Obidoxime Chloride (Obidoxime)

01/05/2023 - "Impairment of liver function was observed in OP poisoning and associated with obidoxime treatment by some reports. "
05/05/2020 - "Transport efficiency of obidoxime across the BBB is a major challenge in the prevention of the CNS, the effectiveness of NA poisoning and new strategies like using obidoxime-loaded PEG-b-PLGA nanoparticles could overcome this challenge for the management of NA-induced brain damage."
01/19/1968 - "[Cholestatic hepatosis following toxogonin treatment in a clinical case of alkylphosphate poisoning]."
08/01/1997 - "4 Obidoxime was effective in life-threatening parathion poisoning, in particular when the dose absorbed was comparably low. "
01/01/1997 - "Factors influencing the efficacy of obidoxime in organophosphate pesticides poisoning."

01/01/1995 - "Efficacy of obidoxime in human organophosphorus poisoning: determination by neuromuscular transmission studies."
03/01/2016 - "Intranasal delivery of obidoxime to the brain prevents mortality and CNS damage from organophosphate poisoning."
09/01/2009 - "The effects of obidoxime in the treatment of organophosphate poisoning were assessed by biochemical and biological effect monitoring. "
09/01/2009 - "Obidoxime in acute organophosphate poisoning: 2 - PK/PD relationships."
09/01/2009 - "Obidoxime in acute organophosphate poisoning: 1 - clinical effectiveness."

01/01/1993 - "Intraperitoneal (i.p.) injection of HI-6 or Toxogonin (50 mg/kg), immediately after 10 min inhalation exposure to soman, also significantly improved the ex vivo cholinergic contraction response of the trachea (decapitation 15 min after oxime administration). "

10/01/2002 - "Combined use of suitable dose of obidoxime and atropine with artificial ventilation for respiratory muscle paralysis caused by omethoate poisoning could promote the recovery of diaphragm function and reduce the death rate in poisoned rats."
10/01/2002 - "[Study on the therapeutic effect of combined use of obidoxime and atropine with respiratory machine on respiratory muscle paralysis caused by omethoate poisoning of rats]."
10/01/2002 - "To examine the therapeutic effect of combined use of obidoxime and atropine with artificial ventilation on respiratory muscle paralysis caused by omethoate poisoning in rats. "

02/01/2003 - "The clinical course of this patient did not support a cause-and-effect relationship between obidoxime and the abnormal liver function."
09/01/2009 - "The effects of obidoxime in the treatment of organophosphate poisoning were assessed by comparing the clinical course with its effects on laboratory parameters relevant to poisoning. "
04/20/2007 - "To this end, the clinical course of poisoning and the effectiveness of antidotal therapy were investigated in patients requiring artificial ventilation being treated with atropine and obidoxime. "