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Neurotensin

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A biologically active tridecapeptide isolated from the hypothalamus. It has been shown to induce hypotension in the rat, to stimulate contraction of guinea pig ileum and rat uterus, and to cause relaxation of rat duodenum. There is also evidence that it acts as both a peripheral and a central nervous system neurotransmitter.

Networked: 657 relevant articles (7 outcomes, 68 trials/studies) for this Bio-Agent, Comments

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Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 58375
  - Nerve Tissue Proteins: 2
    - Neuropeptides: 3534
      - Neurotensin: 657
        neuromedin N: 18
        neurotensin 69L: 15
        (VIP-neurotensin) hybrid antagonist: 11
        neuromedin N precursor: 4
        proneurotensin: 4
        N-alpha-(fluoresceinylthiocarbamyl)glutamyl(1)- neurotensin: 2
        neurotensin (8-13): 2
        neurotensin (1-13): 1
        stearyl-Nle(17)-neurotensin(6-11)VIP(7-28): 1
        technetium Tc 99m NT-XI: 1
        acetylneurotensin (8-13)
        Arg(9)- neurotensin
        Asp(12)- neurotensin (8-13)
        Asp(13)- neurotensin (8-13)
        azidobenzoyl-Lys(6)-Trp(11)- neurotensin
        Gln(4)- neurotensin
        iodo-Tyr(11)- neurotensin
        iodo-Tyr(3)- neurotensin
        JMV 1193
        KK13 peptide
        Lys(8)- neurotensin (8-13)
        N-methyl-Arg(8)-Lys(9)-neo-Trp(11)-neo-Leu(12)- neurotensin (8-13)
        neurotensin (1-10)
        neurotensin (1-11)
        neurotensin (1-6)
        neurotensin (1-8)
        neurotensin (9-13)
        PD 149163
        Phe(11)- neurotensin
        rat NT77
        Ser(7)- neurotensin
        TJN 950
        Trp(11)- neurotensin
        Tyr(11)- neurotensin
        vasoactive intestinal peptide-neurotensin hybrid
- Peptides: 16242
  - Neuropeptides: 3534
    - Neurotensin: 657

