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Hereditary Neoplastic Syndromes (Cancer Syndrome, Hereditary)

The condition of a pattern of malignancies within a family, but not every individual's necessarily having the same neoplasm. Characteristically the tumor tends to occur at an earlier than average age, individuals may have more than one primary tumor, the tumors may be multicentric, usually more than 25 percent of the individuals in direct lineal descent from the proband are affected, and the cancer predisposition in these families behaves as an autosomal dominant trait with about 60 percent penetrance.
Also Known As:
Cancer Syndrome, Hereditary; Neoplastic Syndromes, Hereditary; Hereditary Cancer Syndromes; Hereditary Cancer Syndrome; Hereditary Neoplastic Syndrome; Neoplastic Syndrome, Hereditary; Syndrome, Hereditary Cancer; Syndrome, Hereditary Neoplastic; Syndromes, Hereditary Cancer; Syndromes, Hereditary Neoplastic; Cancer Syndromes, Hereditary
Networked: 112 relevant articles (1 outcomes, 8 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Neoplasms (Cancer)
2. Pheochromocytoma
3. Multiple Endocrine Neoplasia Type 2a (MEN 2)
4. von Hippel-Lindau Disease (von Hippel Lindau Disease)
5. Paraganglioma (Paragangliomas)

Experts

1. Lynch, Henry T: 4 articles (01/2019 - 08/2007)
2. Dey, Anwesha: 3 articles (01/2020 - 09/2012)
3. Meier, Jordan L: 3 articles (01/2020 - 01/2019)
4. Kurzrock, Razelle: 3 articles (12/2014 - 05/2007)
5. Kaelin, William G: 3 articles (01/2006 - 11/2003)
6. Kaelin, W G: 3 articles (09/2001 - 07/2000)
7. Black, Michael A: 2 articles (03/2022 - 01/2019)
8. Regier, Dean A: 2 articles (01/2022 - 01/2020)
9. Schrader, Kasmintan A: 2 articles (01/2022 - 01/2020)
10. Sun, Sophie: 2 articles (01/2022 - 01/2020)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hereditary Neoplastic Syndromes:
1. Biomarkers (Surrogate Marker)IBA
2. Proteins (Proteins, Gene)FDA Link
3. Prostaglandins DIBA
4. Succinate Dehydrogenase (Fumarate Reductase)IBA
5. Oxygen (Dioxygen)IBA
6. FatsIBA
7. DNA (Deoxyribonucleic Acid)IBA
8. Retinaldehyde (Retinal)IBA
9. Fumarate Hydratase (Fumarase)IBA
10. EnzymesIBA

Therapies and Procedures

1. Therapeutics
2. Precision Medicine
3. Drug Therapy (Chemotherapy)
4. Chemoprevention
5. Molecular Targeted Therapy