|1.||Congenital Abnormalities (Deformity)
|2.||Spinal Dysraphism (Spina Bifida)
|3.||Neural Tube Defects (Exencephaly)
|5.||Heart Diseases (Heart Disease)
|1.||Finnell, Richard H: 46 articles (09/2015 - 01/2002)|
|2.||Shaw, Gary M: 30 articles (11/2015 - 01/2002)|
|3.||Scott, John M: 30 articles (06/2015 - 11/2002)|
|4.||Ren, Aiguo: 29 articles (09/2015 - 11/2003)|
|5.||Koren, Gideon: 24 articles (06/2015 - 01/2002)|
|6.||Molloy, Anne M: 24 articles (06/2015 - 01/2002)|
|7.||Mills, James L: 23 articles (06/2015 - 11/2002)|
|8.||Zhang, Le: 22 articles (09/2015 - 06/2006)|
|9.||Copp, Andrew J: 22 articles (01/2015 - 02/2002)|
|10.||Zhang, Ting: 21 articles (12/2015 - 01/2008)|
|1.||Folic Acid (Vitamin M)FDA LinkGeneric
01/01/2012 - "Folate deficiency is linked to adverse health conditions, and dietary supplementation with folate has proven highly beneficial in the prevention of neural tube defects. "
06/01/2015 - "To conduct a systematic review evaluating the effectiveness of a folate-fortified oral contraceptive preparation in increasing blood folate concentrations to levels providing optimal protection against neural tube defects (> 906 nmol/L). "
06/01/2015 - "Two-thirds of young women had suboptimal RBC folate for protection against neural tube defects (NTDs); among nonconsumers of folic acid, only 16% attained optimal RBC folate. "
02/01/2009 - "Folates are important for normal neural tube closure in early gestation, and the efficacy of diet fortification with folic acid in reducing the incidence of neural tube defects is a major success story for public health nutrition. "
06/01/2008 - "A folic acid supplementation program targeting couples prior to marriage in China has led to optimal consumption of supplements containing folic acid and a significant reduction of neural tube defects (NTD). "
08/15/1981 - "The gel-AChE test was thus found to be very effective when applied to amniotic fluid samples with positive AFP results, substantially reducing the number of false positives with only a very small loss in the detection of open neural-tube defects. "
04/01/2002 - "Fetal sonography is effective in identifying neural tube defects, although alpha-fetoprotein screening seems to give a greater sensitivity. "
04/01/2000 - "Fetal ultrasound is effective in identifying neural tube defects, although alpha-fetoprotein screening seems to yield a greater sensitivity. "
09/01/1989 - "To assess the relative efficacy of amniocentesis versus targeted (detailed) ultrasonography, 225 patients referred because of an elevated maternal serum alpha-fetoprotein level (79.6%) or a family history of neural tube defect (20.4%) were evaluated. "
10/01/1987 - "Because the incidence of open neural tube defects is lower for blacks than for others, excessive false positive results for blacks (estimated to be 8817 to 28,215 cases annually) would be a pernicious misapplication of maternal serum alpha-fetoprotein screening. "
10/01/2011 - "Women who had given birth to one or more infants with a neural tube defect were recruited into a trial of periconceptional vitamin supplementation. "
03/01/2008 - "Considering the high frequency of central nervous system anomalies recorded in our study, it seems to be reasonable to pay more attention to the role of periconception vitamin supplementation for the primary prevention of congenital anomalies, particularly neural tube defects."
04/01/1996 - "Stored blood samples collected as part of a randomised trial of vitamin supplementation in the prevention of neural tube defects were retrieved from affected pregnancies (cases) and unaffected pregnancies (controls). "
08/01/1993 - "Recent studies have resolved the debate over the role of vitamins in preventing neural tube defects. "
08/01/1993 - "Stored serum samples collected as part of the Medical Research Council's multicentre randomised trial section of vitamin supplementation in the prevention of neural tube defects were retrieved in respect of women who had had an affected pregnancy together with four matched unaffected controls per case. "
|4.||Glucose (Dextrose)FDA LinkGeneric
12/01/1985 - "Although the teratogenic effects of excess glucose have been investigated in in vivo and in vivo studies, a cellular basis for neural tube defects has not been elucidated. "
01/01/2016 - "High glucose in vivo and in vitro induces neural tube defects (NTDs). "
06/01/2015 - "Association between maternal single nucleotide polymorphisms in genes regulating glucose metabolism and risk for neural tube defects in offspring."
