Neurotoxins

Toxic substances from microorganisms, plants or animals that interfere with the functions of the nervous system. Most venoms contain neurotoxic substances. Myotoxins are included in this concept.

Also Known As:

Alpha-Neurotoxins; Excitatory Neurotoxins; Excitotoxin; Alpha Neurotoxin; Alpha Neurotoxins; Neurotoxin, Excitatory; Neurotoxins, Excitatory; Alpha-Neurotoxin; Excitatory Neurotoxin; Excitotoxins; Myotoxin; Myotoxins; Neurotoxin

Networked: 3653 relevant articles (84 outcomes, 302 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Toxic Actions: 365
  - Noxae: 123
    - Neurotoxins: 3653

Experts

1.	Montecucco, Cesare: 23 articles (04/2022 - 06/2005)
2.	Youdim, Moussa B H: 18 articles (01/2014 - 08/2002)
3.	Louis, Elan D: 14 articles (01/2020 - 05/2007)
4.	Pirazzini, Marco: 13 articles (04/2022 - 01/2013)
5.	Rossetto, Ornella: 13 articles (04/2022 - 04/2006)
6.	Deng, Yulin: 13 articles (03/2022 - 03/2013)
7.	Lomonte, Bruno: 12 articles (04/2022 - 12/2002)
8.	Segura-Aguilar, Juan: 12 articles (01/2022 - 07/2004)
9.	Fornai, Francesco: 12 articles (04/2021 - 06/2002)
10.	Zheng, Wei: 12 articles (01/2020 - 08/2007)

Related Diseases

1.	Parkinson Disease (Parkinson's Disease) 12/01/2022 - "However, its protective effects against cytotoxicity induced by endogenous neurotoxins involved in Parkinson's disease (PD) pathogenesis have never been investigated. " 02/01/2019 - "Inhibition or suppression of miR-34a improved neuronal survival against a variety of neurotoxins implicated in Parkinson's disease. " 01/01/2022 - "Application of Neurotoxin-Induced Animal Models in the Study of Parkinson's Disease-Related Depression: Profile and Proposal." 06/01/2021 - "Both neurotoxins can induce Parkinson's disease-like symptoms, and have been used to study this disease in animals. " 11/01/2018 - "In Parkinson's disease, a long list of clinical studies, based on preclinical models with exogenous neurotoxins, has failed. "
2.	Pain (Aches) 05/01/2015 - "The infiltration of the pectoralis major muscle with neurotoxin in immediate, expander-based reconstruction may be beneficial in reducing pain and expediting expansions." 10/30/2011 - "Among them, SNT-4 was a new neurotoxin identified in this study and showed potential as pain killer. " 01/01/2011 - "Several studies investigating the use of Clostridial neurotoxins for the reduction of pain in ALS patients suggest the potential for a neural specific approach involving focal drug delivery. " 08/01/1984 - "The notion that post-deafferentation autonomy is a pain response is unsupported by the results of studies with neurotoxins. " 11/01/2023 - "Furthermore, like site 3 neurotoxins, LmNaTx15 induced pain in mice. "
3.	Botulism 01/01/2022 - "Currently, the gold standard for neurotoxin detection in cases of clinical botulism is the mouse bioassay. " 11/01/2020 - "botulinum and its neurotoxin genes, improved pathogen detection and discrimination), and support enhanced risk assessments and the prevention of botulism." 09/26/2023 - "This study characterizes the acquisition in Spain of two forms of botulism, i.e., food-borne and infant botulism, which are largely caused by the main neurotoxin BoNT/B2. " 07/01/2023 - "This study sought to determine duration of fecal excretion of Clostridium botulinum organisms and neurotoxin after onset of infant botulism in 66 affected infants. " 12/01/2022 - "This study evaluated canned fish samples for botulism neurotoxin (BoNT)-producing clostridia contamination and can bulging through microbiological contaminant growth. "
4.	Alzheimer Disease (Alzheimer's Disease) 09/04/1989 - "A recent approach to identifying the factors that predispose neurons to an early death in Parkinson's or Alzheimer's disease has been to study how the effect of specific neurotoxins are altered by increasing maturity. " 06/01/2021 - "Zebrafish as a Promising Tool for Modeling Neurotoxin-Induced Alzheimer's Disease." 01/01/2021 - "Gastrointestinal Tract Microbiome-Derived Pro-inflammatory Neurotoxins in Alzheimer's Disease." 01/01/2021 - "Gastrointestinal (GI)-Tract Microbiome Derived Neurotoxins and their Potential Contribution to Inflammatory Neurodegeneration in Alzheimer's Disease (AD)." 12/01/2018 - "We present an overview of how a) NPD1 selectively mediates preconditioning rescue of RPE and PR cells; b) NPD1 restores aberrant neuronal networks in experimental epileptogenesis; c) the decreased ability to biosynthesize NPD1 in memory hippocampal areas of early stages of Alzheimer's disease takes place; d) NPD1 protection of dopaminergic circuits in an in vitro model using neurotoxins; and e) bioactivity elicited by DHA and NPD1 activate a neuroprotective gene-expression program that includes the expression of Bcl-2 family members affected by Aβ42, DHA, or NPD1. "
5.	Neuroblastoma 08/01/2014 - "In the present study, we investigated the effect of various mGluR II/III activators in the in vitro model of PD using human neuroblastoma SH-SY5Y cell line and mitochondrial neurotoxin MPP(+). " 05/01/1986 - "To study the interactions of this potent neurotoxin in an intact cell system, the binding of 125I-tetanus toxin was characterized in a neuroblastoma retina hybrid cell line, N18-RE-105. " 11/22/2022 - "Here, by treating neuroblastoma SK-N-SH cells with neurotoxin MPP+, upregulation and aggregation of TPC6AΔ, along with aggregation of TIAF1, SH3GLB2, Aβ, and tau, occurred. " 04/01/2022 - "A9 treatment on the protection on neurite outgrowth in SH-SY5Y neuroblastoma cells and primary substantia nigra neuron cultures from the neurotoxin MPP+ were analyzed. " 10/22/2020 - "By using high-resolution respirometry, we deeply investigated oxygen consumption related to each respiratory state in differentiated neuroblastoma cells exposed to the neurotoxin. "

Related Drugs and Biologics

1.	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)
2.	incobotulinumtoxinA
3.	Amyloid (Amyloid Fibrils)
4.	Type A Botulinum Toxins (Botox)
5.	Oxidopamine (6 Hydroxydopamine)
6.	Proteins (Proteins, Gene)
7.	Amyloid beta-Peptides
8.	1-Methyl-4-phenylpyridinium (1 Methyl 4 phenylpyridinium)
9.	Glutamic Acid (Glutamate)
10.	Dopamine (Intropin)

Related Therapies and Procedures

1.	Injections
2.	Therapeutics
3.	Denervation
4.	Drug Therapy (Chemotherapy)
5.	Oral Administration