Netropsin

A basic polypeptide isolated from Streptomyces netropsis. It is cytotoxic and its strong, specific binding to A-T areas of DNA is useful to genetics research.

Also Known As:

Congocidine; IA-887; Netropsin Hydrochloride; T-1384; Hydrochloride, Netropsin; Sinanomycin; 1H-Pyrrole-2-carboxamide, 4-((((aminoiminomethyl)amino)acetyl)amino)-N-(5-(((3-amino-3-iminopropyl)amino)carbonyl)-1-methyl-1H-pyrrol-3-yl)-1-methyl-

Networked: 26 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Galegov, G A: 2 articles (01/2013 - 03/2007)
2.	Hadwiger, Lee A: 1 article (12/2020)
3.	Abou Gamra, Maha Marzouk: 1 article (12/2019)
4.	Ezz Eldin, Hayam Mohamed: 1 article (12/2019)
5.	Kamel, Hanan Hussein: 1 article (12/2019)
6.	Taha Zahran, Fatima Mohamed: 1 article (12/2019)
7.	Boehm, Belinda J: 1 article (05/2018)
8.	Button, Alexander L: 1 article (05/2018)
9.	Huang, David M: 1 article (05/2018)
10.	Pukala, Tara L: 1 article (05/2018)

Related Diseases

1.	Neoplasms (Cancer) 09/26/2002 - "These conjugates' in vitro antitumor activity, inhibition of a variety of human tumor cell growth, revealed that AHMA-ethylcarbamate-O-netropsin derivatives were more cytotoxic than AHMA-N-netropsin compounds. " 12/14/2020 - "Chitosan may share with cancer-treatment compounds, netropsin and some anti-cancer drugs, a DNA minor groove target in plant host tissue. " 07/19/2010 - "In a cell proliferation assay, a significant decrease in cytotoxicity was observed for PT-ACRAMTU, when cancer cells were pretreated with netropsin, suggesting that minor-groove adducts in cellular DNA contribute to the biological activity of the hybrid agent." 11/01/2010 - "Here, we use magnetic tweezers, which control the force and torque applied to single DNAs, to study three small molecules: ethidium bromide (EtBr), a well-known intercalator; netropsin, a minor-groove binding anti-microbial drug; and topotecan, a clinically used anti-tumor drug. " 10/01/2002 - "The antitumor effects of several concentrations of cisplatin, bleomycin, doxorubicin, and netropsin as single agents delivered with electric pulses were investigated based on post-treatment tumor volumes and histology. "
2.	Infections 03/01/2007 - "Effect of dimeric derivatives of netropsin and their combinations with acyclovir on herpes simplex virus type 1 infection in mice." 12/01/2019 - "Taken together, these observations suggest that netropsin is a promising therapy for T. vaginalis infection affecting its viability, virulence, cytopathogenic and hemolytic activity with a mechanism of action that might overcome T. vaginalis resistance to metronidazole." 01/01/2016 - "We propose a netropsin combination therapy that minimises the use of polymyxin B when treating infections with multidrug resistant Gram-negative bacteria." 01/01/2013 - "Using the model of an experimental cutaneous infection of guinea pig males caused by herpes simple virus type 1, it is shown that application of dimerico derivatives of netropsin Lys-bis Nt and 15Lys-bis Nt in the form of polietilenglicol-based ointment suppresses viral infection more effectively than acyclovir." 01/01/2017 - "Furthermore, netropsin reduced RNA and protein expression of two viral regulatory proteins (bICP0 and bICP22) during productive infection, but increased bICP4 levels. "
3.	Decompression Sickness (Bends) 02/01/1998 - "Both Hoe and netropsin (Nt) prefer binding to AT rich DNA segments, which are candidates for intrinsic DNA helix bends. " 06/01/1993 - "It is argued that the enhancement of the apparent DNA contour length by the specifically binding non-intercalating drug netropsin (Nt) (Reinert et al., NAR 9, 2335, 1981) at very low Nt/DNA-phosphate ratios essentially is the result of an abolition of periodically arranged intrinsic helix bends in A.T rich tracts of base pairs. "
4.	Alzheimer Disease (Alzheimer's Disease) 08/01/2000 - "The DNA minor groove binders SN6999, SN6570, and SN6113, structurally related to netropsin and distamycin, were investigated for sequence-specific interactions with the 154 base pair cDNA fragment of the human tau 40 protein, involved in pathology of Alzheimer's disease. " 01/01/1997 - "The DNA minor groove binders netropsin, distamycin and four structurally related bisquaternary ammonium heterocycles (BQA), SN 6999, SN 6570, SN 6132 and SN 6131, were investigated for sequence-specific interactions with the 154 base pair fragment of cDNA of the human Tau 40 protein (h Tau 40 protein), involved in pathology of Alzheimer's disease. "
5.	Neurodegenerative Diseases (Neurodegenerative Disease) 05/23/2018 - "Molecular dynamics simulations are used to elucidate the structure and thermodynamics of DNA triplexes associated with the neurodegenerative disease Friedreich's ataxia (FRDA), as well as complexes of these triplexes with the small molecule netropsin, which is known to destabilise triplexes. "

Related Drugs and Biologics

1.	Topotecan (Hycamtin)
2.	Ethidium (Ethidium Bromide)
3.	Intercalating Agents
4.	DNA (Deoxyribonucleic Acid)
5.	stallimycin
6.	Anti-Bacterial Agents (Antibiotics)
7.	Complementary DNA (cDNA)
8.	Proteins (Proteins, Gene)
9.	Mitoxantrone (Novantrone)
10.	Doxorubicin (Adriamycin)

Related Therapies and Procedures

1.	Therapeutics