|1.||Klinman, Dennis M: 15 articles (01/2015 - 05/2004)|
|2.||Agrawal, Sudhir: 11 articles (08/2007 - 01/2002)|
|3.||Hartmann, Gunther: 8 articles (01/2012 - 11/2002)|
|4.||Zhang, Ruiwen: 8 articles (09/2006 - 01/2002)|
|5.||Wang, Hui: 8 articles (09/2006 - 01/2002)|
|6.||Shirota, Hidekazu: 7 articles (01/2015 - 10/2004)|
|7.||Endres, Stefan: 7 articles (01/2012 - 11/2002)|
|8.||Gilchrest, Barbara A: 7 articles (01/2010 - 02/2003)|
|9.||Cogoi, Susanna: 6 articles (12/2015 - 01/2007)|
|10.||Jing, Naijie: 6 articles (05/2014 - 09/2004)|
09/01/2012 - "To validate the tumor-promoting effect of miR-221, we showed that in vivo delivery of anti-miR-221 oligonucleotides leads to a significant reduction of the number and size of tumor nodules. "
01/01/2008 - "Here we review the key properties of LNA oligonucleotides in the context of their use as safe and effective antisense drugs and provide a status on their therapeutic development in the field of cancer."
03/01/2007 - "These data confirm and expand our earlier work suggesting that such telomere homolog oligonucleotides (T-oligos) target an innate anti-cancer defense system in human cells and may provide an effective treatment for cancers of multiple different cellular origins and genetic profile."
01/01/2004 - "These mechanisms might help us to understand the biodistribution of oligo within tumors and might be helpful in evaluating the therapeutic effects of oligonucleotides and rational drug design."
07/01/2014 - "This review covers research and patent literature from the last three years, focusing on the development of safe and effective non-viral drug delivery systems for the treatment of diseases such as cancer or genetic disorders by using oligonucleotides. "
03/15/2002 - "However, if APCs were activated concomitantly in vivo using either anti-CD40 Abs or CpG oligonucleotides, the CTL responses induced were fully protective against infection with lymphocytic choriomeningitis virus or recombinant vaccinia virus. "
01/01/2015 - "Sets of virus-specific oligonucleotides and oligofluorophores were designed and used in a reverse-transcription loop-mediated multiplexed isothermal amplification reaction for detection and gel electrophoretic identification of human Immunodeficiency virus (HIV), hepatitis-B virus (HBV), hepatitis-C virus (HCV), hepatitis-E virus (HEV), dengue virus (DENV), and West Nile (WNV) virus infection in blood plasma. "
01/01/2015 - "When MARC-145 cells or PAM were infected with PRRSV followed by transfection with AS-ONs, four AS-ON sequences targeting 5'-UTR, ORF5 or NSP9 were found to be the most effective oligonucleotides in decreasing the cytopathic effect (CPE) induced by PRRSV infection. "
09/01/2014 - "We demonstrate a significant effect on HSV-1 replication in ARPE-19 and Vero cells when oligonucleotides designed to inhibit TLR9 are added 2h prior to infection. "
09/01/2014 - "Oligonucleotides designed to inhibit TLR9 block Herpes simplex virus type 1 infection at multiple steps."
|3.||Melanoma (Melanoma, Malignant)
04/15/2008 - "In vitro and in vivo functional studies, including the use of antisense "antagomir" oligonucleotides, confirmed the key role of miR-221/-222 in regulating the progression of human melanoma; this suggests that targeted therapies suppressing miR-221/-222 may prove beneficial in advanced melanoma."
01/01/2015 - "A high-throughput screening assay for the functional delivery of splice-switching oligonucleotides in human melanoma cells."
01/01/2013 - "In accordance, the reverse functional effects were obtained by knocking down miR-126&126* by transfecting antisense LNA oligonucleotides in melanoma cells. "
01/01/2010 - "Inhibition of melanoma angiogenesis by telomere homolog oligonucleotides."
10/01/2000 - "Microsatellite analysis of melanoma lesions using (CA)13 oligonucleotides as an internal probe."
|4.||Breast Neoplasms (Breast Cancer)
02/01/2007 - "To confirm these results and explore pathways other than those implicated in breast cancer, for this study we used pangenomic arrays containing 25,000 oligonucleotides. "
07/01/2015 - "This paper mainly focuses on the influence of polymeric chain length on the particle properties and their drug-carrying ability to deliver oligonucleotides into breast cancer cells. "
01/28/2014 - "This AEGIS-SELEX was designed to create AEGIS oligonucleotides that bind to a line of breast cancer cells. "
04/01/2013 - "In ERα-positive and ERα-negative breast cancer cells, proliferative and invasiveness properties were suppressed by hsa-miR-196a2* expression and enhanced by hsa-miR-196a2* antagonism or TP63 target protector oligonucleotides. "
01/01/2012 - "Furthermore, transfection of miR-133a oligonucleotides slightly inhibited growth but significantly decreased migration and invasion capacity of breast cancer cells, compared with negative controls, whereas knockdown of miR-133a expression induced breast cancer cell migration and invasion. "
|5.||Communicable Diseases (Infectious Diseases)
10/21/2008 - "in the examination of specific RNA sequences for infectious diseases, however, a major limiting factor in oligonucleotide-based diagnostics is poor cellular uptake of naked oligonucleotides. "
08/01/2005 - "The immunomodulatory oligonucleotides are also being investigated for the potential treatment of infectious diseases and immune disorders."
08/01/2003 - "Modified oligonucleotides continue to play an important role as antisense compounds that inhibit the expression of genes associated with metabolic disorders, cancer, and infectious diseases. "
05/01/2001 - "This antisense strategy has been used to develop therapeutic oligonucleotides against cancer and various infectious diseases in humans. "
03/28/2009 - "CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases."
|1.||DNA (Deoxyribonucleic Acid)
|2.||RNA (Ribonucleic Acid)
|5.||Telomerase (Telomerase Reverse Transcriptase)
|6.||Messenger RNA (mRNA)
|7.||NF-kappa B (NF-kB)
|1.||Heterologous Transplantation (Xenotransplantation)
|3.||Drug Therapy (Chemotherapy)