HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Oligodendroglioma

A relatively slow-growing glioma that is derived from oligodendrocytes and tends to occur in the cerebral hemispheres, thalamus, or lateral ventricle. They may present at any age, but are most frequent in the third to fifth decades, with an earlier incidence peak in the first decade. Histologically, these tumors are encapsulated, relatively avascular, and tend to form cysts and microcalcifications. Neoplastic cells tend to have small round nuclei surrounded by unstained nuclei. The tumors may vary from well-differentiated to highly anaplastic forms. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2052; Adams et al., Principles of Neurology, 6th ed, p655)
Also Known As:
Anaplastic Oligodendroglioma; Mixed Oligodendroglioma-Astrocytoma; Mixed Oligodendroglioma-Ependymoma; Oligodendroglioma, Adult; Oligodendroglioma, Childhood; Oligodendroglioma, Well-Differentiated; Well-Differentiated Oligodendroglioma; Adult Oligodendroglioma; Adult Oligodendrogliomas; Anaplastic Oligodendrogliomas; Childhood Oligodendroglioma; Childhood Oligodendrogliomas; Mixed Oligodendroglioma Astrocytoma; Mixed Oligodendroglioma Ependymoma; Mixed Oligodendroglioma-Astrocytomas; Mixed Oligodendroglioma-Ependymomas; Oligodendroblastomas; Oligodendroglioma, Anaplastic; Oligodendroglioma, Well Differentiated; Oligodendroglioma-Astrocytoma, Mixed; Oligodendroglioma-Astrocytomas, Mixed; Oligodendroglioma-Ependymoma, Mixed; Oligodendroglioma-Ependymomas, Mixed; Oligodendrogliomas; Oligodendrogliomas, Adult; Oligodendrogliomas, Anaplastic; Oligodendrogliomas, Childhood; Oligodendrogliomas, Well-Differentiated; Well Differentiated Oligodendroglioma; Well-Differentiated Oligodendrogliomas; Oligodendroblastoma
Networked: 986 relevant articles (40 outcomes, 138 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Astrocytoma (Pilocytic Astrocytoma)
2. Glioblastoma (Glioblastoma Multiforme)
3. Neoplasms (Cancer)
4. Glioma (Gliomas)
5. Oligodendroglioma

Experts

1. Sanson, Marc: 15 articles (01/2015 - 05/2004)
2. van den Bent, Martin J: 14 articles (04/2015 - 03/2003)
3. Cairncross, J Gregory: 14 articles (09/2014 - 01/2002)
4. von Deimling, Andreas: 13 articles (10/2014 - 08/2006)
5. Ohgaki, Hiroko: 11 articles (11/2012 - 03/2002)
6. Hartmann, Christian: 10 articles (10/2014 - 08/2006)
7. Kros, Johan M: 10 articles (10/2013 - 03/2002)
8. Delattre, Jean-Yves: 9 articles (01/2015 - 05/2004)
9. Brat, Daniel J: 8 articles (12/2015 - 11/2005)
10. Zhang, Wei: 8 articles (11/2015 - 01/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Oligodendroglioma:
1. temozolomide (Temodar)FDA LinkGeneric
2. Procarbazine (Matulane)FDA Link
12/01/2002 - "Combination chemotherapy (including procarbazine and a nitrosourea) provides dramatic benefit for many recurrent anaplastic or aggressively behaving oligodendrogliomas and anaplastic mixed oligoastrocytomas. "
04/18/2007 - "Patients with 1p+/- anaplastic oligodendroglioma frequently respond to procarbazine, 1-(2-chloroethyl)-3-cyclohexyl-l-nitrosourea, and vincristine. "
03/01/2010 - "We determined the effect of IDH1 mutations on progression-free survival and overall survival (OS), and its correlation with other clinical and molecular features in the prospective randomized European Organization for Research and Treatment of Cancer study 26951 on adjuvant procarbazine, 1-(2-chloroethyl)-3-cyclohexyl-l-nitrosourea, and vincristine (PCV) in anaplastic oligodendroglioma. "
03/01/2003 - "However, the recent success of procarbazine, N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea and vincristine (PCV) chemotherapy for oligodendrogliomas that have lost chromosomes 1p and 19q has encouraged the authors to evaluate the biological behavior of brain tumors by means of genetic analysis. "
06/01/2006 - "Previous studies using comparative genomic hybridization (CGH) demonstrated that copy number aberrations(CNAs) were frequently recognized in these tumors, and revealed that a gain on chromosomal arm 7q was the most common CNA in diffuse astrocytomas, whereas a small population of the tumor showed losses on 1p/19q which characterizes oligodendrogliomas with good responsiveness to chemotherapeutic regime using procarbazine, nitrosourea and vincristine. "
3. Vincristine (Oncovin)FDA LinkGeneric
04/18/2007 - "Patients with 1p+/- anaplastic oligodendroglioma frequently respond to procarbazine, 1-(2-chloroethyl)-3-cyclohexyl-l-nitrosourea, and vincristine. "
03/01/2010 - "We determined the effect of IDH1 mutations on progression-free survival and overall survival (OS), and its correlation with other clinical and molecular features in the prospective randomized European Organization for Research and Treatment of Cancer study 26951 on adjuvant procarbazine, 1-(2-chloroethyl)-3-cyclohexyl-l-nitrosourea, and vincristine (PCV) in anaplastic oligodendroglioma. "
03/01/2003 - "However, the recent success of procarbazine, N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea and vincristine (PCV) chemotherapy for oligodendrogliomas that have lost chromosomes 1p and 19q has encouraged the authors to evaluate the biological behavior of brain tumors by means of genetic analysis. "
06/01/2006 - "Previous studies using comparative genomic hybridization (CGH) demonstrated that copy number aberrations(CNAs) were frequently recognized in these tumors, and revealed that a gain on chromosomal arm 7q was the most common CNA in diffuse astrocytomas, whereas a small population of the tumor showed losses on 1p/19q which characterizes oligodendrogliomas with good responsiveness to chemotherapeutic regime using procarbazine, nitrosourea and vincristine. "
10/01/2015 - "While procarbazine with 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (PC) added to vincristine (PCV) was proven beneficial in the treatment of co-deleted anaplastic oligodendroglioma (AO), the question of whether PC alone is sufficient is important, as vincristine adds toxicity with uncertain benefit. "
4. ranimustineIBA
5. Lomustine (CCNU)FDA Link
6. Carbon MonoxideIBA
7. Complementary DNA (cDNA)IBA
8. Carmustine (FIVB)FDA Link
9. irinotecan (Camptosar)FDA LinkGeneric
10. Paclitaxel (Taxol)FDA LinkGeneric

Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Radiotherapy
3. Adjuvant Chemotherapy
4. Combination Drug Therapy (Combination Chemotherapy)
5. Craniotomy