Oligodendroglioma

678  relevant articles (26 outcomes, 94 trials/studies) found for this Disease

Anaplastic Oligodendroglioma; Mixed Oligodendroglioma-Astrocytoma; Mixed Oligodendroglioma-Ependymoma; Oligodendroglioma, Adult; Oligodendroglioma, Childhood; Oligodendroglioma, Well-Differentiated; Well-Differentiated Oligodendroglioma; Adult Oligodendroglioma; Adult Oligodendrogliomas; Anaplastic Oligodendrogliomas; Childhood Oligodendroglioma; Childhood Oligodendrogliomas; Mixed Oligodendroglioma Astrocytoma; Mixed Oligodendroglioma Ependymoma; Mixed Oligodendroglioma-Astrocytomas; Mixed Oligodendroglioma-Ependymomas; Oligodendroblastomas; Oligodendroglioma, Anaplastic; Oligodendroglioma, Well Differentiated; Oligodendroglioma-Astrocytoma, Mixed; Oligodendroglioma-Astrocytomas, Mixed; Oligodendroglioma-Ependymoma, Mixed; Oligodendroglioma-Ependymomas, Mixed; Oligodendrogliomas; Oligodendrogliomas, Adult; Oligodendrogliomas, Anaplastic; Oligodendrogliomas, Childhood; Oligodendrogliomas, Well-Differentiated; Well Differentiated Oligodendroglioma; Well-Differentiated Oligodendrogliomas; Oligodendroblastoma

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Astrocytoma (Pilocytic Astrocytoma)
2.	Glioblastoma (Glioblastoma Multiforme)
3.	Neoplasms (Cancer)
4.	Glioma (Gliomas)
5.	Meningioma (Meningiomas)

Experts

1.	Forsyth, Peter: 4 articles (09/2008 - 11/2003)
2.	Brandes, Alba A: 4 articles (12/2007 - 06/2006)
3.	Kros, J M: 4 articles (06/2005 - 07/2001)
4.	Paleologos, Nina: 3 articles (09/2008 - 11/2003)
5.	Stewart, Douglas: 3 articles (09/2008 - 11/2003)
6.	Cairncross, J Gregory: 3 articles (09/2008 - 11/2003)
7.	Abrey, Lauren E: 3 articles (09/2008 - 11/2003)
8.	Taphoorn, Martin J B: 3 articles (12/2007 - 06/2006)
9.	van den Bent, Martin J: 3 articles (12/2007 - 06/2006)
10.	Brandes, A A: 3 articles (09/2004 - 07/2001)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Oligodendroglioma:

