|5.||Spinal Cord Injuries (Spinal Cord Injury)
|1.||Eisenach, James C: 41 articles (10/2015 - 01/2002)|
|2.||Inoue, Kazuhide: 41 articles (01/2015 - 02/2004)|
|3.||Moore, R Andrew: 40 articles (01/2015 - 04/2004)|
|4.||Narita, Minoru: 39 articles (06/2014 - 09/2002)|
|5.||Suzuki, Tsutomu: 38 articles (01/2015 - 09/2002)|
|6.||Ueda, Hiroshi: 37 articles (08/2015 - 10/2002)|
|7.||Porreca, Frank: 37 articles (05/2015 - 01/2002)|
|8.||Derry, Sheena: 37 articles (01/2015 - 04/2004)|
|9.||Tsuda, Makoto: 36 articles (02/2015 - 02/2004)|
|10.||Watkins, Linda R: 35 articles (06/2015 - 02/2003)|
|1.||gabapentin (Neurontin)FDA LinkGeneric
06/01/2004 - "Ease of use and broad therapeutic range, in addition to demonstrated efficacy, make gabapentin the drug of choice for most neuropathic pain disorders. "
01/01/2012 - "The anticonvulsant gabapentin has been proven effective for treating neuropathic pain in large placebo-controlled clinical trials. "
09/01/2002 - "The anticonvulsant gabapentin has proven effective for neuropathic pain in three large placebo-controlled clinical trials. "
01/01/2014 - "Second tier evidence, with potentially important residual biases, showed that gabapentin at doses of 1200 mg or more was effective for some people with some painful neuropathic pain conditions. "
09/01/2012 - "The results of this study show that gabapentin is effective in acute herpetic neuralgia in different doses with 600 mg/day being the more appropriate dose in terms of safety and efficacy."
|2.||pregabalin (Lyrica)FDA Link
11/01/2007 - "Although pregabalin shows efficacy against neuropathic pain, very limited evidence supports postoperative analgesic efficacy. "
01/01/2012 - "Although pregabalin therapy is beneficial for neuropathic pain (NeP) by targeting the CaVα2δ-1 subunit, its site of action is uncertain. "
11/01/2008 - "These results suggest that pregabalin may be beneficial in patients with neuropathic pain who have had an unsatisfactory response to treatment with other medications."
01/01/2015 - "Pregabalin is a commonly used therapy currently recommended as first-line treatment for a number of neuropathic pain (NeP) conditions. "
08/01/2010 - "Flexible-dose pregabalin 150-600 mg/day was effective in relieving neuropathic pain, improving disturbed sleep, improving overall patient status, and was generally well tolerated in patients with post-traumatic peripheral neuropathic pain."
|3.||Opioid Analgesics (Opioids)IBA
01/01/2006 - "Short-term studies provide only equivocal evidence regarding the efficacy of opioids in reducing the intensity of neuropathic pain, whereas intermediate-term studies demonstrate significant efficacy of opioids over placebo, which is likely to be clinically important. "
06/22/2005 - "Intermediate-term studies demonstrate significant efficacy of opioids over placebo for neuropathic pain, which is likely to be clinically important. "
01/01/2015 - "Several studies demonstrated promising results in the management of both nociceptive and neuropathic pain and good tolerability profi le, particularly concerning side effects, compared to traditional opioids. "
12/01/2010 - "A number of high quality studies demonstrated that opioids are effective in relieving neuropathic pain including PHN. "
10/05/2015 - "An interesting research and therapeutic problem is the reduced beneficial efficacy of opioids in the treatment of neuropathic pain. "
|4.||Lidocaine (Xylocaine)FDA LinkGeneric
06/01/2012 - "Quality of life markedly improved in a variety of neuropathic pain conditions and long-term treatment provided sustained relief in patients with neuropathic pain who are responsive to lidocaine plaster. "
07/01/2011 - "Treatment of refractory neuropathic pain with 5% lidocaine-medicated plaster clearly demonstrated efficacy and an excellent safety profile in patients with refractory neuropathic pain."
01/01/2004 - "Because of its proven efficacy and safety profile, the lidocaine patch 5% has been recommended as a first-line therapy for the treatment of the neuropathic pain of PHN."
04/01/2011 - "High-concentration lidocaine was effective in decreasing microglia activation in the CN and in attenuating neuropathic pain sensations at the early stage following nerve injury, when microglia had not yet been activated."
