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Neurofibroma

A moderately firm, benign, encapsulated tumor resulting from proliferation of SCHWANN CELLS and FIBROBLASTS that includes portions of nerve fibers. The tumors usually develop along peripheral or cranial nerves and are a central feature of NEUROFIBROMATOSIS 1, where they may occur intracranially or involve spinal roots. Pathologic features include fusiform enlargement of the involved nerve. Microscopic examination reveals a disorganized and loose cellular pattern with elongated nuclei intermixed with fibrous strands. (From Adams et al., Principles of Neurology, 6th ed, p1016)
Also Known As:
Neurofibromas
Networked: 703 relevant articles (12 outcomes, 47 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Neoplasms (Cancer)
2. Nerve Sheath Neoplasms (Nerve Sheath Neoplasm)
3. Neurilemmoma (Schwannoma)
4. Neurofibromatosis 1 (Neurofibromatosis Type I)
5. Melanoma (Melanoma, Malignant)

Experts

1. Ratner, Nancy: 14 articles (10/2015 - 12/2003)
2. Kluwe, Lan: 10 articles (05/2014 - 08/2004)
3. Upadhyaya, Meena: 9 articles (04/2012 - 02/2004)
4. Friedrich, Reinhard E: 8 articles (12/2015 - 08/2004)
5. Wu, Jianqiang: 8 articles (10/2015 - 01/2005)
6. Rizvi, Tilat A: 7 articles (10/2015 - 01/2005)
7. Wolkenstein, Pierre: 7 articles (01/2015 - 06/2004)
8. Carroll, Steven L: 7 articles (04/2014 - 01/2005)
9. Yang, Feng-Chun: 6 articles (01/2012 - 12/2003)
10. Hagel, Christian: 5 articles (12/2015 - 06/2011)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Neurofibroma:
1. Dermatofibrosarcoma protuberansIBA
2. ProgesteroneFDA LinkGeneric
3. Somatostatin Receptors (Somatostatin Receptor)IBA
11/01/1987 - "Tumors originating from neuroblasts, i.e., ganglioneuroblastoma and medulloblastoma, contained a high density of somatostatin receptors, whereas neurinomas and neurofibromas as well as the ependymomas, one teratoma, and one plexus papilloma were lacking such receptors. "
11/01/1987 - "Fifty-two brain tumors, consisting of 17 astrocytomas, 4 oligodendrogliomas, 20 glioblastomas, 3 neurinomas, 2 ependymomas, 1 neurofibroma, 1 ganglioneuroblastoma, 1 medulloblastoma, 1 plexus papilloma, 1 teratoma, and 1 germinoma, were tested for their content of specific somatostatin receptors using autoradiographic techniques or in vitro binding assays with membrane homogenates. "
07/01/2001 - "Imaging of somatostatin receptors (SSTRs) using [111In]diethylenetriaminepentaacetic-acid-octreotide (DTPAOC) has proven to be helpful in the differentiation of meningiomas, neurinomas or neurofibromas, and metastases as well as in the follow-up of meningiomas. "
12/01/2005 - "In the present study, we examined the expression of all 5 somatostatin receptor subtypes (sst1-5) in 3 normal peripheral nerves, 3 traumatic neuromas, 27 schwannomas, 18 neurofibromas, and 177 malignant peripheral nerve sheath tumors (MPNSTs) by immunohistochemistry as well as by Western blot and reverse transcriptase-polymerase chain reaction investigations in 2 normal peripheral nerves, one neurofibroma, 5 schwannomas, and 5 MPNSTs. "
01/15/1987 - "The following tumors did not contain somatostatin receptors: prostate carcinomas (n = 17); prostate hyperplasia (n = 2); ovarian carcinomas (n = 6); endometrial carcinomas (n = 4); primary liver cell carcinomas (n = 3); pheochromocytomas (n = 3); aldosteronomas (n = 2); medullary thyroid carcinomas (n = 2); one adrenocorticotropic hormone-secreting pulmonary carcinoid; one astrocytoma; one neurofibroma; one lung tumor; and one bladder tumor. "
4. CosmeticsIBA
5. tranilast (N 5')IBA
6. MART-1 AntigenIBA
7. Octreotide (Sandostatin)FDA LinkGeneric
8. VitaminsIBA
9. Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA
10. 1-phenyl-3,3-dimethyltriazene (PDT)IBA

Therapies and Procedures

1. Lasers (Laser)
2. Radiotherapy
3. Tissue Expansion
4. Solid-State Lasers
5. Light Coagulation