Nervous System Neoplasms (Neoplasms, Nervous System)

Benign and malignant neoplastic processes arising from or involving components of the central, peripheral, and autonomic nervous systems, cranial nerves, and meninges. Included in this category are primary and metastatic nervous system neoplasms.

Also Known As:

Networked: 235 relevant articles (4 outcomes, 26 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Brain Neoplasms (Brain Tumor)
3.	Edema (Dropsy)
4.	Alzheimer Disease (Alzheimer's Disease)
5.	Parkinson Disease (Parkinson's Disease)

Experts

1.	Ammoun, Sylwia: 5 articles (11/2012 - 01/2009)
2.	Hanemann, C Oliver: 4 articles (11/2012 - 01/2009)
3.	Carpén, Olli: 3 articles (07/2007 - 04/2004)
4.	Grönholm, Mikaela: 3 articles (07/2007 - 04/2004)
5.	Jones, David T W: 2 articles (01/2019 - 03/2015)
6.	Pfister, Stefan M: 2 articles (01/2019 - 03/2015)
7.	Sahm, Felix: 2 articles (01/2019 - 03/2015)
8.	Schrimpf, Daniel: 2 articles (01/2019 - 03/2015)
9.	von Deimling, Andreas: 2 articles (01/2019 - 03/2015)
10.	Mittelbronn, Michel: 2 articles (03/2015 - 09/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Nervous System Neoplasms:

