Nogalamycin

An anthrocycline from a Streptomyces nogalater variant. It is a cytolytic antineoplastic that inhibits DNA-dependent RNA synthesis by binding to DNA.

Also Known As:

U-15167; U 15167; U15167; 2,6-Epoxy-2H-naphthaceno(1,2-b)oxocin-14-carboxylic acid, 11-((6-deoxy-3-C-methyl-2,3,4-tri-O-methyl-alpha-L-mannopyranosyl)oxy)-4-(dimethylamino)-3,4,5,6,9,11,12,13,14,16-decahydro-3,5,8,10,13-pentahydroxy-6,13-dimethyl-9,16-dioxo-, methyl ester, (2R-(2alpha,3beta,4alpha,5beta,6alpha,11beta,13alpha,14alpha))-

Networked: 19 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Metsä-Ketelä, Mikko: 1 article (11/2020)
2.	Nji Wandi, Benjamin: 1 article (11/2020)
3.	Palmu, Kaisa: 1 article (11/2020)
4.	Siitonen, Vilja: 1 article (11/2020)
5.	Alam, Neyaz: 1 article (03/2019)
6.	Dasgupta, Hemantika: 1 article (03/2019)
7.	Islam, Md Saimul: 1 article (03/2019)
8.	Panda, Chinmay Kumar: 1 article (03/2019)
9.	Roy, Anup: 1 article (03/2019)
10.	Roychoudhury, Susanta: 1 article (03/2019)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 01/01/1991 - "Among nogalamycin derivatives, menogaril showed distinct biochemical effects as well as superior cytotoxicity and antitumor activity and also proved to be effective against breast cancer clinically." 12/06/2018 - "Nogalamycin monoxygenase (NMO) is a member of a family of enzymes that catalyze a key step in the biosynthesis of tetracycline antibiotics used to treat, for example, breast cancer in humans, using molecular oxygen for substrate oxidation but without an apparent cofactor. " 11/01/1992 - "The therapeutic effects of orally administered menogaril, a semisynthetic analog of the anthracycline antibiotic nogalamycin, were studied on a panel of human stomach and breast cancer xenografts. "
2.	Neoplasms (Cancer) 07/01/1976 - "Chemically induced fibrosarcoma tumors and tumors of spontaneous origin in rats were successfully regressed following the administration of nogalamycin. " 07/01/1976 - "Cytological effect of nogalamycin in mammals and regression of methylcholanthrene-induced and spontaneous tumors in rats." 07/01/1976 - "Simultaneous transplantation of chemically induced fibrosarcoma tumors and intraperitoneal administration of nogalamycin, irreversibly inhibited growth of primary tumors in rats. " 07/01/1976 - "The most effective concentration of nogalamycin for either regression of actively growing fibrosarcoma tumors or inhibition of transplanted fibrosarcoma cells was 556 mug/kg of body weight." 11/02/2020 - "Nogalamycin is an anthracycline anti-cancer agent that intercalates into the DNA double helix. "
3.	Cardiotoxicity 10/01/1989 - "Menogaril, an anthracycline analog of nogalamycin, is reported to have greater cytotoxicity against certain malignant cell lines and less cardiotoxicity in rabbits than doxorubicin. " 01/01/1987 - "Menogaril (7-con-O-methylnogarol) is a semisynthetic anthracycline analogue of nogalamycin that has shown good activity against a variety of experimental tumor systems as well as decreased cardiac toxicity when compared with doxorubicin in preclinical studies. "
4.	Leukemia 11/01/1993 - "Fifteen patients with relapsed or refractory acute leukemia were treated in this phase I study of menogaril (7-con-O-methylnogarol), a nogalamycin anthracycline derivative. " 11/01/1979 - "The chemotherapeutic activity of analogs of the anthracycline antibiotic, nogalamycin, was investigated in the P388 and L1210 leukemias and the B16 melanoma in mice. "
5.	Experimental Melanoma 01/01/1981 - "We compare here the lethality of several nogalamycin analogs against Chinese hamster ovary (CHO), mouse leukemia (L1210), and mouse melanoma (B16) cells in culture. " 01/01/1981 - "Cell kill kinetics of several nogalamycin analogs and adriamycin for Chinese hamster ovary, L1210 leukemia, and B16 melanoma cells in culture." 11/01/1979 - "The chemotherapeutic activity of analogs of the anthracycline antibiotic, nogalamycin, was investigated in the P388 and L1210 leukemias and the B16 melanoma in mice. "

Related Drugs and Biologics

1.	Menogaril
2.	Anthracyclines
3.	Doxorubicin (Adriamycin)
4.	Anti-Bacterial Agents (Antibiotics)
5.	DNA (Deoxyribonucleic Acid)
6.	Daunorubicin (Cerubidine)
7.	Therapeutic Uses
8.	Mitomycin (Mitomycin-C)
9.	Aclarubicin
10.	Tubercidin

Related Therapies and Procedures

1.	Transplantation
2.	Aftercare (After-Treatment)

HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Application Error

An application error has occurred and our support engineers have been notified.

Please use the browser "Back" button and try your operation again.

OR if the error persists and you require an email response
please contact us at "cs at curehunter.com":

Your request
The circumstances of the error
Your login id/nickname or email

Return to Top Page