Nucleic Acid Heteroduplexes (Heteroduplex DNA)

Double-stranded nucleic acid molecules (DNA-DNA or DNA-RNA) which contain regions of nucleotide mismatches (non-complementary). In vivo, these heteroduplexes can result from mutation or genetic recombination; in vitro, they are formed by nucleic acid hybridization. Electron microscopic analysis of the resulting heteroduplexes facilitates the mapping of regions of base sequence homology of nucleic acids.

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Networked: 18 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Delwart, Eric L: 2 articles (04/2004 - 12/2003)
2.	Cooper, Deani L: 1 article (02/2016)
3.	Lovett, Susan T: 1 article (02/2016)
4.	Lieber, Michael R: 1 article (03/2010)
5.	Naik, Abani Kanta: 1 article (03/2010)
6.	Raghavan, Sathees C: 1 article (03/2010)
7.	Balogh, Gabriela A: 1 article (08/2004)
8.	Russo, Irma H: 1 article (08/2004)
9.	Russo, Jose: 1 article (08/2004)
10.	Bernardin, Flavien: 1 article (04/2004)

Related Diseases

1.	Neoplasms (Cancer) 08/01/1992 - "Improved detection of mutations in the p53 gene in human tumors as single-stranded conformation polymorphs and double-stranded heteroduplex DNA."
2.	Junctional Epidermolysis Bullosa (Epidermolysis Bullosa Letalis) 04/01/1996 - "In this study, we searched for mutations in BPAG2 in a large Austrian pedigree with generalized atrophic benign epidermolysis bullosa, a distinct nonlethal form of junctional epidermolysis bullosa, using polymerase chain reaction amplification of genomic DNA, heteroduplex analysis of the polymerase chain reaction products, and direct nucleotide sequencing. "
3.	Epidermolysis Bullosa Dystrophica (Dystrophic Epidermolysis Bullosa) 05/01/1999 - "In this study we searched for mutations in the type VII collagen gene (COL7A1) in 10 families from Southern Italy with severe generalised recessive dystrophic epidermolysis bullosa using PCR amplification of genomic DNA, heteroduplex analysis and direct nucleotide sequencing. "
4.	Epidermolysis Bullosa 04/01/1996 - "In this study, we searched for mutations in BPAG2 in a large Austrian pedigree with generalized atrophic benign epidermolysis bullosa, a distinct nonlethal form of junctional epidermolysis bullosa, using polymerase chain reaction amplification of genomic DNA, heteroduplex analysis of the polymerase chain reaction products, and direct nucleotide sequencing. "
5.	Infections 12/01/2003 - "Using a combination of DNA heteroduplex mobility and DNA sequence analyses of the env and gag regions of HIV-1 we determined that 285 of 312 infections were caused by HIV-1B and six by non-subtype B HIV-1 (four HIV-1C, one HIV-1AE, one HIV-1A). " 10/01/1997 - "The evolution of human immunodeficiency virus type 1 (HIV-1) quasispecies at the envelope gene was studied from the time of infection in 11 men who experienced different rates of CD4+ cell count decline and 6 men with unknown dates of infection by using DNA heteroduplex mobility assays. " 09/01/1976 - "Fate of mismatched base-pair regions in polyoma heteroduplex DNA during infection of mouse cells." 04/25/2004 - "The total number of circulating CD4+ and CD8+ T-cells undergoing clonal expansions following SIV(mac251) infection was determined using a T-cell receptor Vbeta chain (TRBV) third complementarity-determining region (CDR3) DNA heteroduplex tracking assay (HTA). "

Related Drugs and Biologics

1.	Nucleotides
2.	Collagen Type VII
3.	Lectins
4.	WT1 Proteins
5.	Complementarity Determining Regions (Complementarity Determining Region)
6.	Pancreatic Ribonuclease (Ribonuclease A)
7.	Repressor Proteins
8.	T-Cell Antigen Receptors (T-Cell Receptor)
9.	Purines
10.	Proteins (Proteins, Gene)