Nerve Degeneration

Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.

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Networked: 525 relevant articles (24 outcomes, 50 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease)
2.	Wounds and Injuries (Trauma)
3.	Infarction (Infarctions)
4.	Fibrosis (Cirrhosis)
5.	Wallerian Degeneration

Experts

1.	Le, Weidong: 7 articles (01/2014 - 06/2007)
2.	Cai, Min: 4 articles (01/2022 - 01/2018)
3.	Chao, Chi-Chao: 4 articles (01/2022 - 05/2015)
4.	Hsieh, Sung-Tsang: 4 articles (01/2022 - 05/2015)
5.	Yao, Dengbing: 4 articles (01/2022 - 12/2014)
6.	Sommer, Claudia: 4 articles (01/2021 - 03/2005)
7.	Bellucci, Arianna: 4 articles (10/2018 - 07/2015)
8.	Pizzi, Marina: 4 articles (10/2018 - 07/2015)
9.	Yamanaka, Akihiro: 3 articles (02/2022 - 02/2016)
10.	Gao, Nannan: 3 articles (01/2022 - 01/2018)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Nerve Degeneration:

1.	Dopamine (Intropin)FDA LinkGeneric 04/01/2012 - "Neuroimaging studies provide evidence that increased motor-related cortical activity can compensate for progressive dopaminergic nerve degeneration in carriers of a single mutant Parkin or PINK1 gene, who show a mild but significant reduction of dopamine metabolism in the basal ganglia in the complete absence of clinical motor signs. " 01/01/2023 - "Determinations of dopamine (DA) neuron degeneration, food perception, and ROS content were performed in 6-OHDA-exposed BZ555 nematodes. " 01/01/2020 - "The focus of PD research has been primarily on the neurobiological basis and consequences of dopamine (DA) neuron degeneration given that the loss of DA neurons projecting from the substantia nigra to the dorsal striatum results in the development of cardinal PD motor symptoms. " 01/01/2018 - "Multiple lines of LRRK2 transgenic or knockin mice have been developed, yet none exhibit substantial dopamine (DA)-neuron degeneration. " 09/20/2023 - "elegans model including DA neuron degeneration, dopamine-mediated food sensitivity behavioral disorders, and shortened lifespan. "
2.	Oxidopamine (6 Hydroxydopamine)IBA 01/01/2018 - "The aim of this study was to investigate the effects of Kv7/KCNQ channel blocker, XE991, on 6-hydroxydopamine (6-OHDA)-induced nigral DA neuron degeneration and motor dysfunction. " 02/09/2005 - "While 6-hydroxydopamine (6-OHDA) is often used in animal models of DA neuron degeneration, there have been relatively few studies that have examined the effects of 6-OHDA in older animals. " 07/01/1996 - "Subthalamic nucleus lesion in rats prevents dopaminergic nigral neuron degeneration after striatal 6-OHDA injection: behavioural and immunohistochemical studies." 07/01/2023 - "We observed that REO reduced α-Syn aggregations and diminished DA neuron degenerations induced by 6-OHDA, reduced food-sensing behavioural disabilities, and prolonged the lifespan of the nematode. " 12/01/2022 - "We observed that CBD at 0.025 mM (24.66 %), 0.05 mM (52.41 %) and 0.1 mM (71.36 %) diminished DA neuron degenerations induced by 6-hydroxydopamine (6-OHDA), reduced (0.025, 27.1 %), (0.05, 38.9 %), (0.1, 51.3 %) food-sensing behavioural disabilities in BZ555, reduced 40.6 %, 56.3 %, 70.2 % the aggregative toxicity of α-Syn and expanded the nematodes' lifespan up to 11.5 %, 23.1 %, 28.8 %, dose-dependently. "
3.	Nerve Growth Factor (NGF)IBA 01/01/2016 - "Moreover, other recent studies have shown that NGF has direct clinical relevance in certain human brain neuron degeneration and a number of human ocular disorders. " 10/05/1981 - "This finding shows that nerve degeneration is not essential for nodal sprouting and supports the hypothesis that inactive muscle liberates a motor nerve growth factor." 01/01/2002 - "In the present study, changes were made in the environment into which the cells were placed to test whether reinnervation was improved by: 1) prior nerve degeneration, induced by sciatic nerve transection 1 week before cell transplantation; 2) transplantation of 1 million versus 5 million cells; 3) addition of nerve growth factor (NGF) to the transplant. " 07/01/1998 - "CRIB implants secreting nerve growth factor (NGF) were effective in preventing nerve degeneration in a monkey model of Alzheimer's disease. " 06/01/2014 - "Nerve growth factor (NGF) and analog reagents to promote the neurite outgrowth of nerve cells against the neuron degeneration are expected to be potentially useful for the medical treatment of Alzheimer's disease. "
4.	Reactive Oxygen Species (Oxygen Radicals)IBA 11/01/2023 - "This damage in the form of neuron degeneration seen in the cortex was associated with apoptosis involving Cas-3 activation, increased DNA damage, and free oxygen radicals. " 01/01/2022 - "Significance: Reactive oxygen species (ROS) contribute to multiple aspects of peripheral nervous system (PNS) biology ranging from physiological processes (e.g., axonal outgrowth and regeneration) to pathophysiology (e.g., nerve degeneration). " 03/01/2016 - "It has been claimed that oxidative stress and the production of reactive oxygen radicals can contribute to neuron degeneration and might be one factor in the development of different neurological diseases. " 12/15/1999 - "These data indicate a role for low levels of HNE in promoting reactive oxygen species accumulation and neuron degeneration by altering mitochondrial homeostasis. " 10/01/2014 - "Loss of Fer2 expression in adulthood causes progressive PAM neuron degeneration in aging flies along with mitochondrial dysfunction and elevated reactive oxygen species (ROS) production, leading to the progressive locomotor deficits. "