01/01/2013 - "We established that high glucose altered the central nervous system mophologically, such that neural tube defects (NTDs) developed. "
01/01/2008 - "In the search for genes responsible for neural tube defects, glucose metabolism matters."
|5.||Valproic Acid (Valproate, Semisodium)FDA LinkGeneric
06/01/2011 - "Microarray studies in P19 mouse embryocarcinoma cells and mouse embryos have indicated that valproic acid (VPA), an inducer of neural tube defects, deregulates the expression of many genes, including those critically involved in neural tube development. "
12/01/2003 - "In the current study, we wanted to extend our findings and test the hypothesis that Folbp2(-/-) mice are more susceptible to the teratogenic effects of valproic acid (VPA), a commonly used antiepileptic drug that is known to induce neural tube defects (NTDs) in both humans and laboratory animals. "
05/01/1997 - "The present study shows that the multifactorial genetic liability to spontaneous exencephaly in the SELH/Bc mouse strain (10-20% of embryos) also confers an elevated risk of exencephaly induced by valproic acid. "
09/01/1996 - "The objectives of this study were to determine if sodium valproate (VPA) would augment this background frequency of exencephaly and to characterize its gross and histologic bases. "
01/01/2013 - "Effects of Korean red ginseng extracts on neural tube defects and impairment of social interaction induced by prenatal exposure to valproic acid."
03/01/1985 - "Measurement of amniotic fluid alpha-foetoprotein and acetylcholinesterase for the detection of neural tube defects has been used in 285 normal or neural tube defects affected pregnancies: 18 false positive results (with non neural tube defects fetal malformations) have been reported. "
11/01/2001 - "Levels of amniotic fluid alpha-foetoprotein and acetylcholinesterase activity are elevated in neural tube defects. "
04/01/2000 - "Electrophoresis of acetylcholinesterase in the amniotic fluid can provide the diagnosis of open neural tube defect between 13 and 24 weeks gestation. "
01/01/1998 - "Raised levels of maternal serum secretory acetylcholinesterase may provide a useful indicator of neural tube defects in early pregnancy."
01/01/1998 - "To investigate the levels of maternal serum secretory acetylcholinesterase from a sample of pregnancies involving fetal neural tube defects and compare those results with alphafetoprotein levels. "
|7.||Methionine (L-Methionine)FDA Link
02/01/2002 - "Pre-treatment with methionine only produced a numerical but not statistically significant reduction in alcohol-induced exencephaly. "
06/01/2010 - "Dietary methionine intake and neural tube defects in Mexican-American women."
02/01/2002 - "The low dose of methionine only numerically reduced the spontaneous exencephaly. "
02/01/2002 - "Effect of maternal methionine pre-treatment on alcohol-induced exencephaly and axial skeletal dysmorphogenesis in mouse fetuses."
10/01/2001 - "Dietary methionine is involved in the etiology of neural tube defect-affected pregnancies in humans."
03/01/2005 - "Periconceptional dietary intake of myo-inositol and neural tube defects in offspring."
01/01/2003 - "These data can be used in further research into the association between myo-inositol and neural tube defects."
01/01/2003 - "A deranged myo-inositol metabolism has been associated with neural tube defects. "
02/01/1998 - "Dietary myo-inositol supplementation of diabetic mothers resulted in a significant decrease in the incidence of neural tube defects when compared with diabetics not receiving supplements (9.5 vs. 20.4%; P < 0.05). "
05/01/1997 - "Inositol prevents expression of a genetic model of neural tube defects in mice."
|9.||Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
12/01/1994 - "Aspirin also reduced the frequency of alcohol-induced arched palate and the baseline exencephaly. "
12/01/1994 - "The lack of a clear dose-dependent antagonistic effect of aspirin on alcohol-induced exencephaly suggests that the production of this malformation is probably not mediated by prostaglandin as it was shown for limb and renal abnormalities (Randall, C.L., Anton, R.F. "
12/01/1994 - "Pre-treatment with aspirin (both 150 and 200 mg/kg) on day 8 of gestation resulted in a numerical, though not statistically significant increase in alcohol-induced exencephaly. "
12/01/1994 - "Effect of pre-treatment with aspirin on alcohol-induced neural tube defects in the TO mouse fetuses."
06/01/1994 - "Mechanism of aspirin induced neural tube defect in chick embryo."
|10.||Pantothenic Acid (Calcium Pantothenate)FDA Link
09/01/1995 - "Pantothenic acid decreases valproic acid-induced neural tube defects in mice (I)."
03/01/2006 - "Folic acid and pantothenic acid protection against valproic acid-induced neural tube defects in CD-1 mice."
02/01/1984 - "Evidence is conflicting or inconclusive as to the use of vitamin C in the common cold, asthma and enhancement of athletic capacity, of pantothenic acid in osteoarthritis, and folic acid (folacin) in neural tube defects. "
11/01/1979 - "Optimum growth and differentiation, virtually indentical with that obtained in while serum and to that seen during the corresponding period in vivo, were obtained with the addition of glucose and certain vitamins: pantothenic acid and riboflavin had a general beneficial effect on development, i-inositol suppressed neural tube defects, and folic acid significantly improved growth of the embryos."
|1.||Induced Hyperthermia (Thermotherapy)
06/01/2002 - "Immunohistochemical study on the fetal rat pituitary in hyperthermia-induced exencephaly."
