|3.||Nephrotic Syndrome (Syndrome, Nephrotic)
|4.||Systemic Lupus Erythematosus (Libman-Sacks Disease)
|1.||Putterman, Chaim: 23 articles (09/2015 - 03/2002)|
|2.||Madaio, Michael P: 16 articles (10/2015 - 05/2002)|
|3.||Cook, H Terence: 15 articles (05/2015 - 10/2002)|
|4.||Mohan, Chandra: 15 articles (03/2015 - 01/2006)|
|5.||Pusey, Charles D: 13 articles (05/2015 - 10/2002)|
|6.||Kawasaki, Yukihiko: 13 articles (01/2014 - 04/2003)|
|7.||Zhou, Xin J: 12 articles (11/2015 - 01/2006)|
|8.||Panzer, Ulf: 12 articles (07/2015 - 07/2007)|
|9.||Stahl, Rolf A K: 12 articles (07/2015 - 03/2002)|
|10.||Suzuki, Hitoshi: 12 articles (07/2011 - 01/2002)|
|1.||Cyclophosphamide (Cytoxan)FDA LinkGeneric
01/01/1994 - "From a cohort of SLE patients followed over a period of twelve years, we review the charts of the eleven with histologic evidence of class IV nephritis who reached complete remission with cyclophosphamide and who were followed for more than four years after the discontinuation. "
05/01/1984 - "Cyclophosphamide used as a comparative drug showed more clearly remission of the onset and development of NTS nephritis and RGG accelerated NTS nephritis in ddY mice by means of the changes of urinary and selorogical parameters. "
01/01/2005 - "CTLA4Ig, an antagonist of the CD28/B7 costimulatory interaction, effectively prevents SLE onset in several murine models and, when used in combination with cyclophosphamide, can induce remission of active SLE nephritis. "
01/01/2001 - "Controlled trials have shown that pulse cyclophosphamide is the treatment of choice for patients with moderate to severe proliferative nephritis. "
02/03/1972 - "[Histological and immune histological studies on the effect of cyclophosphamide on Masugi nephritis in rabbits]."
|2.||Antigen-Antibody Complex (Immune Complex)IBA
02/01/1984 - "The therapeutic efficacy of TLI in immune glomerular disease was explored in two animal models: the accelerated autologous form of nephrotoxic serum nephritis (AA-NTSN) and autologous immune complex nephritis (AICN). "
11/01/2015 - "Treatment with MMF + MP or CTX + MP both improved survival, renal function, and decreased anti-dsDNA antibody level and immune complex deposition in kidneys of mice with active nephritis. "
09/01/1979 - "The clearance of pre-formed immune complexes in rats with Heymann's nephritis."
03/01/2012 - "The differential diagnostic categories of crescentic GN include pauci-immune GN, anti-glomerular basement membrane (GBM) nephritis and immune complex-mediated GN, distinguished from one another by immunofluorescence and electron microscopic study of the renal biopsy. "
03/01/1993 - "A study was performed to elucidate the mechanisms of charge-based immune complex nephritis. "
|3.||Prednisolone (Predate)FDA LinkGeneric
08/01/1983 - "A moderate remission of the onset and development of these two experimental types of nephritis was recognized by the administration of prednisolone. "
01/01/2015 - "Between 2002 and 2008, five elderly Japanese patients (>65 years old) (mean age, 68 years, ranging from 65 to 72) with severe forms of HSP nephritis were entered into a prospective study to evaluate prednisolone therapy on the outcome of nephropathy in terms of clinical symptoms and histopathological changes. "
01/01/2004 - "On repeat kidney biopsy after the combined treatment, Patient 1 showed a profound reduction of nephritis activity, and she was maintained on low-dose prednisolone only. "
01/01/2002 - "The cumulative dose of prednisolone and presence of nephritis were independent risk factors for the development of TB using multivariate regression analysis. "
07/01/1981 - "Three patients were taking prednisolone, and 3 had evidence of nephritis. "
|4.||Immunoglobulin A (IgA)IBA
03/01/1992 - "One of the two patients with SLE showed improvement during CyA administration, while no response was observed in the patient with IgA nephritis. "
02/01/2014 - "Forty-three patients diagnosed with IgA nephritis with renal biopsy between the years 2005 and 2009 were included in this retrospective observational study. "
10/01/2006 - "Our work spans a 30-year period, involving laboratory-based research, clinical trials and genomics of IgA nephritis (Nx). "
01/01/2005 - "This study was designed to investigate whether the serum IgA/C3 ratio can be a serologic marker of disease activity in children with severe Henoch-Schönlein nephritis (HSN). "
11/01/1999 - "Our study confirmed the existence of a "point of no return" at 3 mg/dl (265 micromol/l) during the natural course of chronic IgA nephritis."
|5.||antiglomerular basement membrane antibodyIBA
11/01/1992 - "These results indicate that OB-5 was effective in crescentic-type anti-GBM nephritis and the antinephritic mechanisms of this agent may be due to its ability to inhibit the proliferation or the migration of macrophages and cytotoxic T lymphocytes in the glomeruli."
