Pigmented Nevus (Melanocytic Nevus)

A nevus containing melanin. The term is usually restricted to nevocytic nevi (round or oval collections of melanin-containing nevus cells occurring at the dermoepidermal junction of the skin or in the dermis proper) or moles, but may be applied to other pigmented nevi.

Also Known As:

Networked: 750 relevant articles (30 outcomes, 75 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Melanoma (Melanoma, Malignant)
2.	Nevus (Nevi)
3.	Neoplasms (Cancer)
4.	Neurofibroma
5.	Nevus of Ota

Experts

1.	Florell, Scott R: 9 articles (01/2022 - 01/2005)
2.	Grossman, Douglas: 9 articles (01/2022 - 01/2005)
3.	Prieto, Victor G: 7 articles (11/2021 - 01/2002)
4.	Garbe, Claus: 7 articles (12/2019 - 04/2004)
5.	Carlson, J Andrew: 7 articles (01/2018 - 01/2002)
6.	Boucher, Kenneth M: 5 articles (01/2022 - 11/2008)
7.	Krengel, Sven: 5 articles (01/2022 - 08/2002)
8.	Liu, Tong: 5 articles (01/2022 - 06/2007)
9.	Massi, Daniela: 5 articles (11/2021 - 06/2005)
10.	Morimoto, Naoki: 5 articles (07/2021 - 01/2017)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pigmented Nevus:

