Nucleosomes (Nucleosome)

The repeating structural units of chromatin, each consisting of approximately 200 base pairs of DNA wound around a protein core. This core is composed of the histones H2A, H2B, H3, and H4.

Also Known As:

Networked: 1333 relevant articles (21 outcomes, 124 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Holdenrieder, Stefan: 30 articles (07/2021 - 09/2004)
2.	Stieber, Petra: 17 articles (12/2013 - 09/2004)
3.	Zeerleder, Sacha: 16 articles (01/2019 - 07/2003)
4.	Nagel, Dorothea: 15 articles (12/2013 - 09/2004)
5.	Torchilin, Vladimir P: 14 articles (01/2020 - 11/2004)
6.	Kumar, Rakesh: 13 articles (01/2022 - 05/2003)
7.	Rekvig, Ole Petter: 10 articles (07/2013 - 03/2003)
8.	Herzog, Marielle: 9 articles (01/2021 - 05/2014)
9.	van der Poll, Tom: 9 articles (10/2017 - 01/2011)
10.	Decker, Patrice: 8 articles (01/2021 - 07/2003)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2023 - "This study provides insights into the dynamics of nucleosome positioning and gene regulation associated with cancer phenotypes that can be ascertained from ctDNA. " 08/31/2022 - "The objectives of this study were to quantify and better characterize nucleosome concentrations in 528 dogs with various common malignancies and compare them to 134 healthy dogs. " 01/01/2020 - "The objectives of this study are to identify the optimal sample type for the Nu.Q™ H3.1 assay and to determine if it can accurately detect nucleosomes in the blood of healthy canines as well as those with cancer. " 12/01/2018 - "Recent studies indicate the broad role of epigenetic mechanisms in the initiation and development of cancers, that they are including DNA methylation, histone modifications, nucleosomes changes, non-coding RNAs. " 08/01/2008 - "Several studies have shown that levels of nucleosomes are significantly higher in serum and plasma of cancer patients in comparison to healthy controls. "
2.	Systemic Lupus Erythematosus (Libman-Sacks Disease) 06/01/2007 - "Circulating nucleosomes due to a defective clearance of dying cells: consequences for systemic lupus erythematosus." 12/01/2001 - "Defective clearance of nucleosomes and systemic lupus erythematosus." 09/01/2023 - "Our study aims to investigate the serum levels of anti-nucleosome antibody (ANuA) isotypes in patients with systemic lupus erythematosus (SLE) and clarify ANuA isotypes that may diagnose and predict SLE. " 12/22/2017 - "Nitrated nucleosome levels and neuropsychiatric events in systemic lupus erythematosus; a multi-center retrospective case-control study." 02/07/2014 - "Circulating nucleosomes released from apoptotic cells are important in the pathogenesis of systemic lupus erythematosus (SLE). "
3.	Infections 12/01/2018 - "During the late phase of infection (i.e., active DNA replication ∼12-24 h), association with H3 was dramatically reduced and the repeating nucleosome-like pattern was no longer evident. " 01/01/2023 - "Infection of bacterial leaf blight Xoo (Xanthomonas oryzae pv. oryzae) repressed genome-wide nucleosome occupancy, and this process depended on OsCHR11 function. " 01/01/2023 - "However, nucleosome dynamics induced by pathogen infection and its association with gene transcription are largely unexplored in plants. " 01/01/2017 - "The location of nucleosomes in SV40 virions and minichromosomes isolated during infection were determined by next generation sequencing (NGS). " 02/01/2015 - "Moreover, virus-mediated nuclear localization of actin early during infection may contribute to nucleosome management. "
4.	Lymphoma (Lymphomas) 08/16/2021 - "The objectives of this study were to determine if nucleosome levels could be used to distinguish between healthy dogs and dogs with various stages of lymphoma (LSA) using the Nu.Q™ H3.1 assay. " 08/16/2021 - "Characterizing circulating nucleosomes in the plasma of dogs with lymphoma." 03/01/2021 - "This proof of concept study demonstrates that dogs with aGE and cGE have presence of nucleosomes with marked increase in one dog with GI-lymphoma. " 03/01/2021 - "One dog with GI-lymphoma demonstrated a markedly increased concentration of nucleosomes (0.256 AU). " 01/01/2020 - "Finally, significantly elevated concentrations of nucleosomes were seen in a small cohort of dogs that had been newly diagnosed with lymphoma. "
5.	Sepsis (Septicemia) 07/01/2012 - "The aim of this study was to evaluate the diagnostic/prognostic value of circulating nucleosomes in sepsis. " 01/08/2010 - "The general objective of this study was to assess whether dynamic temporal, structural, and positional changes of nucleosomes influence the sepsis phenotype. " 10/17/2023 - "Additional investigations are required to evaluate the potential association between sustained elevation of nucleosome and sepsis-induced immunosuppression." 07/01/2022 - "The primary outcome was to compare the predictability of nucleosomes and TIMP1 in estimating sepsis mortality. " 11/01/2018 - "Nucleosome concentrations were significantly higher in dogs with sepsis compared to healthy controls (P = 0.007). "

Related Drugs and Biologics

1.	Cell-Free Nucleic Acids
2.	DNA (Deoxyribonucleic Acid)
3.	Antibodies
4.	Biomarkers (Surrogate Marker)
5.	Histones (Histone)
6.	Proteins (Proteins, Gene)
7.	Chromatin
8.	Autoantibodies
9.	Liposomes (Liposome)
10.	Deoxyribonucleases (DNase)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics
3.	Artificial Liver (Bioartificial Liver)
4.	Neoadjuvant Therapy
5.	Renal Dialysis (Hemodialysis)