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Hereditary Nephritis (Alport Syndrome)

A group of inherited conditions characterized initially by HEMATURIA and slowly progressing to RENAL INSUFFICIENCY. The most common form is the Alport syndrome (hereditary nephritis with HEARING LOSS) which is caused by mutations in genes for TYPE IV COLLAGEN and defective GLOMERULAR BASEMENT MEMBRANE.
Also Known As:
Alport Syndrome; Alport's Syndrome; Syndrome, Alport; Nephritis, Hereditary; Alport Syndrome, Autosomal Dominant; Alport Syndrome, Autosomal Recessive; Alport Syndrome, X-Linked; Congenital Hereditary Hematuria; Hematuria-Nephropathy-Deafness Syndrome; Hematuric Hereditary Nephritis; Hemorrhagic Familial Nephritis; Hemorrhagic Hereditary Nephritis; Hereditary Familial Congenital Hemorrhagic Nephritis; Hereditary Hematuria Syndrome; Hereditary Interstitial Pyelonephritis; Alport Syndrome, X Linked; Familial Nephritis; Hematuria Nephropathy Deafness Syndrome; Hematuria, Congenital Hereditary; Nephritis, Hematuric Hereditary; Nephritis, Hemorrhagic Familial; Nephritis, Hemorrhagic Hereditary; Pyelonephritis, Hereditary Interstitial; Syndrome, Hematuria-Nephropathy-Deafness; X-Linked Alport Syndrome; Nephritis, Familial
Networked: 909 relevant articles (23 outcomes, 87 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Proteinuria
2. Chronic Kidney Failure (Chronic Renal Failure)
3. Membranous Glomerulonephritis (Membranous Nephropathy)
4. Anti-Glomerular Basement Membrane Disease (Goodpasture's Syndrome)
5. Hematuria

Experts

1. Gross, Oliver: 35 articles (11/2022 - 04/2000)
2. Ding, Jie: 25 articles (11/2021 - 04/2004)
3. Kashtan, Clifford E: 24 articles (09/2022 - 02/2001)
4. Iijima, Kazumoto: 23 articles (01/2022 - 12/2006)
5. Nozu, Kandai: 22 articles (01/2022 - 12/2006)
6. Savige, Judy: 22 articles (01/2022 - 10/2002)
7. Miner, Jeffrey H: 21 articles (03/2022 - 02/2001)
8. Wang, Fang: 19 articles (11/2021 - 04/2004)
9. Cosgrove, Dominic: 16 articles (01/2022 - 05/2003)
10. Nakanishi, Koichi: 16 articles (01/2022 - 12/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hereditary Nephritis:
1. Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA
2. Ramipril (Altace)FDA LinkGeneric
3. bardoxolone methylIBA
4. Cyclosporine (Ciclosporin)FDA LinkGeneric
5. Hydroxychloroquine (Plaquenil)FDA LinkGeneric
6. Proteins (Proteins, Gene)FDA Link
7. Angiotensin Receptor AntagonistsIBA
8. Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
9. dapagliflozinIBA
10. Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA

Therapies and Procedures

1. Phacoemulsification
2. Therapeutics
3. Intraocular Lens Implantation
4. Capsulorhexis
5. Contact Lenses