Nucleic Acid Precursors

01/01/1971 - "[Studies on the effect of temperature and pH change on the in-vitro incorporation of nucleic acid precursors in malignant tumors and normal tissues]."
09/01/2004 - "The rationale for their synthesis was based on the fact that proliferating neoplastic cells have increased requirements for nucleic acid precursors, and, therefore, they should preferentially localize in the tumor. "
05/01/1964 - "EXCHANGE OF NUCLEIC ACID PRECURSORS BETWEEN HUMAN CANCER CELLS IN CULTURE."
05/01/1984 - "A simple, easily performed short-term in vitro test is described whose basic feature is measurement of changes in incorporation of radioactive nucleic acid precursors into tumor cells after addition of cytostatic agents. "
01/01/1984 - "For the evaluation of the results of in vitro testing and in vivo effectiveness the close correlation should be considered between the type of cytostatic agent and proliferation kinetics of the tumor, cytostatic agent and effect on tumor metabolism as well as the effect of the cytostatics and the nucleic acid precursors used for the short-term test. "

01/01/1979 - "Incorporation studies of nucleic acid precursors in gastric cancer: an attempt in individualized chemotherapy."

08/01/1984 - "This study was undertaken to determine if salvage of nucleic acid precursors might constitute a mechanism of resistance to acivicin in human colon cancer cells and, if so, to establish whether dipyridamole, an inhibitor of nucleoside and nucleobase transport, can block the salvage process and restore sensitivity to acivicin. "

05/01/1987 - "It is possible that the intensification of G6PDH activity in carcinomas is a sign of the shift of the carbohydrate metabolism from an aerobic path or that the activity of the pentose shunt is higher because of the increased need for nucleic acid precursors in tissues with faster growth rates."
01/01/1976 - "Mono and dihydroxyanthraquinones and their derivatives affected the utilization of 14C-labeled precursors nucleic acid and protein synthesis into Ehrlich ascites carcinoma (EAC) cells. "
05/01/1990 - "A short-term antimetabolic assay based upon the inhibition of incorporation of nucleic acid precursors was used to compare the cytotoxicity of a new halogenated anthracycline, 4'-iodo-4'-deoxydoxorubicin (IDX), with that of its parent compound doxorubicin (DX) on human colo-rectal carcinoma specimens. "
01/01/1979 - "Measurements of the rate of incorporation of radioactively labeled nucleic acid precursors into the DNA and RNA of gastric carcinoma cell suspensions indicated variable rates of proliferation for the tumors. "

03/10/1967 - "Effects of nucleic acid precursors on liver injuries. "
03/10/1967 - "Effects of nucleic acid precursors on liver injuries. "