1.	Proteins (Proteins, Gene)FDA Link 03/01/2023 - "A3B protein levels were significantly higher in oral and sinonasal MMs than intraoral melanocytic nevi (P < 0.0001 and P = 0.0022, respectively), which were A3B-negative (H-score range = 1-8, median = 4). " 01/27/2016 - "We observed high expression of LC3 in melanosome-associated pigment-rich melanocytic nevi of sun-exposed skin, as indicated by patterns of melanosomal protein MART1 expression. " 08/01/2013 - "[Evaluation of COX-2 protein expression in melanocytic nevi in children]." 11/01/2012 - "For the conjunctival melanocytic nevi, the intensity of Raman spectrum region between 1,550 cm(-1) and 1,650 cm(-1) that belong to protein has increased, which indicates that the content of protein in conjunctival melanocytic nevi is more richer than the normal ones." 03/01/2006 - "Expression profiles of melanogenesis-related genes and proteins in acquired melanocytic nevus."
2.	MART-1 AntigenIBA 10/01/2012 - "melanocytic nevi, because of their histopathologic attributes (symmetric silhouette, benign cytologic features) and results from immunohistochemical studies (all lesions strongly expressed Melan-A and p16) and fluorescence in situ hybridization (FISH). " 10/01/2020 - "An unexpected feature was the presence of a Melan A- and Sox10-positive population amongst the GCR-SFT, postulated to be a subepithelial melanocytic nevus colliding with the GCR-SFT." 01/01/2020 - "Microscopically, all lesions comprised a conventional melanocytic nevus with focal granular cell change and immunoreactivity for Melan-A, SOX10, and HMB-45, with Ki-67 proliferative index of less than 2%. " 07/01/2012 - "Our data indicate that Melan-A immunohistochemical staining is helpful in differentiating neurotized melanocytic nevi from neurofibromas when distinction on histomorphology alone is difficult." 06/01/2000 - "The presence or absence of staining for Mart-1 antigen cannot be used to differentiate benign melanocytic nevi from malignant melanocytic tumors."
3.	Proliferating Cell Nuclear Antigen (PCNA)IBA 04/08/2008 - "89, P < 0.01) and normal skin group (4.0% +/- 2.0%, t = 22.63, P < 0.01), however, there was no significant difference in the PCNA PI between the melanocytic nevus and normal skin groups (P > 0.05). " 04/08/2008 - "The positive index (PI) of PCNA of the MM group was 55.0% +/- 14.8%, significantly higher than those of the melanocytic nevus group (6.2% +/- 3.0%, t = 19. " 04/08/2008 - "The PCNA positive rate of the MM group was 100% (35/35), significantly higher than those of the melanocytic nevus group (33.33%, 7/21) and normal skin group (10.71%, 3/28) (chi2 = 54.4, v = 2, P < 0.01). " 12/01/1998 - "Enhanced expression of Ki-67, topoisomerase IIalpha, PCNA, p53 and p21WAF1/Cip1 reflecting proliferation and repair activity in UV-irradiated melanocytic nevi." 01/01/1993 - "These results indicate that staining with PCNA would be very useful in the differentiation of malignant melanoma from melanocytic nevi manifesting cellular and/or structural atypia by virtue of a significant difference in the proportion of PCNA-positive cells. "
4.	ErbiumIBA 08/01/2017 - "Congenital melanocytic nevus on the lower eyelid treated with continuous wave and superpulsed CO2 laser followed by erbium laser." 02/01/2006 - "To date, no study has evaluated the efficacy and safety of an erbium:yttrium-aluminum-garnet (YAG) laser, with its small penetration depth and fewer adverse effects, in the treatment of acquired melanocytic nevi. " 02/01/2017 - "Intense Pulsed Light Alone and in Combination with Erbium Yttrium-Aluminum-Garnet Laser on Small-to-Medium Sized Congenital Melanocytic Nevi: Single Center Experience Based on Retrospective Chart Review." 04/01/2015 - "To investigate the efficacy and safety of combined treatment with the short-pulsed erbium:yttrium-aluminum-garnet (Er:YAG) and long-pulsed alexandrite laser for acquired melanocytic nevi (AMN) and small congenital melanocytic nevi (CMN). " 01/01/2014 - "Thus, normal mode pigment-specific lasers and pulsed ablative lasers (CO2/erbium [Er]:yttrium aluminum garnet [YAG]) are more suited to treat acquired melanocytic nevi. "
5.	yttrium-aluminum-garnetIBA 02/01/2006 - "To date, no study has evaluated the efficacy and safety of an erbium:yttrium-aluminum-garnet (YAG) laser, with its small penetration depth and fewer adverse effects, in the treatment of acquired melanocytic nevi. " 02/01/2017 - "Intense Pulsed Light Alone and in Combination with Erbium Yttrium-Aluminum-Garnet Laser on Small-to-Medium Sized Congenital Melanocytic Nevi: Single Center Experience Based on Retrospective Chart Review." 04/01/2015 - "To investigate the efficacy and safety of combined treatment with the short-pulsed erbium:yttrium-aluminum-garnet (Er:YAG) and long-pulsed alexandrite laser for acquired melanocytic nevi (AMN) and small congenital melanocytic nevi (CMN). " 10/01/2019 - "Capillary malformation was almost cleared in 28.6% of patients using pulsed dye laser, whereas pigmented nevus was almost cleared in 23.7% and completely cleared in 42.1% of patients using Q-switched neodymium:yttrium-aluminum-garnet laser. " 01/01/2014 - "Thus, normal mode pigment-specific lasers and pulsed ablative lasers (CO2/erbium [Er]:yttrium aluminum garnet [YAG]) are more suited to treat acquired melanocytic nevi. "
6.	Ki-67 Antigen (Ki 67 Antigen)IBA 04/30/1998 - "In addition, a greater proportion of cells were immunopositive for Ki67 antigen, p53 and p21WAF1 protein in the primary melanomas than in the benign melanocytic nevi, however, only p53 over-expression was significantly associated with improved survival (P=0.041)." 03/01/1989 - "Monoclonal antibodies (MoAbs) against six well-defined progression-associated melanoma antigens (PAMAs) and a MoAb against the nuclear proliferation-associated antigen Ki67 were used for an immunoperoxidase study on 44 biopsies from 36 congenital melanocytic nevi (CMN). " 10/01/1994 - "Formalin-fixed and paraffin-embedded tissues from 4 cutaneous melanoma metastases, 10 primary invasive melanomas, and 10 intradermal melanocytic nevi were immunolabeled with monoclonal antibodies directed against BCL-2 protein (Dako, clone 124) and Ki-67 antigen (Amac, clone MIB-1), after antigen retrieval techniques. "
7.	Carbon DioxideIBA 04/01/2019 - "Carbon dioxide (CO2) laser ablation treatment generating 10,600nm of infrared radiation has shown promising results in patients with small-sized congenital melanocytic nevi (CMN). " 02/01/2021 - "Carbon dioxide ablative laser treatment of acquired junctional melanocytic nevi." 01/01/2020 - "We conclude that carbon dioxide cryotherapy is an effective treatment modality for nasal and perinasal congenital melanocytic nevi that should be used by others to stand on its long-term persistence and possible complications." 01/01/2020 - "Carbon Dioxide Cryotherapy for Treatment of Nasal and Perinasal Congenital Melanocytic Nevi." 01/01/2022 - "The effect of carbon dioxide lattice laser cosmetic technique in the treatment of pigmented nevus and the evaluation of the improvement of patients' appearance."
8.	NeodymiumIBA 03/01/1997 - "Both the Q-switched ruby laser and the neodymium: YAG laser often removed only the superficial portion of the congenital melanocytic nevi. " 10/01/2019 - "Capillary malformation was almost cleared in 28.6% of patients using pulsed dye laser, whereas pigmented nevus was almost cleared in 23.7% and completely cleared in 42.1% of patients using Q-switched neodymium:yttrium-aluminum-garnet laser. " 01/01/2023 - "PubMed was searched December 5, 2022 for articles evaluating changes in melanocytic nevi after LHR treatment using the following search terms: "nevi laser hair removal," "nevi diode," "nevi long pulse alexandrite," "nevi long pulse neodymium doped yttrium aluminum garnet," and "melanoma laser hair removal." All English language patient-based reports discussing incidental treatment of melanocytic nevi while undergoing LHR with a laser were eligible for inclusion, while reports of changes following hair removal with non-laser devices such as intense pulsed light were excluded. "
9.	ArgonIBA 02/01/2006 - "To evaluate the efficacy of an argon laser in the ablation of benign conjunctival pigmented nevi. " 07/01/2016 - "To evaluate the outcomes of argon laser photoablation of benign conjunctival pigmented nevi with different clinical presentations. " 02/01/2006 - "The argon-laser ablation of conjunctival pigmented nevi uniformaly resulted in excellent clinical outcomes. " 02/01/2006 - "We conducted argon laser ablations for conjunctival pigmented nevus in 30 eyes of 28 patients. " 02/01/2006 - "Argon laser photoablation of conjunctival pigmented nevus."
10.	IpilimumabIBA 01/01/2017 - "Primary Leptomeningeal Melanoma in a Patient With Multiple Congenital Melanocytic Nevi Treated With Ipilimumab." 01/01/2019 - "We report a case of major regression of multiple atypical melanocytic nevi with a vitiligoid reaction in a patient with metastatic melanoma who achieved long-lasting complete remission after ipilimumab therapy. " 12/01/2021 - "Regression of benign melanocytic nevi ipilimumab-induced in an adult patient affected by metastatic melanoma: is it a sign of response to therapy?"

