Oligomycins

A closely related group of toxic substances elaborated by various strains of Streptomyces. They are 26-membered macrolides with lactone moieties and double bonds and inhibit various ATPases, causing uncoupling of phosphorylation from mitochondrial respiration. Used as tools in cytochemistry. Some specific oligomycins are RUTAMYCIN, peliomycin, and botrycidin (formerly venturicidin X).

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Networked: 193 relevant articles (4 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Moreno-Sánchez, Rafael: 4 articles (01/2018 - 06/2003)
2.	Rodríguez-Enríquez, Sara: 3 articles (01/2018 - 09/2006)
3.	Lee, Hsin-Chen: 3 articles (11/2016 - 03/2010)
4.	Yin, Pen-Hui: 3 articles (11/2016 - 03/2010)
5.	Bernardi, Paolo: 3 articles (01/2014 - 12/2003)
6.	Marín-Hernández, Alvaro: 3 articles (05/2012 - 06/2003)
7.	Grover, Gary J: 3 articles (01/2008 - 10/2004)
8.	Gallardo-Pérez, Juan Carlos: 2 articles (01/2018 - 05/2012)
9.	Li, Tao: 2 articles (01/2017 - 11/2008)
10.	Liu, Liangming: 2 articles (01/2017 - 11/2008)

Related Diseases

1.	Hypoxia (Hypoxemia) 01/01/2021 - "This can be achieved via hypoxia, pretreatment with small molecule-metabolic mediators such as oligomycin, or AKT/mTOR pathway modulation. " 01/01/2019 - "The hypoxia-tolerant sculpins had higher mitochondrial H2O2 emission per O2 consumed (H2O2/O2) under oligomycin-induced state 4 conditions compared with less hypoxia-tolerant sculpins. " 04/23/2010 - "We also demonstrate that the adaptation to oligomycin does not invoke activation of hypoxia-induced factor. " 12/01/2008 - "The nuclear translocation of HIF-1alpha induced by hypoxia was also obviously inhibited by oligomycin pretreatment. " 12/01/2008 - "Intestinal epithelial cells were randomly divided into normal control group, hypoxia group and hypoxia plus oligomycin group (oligomycin group). "
2.	Mitochondrial Diseases (Mitochondrial Disease) 04/01/2015 - "Mitochondrial dysfunction was induced by treatment with oligomycin, which significantly decreased mitochondrial membrane potential (ΔΨm). " 07/01/2014 - "Interestingly, mitochondrial dysfunction induced by pretreatment of synoviocytes with oligomycin synergized with IL-1β to increase the expression of these inflammatory mediators. " 07/01/2014 - "Mitochondrial dysfunction was induced with the inhibitor oligomycin. " 12/01/2003 - "We found a latent mitochondrial dysfunction in myofibers of Col6a1-/- mice on incubation with the selective F1F(O)-ATPase inhibitor oligomycin, which caused mitochondrial depolarization, Ca2+ deregulation and increased apoptosis. " 10/01/1988 - "Uncoupling, oligomycin-inhibited, and aging/swelling conditions comprise three models for mitochondrial dysfunction. "
3.	Insulin Resistance 10/01/2016 - "Importantly, ALA treatment could decrease oligomycin-induced mitochondrial dysfunction and then improved insulin resistance. " 07/01/2007 - "In order to better understand the impact of reduced mitochondrial function for the development of insulin resistance and cellular metabolism, human myotubes were established from lean, obese, and T2D subjects and exposed to mitochondrial inhibitors, either affecting the electron transport chain (Antimycin A), the ATP synthase (oligomycin) or respiratory uncoupling (2,4-dinitrophenol). " 07/01/2007 - "Antimycin A and oligomycin treatment induced insulin resistance at the level of glucose and palmitate uptake in all three study groups while, at the level of glycogen synthesis, insulin resistance was only seen in lean myotubes. "
4.	Acidosis 01/01/1999 - "This effect of acidosis was attenuated in the presence of oligomycin. " 05/01/1998 - "The partial reversal of the cytosolic acidosis and fall of cytosolic Ca2+ were abolished in the presence of oligomycin. " 09/01/2013 - "Striking results were also observed with hypoxia providing protection against cell death in spite of a severe metabolic stress induced by a combination of acidosis and oligomycin. " 03/01/1986 - "Effects of oligomycin and acidosis on rates of ATP depletion in ischemic heart muscle."
5.	Neuroblastoma 02/18/2009 - "In established human neuroblastoma cell lines (SH-SY5Y) treated with mitochondrial toxins, CBD (0.1 and 1 microm) was neuroprotective against the uncoupler FCCP (53% protection), and modestly protective against hydrogen peroxide- (16%) and oligomycin- (15%) mediated cell death, a pattern also confirmed in cultured hippocampal neurons. " 03/01/1999 - "Endogenous ATP production was inhibited by dialyzing N1E115 neuroblastoma cells for 4-5 min with solutions containing (microM): 40 oligomycin, 5 iodoacetate, and 20 rotenone. " 01/04/2022 - "Moreover, the compounds were studied for their neuroprotective effect in a model of oxidative stress achieved by treatment of SH-SY5Y neuroblastoma cells with the rotenone-oligomycin combination and also in a model of hyperphosphorylation induced by treatment with okadaic acid. "

Related Drugs and Biologics

1.	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone (FCCP)
2.	Hydrogen Peroxide (Hydroperoxide)
3.	Adenosine Triphosphate (ATP)
4.	Glucose (Dextrose)
5.	Antimycin A
6.	Proteins (Proteins, Gene)
7.	Palmitates
8.	Glycogen
9.	Cisplatin (Platino)
10.	Nucleotide Aptamers

Related Therapies and Procedures

1.	Light Coagulation
2.	Ligation
3.	Lasers (Laser)
4.	Transcutaneous Electric Nerve Stimulation (TENS)
5.	Contact Lenses