5.	AntioxidantsIBA 06/09/1987 - "Intensive anti-oxidant pretreatment retards motor nerve degeneration." 07/01/2016 - "Brain injury examination revealed a significant decrease in injury scores with NAC and EP therapy, both antioxidant agents, in terms of neuron degeneration (P= .004 and P= .001, respectively). " 01/01/2022 - "Briefly curcuminoids exhibit the capability to be more productive and efficacious compared to many recent treatments due to their antioxidant, delayed neuron degeneration, and anti-inflammatory potential. " 10/31/2023 - "A rapid increase in the levels of reactive oxygen species (ROS) post stroke can overwhelm antioxidant defenses and trigger a series of pathophysiologic events including the inflammatory response, blood-brain barrier (BBB) disruption, apoptosis, and autophagy, ultimately leading to neuron degeneration and apoptosis. " 08/01/1993 - "Moreover, the efficacy of MP in limiting lipid peroxidation and secondary spinal cord or motor nerve degeneration has also been duplicated by a nonglucocorticoid 21-aminosteroid tirilazad mesylate (U-74006F), which suggests the independence of the antioxidant and glucocorticoid effects of MP."
6.	GlucocorticoidsIBA 02/01/1983 - "These results demonstrate an ability of an intensive high-dose glucocorticoid treatment to sustain single and repetitive neuromuscular transmission during early anterograde nerve degeneration." 02/01/1983 - "Beneficial action of glucocorticoid treatment on neuromuscular transmission during early motor nerve degeneration." 08/01/1993 - "Moreover, the efficacy of MP in limiting lipid peroxidation and secondary spinal cord or motor nerve degeneration has also been duplicated by a nonglucocorticoid 21-aminosteroid tirilazad mesylate (U-74006F), which suggests the independence of the antioxidant and glucocorticoid effects of MP." 01/01/1993 - "Moreover, the efficacy of MP in limiting lipid peroxidation and secondary spinal cord or motor nerve degeneration has also been duplicated by a nonglucocorticoid 21-aminosteroid, tirilazad mesylate (U-74006F), which suggests the independence of the antioxidant and glucocorticoid effects of MP."
7.	tirilazadIBA 08/01/1993 - "Moreover, the efficacy of MP in limiting lipid peroxidation and secondary spinal cord or motor nerve degeneration has also been duplicated by a nonglucocorticoid 21-aminosteroid tirilazad mesylate (U-74006F), which suggests the independence of the antioxidant and glucocorticoid effects of MP." 01/01/1993 - "Moreover, the efficacy of MP in limiting lipid peroxidation and secondary spinal cord or motor nerve degeneration has also been duplicated by a nonglucocorticoid 21-aminosteroid, tirilazad mesylate (U-74006F), which suggests the independence of the antioxidant and glucocorticoid effects of MP."
8.	Adenosine Triphosphate (ATP)IBA 04/01/2014 - "In this study, we investigated the role of extracellular ATP on demyelination during Wallerian degeneration (WD) using ex vivo and in vivo nerve degeneration models. " 01/01/2013 - "In this study, we show that a brief exposure to Al(3+) decreases mitochondrial membrane potential and cellular ATP levels, and confers dopamine (DA) neuron degeneration in the genetically tractable nematode Caenorhabditis elegans (C. " 09/15/2012 - "We further found that deficiency of mitochondrial uncoupling protein 2 (UCP2), which reduces reactive oxygen species (ROS) production and functions as upstream to the K-ATP channel in determining vulnerability of DA neurons, abolished the protective effects of H(2)S against either DA neuron degeneration in the PD mouse model or MPP(+)-induced injury in primary mesencephalic neurons. " 01/01/2019 - "The identified proteins were found to mainly participate in ATP generation, protein synthesis, lipid synthesis, cytoskeleton, heat shock proteins, innate immune defense, stress response, neuron degeneration, and muscle assembly. "
9.	Cholinergic Agents (Cholinergics)IBA 01/01/2020 - "Neuropathological studies show that RS results from the selective cholinergic nerve degeneration. " 01/01/2019 - "Taken together, our data suggest that cholinergic degeneration in the medial septal area induced by intracerebroventricular administration of 192IgG-saporin results in an increase in the number of microglial cells and neuron degeneration in the dorsal hippocampus." 04/01/2005 - "Therapeutic neurotrophic intervention might delay or prevent NB neuron degeneration and preserve cholinergic cortical function during prodromal AD." 01/01/2014 - "In conclusion, laser acupuncture at HT7 can improve neuron degeneration and memory impairment in animal model of PD partly via the decreased oxidative stress and the improved cholinergic and dopaminergic functions. " 09/01/1993 - "Furthermore, we evaluated whether GAL hyperinnervation occurs within the basal forebrain in Down's syndrome, a genetic disorder with extensive AD-like pathology including cholinergic basal forebrain neuron degeneration. "
10.	Interleukin-6 (Interleukin 6)IBA 10/01/2016 - "IL-6 Contributes to Corneal Nerve Degeneration after Herpes Simplex Virus Type I Infection." 01/01/2017 - "Detailed bioinformatic studies suggested that multiple immune/inflammatory pathways, including agranulocyte adhesion and diapedesis, granulocyte adhesion and diapedesis, IL-6 signaling, and IL-10 signaling, were sustained activated during nerve degeneration and regeneration. " 12/01/2018 - "We observed increased hemorrhages, neutrophils, leukocytes infiltrations and neuron degeneration in Group II compared to Group I. Caspase 3, G-CSF, IL-6, SAA, iNOS expressions were increased in group II compared to Group I (p < 0.001). " 01/01/2019 - "In a rat model of cerebral I/R, higenamine improved functional state of nerves, significantly inhibited the I/R-induced increase in the serum level of tumor necrosis factor α (TNF-alpha) and interleukins (ILs) such as IL-1, IL-6 and IL-18, and CD14+ cells, while decreasing the axonal nerve degeneration. "

