|1.||Galegov, G A: 2 articles (01/2013 - 03/2007)|
|2.||Sugden, Bill: 1 article (10/2015)|
|3.||Chakravorty, Adityarup: 1 article (10/2015)|
|4.||Grokhovskiĭ, S L: 1 article (01/2013)|
|5.||Surovaia, A N: 1 article (01/2013)|
|6.||Horita, David A: 1 article (01/2013)|
|7.||Ghosh, Supratim: 1 article (01/2013)|
|8.||andronova, V L: 1 article (01/2013)|
|9.||Gurskiĭ, G V: 1 article (01/2013)|
|10.||Deriabin, P G: 1 article (01/2013)|
09/26/2002 - "These conjugates' in vitro antitumor activity, inhibition of a variety of human tumor cell growth, revealed that AHMA-ethylcarbamate-O-netropsin derivatives were more cytotoxic than AHMA-N-netropsin compounds. "
11/01/2010 - "Here, we use magnetic tweezers, which control the force and torque applied to single DNAs, to study three small molecules: ethidium bromide (EtBr), a well-known intercalator; netropsin, a minor-groove binding anti-microbial drug; and topotecan, a clinically used anti-tumor drug. "
07/19/2010 - "In a cell proliferation assay, a significant decrease in cytotoxicity was observed for PT-ACRAMTU, when cancer cells were pretreated with netropsin, suggesting that minor-groove adducts in cellular DNA contribute to the biological activity of the hybrid agent."
10/01/2002 - "The antitumor effects of several concentrations of cisplatin, bleomycin, doxorubicin, and netropsin as single agents delivered with electric pulses were investigated based on post-treatment tumor volumes and histology. "
09/20/1987 - "The NH groups of the benzimidazoles make bridging three-center hydrogen bonds between adenine N-3 and thymine O-2 atoms on the edges of base-pairs, in a manner both mimicking the spine of hydration and calling to mind the binding of the auti-tumor drug netropsin. "
01/01/2013 - "Using the model of an experimental cutaneous infection of guinea pig males caused by herpes simple virus type 1, it is shown that application of dimerico derivatives of netropsin Lys-bis Nt and 15Lys-bis Nt in the form of polietilenglicol-based ointment suppresses viral infection more effectively than acyclovir."
03/01/2007 - "Effect of dimeric derivatives of netropsin and their combinations with acyclovir on herpes simplex virus type 1 infection in mice."
|3.||Decompression Sickness (Bends)
02/01/1998 - "Both Hoe and netropsin (Nt) prefer binding to AT rich DNA segments, which are candidates for intrinsic DNA helix bends. "
06/01/1993 - "It is argued that the enhancement of the apparent DNA contour length by the specifically binding non-intercalating drug netropsin (Nt) (Reinert et al., NAR 9, 2335, 1981) at very low Nt/DNA-phosphate ratios essentially is the result of an abolition of periodically arranged intrinsic helix bends in A.T rich tracts of base pairs. "
|4.||Alzheimer Disease (Alzheimer's Disease)
08/01/2000 - "The DNA minor groove binders SN6999, SN6570, and SN6113, structurally related to netropsin and distamycin, were investigated for sequence-specific interactions with the 154 base pair cDNA fragment of the human tau 40 protein, involved in pathology of Alzheimer's disease. "
01/01/1997 - "The DNA minor groove binders netropsin, distamycin and four structurally related bisquaternary ammonium heterocycles (BQA), SN 6999, SN 6570, SN 6132 and SN 6131, were investigated for sequence-specific interactions with the 154 base pair fragment of cDNA of the human Tau 40 protein (h Tau 40 protein), involved in pathology of Alzheimer's disease. "
|5.||Tumor Virus Infections (Shope Fibroma)
|2.||Ethidium (Ethidium Bromide)
|3.||DNA (Deoxyribonucleic Acid)
|5.||Complementary DNA (cDNA)
|9.||human tau 40 protein
|10.||Topoisomerase I Inhibitors