1.	Ethylnitrosourea (N-Ethyl-N-nitrosourea)IBA 01/01/1992 - "[The inhibiting effect of phytoadaptogenic preparations from bioginseng, Eleutherococcus senticosus and Rhaponticum carthamoides on the development of nervous system tumors in rats induced by N-nitrosoethylurea]." 06/01/1991 - "The activated neu gene was detected in tumors of the nervous system that arose in mice following transplacental exposure to N-ethyl-N-nitrosourea. " 11/01/1972 - "Tumors of the nervous system induced by ethylnitrosourea administered either intracerebrally of subcutaneously to newborn rats. " 01/01/1972 - "[Induction of nervous system neoplasms using methyl- and ethylnitrosourea compounds in newborn rats. " 10/10/1977 - "Quantitative aspects of transplantation have been studied experimentally in ethylnitrosourea-induced nervous system tumors. "
2.	Biomarkers (Surrogate Marker)IBA 01/01/2023 - "Clinical outcome of biomarker-guided therapies in adult patients with tumors of the nervous system." 01/01/2014 - "Due to increased frequency of biopsy or partial resection of tumors from the living patient, biomarkers are needed to serve as accurate prognostic indicators and assist in determining the efficacy of developing therapeutic options in nervous system tumors of dogs and cats." 12/01/2020 - "Spinal glioma is a nervous system tumor that tends to relapse and has no specific prognostic molecular biomarkers. " 10/01/1998 - "This is a comprehensive immunohistochemical study of selected archival tumors of the nervous system applying human anti-neuronal nuclear autoantibodies of types 1 and 2 (ANNA-1 and -2), serum markers of paraneoplastic syndromes associated primarily with small cell lung cancer (SCLC). "
3.	MethylprednisoloneFDA LinkGeneric 04/01/2003 - "Vasogenic edema associated with brain tumor and its induced symptoms was effectively treated by methylprednisolone without adverse effects, Current findings suggest that further study of methylprednisolone in the management of control nervous system tumors is warranted."
4.	TOR Serine-Threonine KinasesIBA 11/01/2012 - "One novel therapeutic target that may offer promise for multiple disease entities that involve Alzheimer's disease, Parkinson's disease, epilepsy, trauma, stroke, and tumors of the nervous system is the mammalian target of rapamycin (mTOR). "
5.	Isotretinoin (Accutane)FDA LinkGeneric 03/01/1985 - "A neurogenic cancer model, involving transplacental administration of ethylnitrosourea (ENU) to Sprague-Dawley rats, was employed to evaluate the efficacy of retinyl acetate, 13-cis-retinoic acid, and all-trans-retinoic acid in prevention of nervous system tumors in the offspring. "
6.	Tretinoin (Retinoic Acid)FDA LinkGeneric 03/01/1985 - "A neurogenic cancer model, involving transplacental administration of ethylnitrosourea (ENU) to Sprague-Dawley rats, was employed to evaluate the efficacy of retinyl acetate, 13-cis-retinoic acid, and all-trans-retinoic acid in prevention of nervous system tumors in the offspring. "
7.	retinol acetateIBA 03/01/1985 - "A neurogenic cancer model, involving transplacental administration of ethylnitrosourea (ENU) to Sprague-Dawley rats, was employed to evaluate the efficacy of retinyl acetate, 13-cis-retinoic acid, and all-trans-retinoic acid in prevention of nervous system tumors in the offspring. "
8.	Proteins (Proteins, Gene)FDA Link 05/01/2011 - "In conclusion, this study demonstrated that nervous system tumor cells showed different alterations in morphology, and different cytoskeletal protein expression patterns, depending on the culture methods." 05/01/2005 - "The results of this study indicate that the expression of hUlip protein is distinctly restricted to the late fetal and early postnatal periods of human nervous system development and to certain subsets of nervous system tumors. " 05/15/2009 - "This method can be used to detect protein markers of tumors, nervous system or other diseases for early diagnostics." 04/18/2008 - "Nanog, nucleostemin (NS) and musashi1 (Msi1) are proteins that are highly expressed in undifferentiated embryonic stem (ES) cells and have been shown to be essential in maintaining the pluripotency and regulating the proliferation and asymmetric division of ES cells and several nervous system tumor cells. " 12/01/2006 - "Bcl-x is an important member of the bcl-2 family of proteins that has been shown to be expressed by both native nervous system tissue and several nervous system tumors. "
9.	AntigensIBA 06/01/2007 - "Therefore, to evaluate the antitumor potential of UCB-derived effector cells, studies were designed to compare the in vitro and in vivo antitumor effects of UCB- and peripheral blood (PB)-derived antigen-nonspecific and antigen-specific effector cells against tumors of the nervous system. " 05/01/2005 - "The exact function of hUlip needs to be further clarified; yet the results of our study strongly imply that hUlip function is important in human nervous system development and its aberrant expression in various types of nervous system tumors suggests a role of hUlip as an oncofetal neural antigen." 01/01/1990 - "All 35 tumors of the nervous system were treated by a panel of immunohistochemical reactions comprising antibodies against cytoskeleton intermediary filaments such as GFAP (glial fibrillary acid protein), neurofilament proteins, vimentin and cytokeratins and some nervous system antigens such as NSE (neuron specific enolase), MBP (myelin basic protein) and S-100 protein. "
10.	Messenger RNA (mRNA)IBA 08/01/1998 - "The human ENC-1 gene appeared to be highly expressed in adult brain and spinal cord, and in a number of cell lines derived from nervous system tumors we detected low steady-state levels of ENC-1 mRNA. " 06/01/1995 - "High Id-1 mRNA expression was found in many human tumor cell lines, including those isolated from nervous system tumors. " 03/01/1994 - "Recently, in normal thyroid and in medullary thyroid carcinoma (MTC), we detected an additional splicing pathway involving the splicing of exon 4 to exon 5 and leading to the expression of a third CALC I mRNA: CT mRNA II. In the present study, we analyzed by polymerase chain reaction the expression of CT mRNAs I and II, CGRP I and II mRNAs in MTC and in human tumors of the nervous system (3 pituitary adenomas, 3 astrocytomas, 2 schwanomas). " 04/01/1990 - "Expression of alternatively terminated unusual human butyrylcholinesterase messenger RNA transcripts, mapping to chromosome 3q26-ter, in nervous system tumors." 06/01/2022 - "The functional and disease association analysis showed ALS has a strong correlation with mRNA processing, protein deubiquitination, and neoplasms, nervous system, immune system disease classes. "