Therapies and Procedures

1.	Therapeutics 01/01/2021 - "MitoPark mice therefore represent an effective tool for studying the sequence of events that occurs in the early stages of DA neuron degeneration following mitochondrial impairment, as well as for testing the efficacy of potential disease-modifying therapies in a progressive model of neurodegeneration. " 01/01/2022 - "The combination therapy developed by Zhang et al. relieved some aspects of nerve degeneration at the injury site and activated an anti-inflammatory response in cells, but did not restore vision. " 05/01/2006 - "Current therapeutic trials will undoubtedly provide additional therapies to moderate symptoms, but once the mechanism(s) of selective striatal projection neuron degeneration are delineated, a revolution in the management of HD will occur." 02/25/2021 - "Finally, we also introduce current information on regenerative therapy, which is expected to be a therapeutic approach when the pathological condition has progressed and nerve degeneration has been completed." 08/22/2017 - "We propose that by enhancing LM511-YAP signaling, it may be possible to prevent mDA neuron degeneration in PD or enhance the survival of mDA neurons in cell replacement therapies."
2.	Lasers (Laser) 08/26/1982 - "Two distributions of axons in the optic nerve of quails: a study of nerve degeneration after laser lesions of the retina." 01/01/2014 - "In conclusion, laser acupuncture at HT7 can improve neuron degeneration and memory impairment in animal model of PD partly via the decreased oxidative stress and the improved cholinergic and dopaminergic functions. " 06/01/1993 - "In vivo rabbit studies were performed to measure temperature changes and nerve degeneration which occurred when the facial canal was decompressed with the laser as compared to the diamond burr. "
3.	Cell Transplantation 01/01/2002 - "In the present study, changes were made in the environment into which the cells were placed to test whether reinnervation was improved by: 1) prior nerve degeneration, induced by sciatic nerve transection 1 week before cell transplantation; 2) transplantation of 1 million versus 5 million cells; 3) addition of nerve growth factor (NGF) to the transplant. "
4.	Transplantation 01/01/2002 - "The mean diameters of large LGS axons (>6 microm) were significantly larger with nerve degeneration before transplantation. " 01/01/2002 - "In the present study, changes were made in the environment into which the cells were placed to test whether reinnervation was improved by: 1) prior nerve degeneration, induced by sciatic nerve transection 1 week before cell transplantation; 2) transplantation of 1 million versus 5 million cells; 3) addition of nerve growth factor (NGF) to the transplant. "
5.	Nerve Crush 11/01/2007 - "Two weeks after nerve crush, the distal nerve and EUS both showed evidence of both nerve degeneration and recovery. " 03/01/1977 - "It was concluded that: (1) nerve crush causes distal nerve degeneration, loss of the normal fiber type pattern, and extensive collateral ramification of subterminal axons; (2) collateral reinnervation imposes a neuronal influence on muscle fibers which dictates transformation of all muscle fibers innervated by a single subterminal axon to a uniform histochemical profile; and (3) the type grouping observed in normal porcine muscle is not a result of neuronal influence mediated by collateral branching of subterminal axons." 01/01/2004 - "Thus despite the inhibition of MMPs by BB-1101, the drug did not appear to essentially affect nerve degeneration or regeneration following nerve crush but that it could be beneficial in promoting the more effective reinnervation of muscles possibly by actions at the level of the muscles."