01/01/2009 - "Anti-GBM antibody nephritis has a poor prognosis, but renal function was maintained for 15 years in this patient, who responded well to the initial treatment. "
03/01/2011 - "This study was performed to demonstrate that combination therapy with a CCR2 antagonist (CA) and an Ang II type 1 receptor blocker (ARB) ameliorated renal injury in the anti-GBM nephritis model. "
12/01/1997 - "In the present study, we have assessed whether preparations of anti-GBM antibody contaminated with different concentrations of endotoxin could influence the severity of glomerular injury in the heterologous phase of nephrotoxic nephritis. "
01/01/1996 - "Antiproteolytic drugs utilized in our studies exert their beneficial effect on autologous anti-GBM nephritis through interference with inflammatory phase of the disease, while sparing its immune induction and mechanisms of coagulation/fibrinolysis."
|6.||Immunoglobulin G (IgG)IBA
09/01/1977 - "The test gave positive results for IgG complexes in most of twenty-four patients with SLE nephritis. "
02/01/2003 - "The frequency of genotypes containing the low-binding IgG2 allele, FcgammaRIIa-R131, was significantly greater than expected in patients with class III or class IV nephritis and in patients with intense IgG2 deposition. "
11/01/2015 - "CD47 deficiency ameliorates autoimmune nephritis in Fas(lpr) mice by suppressing IgG autoantibody production."
01/01/1988 - "On the whole, these data suggest that rats with induced chronic nephritis present an impairment in the immune clearance of IgG aggregates, probably due to decreased processing by Kupffer cells."
03/01/2012 - "Since male SNF(1) mice normally do not develop nephritis, we tested whether administration of 17β-estradiol (E-2) to male SNF(1) mice would increase Id(LN)F(1) IgG levels and autoreactive T cells, and further, induce nephritis. "
11/01/2006 - "The objective of this study is to evaluate the efficacy, toxicity, and long-term outcome of low-dose IV cyclophosphamid therapy with repeated frequent intervals in combination with oral and IV methylprednisolone in patients with SLE nephritis. "
03/01/2006 - "Methylprednisolone pulse therapy by the Tune-Mendoza protocol in a child with severe Henoch-Schönlein nephritis."
01/01/2001 - "These results suggest that methylprednisolone may accelerate the resolution phase of Thy-1.1 nephritis in part by sensitizing mesangial cells to apoptosis."
01/01/2001 - "Methylprednisolone treatment ameliorated mesangial hypercellularity in Thy-1.1 nephritis by decreasing proliferating cells and increasing apoptosis in the glomeruli. "
12/01/2000 - "Intravenous pulse methylprednisolone (MTP) followed by oral steroid therapy was initially administered for HSP nephritis. "
|8.||mycophenolate mofetil (Cellcept)FDA LinkGeneric
05/01/2015 - "Mycophenolate mofetil (MMF), as a relatively new immunosuppressant, is now widely used in the treatment of SLE patients, particularly those with nephritis. "
07/01/2003 - "Mycophenolate mofetil prevents development of urinary protein in autoimmune nephritis."
07/01/2014 - "Treatment of severe henoch-schonlein purpura nephritis with mycophenolate mofetil."
01/01/2013 - "A lupus-like nephritis was detected in his kidney biopsy and the proteinuria subsided after receiving a mycophenolate mofetil regimen. "
05/01/2012 - "Treatment of children with Henoch-Schönlein purpura nephritis with mycophenolate mofetil."
|9.||Cyclosporine (Ciclosporin)FDA LinkGeneric
10/01/2000 - "Successful use of cyclosporin A in progressive anti-glomerular basement membrane nephritis."
01/01/2000 - "Cyclosporine for lupus membranous nephritis: experience with ten patients and review of the literature."
02/01/1993 - "Since cyclosporin A can also directly influence the responses of macrophages and mesangial cells, the effect of the drug on the course of nephritis in this model might not be related to its immunosuppressive action."
02/01/1990 - "The effect of cyclosporin A on the interstitial mononuclear cell infiltration and the induction of Heymann's nephritis."
