Nicotinamidase

10/01/2000 - "tuberculosis pncA gene into the pncA mutant complemented its PZase/nicotinamidase defect. "
06/01/1959 - "[Type differentiation of tuberculosis bacteria with the aid of the nicotinamidase test]."
01/01/2023 - "tuberculosis membrane and is hydrolyzed to its active form, pyrazinoic acid (POA), by a nicotinamidase encoded by the pncA gene. "
01/01/2009 - "Specificity and mechanism of Acinetobacter baumanii nicotinamidase: implications for activation of the front-line tuberculosis drug pyrazinamide."
01/01/2023 - "Here, we showed that an analog of the first-line tuberculosis drug pyrazinamide, which is converted by nicotinamidase/pyrazinamidase (PncA) to its active form, affected NAD+ level in the intestines and liver of mice and disrupted the homeostasis of gut microbiota. "

01/01/1980 - "Purification and characterization of a nicotinamide deamidase released into the growth medium of neuroblastoma in vitro."
09/01/1979 - "Nicotinamide deamidase released by neuroblastoma cell cultures."
01/01/1980 - "Nicotinamide deamidase (nicotinamide amidohydrolase, EC 3.5.1.19) has been demonstrated in the conditioned growth medium of the M1 clonal cell line of mouse C1300 neuroblastoma. "

11/01/2009 - "Mutations in the Caenorhabditis elegans nicotinamidase PNC-1 cause developmental and functional defects in the reproductive system; the development of the gonad is delayed, four uterine cells die by necrosis and the mutant animals are egg-laying defective. "
01/01/2021 - "Excess nicotinamide in a pnc-1 nicotinamidase mutant causes the necrosis of uv1 and OLQ cells and a highly penetrant egg laying defect. "

07/01/2005 - "Furthermore, we investigated the requirement in ticks for the lp25 gene bbe22, which encodes a nicotinamidase that is necessary and sufficient for mammalian infection by B. "
05/01/2003 - "Our results demonstrate that the gene BBE22 encoding a nicotinamidase is capable of replacing the requirement for the 25 kb linear plasmid lp25 during mammalian infection. "

07/01/1979 - "gastri); c) The light sensitivity of nicotinamidase (in photochromogenic M. "