Norethynodrel

A synthetic progestational hormone with actions and uses similar to those of PROGESTERONE. It has been used in the treatment of functional uterine bleeding and ENDOMETRIOSIS. As a contraceptive (CONTRACEPTIVE AGENTS), it has usually been administered in combination with MESTRANOL.

Also Known As:

Networked: 78 relevant articles (0 outcomes, 2 trials/studies)

Drug Context: Research Results

Experts

1.	Afzal, Mohammad: 1 article (06/2005)
2.	Colomer, Ramon: 1 article (06/2005)
3.	Lupu, Ruth: 1 article (06/2005)
4.	Menendez, Javier A: 1 article (06/2005)
5.	Oza, Bharvi P: 1 article (06/2005)
6.	Siddique, Yasir Hasan: 1 article (06/2005)
7.	Mueck, A O: 1 article (11/2001)
8.	Seeger, H: 1 article (11/2001)
9.	Wallwiener, D: 1 article (11/2001)

Related Diseases

1.	Neoplasms (Cancer) 03/01/1982 - "Norethynodrel significantly decreased the induction time of the neoplasms." 03/01/1982 - "Effects of norethynodrel on neoplasms in the buccal pouch of the Syrian hamster." 03/01/1979 - " Studies with animals have been inconclusive so far; norethynodrel with mestranol (Enovid) failed to increase the incidence of hepatic tumors in susceptible mice, though a number of C17 alpha alkyl derivatives of testosterone will increase the expected frequency of hepatic tumors in susceptible mice. " 11/01/1988 - "This hypothesis was only partially proven, due to the unexpected finding that a high dose of the progestagenic agent medroxyprogesterone acetate (MPA), increased tumor incidence, whereas a similar dose of the mostly estrogenic norethynodrel--mestranol (NM) was protective. " 03/01/1969 - "Effects of a norethynodrel-mestranol combination (enovid) on development and growth of carcinogen-induced mammary tumors in female rats."
2.	Chromosome Aberrations (Chromosome Abnormalities) 06/01/2005 - "The genotoxicity study of a synthetic progestin norethynodrel, was carried out on human lymphocytes chromosomes using sister chromatid exchanges (SCEs), replication index (RI) and chromosomal aberrations (CAs) as parameters. "
3.	Endometriosis 01/01/1962 - "Further experience with norethynodrel in treatment of endometriosis." 07/01/1961 - "Effect of norethynodrel on endometriosis." 11/01/1960 - "[Treatment of endometriosis by synthetic progestational drugs (apropos of a case treated by Norethynodrel)]." 08/15/1966 - "Massive norethynodrel therapy in the treatment of endometriosis." 01/01/1979 - "In a comparison of danazol, and mestranol with norethynodrel (Enavid, Searle) in the treatment of endometriosis danazol was shown to be superior. "
4.	Acne Vulgaris 01/01/1963 - "[Norethynodrel in the treatment of acne]." 01/01/1963 - "[Interruption of therapy on the occasion of a publication concerning the use of norethynodrel in the therapy of acne]." 09/27/1964 - "[ANTIBIOTICS AND NORETHYNODREL IN THE TREATMENT OF ACNE IN WOMEN]." 08/01/1964 - "NORETHYNODREL WITH MESTRANOL IN THE TREATMENT OF ACNE." 01/01/1964 - "[AN ANTIBIOTIC AND NORETHYNODREL IN THE TREATMENT OF ACNE IN WOMEN]."
5.	Breast Neoplasms (Breast Cancer) 06/01/2005 - "We found that in estrogen receptor (ER)- and progesterone receptor (PR)-positive MCF-7 human breast cancer cells, synthetic progestins used in oral contraceptives including norethynodrel (NOR) and norethindrone, induced a dose-dependent increase of FAS enzymatic activity, with a maximum response (> or = 4-fold) occurring at a concentration of 10(-8) M. " 02/01/1989 - " Similarly, analyses according to the specific progestin component in combination OCs (ethynodiol diacetate, norethindrone, norethindrone acetate, norethynodrel, and norgestrel) did not suggest an increased risk of breast cancer. " 05/01/1974 - "To determine the relationship of oral contraceptive use and breast cancer, 96 rhesus monkeys were administered either Enovid-E (2.5 mg norethynodrel and .1 mg mestranol) or Ovulen (1 mg ethynodiol diacetate and .1 mg mestranol) cyclically for 5 years at doses of 1, 10 and 50 times the human dose. " 02/01/1998 - "In addition to progesterone, a number of synthetic progestins used in oral contraceptives (e.g., norethindrone, norgestrel, and norethynodrel), hormone replacement therapy (medroxyprogesterone acetate), and high-dose progestin treatment of breast cancer (megestrol acetate) also increase VEGF in the media of cultured T47-D cells. "

Related Drugs and Biologics

1.	Mestranol
2.	Infecundin (Enovid)
3.	Progesterone Congeners
4.	Testosterone (Sustanon)
5.	Progestins (Progestagens)
6.	Oral Contraceptives
7.	Norethindrone (Norethisterone)
8.	Norgestrel (DL-Norgestrel)
9.	Ethynodiol Diacetate
10.	Estrogens (Estrogen)

Related Therapies and Procedures

1.	Therapeutics
2.	Hormone Replacement Therapy (Therapy, Hormone Replacement)
3.	Injections
4.	Contraception (Birth Control)