Nitroimidazoles

01/01/2018 - "To review nitroimidazole-refractory G. intestinalis infection, examine the current efficacy of standard therapeutic agents, consider potential resistance mechanisms which could cause treatment failure and describe the practical aspects of managing this emerging clinical problem. "
01/01/2000 - "The efficacy of a nitroimidazole-containing regimen for the treatment of Helicobacter pylori infection is decreased by nitroimidazole resistance. "
01/01/2019 - "Nitroimidazole Resistance in Trichomonas vaginalis Infection: A Teachable Moment."
07/01/2007 - "Nitroimidazole derivatives are commonly used in the treatment of protozoal and anaerobic infections, and reports of their hepatotoxicity are rare. "
09/01/2006 - "The most commonly administered treatments are betalactams agents combined to anti-anaerobes drugs such as nitroimidazoles, adapted to the location of infection. "

11/01/2015 - "In addition, [(68) Ga]-HP-DO3A-NI displayed very favorable pharmacokinetic properties, as it was cleared largely through the kidneys with little to no accumulation in liver, heart or lung (%ID/g < 0.5%) at 2 h p.i. The specificity of the agent for hypoxic tissues was further validated in a comparative study with a control compound, [(68) Ga]-HP-DO3A, which lacks the nitroimidazole moiety, and by PET imaging of tumor-bearing mice breathing air versus 100% O2 . "
01/01/2020 - "The nitroimidazole tracer Al18F-NOTA-NI steadily accumulated in hypoxic areas in tumors and was rapidly eliminated from normal tissue. "
03/01/2021 - "Our study suggested that the length of the linkers connecting nitroimidazole to a bifunctional chelate affect PET imaging of hypoxic tumors with 68Ga-radiolabeled compounds."
01/01/2017 - "In this review, non-invasive methods dedicated to assessing tumor oxygenation with the ultimate goal of predicting outcome in radiation oncology are presented, including positron emission tomography used with nitroimidazole tracers, magnetic resonance methods using endogenous contrasts (R1 and [Formula: see text]-based methods), and electron paramagnetic resonance oximetry; the goal is to highlight results of studies establishing correlations between tumor hypoxic status and patients' outcome in the preclinical and clinical settings."
01/01/2011 - "In this study, we performed an investigation about the intrinsic cytotoxicity of some derivatives of DHP containing nitroimidazole moiety on their C4 position on four different cancer cell lines (Raji, K562, Fen and HeLa). "

05/26/1995 - "bis(nitroimidazoles) and related Bis(nitroheterocycles): development of derivatives with higher rates of metabolic activation under hypoxia and improved aqueous solubility."
10/01/1999 - "Nitroimidazole compounds hold promise for positive imaging of hypoxia in the heart. "
12/01/2009 - "A phase I study of the nitroimidazole hypoxia marker SR4554 using 19F magnetic resonance spectroscopy."
05/01/2008 - "In rodent studies, the specificity of (111)In-RP748 for alphavbeta3-integrin was confirmed with a negative control compound ((111)In-RP790), and regional uptake of these compounds correlated with (201)Tl perfusion and a (99m)Tc-labeled nitroimidazole (BRU59-21), which was used as a quantitative marker of myocardial hypoxia. "
12/01/1992 - "Nitroimidazole adducts as markers for tissue hypoxia: mechanistic studies in aerobic normal tissues and tumour cells."

07/01/2008 - "vaginalis (ATCC 50143), suggesting that it may be effective for the treatment of nitroimidazole-refractory trichomoniasis. "
09/01/1989 - "All patients with urogenital trichomoniasis were cured with nitroimidazoles. "
12/01/2023 - "A single class drug, nitroimidazoles, is currently available for the trichomoniasis treatment. "
02/01/2023 - "Treatment options for trichomoniasis are limited to nitroimidazole compounds. "
09/01/2021 - "Trichomoniasis treatment consists of the use of nitroimidazole derivatives; however, therapeutic ineffectiveness occurs in 5 to 20 % of the cases. "

01/01/1981 - "It was shown that nitroimidazole derivatives improved the migration of granulocytes in most of the patients with Crohn's disease but that they had no effect on normal cells. "
04/01/2010 - "Nitroimidazole antibiotics are effective in the prevention of post-operative Crohn's disease recurrence, but their side-effects limit acceptability. "
02/15/2010 - "Long-term treatment with nitroimidazoles or clofazimine appears to be effective in patients with Crohn's disease."
01/01/1984 - "Serum concentrations of metronidazole and its main metabolite [1-(2-hydroxyethyl)-2-hydroxymethyl-5-nitroimidazole] have been determined by high performance liquid chromatography in sera of 10 patients with histologically confirmed ileocolitis Crohn, 7 presenting with highly active disease and pathologically increased Crohn's disease activity index (CDAI) and 3 with secreting fistulas but normal CDAI. "
04/01/2005 - "We investigated the efficacy and safety of ornidazole, a nitroimidazole antibiotic, for the prevention of clinical recurrence of Crohn's disease after curative ileocolonic resection in a placebo-controlled double-blind clinical trial. "