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Nephrosclerosis

Hardening of the KIDNEY due to infiltration by fibrous connective tissue (FIBROSIS), usually caused by renovascular diseases or chronic HYPERTENSION. Nephrosclerosis leads to renal ISCHEMIA.
Also Known As:
Nephroscleroses
Networked: 382 relevant articles (18 outcomes, 39 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Proteinuria
2. Hypertension (High Blood Pressure)
3. Glomerulonephritis
4. Nephritis
5. Fibrosis (Cirrhosis)

Experts

1. Ono, Hidehiko: 7 articles (09/2007 - 05/2002)
2. Hartner, Andrea: 6 articles (02/2009 - 03/2003)
3. Matsuoka, Hiroaki: 6 articles (09/2008 - 05/2002)
4. Hilgers, Karl F: 5 articles (02/2009 - 10/2003)
5. Klanke, Bernd: 5 articles (02/2009 - 10/2003)
6. Cordasic, Nada: 4 articles (02/2009 - 10/2003)
7. Ono, Yuko: 4 articles (09/2007 - 05/2002)
8. Frohlich, Edward D: 4 articles (03/2005 - 05/2002)
9. Szeto, Cheuk-Chun: 3 articles (07/2015 - 01/2010)
10. Lai, Fernand Mac-Moune: 3 articles (07/2015 - 01/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Nephrosclerosis:
1. NG-Nitroarginine Methyl Ester (L-NAME)IBA
2. Angiotensin IIIBA
3. Nitric Oxide (Nitrogen Monoxide)FDA Link
4. ReninIBA
5. AldosteroneIBA
6. Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA
7. CalciumIBA
8. CollagenIBA
9. Calcium Channels (Calcium Channel)IBA
06/01/1998 - "We conclude that ACE inhibitors can prevent nephrosclerosis and LVH even in the presence of a reduction in NO production, implying that in rats the inhibition of the renin-angiotensin system is more effective than the blockade of calcium channels in preventing hypertensive tissue injury."
08/01/1992 - "Adverse effect of the calcium channel blocker nitrendipine on nephrosclerosis in rats with renovascular hypertension."
08/01/2004 - "In patients with hypertensive nephrosclerosis, the African American Study of Kidney Disease and Hypertension (AASK) demonstrated the superiority of angiotensin-converting enzyme inhibitor therapy in blunting progression of renal disease compared with a b blocker and a dihydropyridine calcium channel blocker. "
06/01/1998 - "We investigated the ability of the angiotensin converting enzyme (ACE) inhibitor imidapril hydrochloride, and of the calcium channel blocker amlodipine besilate, to prevent nephrosclerosis and left ventricular hypertrophy (LVH) in rats with hypertension induced by chronic inhibition of nitric oxide (NO). "
11/01/2006 - "We randomly assigned 1,094 African Americans with hypertensive nephrosclerosis (glomerular filtration rate [GFR], 20 to 65 mL/min/1.73 m(2) [0.33 to 1.08 mL/s]) to initial antihypertensive treatment with either: (1) a beta-blocker, metoprolol; (2) an angiotensin-converting enzyme inhibitor, ramipril; or (3) a dihydropyridine calcium channel blocker, amlodipine, and either a usual-blood pressure (BP) or low-BP treatment goal. "
10. Arginine (L-Arginine)FDA Link

Therapies and Procedures

1. Nephrectomy
2. Protein-Restricted Diet (Diet, Protein Restricted)
3. Kampo Medicine (Kampo)
4. Diet Therapy (Therapy, Diet)
5. Surgical Instruments (Clip)