Norfenfluramine

A FENFLURAMINE analog that inhibits serotonin uptake and may provoke release of serotonin. It is used as an appetite depressant and an experimental tool in animal studies.

Also Known As:

Networked: 17 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ceulemans, Berten: 1 article (01/2022)
2.	Dewals, Wendy: 1 article (01/2022)
3.	Paelinck, Bernard P: 1 article (01/2022)
4.	Roosens, Laurence: 1 article (01/2022)
5.	Schoonjans, An-Sofie: 1 article (01/2022)
6.	Bialer, Meir: 1 article (10/2021)
7.	Gallily, Tamar: 1 article (10/2021)
8.	Invernizzi, Roberto William: 1 article (10/2021)
9.	Odi, Reem: 1 article (10/2021)
10.	Perucca, Emilio: 1 article (10/2021)

Related Diseases

1.	Seizures (Absence Seizure) 01/01/2023 - "All compounds tested were active against MES-induced seizures in rats and mice after acute (single-dose) administration, but no activity against 6-Hz seizures was found even at doses up to 30 mg/kg. Estimates of median effective doses (ED50 ) in the rat-MES test were obtained for all compounds except for d-norfenfluramine, which caused dose-limiting neurotoxicity. " 01/01/2023 - "Although there are differences in antiseizure activity and pharmacokinetics among the enantiomers of fenfluramine and norfenfluramine, all compounds tested are effective in protecting against MES-induced seizures in rodents. " 10/01/2021 - "Particular emphasis is placed on the remarkable lack of publicly accessible information about the comparative activity of the individual enantiomers of fenfluramine and norfenfluramine in experimental models of seizures and epilepsy, and on receptors systems considered to be involved in antiseizure effects. "
2.	Myoclonic Epilepsies (Myoclonic Encephalopathy) 09/01/2021 - "Efficacy of Fenfluramine and Norfenfluramine Enantiomers and Various Antiepileptic Drugs in a Zebrafish Model of Dravet Syndrome."
3.	Drug Resistant Epilepsy 01/01/2022 - "This study was undertaken to determine the plasma concentration and pharmacokinetic variability of fenfluramine (FFA) and its main active metabolite norfenfluramine (norFFA) in relation to the prevalence of adverse effects in patients with refractory epilepsy treated with FFA. "
4.	Weight Loss (Weight Reduction) 06/08/1982 - "The weight loss, the plasma level concentration of fenfluramine (F) and norfenfluramine (NF) have been evaluated during a period of about 9 weeks. " 01/01/1982 - "In contrast to two previous reports, however, there was no correlation between plasma levels of fenfluramine and its metabolite norfenfluramine and weight loss, nor was there any correlation between these levels and side effects. " 11/19/1977 - "There was a highly significant relation between weight loss and plasma fenfluramine and norfenfluramine concentrations and also between weight loss and the presence of sustained anorexia. " 10/01/2005 - "Much of the weight loss produced by fenfluramine was attributed to the direct activation of serotonin 5-HT(2C) receptors in the central nervous system via the desmethyl-metabolite of fenfluramine, norfenfluramine. "
5.	Anorexia 11/19/1977 - "Every two weeks details of weight change, drug dose, degree of anorexia, and any side effects were recorded and plasma was obtained for fenfluramine and norfenfluramine measurements. " 11/19/1977 - "There was a highly significant relation between weight loss and plasma fenfluramine and norfenfluramine concentrations and also between weight loss and the presence of sustained anorexia. " 03/01/2004 - "Relationship between anorexia and loss of serotonin uptake sites in brain of mice and rats receiving d-norfenfluramine or d-fenfluramine." 01/01/1988 - "Several findings suggest that d-fenfluramine and d-norfenfluramine cause anorexia by increasing the availability of serotonin at postsynaptic receptors. "

Related Drugs and Biologics

1.	Fenfluramine
2.	Anticonvulsants (Antiepileptic Drugs)
3.	Serotonin (5 Hydroxytryptamine)
4.	benfluorex (S 780)
5.	Desoxycorticosterone Acetate (DOCA)
6.	5-HT2B Serotonin Receptor
7.	Dexfenfluramine (Redux)
8.	Spironolactone (Aldactone)
9.	Salts
10.	Serotonin Receptors