HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Niemann-Pick Diseases (Niemann Pick Disease)

A group of autosomal recessive disorders in which harmful quantities of lipids accumulate in the viscera and the central nervous system. They can be caused by deficiencies of enzyme activities (SPHINGOMYELIN PHOSPHODIESTERASE) or defects in intracellular transport, resulting in the accumulation of SPHINGOMYELINS and CHOLESTEROL. There are various subtypes based on their clinical and genetic differences.
Also Known As:
Niemann Pick Disease; Niemann Pick Diseases; Niemann-Pick Disease
Networked: 328 relevant articles (6 outcomes, 23 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Central Nervous System Diseases (CNS Diseases)
2. Gaucher Disease (Gaucher's Disease)
3. Mucolipidoses (Sialidosis)
4. Lysosomal Storage Diseases (Lysosomal Storage Disease)
5. Mucopolysaccharidoses

Experts

1. Schuchman, Edward H: 32 articles (03/2015 - 05/2002)
2. Schuchman, E H: 10 articles (01/2009 - 10/2000)
3. Sandhoff, Konrad: 7 articles (09/2015 - 08/2003)
4. He, Xingxuan: 7 articles (07/2010 - 07/2002)
5. Wasserstein, Melissa P: 6 articles (09/2015 - 07/2004)
6. Muro, Silvia: 6 articles (08/2014 - 01/2006)
7. McGovern, Margaret M: 6 articles (08/2013 - 07/2002)
8. Thurberg, Beth L: 5 articles (09/2015 - 05/2009)
9. Dhami, Rajwinder: 5 articles (05/2008 - 03/2003)
10. Gatt, Shimon: 5 articles (06/2007 - 09/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Niemann-Pick Diseases:
1. Sphingomyelin Phosphodiesterase (Sphingomyelinase)IBA
2. neodymium pyrocatechin disulfonate (NPD)IBA
3. CholesterolIBA
4. Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA
5. Sphingomyelin lipidosisIBA
6. LipidsIBA
7. Proteins (Proteins, Gene)IBA
8. Lipoproteins (Lipoprotein)IBA
9. EnzymesIBA
10. Phosphatidylcholines (Phosphatidylcholine)IBA

Therapies and Procedures

1. Enzyme Replacement Therapy
2. Bone Marrow Transplantation (Transplantation, Bone Marrow)
3. Subcutaneous Infusions
4. Liver Transplantation
5. Stem Cell Transplantation
01/01/2009 - "Stem cell transplantation was performed for various diseases including acute myelogenous leukemia, acute lymphoblastic leukemia, chronic myelogenous leukemia, chronic lymphoblastic leukemia, thalassemia major, sickle cell thalassemia, sickle cell disease, multiple myeloma, myelodysplasia, mucopolysaccharidosis, paroxysmal nocturnal hemoglobinuria, non-Hodgkin's lymphoma, Hodgkin's disease, severe aplastic anemia, plasma cell leukemia, Niemann-Pick disease, Fanconi anemia, severe combine immunodeficiency, congenital neutropenia, leukocyte adhesion deficiencies, Chediak-Higashi syndrome, osteopetrosis, histiocytosis X, Hurler syndrome, amyloidosis, systemic sclerosis, breast cancer, Ewing's sarcoma, testicular cancer, germ cell tumors, neuroblastoma, medulloblastoma, renal cell carcinoma, nasopharyngeal carcinoma, ovarian cancer, Wilms' tumor, rhabdomyosarcoma, pancreatoblastoma, and multiple sclerosis. "
02/01/2013 - "Stem cell transplantation was performed for treatment of various diseases such as acute myelogenous leukemia, acute lymphoblastic leukemia, chronic myelogenous leukemia, chronic lymphoblastic leukemia, beta-thalassemia major, sickle- cell thalassemia, sickle- cell disease, multiple myeloma, myelodysplasia, mucopolysaccharidosis, paroxysmal nocturnal hemoglobinuria, non-Hodgkin's lymphoma, Hodgkin's disease, severe aplastic anemia, plasma cell leukemia, Niemann-Pick disease, Fanconi anemia, severe combined immunodeficiency, congenital neutropenia, leukocyte adhesion deficiencies, Chediak-Higashi syndrome, osteopetrosis, histiocytosis X, Hurler syndrome, amyloidosis, systemic sclerosis, breast cancer, Ewing's sarcoma, testicular cancer, germ cell tumors, neuroblastoma, medulloblastoma, renal cell carcinoma, nasopharyngeal carcinoma, ovarian cancer, Wilms' tumor, rhabdomyosarcoma, pancreatoblastoma, and multiple sclerosis. "