1.	Procarbazine (Matulane)FDA Link 12/01/2002 - "Combination chemotherapy (including procarbazine and a nitrosourea) provides dramatic benefit for many recurrent anaplastic or aggressively behaving oligodendrogliomas and anaplastic mixed oligoastrocytomas" 04/18/2007 - "Patients with 1p+/- anaplastic oligodendroglioma frequently respond to procarbazine, 1-(2-chloroethyl)-3-cyclohexyl-l-nitrosourea, and vincristine" 03/01/2003 - "However, the recent success of procarbazine, N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea and vincristine (PCV) chemotherapy for oligodendrogliomas that have lost chromosomes 1p and 19q has encouraged the authors to evaluate the biological behavior of brain tumors by means of genetic analysis" 06/01/2006 - "Previous studies using comparative genomic hybridization (CGH) demonstrated that copy number aberrations(CNAs) were frequently recognized in these tumors, and revealed that a gain on chromosomal arm 7q was the most common CNA in diffuse astrocytomas, whereas a small population of the tumor showed losses on 1p/19q which characterizes oligodendrogliomas with good responsiveness to chemotherapeutic regime using procarbazine, nitrosourea and vincristine" 11/01/2003 - "To improve disease control and postpone cranial radiotherapy, we designed a phase II study of intensive procarbazine, lomunstine and vincristine followed by high-dose thiotepa with autologous stem cell rescue for patients with newly diagnosed anaplastic or aggressive oligodendroglioma" Order ALL the reference details at left...
2.	Vincristine (Oncovin)FDA LinkGeneric 04/18/2007 - "Patients with 1p+/- anaplastic oligodendroglioma frequently respond to procarbazine, 1-(2-chloroethyl)-3-cyclohexyl-l-nitrosourea, and vincristine" 03/01/2003 - "However, the recent success of procarbazine, N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea and vincristine (PCV) chemotherapy for oligodendrogliomas that have lost chromosomes 1p and 19q has encouraged the authors to evaluate the biological behavior of brain tumors by means of genetic analysis" 06/01/2006 - "Previous studies using comparative genomic hybridization (CGH) demonstrated that copy number aberrations(CNAs) were frequently recognized in these tumors, and revealed that a gain on chromosomal arm 7q was the most common CNA in diffuse astrocytomas, whereas a small population of the tumor showed losses on 1p/19q which characterizes oligodendrogliomas with good responsiveness to chemotherapeutic regime using procarbazine, nitrosourea and vincristine" 11/01/2003 - "To improve disease control and postpone cranial radiotherapy, we designed a phase II study of intensive procarbazine, lomunstine and vincristine followed by high-dose thiotepa with autologous stem cell rescue for patients with newly diagnosed anaplastic or aggressive oligodendroglioma" 11/01/2007 - "The combination of procarbazine, lomustine, and vincristine (PCV) is not recommended for patients with anaplastic oligodendroglioma and oligoastrocytoma." Order ALL the reference details at left...
3.	temozolomide (Temodar)FDA Link 09/01/2006 - "Temozolomide treatment for newly diagnosed anaplastic oligodendrogliomas: a clinical efficacy trial." 04/15/2006 - "Recent studies demonstrated that temozolomide (TMZ), an oral alkylating agent, has efficacy in the treatment of patients with progressive, low-grade oligodendroglioma (LGO)" 08/01/2001 - "An open-label, phase II trial of temozolomide in 47 patients with relapsed oligodendroglioma showed an objective response rate of 43%, of which seven (15%) were complete responses" 08/01/2001 - "Several small trials have shown the safety and activity of temozolomide (Temodar in the United States, Temodal globally; Schering Corporation, Kenilworth, NJ) in oligodendroglioma, regardless of prior PCV therapy" 10/10/2006 - "PURPOSE: To date, no data are available on the relationship between 1p/19q deletions and the response to temozolomide (TMZ) in primary anaplastic oligodendroglioma (AO) and anaplastic oligoastrocytoma (AOA) recurrent after surgery and standard radiotherapy" Order ALL the reference details at left...
4.	ranimustineIBA 11/01/2005 - "The safety, tolerance and preliminary efficacy of a chemotherapy regimen consisting of procarbazine (PCB), ranimustine (MCNU) and vincristine (VCR) were assessed for patients with newly diagnosed supratentorial anaplastic oligodendroglioma" 11/01/2005 - "Efficacy and feasibility of procarbazine, ranimustine and vincristine chemotherapy, and the role of surgical resection in anaplastic oligodendroglioma." 01/01/2000 - "On the other hand, regarding anaplastic oligodendroglial tumors, patients with anaplastic oligoastrocytoma responded well to combination chemotherapy with interferon beta, nitrosourea derivatives (ACNU/ MCNU), and radiation therapy (referred to as IAR/IMR) and survived longer than patients with anaplastic oligodendroglioma" Order ALL the reference details at left...
