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Experimental Autoimmune Neuritis

An experimental animal model for the demyelinating disease of GUILLAINE-BARRE SYNDROME. In the most frequently used protocol, animals are injected with a peripheral nerve tissue protein homogenate. After approximately 2 weeks the animals develop a neuropathy secondary to a T cell-mediated autoimmune response directed towards the MYELIN P2 PROTEIN in peripheral nerves. Pathologic findings include a perivascular accumulation of macrophages and T lymphocytes in the peripheral nervous system, similar to that seen in the Guillaine-Barre syndrome. (From Adams et al., Principles of Neurology, 6th ed, p1314; J Neuroimmunol 1998 Apr 1;84(1):40-52)
Also Known As:
Neuritis, Autoimmune, Experimental; EAN (Experimental Allergic Neuritis); EAN (Experimental Autoimmune Neuritis); Experimental Allergic Neuritis; Experimental Autoimmune Neuropathy; Neuritis, Experimental Autoimmune; Autoimmune Neuropathies, Experimental; Autoimmune Neuropathy, Experimental; Experimental Autoimmune Neuropathies; Neuropathies, Experimental Autoimmune; Neuropathy, Experimental Autoimmune; Allergic Neuritis, Experimental; Autoimmune Neuritis, Experimental; Neuritis, Experimental Allergic
Networked: 377 relevant articles (27 outcomes, 37 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Inflammation
2. Demyelinating Diseases (Demyelinating Disease)
3. Multiple Sclerosis
4. Autoimmune Diseases (Autoimmune Disease)
5. Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)

Experts

1. Zhu, Jie: 19 articles (10/2013 - 07/2002)
2. Shin, Taekyun: 13 articles (12/2012 - 05/2002)
3. Zhu, J: 10 articles (09/2014 - 01/2000)
4. Moon, Changjong: 10 articles (12/2012 - 11/2004)
5. Ahn, Meejung: 10 articles (12/2012 - 11/2004)
6. Mix, Eilhard: 9 articles (08/2011 - 07/2002)
7. Zhang, Zhiren: 8 articles (06/2014 - 04/2008)
8. Adem, Abdu: 8 articles (05/2012 - 12/2004)
9. Matsumoto, Yoh: 8 articles (06/2010 - 11/2004)
10. Gold, R: 8 articles (12/2002 - 05/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Experimental Autoimmune Neuritis:
1. Immunoglobulins (Immunoglobulin)IBA
2. Myelin P2 ProteinIBA
3. AntigensIBA
4. Interleukin-4 (Interleukin 4)IBA
5. Intravenous Immunoglobulins (IVIG)FDA Link
6. ErythropoietinFDA Link
7. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
8. CytokinesIBA
9. Type I Tumor Necrosis Factor ReceptorsIBA
10. Immunoglobulin G (IgG)IBA

Therapies and Procedures

1. Transplantation (Transplant Recipients)
2. Intravenous Injections
3. Injections
4. Immunotherapy
5. Intradermal Injections