06/01/2012 - "The topical 5% lidocaine medicated plaster is recommended as first-line treatment for localized peripheral neuropathic pain. "
|5.||Anticonvulsants (Antiepileptic Drugs)IBA
08/01/2008 - "Despite important advances in available knowledge, management of neuropathic pain remains incomplete, and results from experimental and clinical studies indicate that some anticonvulsants show promise for treating neuropathic pain. "
04/01/2009 - "Unfortunately, even when effective in other types of neuropathic pain, anti-depressants and anticonvulsants have not yet proven effective for treating the symptoms of CIPN."
01/01/2009 - "Antiepileptic drugs (AED) have proved effective in relieving neuropathic pain. "
06/01/2006 - "Both basic and clinical research has demonstrated that antiepileptic drugs can be effective in alleviating neuropathic pain. "
08/01/2005 - "First-generation antiepileptic drugs have been shown to be effective in neuropathic pain. "
|6.||Antidepressive Agents (Antidepressants)IBA
01/01/2013 - "Existing data are insufficient to conclude which of these new classes of antidepressants has the best clinical profile and will be the most effective in the treatment of neuropathic pain; in addition, a lower incidence of side effects should be considered. "
03/15/2008 - "A large body of clinical evidence indicates that antidepressant drugs can also be highly effective against chronic neuropathic pain. "
01/01/2009 - "These results indicate a considerable difference to exist in the development and/or maintenance between these two animal models of neuropathic pain and suggest that each of these three antidepressants may be effective for the treatment of diabetic neuropathic pain."
01/01/1999 - "Newer antidepressants appear to be safer and better tolerated than older agents for medically ill patients, but do not appear to be as effective for neuropathic pain. "
11/15/2015 - "As antidepressant drugs are clinically used to treat chronic neuropathic pain, this work aimed to investigate the potential analgesic efficacy of SDG against diabetic neuropathic pain in a mouse model of type 1 diabetes. "
|7.||Analgesics (Analgesic Drugs)IBA
05/01/2009 - "Clinicians who treat neuropathic pain face daunting therapeutic challenges, but specific analgesic agents have proven effective in relieving that excruciating discomfort. "
12/01/1996 - "These results show that: 1) selective N-type VSCC blockers are potent and efficacious antinociceptive agents when they are administered by the spinal route; 2) selective N-type VSCC blockers are effective in rat models of acute, persistent and neuropathic pain; and 3) N-type VSCCs play a significant role in the spinal processing of noxious somatosensory input."
01/01/2016 - "Functional imaging with central sensitization can be used as a sensitive mechanism-based assay to guide go/no-go decisions on selecting analgesics effective in neuropathic pain in early human drug development. "
11/01/2001 - "To optimize analgesic therapy in patients with neuropathic pain, both opioid and adjuvant analgesics must be used effectively."
01/01/2013 - "Therefore, novel target molecules that may lead to the development of promising analgesics are eagerly anticipated for improved treatment of neuropathic pain. "
|8.||Morphine (MS Contin)FDA LinkGeneric
01/01/2016 - "Morphine is effective treatment for neuropathic pain but produces tolerance on chronic use. "
01/01/2014 - "In addition, morphine is not always effective in neuropathic pain. "
01/01/1995 - "The continuous intrathecal administration of low-dose morphine is an effective treatment for chronic neuropathic pain. "
08/01/2014 - "The plasticity of the descending serotonergic system may contribute to the reduced efficacy of systemic morphine in neuropathic pain."
09/15/2013 - "Thus, the HINT1 protein stabilises the association between MOP receptor and GluN receptor, necessary for the analgesic efficacy of morphine, and this coupling is reduced following the activation of GluN receptors, similar to what is observed in neuropathic pain."
|9.||Amitriptyline (Elavil)FDA LinkGeneric
04/01/2008 - "Amitriptyline is effective in relieving neuropathic pain. "
01/01/2008 - "Oral amitriptyline, a tricyclic antidepressant, is effective for treating neuropathic pain. "
09/01/2007 - "It has also been suggested that topical application of amitriptyline could be useful for the treatment of neuropathic pain. "
01/01/2015 - "To assess the analgesic efficacy of amitriptyline for relief of chronic neuropathic pain, and the adverse events associated with its use in clinical trials. "
01/01/2015 - "Amitriptyline has been a first-line treatment for neuropathic pain for many years. "
|10.||Capsaicin (Zostrix)FDA Link
01/01/2016 - "Topical high-dose capsaicin acting on TRPV1 receptors and inducing an intraepidermal decrease in the small nerve fibre count is effective in treating neuropathic pain (NP). "
04/01/1990 - "Clinical trials of topical capsaicin treatment for post-herpetic neuralgia have yielded promising results. "
06/01/2013 - "Analgesic treatment of peripheral neuropathic pain with the capsaicin 8% cutaneous patch is safe and effective. "
05/01/2013 - "The capsaicin 8% cutaneous patch is an emergent new treatment option for patients with peripheral neuropathic pain. "
01/01/2013 - "The capsaicin 8% patch is a novel treatment option that directly targets the source of peripheral neuropathic pain. "
06/01/2012 - "In a model of neuropathic pain, sciatic nerve ligation caused a marked decrease in the latency of paw withdrawal in response to a thermal stimulus only on the ipsilateral side. "
07/01/2011 - "In a model of neuropathic pain, sciatic nerve ligation caused a marked decrease in the latency of paw withdrawal in response to a thermal stimulus only on the ipsilateral side. "
03/01/2014 - "Experiments on white rats showed that sciatic nerve ligation induced the development of neuropathic pain syndrome: thermal pain threshold decreased, significant reduction in weight bearing of the injured limb, and degenerative changes in the foot tissues. "
04/01/2014 - "Ethanolic extract of Aloe vera ameliorates sciatic nerve ligation induced neuropathic pain."