06/01/1988 - "Antiproteinuric effect of cyclosporine A in passive antiglomerular basement membrane nephritis in the mouse."
|10.||Complement System Proteins (Complement)IBA
11/01/1986 - "Anti-RNP and serum complement were not helpful in predicting nephritis. "
07/01/1981 - "Serial determinations of serum levels of complement protein provide a sensitive and reliable method for early determination of efficacy of therapy in shunt nephritis."
08/01/1998 - "Studies were undertaken to characterize the cellular composition that occurs in glomeruli and the tubulointerstitium of a passive model of complement-independent crescentic nephritis in mice. "
03/01/1990 - "In the present studies, the role of the terminal complement pathway in the accelerated autologous phase of anti-glomerular basement membrane (GBM) nephritis in the rabbit was investigated. "
11/01/1974 - "Studies of serum complement in the hypocomplementaemic nephritides."
04/01/1968 - "[Clinical study of tonsillectomy in nephritis]."
05/01/2007 - "We report our experience performing tonsillectomy combined with steroid therapy for 16 pediatric proteinuric Henoch-Schönlein nephritis (HSN) patients. "
05/01/2007 - "Tonsillectomy in the treatment of pediatric Henoch-Schönlein nephritis."
06/01/1972 - "[Tonsillectomy in subchronic nephritis]."
11/20/1965 - "[Indications for tonsillectomy in nephritis. "
|2.||Drug Therapy (Chemotherapy)
08/01/2013 - "Although 1 of the patients who received chemotherapy achieved complete remission, this patient died of BK virus nephritis. "
01/01/2002 - "Antituberculous chemotherapy was effective in severe and long-standing nephritis. "
07/01/1987 - "We conclude that PE may provide a safe and effective therapeutic option for the treatment of severe progressive SLE nephritis in selected children who are unresponsive to steroid or cytotoxic drug therapy."
04/01/2015 - "Most clinical evidence of efficacy concerns the use of PLEX for the recovery of renal function in severe nephritis, when used in conjunction with immunosuppressive drug therapy. "
06/01/1983 - "This case and similar previous reports suggest a potentiating effect by the chemotherapy of the renal damage by radiation which may cause radiation nephritis to develop at radiation doses normally within renal tolerance."
02/01/1991 - "These studies show that radiation nephritis can be precipitated by low doses of nephrotoxic drugs, and may help to explain the incidence of early radiation nephritis in bone marrow transplant patients conditioned with total body irradiation."
01/01/1992 - "Upon increased immunosuppressive therapy, renal and serological signs improved but one graft was later lost due to recurrent SLE nephritis."
10/01/2015 - "BK virus (BKV) causes BKV nephritis in renal transplant patients and contributes significantly to the increase of probability of graft loss. "
07/01/2015 - "An ¹¹¹In leukocyte scan showed increased renal transplant uptake consistent with nephritis and linear uptake in the knee. "
04/01/2015 - "In the past 15 years, adenovirus nephritis has emerged as a potentially life-threatening disease in renal transplant patients in developed countries. "
07/01/1955 - "[A new case of postabortion nephritis caused by Clostridium perfringens cured by exchange transfusions]."
01/01/1999 - "Serum soluble receptor (srIL-2alphac, p55 srTNFa, p75 srTNFalpha) levels were higher in patients with nephritis before treatment and decreased significantly 6 months after treatment (p=0.005). "
07/01/2012 - "Pediatric patients with Henoch-Schönlein purpura nephritis who presented with heavy proteinuria had favorable outcome after treatment. "
08/01/2010 - "As expected, the patients with membranous nephritis had lower anti-dsDNA titres and higher complement C3 levels at baseline, but in both groups a significant reduction in anti-dsDNA titre and improvements in complement C3 levels were seen during the first 6 months after treatment; the kinetics of improvement were similar in both groups. "
01/01/2015 - "Baseline levels of IL-17 were higher in patients with persisting active nephritis (WHO III, IV, V) after treatment, i.e. "
|5.||Transplantation (Transplant Recipients)
01/01/2013 - "The current study aimed to determine the mechanisms by which murine BM-MSC transplantation (MSCT) ameliorates nephritis in MRL/lpr mice. "
01/01/2012 - "Systemic SHED-Cryo-transplantation improved SLE-like disorders including short lifespan, elevated autoantibody levels and nephritis-like renal dysfunction. "
02/01/2002 - "Renal transplant recipients who were diagnosed to have PVi nephritis at the Medical College of Wisconsin were included in this study. "
04/01/2013 - "Such viral complications may cause nephritis of the donated kidney and eventually dysfunction and transplantation failure. "
04/27/2012 - "Transplantation with pathologic kidneys to improve the pool of donors: an example of shunt nephritis."