03/01/2002 - "The risk of neural tube defects due to exercise-induced hyperthermia that is suggested by animal studies is less likely in women, because of more effective mechanisms of heat dissipation in humans. "
04/01/1986 - "In a study designed to elucidate the genetic factors involved in a mouse model of hyperthermia-induced neural tube defects, it is apparent that a hierarchy of susceptibility exists among various inbred mouse strains. "
06/01/2003 - "The data demonstrate that a single fetal genetic locus, plus a maternal effect, have likely caused the strain differences in the susceptibility to hyperthermia-induced exencephaly. "
06/01/2003 - "Genetic dissection of hyperthermia-induced neural tube defects in mice."
01/01/1993 - "A technique for percutaneous catheter drainage of cystic masses in the subarachnoid space was developed and shown to be safe and effective in an 18-year-old boy with life-threatening, recurrent neuroenteric cysts that compressed the brain stem, cerebellum, and spinal cord. "
08/01/1992 - "Patients excluded from the study were those with neural tube defects or CSF catheters, those admitted directly to the Intensive Care Nursery (ICN), those whose positive CSF cultures were determined to be a contaminant, those whose medical records were not found, or those older than 16 years. "
|3.||Neonatal Intensive Care
07/01/2013 - "The aim of this study was to analyze the sociodemographic features, postoperative complications, long-term problems, and cost of care of patients followed in the neonatal intensive care unit (NICU) with a diagnosis of neural tube defects (NTDs). "
07/01/2006 - "There was a significant reduction in the proportion of deaths from chromosomal abnormalities, and from neural tube defects in epoch 2. There have been substantial changes in the illnesses leading to death in the neonatal intensive care unit. "
10/01/1977 - "Maximum resorption (52.6%) was seen with treatment on day 7 whereas the highest rate of malformation (51.9%) was observed with treatment on day 9. Cranial defects predominated with treatment early in pregnancy (highest incidence of day 9) while limb defects were not observed with any treatment administered before day 9. Exencephaly occurred with treatments on day 6 and 8, with a single case after treatment on day 10. "
08/01/1976 - "The types of abnormality generally resembled those produced by lathyrogens in other species except for exencephaly and encephalocele, which occurred after treatment on day 7. These results indicate that betaAPN is a typical teratogen, capable of producing abnormalities of the central nervous system early in gestation, and may reflect a broader mechanism for its activity than previously suggested."
04/01/1996 - "After treatment in 6 patients bladder dysfunction improved (18%), hyperreflexia disappeared in 4 and sphinteric resistance increased in 2. In patients with tethered cord syndrome, untethering is recommended treatment in preventing further, sometimes rapid neurologic dysfunction and better results are got in childs whose condition is repaired at an early ages."
08/01/1988 - "Depending on the exact time of gestation when lithium carbonate is administered, the frequencies of exencephaly and spinal kinking after treatment 1 hour into the ninth day are compared with those after treatment 2 or 3 hours into the ninth day, incidence of exencephaly is increased at the later time and the incidence of spinal kinking is decreased."
10/01/1985 - "When treatments were given on day 9 of gestation, 500 mg/kg BUdR caused cell necrosis in the neuroepithelium about 15 hours after treatment but no neural tube defects were produced by day 9 after treatment. "
03/01/2002 - "According to the American College of Obstetricians and Gynecologists, it has become standard in prenatal care to offer screening tests for neural tube defects and genetic abnormalities. "
09/01/2002 - "ALTHOUGH ADVANCES IN prenatal care and diagnosis have reduced the incidence of spina bifida, repair of neural tube defects remains one of the standard cases encountered by pediatric neurosurgeons. "
01/01/1999 - "Interviews (based on the Health Belief Model) concerning folate and neural tube defects were conducted in a prenatal care clinic. "
01/01/1989 - "Reliability of detecting open neural tube defects in prenatal care had been proved by quantitative analysis of acetylcholinesterase activity in amniotic fluid. "
01/16/2003 - "In spite of the fact that in the majority of cases of mental retardation the etiology is unknown, and for that reason, in them it is not possible to establish preventive strategies, within the last three decades, important research advances have helped to prevent thousands of cases of mental retardation of illnesses caused by Haemophilus influenzae B, measles encephalitis, Rh disease and severe jaundice in newborn infants, congenital hypothyroidism, phenylketonuria and congenital rubella; as well as removing lead from the environment, intervention programs for the proper use of seat belts, child safety seats, and motorcycle and bicycle helmets; early and adequate prenatal care, dietary supplementation with folic acid beginning before conception to reduce the risk of neural tube defects, avoidance of toxic substances during pregnancy like alcohol, and the use of newborn screening tests. "