5.	Lomustine (CCNU)FDA Link 06/01/2005 - "Twelve (92%) patients treated with CCNU had MGMT-negative lesions and their median survival was 73 months; 1 patient had an MGMT-positive oligodendroglioma and is alive at 28 months" 06/01/2005 - "We evaluated the immunohistochemical MGMT expression in 28 consecutive oligodendroglial tumors (21 oligodendrogliomas, 5 mixed oligoastrocytomas, and 2 glioblastomas with prominent oligodendroglial features; 13 treated with CCNU) and compared it with that of 13 glioblastomas" 11/01/2007 - "The combination of procarbazine, lomustine, and vincristine (PCV) is not recommended for patients with anaplastic oligodendroglioma and oligoastrocytoma." 01/20/2002 - "PCV combination (procarbazine, CCNU, vincristine) was applied to 16 patients with AA and 14 cases with recurrent oligodendroglioma (O)" 08/01/2001 - "Approximately two thirds of patients with the more aggressive form (anaplastic oligodendroglioma) have shown substantial response to first-line procarbazine/lomustine/vincristine (PCV) therapy" Order ALL the reference details at left...
6.	Complementary DNA (cDNA)IBA 10/01/2002 - "CONCLUSION: cDNA array is effective for studying the gene expression profiles of oligodendrogliomas and provides new information for the further research on their molecular mechanisms." 10/01/2002 - "OBJECTIVE: To study the gene expression profiles of oligodendrogliomas with gene cDNA array" 01/01/1995 - "From a human oligodendroglioma cell line cDNA library, ten intermediate filament (IF) cDNA clones were isolated" 10/01/2005 - "To search for potential molecular mechanisms underlying its benign biologic behavior, we compared gene expression profiles of pilocytic astrocytomas (8 cases) with those of normal cerebellum (4 cases), low-grade astrocytomas (WHO grade II; 15 cases), and oligodendrogliomas (WHO grade II; 17 cases) by cDNA array analysis" 08/05/2004 - "We carried out gene expression profiling on 17 oligodendrogliomas (93% with LOH 1p and/or 19q) and 15 low-grade astrocytomas (71% with a TP53 mutation), using a cDNA array containing 1176 cancer-related genes" Order ALL the reference details at left...
7.	Carmustine (FIVB)FDA Link 07/15/1997 - "METHODS AND MATERIALS: One hundred nine patients who had AAF and 24 patients with mixed AAF/oligodendrogliomas (AAF/OL) were enrolled in a Phase I/II trial of randomized dose-escalation hyperfractioned radiotherapy plus BCNU" 07/01/2004 - "The current experiments correlate decreased expression of both Bcl-xL and Bcl-2 after BCNU chemotherapy and cell death in two oligodendroglioma-derived cell lines" 03/01/1995 - "Thirty-five patients in whom computerized tomography (CT) or magnetic resonance (MR) evidence was obtained of progressive astrocytoma, oligoastrocytoma, or oligodendroglioma received recombinant IFN-alpha 2a (12 x 10(6) U/m2 intramuscularly) on Days 1 through 3 and BCNU (150 mg/m2 intravenously) on Day 3 of each 6-week cycle" 11/01/1987 - "A 40-year-old female with a recurrent mixed astrocytoma/oligodendroglioma was treated with intra-arterial BCNU at six week intervals" 07/01/2004 - "BCNU down-regulates anti-apoptotic proteins bcl-xL and Bcl-2 in association with cell death in oligodendroglioma-derived cells." Order ALL the reference details at left...
8.	Paclitaxel (Taxol)FDA LinkGeneric 12/01/1997 - "CONCLUSION: Paclitaxel demonstrated modest efficacy with minimal toxicity in this pretreated cohort of adult patients with recurrent hemispheric oligodendrogliomas." 12/01/1997 - "PURPOSE: A prospective phase II study of paclitaxel was performed in adult patients with recurrent hemispheric oligodendrogliomas" 12/01/1997 - "Salvage chemotherapy with paclitaxel for recurrent oligodendrogliomas." 06/01/2002 - "In a similar fashion, oligodendrogliomas displayed extreme drug resistance to vincristine (60%, n = 5) and paclitaxel (50% n = 6)" Order ALL the reference details at left...
9.	CAV protocol (CHO)FDA Link 10/01/2007 - "Cho(G/WM) and Lip+Lac(G)/Cr(WM) were also significantly higher in the "hyperperfused" regions of high-grade oligodendrogliomas" 09/01/1998 - "Low grade oligodendrogliomas are characterized by low Cho/Cr ratios" 05/01/1996 - "Interesting, but inconclusive, are the data concerning oligodendrogliomas, which, also in well differentiated forms, exhibit increased levels of b"Cho"/(Cr + PCr) ratio" 09/01/1994 - "Absolute Cho was some 50% higher in both benign astrocytomas and oligodendrogliomas in vivo than in normal brain" 03/01/2004 - "Changes in NAA and Cho helped differentiate low-grade gliomas from FCDMs, and changes in Cho and Cr helped differentiate astrocytomas from oligodendrogliomas and oligoastrocytomas" Order ALL the reference details at left...
10.	NimustineIBA 01/01/1988 - "Experience so far suggests that in anaplastic astrocytomas and oligodendrogliomas intraarterial ACNU might be as effective as intravenous BCNU against the tumours but causes less systemic side-effects." 05/01/1988 - "Comparative studies were carried out to evaluate the cytotoxic effectiveness of the nitrosureas ACNU (Nimustine) and BCNU (Carmustine) at equitoxic dose levels in xenografts from two astrocytomas grades III/IV (Li, Re) and one oligodendroglioma grade III (Oe) on nude mice" 04/01/1987 - "Our treatment for oligodendrogliomas was surgical removal and postoperative radiochemotherapy (radiation + ACNU + FT-207 + PSK) for several years" 01/01/2000 - "On the other hand, regarding anaplastic oligodendroglial tumors, patients with anaplastic oligoastrocytoma responded well to combination chemotherapy with interferon beta, nitrosourea derivatives (ACNU/ MCNU), and radiation therapy (referred to as IAR/IMR) and survived longer than patients with anaplastic oligodendroglioma" Order ALL the reference details at left...