Experts

1.	Carraway, Robert E: 11 articles (04/2008 - 11/2003)
2.	Rozengurt, Enrique: 8 articles (05/2010 - 01/2002)
3.	Richelson, Elliott: 8 articles (02/2010 - 01/2002)
4.	Dobner, Paul R: 7 articles (05/2009 - 08/2004)
5.	Evers, B Mark: 7 articles (02/2008 - 07/2004)
6.	Boules, Mona: 6 articles (02/2010 - 01/2002)
7.	Forgez, Patricia: 6 articles (02/2010 - 07/2002)
8.	Tourwé, Dirk: 6 articles (01/2009 - 03/2002)
9.	Hassan, Sazzad: 6 articles (04/2008 - 04/2004)
10.	Guha, Sushovan: 5 articles (05/2010 - 01/2002)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 01/01/1997 - "This study examined the effects of neurotensin infused into the nucleus accumbens on prepulse inhibition (PPI) of the rat's acoustic startle reflex, a measure which is relevant to the sensorimotor gating deficits seen in schizophrenia. " 01/01/2010 - "BACKGROUND: Converging evidence has implicated endogenous neurotensin (NT) in the pathophysiology of brain processes relevant to schizophrenia. " 07/01/2009 - "The potential of neurotensin agonists as putative treatments for cognitive deficits of schizophrenia was also supported." 01/01/2007 - "Neurotensin agonists: potential in the treatment of schizophrenia." 07/01/2006 - "Intra-VTA neurotensin activates dopaminergic neurons and plays an important role in the development of behavioural sensitization to psychostimulant drugs and possibly in schizophrenia. " Order ALL the reference details at left...
2.	Parkinson Disease (Parkinson's Disease) 12/01/2006 - "These data indicate that the neurotensin polyplex holds great promise for the neuroprotective therapy of Parkinson disease." 01/11/1991 - "The aim of the present study was to examine the effects of neurotensin in an animal model of Parkinson's disease (PD). " 01/01/2009 - "Based on the excitatory effects of neurotensin in globus pallidus of parkinsonian rats, we hypothesize that the pallidal neurotensinergic system may be involved in its possible therapy in Parkinson's disease." 06/01/2001 - "Increased plasma neurotensin concentrations in patients with Parkinson's disease." 06/01/1996 - "Neurotensin levels were increased in the substantia nigra in Parkinson's disease. " Order ALL the reference details at left...
3.	AIDS-Related Complex (ARC) 01/15/1996 - "Two series of experiments were done in the rat to investigate whether neurons in arcuate nucleus of the hypothalamus (Arc) containing neurotensin (NT)-like immunoreactivity projected to subfornical organ (SFO). " 02/05/1986 - "The effects of neurotensin (NT) on 41 spontaneously active neurons in the rat hypothalamic arcuate nucleus (ARC) were determined using an in vitro brain slice technique. " 07/01/1990 - "Neuropeptide Y and neurotensin levels varied in opposite directions: In the hyperphagic obese Zucker rats, the NPY concentrations were significantly greater than those in the lean normophagic rats in the ARC (+30%), PVN (+60%) and SCH (+94%) nuclei, whereas the NT levels were significantly lower in the ARC (-40%), PVN (-31%) VMN (-66%) and SCH (-47%) nuclei. " 01/01/1993 - "Using extracellular single-unit recording in brain tissue slices, the effects of bombesin (Bomb), neurotensin (NT), and their analogs on hypothalamic arcuate (ARC) neurons were tested in this study. " 03/26/2001 - "In the Arc, a few CART neurons coexpress neurotensin (NT) mRNA. " Order ALL the reference details at left...
4.	Dyskinesias (Dyskinesia) 01/01/2003 - "Thus, treatments that reduce or prevent the effects of increased neurotensin expression and release may be useful in the management of tardive dyskinesia." 04/01/1995 - "The role of neurotensin (NT) in a putative model of tardive dyskinesia (TD) was examined in the rat. " 04/01/1995 - "Effects of neurotensin in a rodent model of tardive dyskinesia." 12/15/1989 - "Autoradiographic evidence of [3H]neurotensin binding changes in discrete regions of brain in the rat model of persistent spasmodic dyskinesia induced by iminodipropionitrile." 01/01/2003 - "In order to determine whether increased levels of striatal neurotensin mRNA in the direct striatonigral or the indirect striatopallidal pathway play a more influential role in the development of tardive dyskinesia, we explored the effects of a specific neurotensin antagonist in a rodent model (vacuous chewing movements [VCMs] induced by chronic neuroleptics). " Order ALL the reference details at left...
5.	Heart Arrest (Cardiac Arrest) 03/01/2004 - "CONCLUSIONS: Neurotensin-induced hypothermia improved neurologic outcome after asphyxial cardiac arrest in rats vs. brief external cooling but was comparable to prolonged external cooling." 03/01/2004 - "Latency time in the Morris water maze 15 days after asphyxial cardiac arrest was decreased with neurotensin-induced hypothermia (14+/-11 secs) and prolonged external cooling (18+/-9 secs) vs. normothermic control (74+/-17 secs) and brief external cooling (78+/-18 secs, p <.05). " 03/01/2004 - "DESIGN: Rats were randomized to a normothermic control, neurotensin-induced hypothermia, brief external cooling, or prolonged external cooling group after asphyxial cardiac arrest. " 08/13/2004 - "We induced regulated hypothermia with a neurotensin analogue (NT77) to determine whether it could reduce oxidative stress in the brain during reperfusion from asphyxial cardiac arrest (ACA) in rats. " 03/01/2004 - "MAIN RESULTS: Neurologic deficit score at 72 hrs after asphyxial cardiac arrest was lower with neurotensin-induced hypothermia (score, 0) and prolonged external cooling (score, 0) vs. normothermic control (score, 20) and brief external cooling (score, 18; p <.05). " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Neuropeptides
2.	Neuropeptide Y
3.	Antipsychotic Agents (Antipsychotics)
4.	neurotensin 69L
5.	Somatostatin (Somatotropin Release-Inhibiting Factor)
6.	Bombesin
7.	Peptides
8.	Substance P
9.	Gastrins
10.	Cholecystokinin (Pancreozymin)

Related Therapies and Procedures

1.	Induced Hypothermia
2.	Analgesia
3.	Injections
4.	Renal Dialysis (Hemodialysis)
5.	Enteral Nutrition (Feeding, Tube)

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