophil counts and for serum EDN/EPX and IgE in generalized onchocerciasis, and for urinary ECP in sowda, indicating stimulation of the eosinophil potential of O. "
11/01/1989 - "Concentrations of total serum IgE were measured by an immunoenzymatic assay (Phadezym-PRIST) in 60 mexican onchocerciasis patients. "
11/01/1989 - "[Immunoenzymatic evaluation of serum IgE in onchocerciasis in Chiapas, Mexico]."
01/01/2015 - "These vaccines could be based on one or more of three lead candidates identified by a newly formed transatlantic partnership, The Onchocerciasis Vaccine for Africa Initiative. "
01/01/2015 - "Here, we argue that prophylactic and therapeutic vaccines would accelerate elimination efforts and safeguard the enormous strides made in onchocerciasis control. "
08/01/1995 - "Although there was some inconsistency in antibody responses observed in each treatment group, the results suggest that OC 9.3 may be more useful than OC 3.6 for monitoring the efficacy of prophylactic drugs or vaccines for onchocerciasis while OC 3.6 may be useful for detecting exposure to the parasite and early infection, regardless of the later outcome of the infection."
01/01/2000 - "4. ongoing work in clinical trials of new approaches to prevent or delay the onset of vision loss from eye disease, including future vaccines for chlamydia and onchocerciasis. "
06/01/2000 - "volvulus as well as for the identification of novel targets for filaricidal agents and/or vaccines against onchocerciasis based on immunological and rational hypothesis-driven research."
|1.||Drug Therapy (Chemotherapy)
01/01/1990 - "The primary objective of the Wellcome Foundation/World Health Organisation Onchocerciasis Chemotherapy Project, which began in July 1982, was the discovery and development of a safe and effective macrofilaricide for the treatment of onchocerciasis in man. "
02/01/1985 - "The efficacy of the drug on single dosage and the mild adverse reactions produced, if confirmed in subsequent controlled studies, would greatly simplify the treatment of onchocerciasis and would reintroduce new concepts of the role of chemotherapy in the control of onchocerciasis."
01/01/1990 - "In the context of the future of the OCP and of the control of onchocerciasis elsewhere in the world, the need for improved chemotherapy is discussed. "
08/01/1993 - "The primate and rodent models developed in the present study will be useful for the study of the immunology and chemotherapy of onchocerciasis."
09/01/1989 - "The present study has shown for the first time that mass chemotherapy can significantly reduce onchocerciasis transmission. "
08/01/1990 - "Changes in antibody profile after treatment of human onchocerciasis."
01/01/1989 - "Side effects starting 12 to 24 hours after treatment are similar to those appearing during the normal evolution of onchocerciasis. "
09/01/1993 - "The long-term efficacy of a single dose of ivermectin (150 micrograms/kg) on skin microfilarial densities was evaluated by comparing parasite levels, before and after treatment, in 192 patients living in an area endemic for onchocerciasis in North Cameroon. "
09/01/2011 - "Data from two separate studies conducted in Cameroon on onchocerciasis patients treated for the first time with ivermectin were analyzed to identify host factors associated with microfilarial density at different time-points after treatment. "
12/01/1997 - "Immunohistological studies on macrophages in lymph nodes of onchocerciasis patients after treatment with ivermectin."
12/01/2015 - "However, a new formulation that provided sufficient bioavailability following oral administration could render FLBZ an effective treatment for onchocerciasis and LF. "
09/01/1991 - "Influence of food related to dose on the pharmacokinetics of amocarzine and of its N-oxide metabolite, CGP 13 231, after oral administration to 20 onchocerciasis male patients from Guatemala."
10/01/1990 - "The influence of food on the pharmacokinetics of CGP 6140 (amocarzine) after oral administration of a 1200 mg single dose to patients with onchocerciasis."
10/01/1990 - "Pharmacokinetics of CGP 6140 (amocarzine) after oral administration of single 100-1600 mg doses to patients with onchocerciasis."
06/01/1994 - "Lymph node and skin biopsies from Liberian patients with generalized and localized (sowda) onchocerciasis were studied 12-68 hours after oral administration of ivermectin at a single dose of 150 micrograms/kg body weight. "
|4.||Investigational Therapies (Experimental Therapy)
01/01/2009 - "The African Programme for Onchocerciasis Control has adopted an additional objective to assess progress towards elimination endpoints in all onchocerciasis control projects and to guide countries on cessation of treatment where feasible."
01/01/2015 - "Data from the first clinical study of moxidectin were used to parameterise the onchocerciasis transmission model EPIONCHO to investigate, for different epidemiological and programmatic scenarios in African savannah settings, the number of years and in-country costs necessary to reach the operational thresholds for cessation of treatment, comparing annual and biannual ivermectin with annual moxidectin treatment. "