Therapies and Procedures

1.	Solid-State Lasers 04/01/2015 - "Combined treatment with Er:YAG laser and long-pulsed alexandrite laser is effective for the removal of small benign melanocytic nevi with minimal adverse effects and low recurrence rates." 05/01/1997 - "The Q-switched ruby laser is effective in removing small melanocytic nevi. " 01/01/2014 - "The long-pulsed, 532-nm Nd:YAG laser is safe and effective in the removal of small acquired melanocytic nevi in Yemeni patients." 05/01/2012 - "Use of the 1,064 nm Q-switched Nd:YAG laser is a safe and effective treatment modality for melanocytic nevi." 02/01/2006 - "Short-pulse erbium:YAG laser treatment is an effective and safe method for removing acquired melanocytic nevi."
2.	Lasers (Laser) 01/01/2022 - "Laser treatment of pigmented melanocytic nevi is not recommended. " 01/01/2022 - "Laser treatment for congenital melanocytic nevi (CMN) is controversial. " 01/01/2022 - "Facial anatomical site-related variation in short-term outcomes of laser treatment for congenital melanocytic nevi" 10/01/2019 - "Pigmented nevus demonstrated better treatment response to lasers than did capillary malformation. " 10/01/2019 - "Treatment of Congenital Melanocytic Nevi in the Eyelid and Periorbital Region With Ablative Lasers."
3.	Therapeutics 09/01/2015 - "Melanocytic nevi excised during B-Raf proto-oncogene (BRAF) inhibitor therapy: A study of 19 lesions from 10 patients." 06/01/2021 - "A Case of Giant Congenital Melanocytic Nevus Treated with Combination Therapy of Autologous Mesh-skin Grafts and Cultured Epithelial Autografts." 01/01/2018 - "Giant Congenital Melanocytic Nevi: An Update and Emerging Therapies." 01/01/2018 - "Serial excision with power-stretching of the skin in giant melanocytic nevi therapy." 07/25/2017 - "Giant Congenital Melanocytic Nevus (GCMN) - A New Hope for Targeted Therapy?"
4.	Gas Lasers 02/01/2021 - "CO2 laser is effective in completely removing small acquired junctional melanocytic nevus. " 04/01/2019 - "Retrospective Analysis of the Efficacy of 10,600nm Carbon Dioxide Laser Ablation for Small Congenital Melanocytic Nevi in Adults." 04/01/2014 - "Efficacy of serial excisions of melanocytic nevi on the face using a carbon dioxide laser: a cosmetic point of view." 09/01/2021 - "Treatment of congenital melanocytic nevi in the periorbital area with dual-wavelength copper vapor laser." 01/01/2021 - "Treatment of Congenital Melanocytic Nevi With a Dual-Wavelengths Copper Vapor Laser: A Case Series."
5.	Laser Therapy (Surgery, Laser) 02/01/1987 - "For instance, congenital melanocytic nevi may be improved, but are incompletely removed by laser surgery. " 05/01/2020 - "The purpose of this study is to review the published articles regarding different surgical modalities including laser therapy in the treatment of congenital melanocytic nevi (CMN). " 05/01/2020 - "The outcome of using different surgical modalities and laser therapy in the treatment of small- and medium-sized congenital melanocytic nevi: a systematic review." 01/01/2020 - "Giant Congenital Melanocytic Nevi Successfully Treated with Combined Laser Therapy." 12/01/2019 - "Combination laser therapy as a non-surgical method for treating congenital melanocytic nevi from cosmetically sensitive locations on the body."