Therapies and Procedures

1.	Therapeutics 01/01/2022 - "This review provides an update on progress in the treatment of the main embryonal tumors of the nervous system using nanotechnology and cell-based therapies and discusses key issues behind the gap between preclinical studies and clinical trials in this specific area. " 11/01/2001 - "New approaches to the molecular biology, classification, and therapy of nervous system tumors: a workshop of the National Institutes of Health Pathology B study section." 11/28/2023 - "In this comprehensive review, we elucidate the regulatory functions of tumor-nervous system crosstalk, provide a succinct overview of the relationship between tumor-nervous system dialogue and clinical symptomatology, and deliberate the current research progress and forthcoming avenues of neural therapy for PDAC." 10/31/2023 - "E-8-O-G seems to be a promising natural antitumor compound in the therapy of nervous system tumors." 01/01/2022 - "Nanomedicines and cell-based therapies for embryonal tumors of the nervous system."
2.	Conformal Radiotherapy 12/01/2001 - "Further studies evaluating the use of three-dimensional conformal radiotherapy in patients with nervous system neoplasms should focus on determining the effects on quality of life for the patient and survival compared with more standard treatment techniques."
3.	Drug Therapy (Chemotherapy) 04/01/2009 - "This review presents the role of and current challenges to pharmacotherapy of malignant tumors of the nervous system during childhood and adolescence and discusses novel approaches aimed at overcoming these challenges." 04/01/2009 - "New approaches to pharmacotherapy of tumors of the nervous system during childhood and adolescence." 12/01/2003 - "The major therapeutic options for tumors of the nervous system include surgical resection, radiotherapy using various strategies of fractionation, total dose, and target volume, and different approaches of chemotherapy such as systemic, intrathecal, and interstitial chemotherapy as well as high-dose chemotherapy with stem cell rescue. " 01/01/2021 - "The mainstays of treatment for most nervous system tumors include surgical intervention, radiation therapy, and medical treatment with chemotherapy, immunotherapy, and/or targeted therapy. " 03/01/2012 - "Neuropathic cancer pain (NCP), commonly encountered in clinical practice, may be cancer-related, namely resulting from nervous system tumor invasion, surgical nerve damage during tumor removal, radiation-induced nerve damage and chemotherapy-related neuropathy, or may be of benign origin, unrelated to cancer. "
4.	Radiotherapy 06/01/2006 - "There is a significantly increased risk of second nervous system tumors in those NF1 patients who received radiotherapy for their OPGs, especially when treated in childhood. " 06/01/2006 - "The relative risk of second nervous system tumor after radiotherapy was 3.04 (95% CI, 1.29 to 7.15). " 06/01/2006 - "We reviewed 80 NF1 OPG patients from two NF1 clinics to evaluate the long-term risk of developing subsequent nervous system tumors, with or without radiotherapy. " 12/01/2003 - "The major therapeutic options for tumors of the nervous system include surgical resection, radiotherapy using various strategies of fractionation, total dose, and target volume, and different approaches of chemotherapy such as systemic, intrathecal, and interstitial chemotherapy as well as high-dose chemotherapy with stem cell rescue. " 01/01/2021 - "The mainstays of treatment for most nervous system tumors include surgical intervention, radiation therapy, and medical treatment with chemotherapy, immunotherapy, and/or targeted therapy. "
5.	Transplantation 10/10/1977 - "Quantitative aspects of transplantation of experimentally induced tumors of the nervous system." 09/01/1974 - "Transplantation of nervous system tumors in diffusion chambers." 10/10/1977 - "Quantitative aspects of transplantation have been studied experimentally in ethylnitrosourea-induced nervous system tumors. "