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 06/01/1999 - "CONCLUSIONS: Combined treatment modality consisting of surgery, postoperative high-dose RT and mPCV chemotherapy for patients with anaplastic oligodendroglioma was effective with acceptable toxicity" 11/01/2005 - "This article reviews the evidence describing the association of such deletions with a favorable response to chemotherapy and improved prognosis of patients with oligodendrogliomas" 04/01/2000 - "PCV chemotherapy was also effective in patients with leptomeningeal spread of oligodendrogliomas" 11/01/1998 - "CONCLUSION: These results suggest that chemotherapy with PCV is effective in the treatment of recurrent low-grade oligodendrogliomas and oligoastrocytomas." 08/01/2008 - "Patients with oligodendrogliomas have benefited from phamacogenomics, as there is a clear relationship between response to chemotherapy and chromosomal profile" Order ALL the reference details at left...
2.	Combination Drug Therapy (Combination Chemotherapy) 05/01/2002 - "Combination chemotherapy with PCV showed efficacy for patients with anaplastic oligodendroglioma and anaplastic oligoastrocytoma" 12/01/2002 - "Combination chemotherapy (including procarbazine and a nitrosourea) provides dramatic benefit for many recurrent anaplastic or aggressively behaving oligodendrogliomas and anaplastic mixed oligoastrocytomas" 10/01/1994 - "PURPOSE: To examine the rate and duration of response of anaplastic oligodendrogliomas to a dose-escalated combination chemotherapy regimen consisting of procarbazine, lomustine (CCNU), and vincristine (PCV) and to evaluate the side effects of this treatment" 01/01/2000 - "On the other hand, regarding anaplastic oligodendroglial tumors, patients with anaplastic oligoastrocytoma responded well to combination chemotherapy with interferon beta, nitrosourea derivatives (ACNU/ MCNU), and radiation therapy (referred to as IAR/IMR) and survived longer than patients with anaplastic oligodendroglioma" Order ALL the reference details at left...
3.	Adjuvant Chemotherapy 06/01/2004 - "PURPOSE: To provide updated outcome data (10 years) of a Phase II study of combined surgery, postoperative radiotherapy, and adjuvant chemotherapy in patients with anaplastic oligodendroglioma and oligoastrocytoma" 05/01/2005 - "The clinical and radiological prognostic factors were investigated in 32 patients with newly diagnosed anaplastic oligodendroglioma treated by combined therapy using surgery, postoperative radiation therapy, and adjuvant chemotherapy between September 1994 and December 2002" 08/01/2002 - "Few reports exist describing the progression-free and overall survival of children with low-grade (WHO grade II) oligodendrogliomas treated uniformly with aggressive surgery but without adjuvant chemotherapy or radiation therapy" 03/01/1993 - "In the anaplastic oligodendroglioma group, eight patients were treated at the time of the initial admission with radiotherapy and adjuvant chemotherapy, and nine patients were treated at the time of recurrence with salvage chemotherapy" 12/20/2007 - "Health-related quality of life in patients treated for anaplastic oligodendroglioma with adjuvant chemotherapy: results of a European Organisation for Research and Treatment of Cancer randomized clinical trial." Order ALL the reference details at left...
4.	Craniotomy 10/01/1995 - "She underwent imaging studies and a left frontotemporal craniotomy that revealed a cystic oligodendroglioma in the suprasellar cistern and spread of neoplastic cells to the spinal leptomeninges" 02/01/2003 - "INTERVENTION: Craniotomy and resection of the lesion established a diagnosis of a malignant oligodendroglioma" 10/01/1978 - "At 16 months, craniotomy and resection of an oligodendroglioma was performed and the shunt was preserved" 09/01/2002 - "Craniotomy and tumor evacuation was performed, and WHO grade III anaplastic oligodendroglioma was confirmed by the pathologic studies" 10/01/2007 - "Total removal of the tumor was performed through left frontoparietal craniotomy, and the histologic diagnosis was anaplastic oligodendroglioma" Order ALL the reference details at left...
5.	Heterologous Transplantation (Xenotransplantation) 12/15/2003 - "These results suggest that subcutaneous xenografts are useful and reproducible models to analyse the molecular profile of malignant astrocytoma and oligodendroglioma" 02/01/2001 - "Four glioblastoma (SWB77, SWB40, SWB39, and D-54) and one anaplastic oligodendroglioma (SWB61) xenografts having O6-alkylguanine-DNA alkyltransferase (AGT) activities of 75, 45, 10, < 10, and 16 fmol/mg protein, respectively, were used" 11/01/2005 - "In this study, several variations of nuclear magnetic resonance spectroscopy (MRS) and spectroscopic imaging (MRSI) were applied to investigate the uptake, clearance and metabolism of the BPA-fructose complex (BPA-F) in normal mouse kidneys, rat oligodendroglioma xenografts, and rat blood" 05/01/1988 - "Comparative studies were carried out to evaluate the cytotoxic effectiveness of the nitrosureas ACNU (Nimustine) and BCNU (Carmustine) at equitoxic dose levels in xenografts from two astrocytomas grades III/IV (Li, Re) and one oligodendroglioma grade III (Oe) on nude mice" Order ALL the reference details at left...