03/15/2008 - "The efficacy of one of these compounds was demonstrated in a rat spinal nerve ligation model of neuropathic pain in rats."
10/01/2014 - "Analgesia is one the principal therapeutic targets of the cannabinoid system and many studies have demonstrated the efficacy of cannabinoid compounds in the treatment of neuropathic pain. "
02/01/2014 - "We tested whether modulation of SCS variables improved analgesia in animals with neuropathic pain by comparing 6-hour vs 30-minute duration and 50%, 75%, or 90% motor threshold (MT) intensity (amplitude). "
08/01/2006 - "The efficacy of ganglionic local opioid analgesia (GLOA) at the superior cervical ganglion (SCG) was retrospectively investigated in 74 consecutive patients with neuropathic pain in the head and face region. "
11/26/1976 - "The findings also might in part explain the analgesia, partial loss of tactile sensibility, and relief from V neuralgia reported after V tractotomy."
03/01/2011 - "This study provides a mechanistic explanation regarding the effectiveness, or lack thereof, of opioid analgesia in the treatment of diabetic neuropathic pain."
|3.||Drug Therapy (Chemotherapy)
01/01/2002 - "These mechanism could be targeted specifically by drugs, or non-drug therapy, enabling more effective treatment of neuropathic pain."
03/01/2006 - "Pharmacotherapy is currently the mainstay of treatment in patients with neuropathic pain, although at present the drugs are used on a mainly "off-label" basis. "
09/26/2011 - "In a five-patient pilot study the modality also improved the symptoms of chemotherapy-induced neuropathic pain. "
01/01/2014 - "This pilot trial found a number needed to treat of five and an average decrease of 2.6 on an 11-point NRS-PI in five "responders" (as compared with a decrease of 0.6 with placebo) and supports that it is worthwhile to study nabiximols in a full randomized, placebo-controlled trial of chemotherapy-induced neuropathic pain."
01/01/2014 - "A double-blind, placebo-controlled, crossover pilot trial with extension using an oral mucosal cannabinoid extract for treatment of chemotherapy-induced neuropathic pain."
09/01/2004 - "After decompression the paraesthesia on the lateral aspect of the right leg resolved completely with no evidence of residual neuralgia."
10/01/1989 - "In each patient, neuralgia was successfully eliminated by microvascular decompression and by section of the upper rootlets of the vagus nerve. "
12/01/2001 - "However, remyelination may help to ensure that relief of symptoms is sustained after decompression of the nerve root and may also be responsible for the spontaneous remission of the neuralgia in some patients. "
07/01/2011 - "Microvascular decompression may be an effective treatment for nervus intermedius neuralgia."
05/01/2011 - "To report microvascular decompression as a possible effective treatment for patients with nervus intermedius neuralgia, and to contribute to the literature regarding both this syndrome and this specific form of treatment. "
|5.||Deep Brain Stimulation
01/01/2004 - "Deep brain stimulation (DBS) of the central gray matter was an important component of the surgical management of chronic, drug-refractory, central neuropathic pain until only a decade ago. "
01/01/2014 - "Both motor cortex stimulation (MCS) and deep brain stimulation (DBS) of the ventralis caudalis (Vc) thalamus have been shown to be effective in chronic neuropathic pain, and the modulation of thalamic and thalamocortical activity is regarded as a possible mechanism. "
04/01/2006 - "Conclusions. Deep brain stimulation is an effective treatment for neuropathic pain. "
04/01/2006 - "Objectives. To determine whether deep brain stimulation is an effective treatment for neuropathic pain of varied etiology. "
04/01/2004 - "The objective of this study is to determine the usefulness of single-patient, randomised, controlled trials (N-of-1 trials) in assessing the efficacy of deep brain stimulation (DBS) in neuropathic pain. "