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Ochronosis

The yellowish discoloration of connective tissue due to deposition of HOMOGENTISIC ACID (a brown-black pigment). This is due to defects in the metabolism of PHENYLALANINE and TYROSINE. Ochronosis occurs in ALKAPTONURIA, but has also been associated with exposure to certain chemicals (e.g., PHENOL, trinitrophenol, BENZENE DERIVATIVES).
Also Known As:
Ochronoses
Networked: 136 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Hyperpigmentation
2. Alkaptonuria
3. Arthritis (Polyarthritis)
4. Metabolic Diseases (Metabolic Disease)
5. Osteoarthritis

Experts

1. Bernardini, Giulia: 6 articles (01/2014 - 10/2010)
2. Santucci, Annalisa: 6 articles (01/2014 - 10/2010)
3. Braconi, Daniela: 6 articles (01/2014 - 10/2010)
4. Spreafico, Adriano: 6 articles (01/2014 - 10/2010)
5. Millucci, Lia: 5 articles (01/2014 - 10/2010)
6. Laschi, Marcella: 5 articles (01/2014 - 10/2010)
7. Bernardini, Isa: 5 articles (12/2009 - 09/2002)
8. Gahl, William A: 5 articles (12/2009 - 09/2002)
9. Gallagher, James A: 3 articles (01/2015 - 11/2010)
10. Ranganath, Lakshminarayan R: 3 articles (01/2015 - 12/2011)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Ochronosis:
1. Tretinoin (Retinoic Acid)FDA LinkGeneric
2. SteroidsIBA
3. AlcaptonuriaIBA
4. Homogentisic AcidIBA
5. Melanins (Melanin)IBA
6. Homogentisate 1,2-Dioxygenase (Homogentisate 1,2 Dioxygenase)IBA
7. hydroquinone (Black and White)FDA Link
8. Tyrosine (L-Tyrosine)FDA Link
9. CollagenIBA
10. PolymersIBA

Therapies and Procedures

1. Arthroplasty
2. Lasers (Laser)
3. Hip Replacement Arthroplasty (Total Hip Replacement)
4. Kidney Transplantation
5. Peritoneal Dialysis