Radiation-Induced Neoplasms (Neoplasms, Radiation Induced)

Tumors, cancer or other neoplasms produced by exposure to ionizing or non-ionizing radiation.

Also Known As:

Neoplasms, Radiation Induced; Neoplasms, Radiation-Induced; Cancer, Radiation-Induced; Cancer, Radiation Induced; Cancers, Radiation-Induced; Neoplasm, Radiation-Induced; Radiation Induced Cancer; Radiation Induced Neoplasms; Radiation-Induced Cancers; Radiation-Induced Neoplasm; Radiation-Induced Cancer

Networked: 162 relevant articles (4 outcomes, 12 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Goiter
2.	Neoplasms (Cancer)
3.	Ankylosing Spondylitis
4.	Breast Neoplasms (Breast Cancer)
5.	Hyperthyroidism

Experts

1.	Schneider, Uwe: 7 articles (11/2018 - 12/2005)
2.	Damilakis, John: 5 articles (01/2016 - 01/2006)
3.	Lam, Wendy: 3 articles (01/2019 - 11/2017)
4.	Law, Martin: 3 articles (01/2019 - 11/2017)
5.	Ma, Wang-Kei: 3 articles (01/2019 - 11/2017)
6.	Yip, Lawrance: 3 articles (01/2019 - 11/2017)
7.	Shay, Jerry W: 3 articles (11/2018 - 03/2010)
8.	Walsh, Linda: 3 articles (11/2018 - 04/2008)
9.	Pandharipande, Pari V: 3 articles (12/2014 - 03/2014)
10.	Yoon, Myonggeun: 3 articles (06/2014 - 08/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Radiation-Induced Neoplasms:

1.	IodineIBA 01/01/2019 - "The risks of radiation-induced cancer and contrast-induced nephropathy (CIN) have always been regarded as concerns which increased demand for CCTA using reduced radiation dose and iodine intake. " 04/01/1997 - "The present paper reviews the current epidemiologic knowledge on radiation-induced cancer, focusing on exposure to radioiodines, and describes the latest findings from the Swedish iodine cohorts." 12/01/1994 - "In addition, prophylaxis of iodine-deficient goiters with 50-200 micrograms of iodide daily leads to a significant reduction of the risk of radiation-induced cancers. "
2.	IodidesIBA 12/01/1994 - "In addition, prophylaxis of iodine-deficient goiters with 50-200 micrograms of iodide daily leads to a significant reduction of the risk of radiation-induced cancers. "
3.	Radioisotopes (Radionuclides)IBA 06/01/2014 - "It is emphasized here that radiation-induced cancers are a complex consequence of biological response to radiation and ingested radionuclides. " 01/01/2003 - "Comparisons can be made between risk estimates for radiation-induced cancer derived for radionuclide exposure and those derived for the A-bomb survivors, exposed mainly to low-LET (linear energy transfer) external radiation. " 01/01/1997 - "This chapter reviews the risks of radiation-induced cancer for the dose range likely to occur after releases of radionuclides into the environment. " 02/01/1985 - "A technique is presented for estimating the number of radiation-induced cancers in organs exposed following the ingestion of radionuclides. " 01/01/2003 - "We concluded that, although the literature reports an increased susceptibility for subsequent malignancies for individuals with naturally-occurring or radiation-induced cancer, the data derived from this study do not confirm the concept that the appearance of soft tissue cancer is strongly associated with an increased risk of developing a radionuclide-induced skeletal malignancy."
4.	Proteins (Proteins, Gene)FDA Link 11/01/2007 - "This study was to compare the protein expression profiles between radiation-induced cancer cells and normal cells. " 01/01/2008 - "In this paper, we summarize the current status of DNA repair proteins as potential targets for radiation-induced cancer risk. " 03/01/1998 - "Immunohistochemically, p53 protein expression was detected in 7/9 (78%) of radiation-induced cancers and in 23/42 (55%) of spontaneous colon cancers. " 02/01/2017 - "To elucidate potential biomarkers and possible mechanisms of radiation-induced cancer, the expression of FKTN, which encodes fukutin protein and causes Fukuyama-type congenital muscular dystrophy, was analyzed in gastric cancer (GC) tissue samples from atomic bomb survivors. "
5.	CarcinogensIBA 09/01/1989 - "Ionizing radiation has long been recognized as a weak carcinogen, and the risk of developing a radiation induced neoplasm after exposure to therapeutic radiation has been established. " 10/01/1983 - "The epidemiology of radiation-induced cancer is important for theoretical and practical insights that these studies give to human cancer in general and because we have more evidence from radiation-exposed populations than for any other environmental carcinogen. "
6.	Cytidine Triphosphate (CTP)IBA 10/15/2013 - "This study provides data on the cumulative life attributable risk (LAR) of radiation-induced cancer from the combination of coronary CT angiography (CCTA), dynamic CT perfusion (CTP) and delayed enhancement (DE) CT scans, required for reliable risk-benefit analysis of the one-stop-shop CCTA + CTP + DECT cardiac examination. "
7.	AntioxidantsIBA 07/01/2010 - "Many studies have demonstrated that non-steroidal anti-inflammatory drugs and antioxidants can reduce the risk of radiation-induced cancer. "
8.	Protons (Proton)IBA 11/01/2018 - "Proton radiation-induced cancer progression." 08/01/2014 - "Both DS protons and IMPT achieved a significantly better dose conformity compared to the photon and electron irradiation techniques resulting in a six times lower overall risk of radiation-induced cancer. " 05/01/2006 - "Excess risk of radiation-induced cancer at the distal part of proton radiation fields can thus be explained using SCCP calculations on the basis of the physical dose distributions. " 10/01/2017 - "Radiation-induced cancer risk predictions in proton and heavy ion radiotherapy." 10/14/2021 - "Estimated Risk of Radiation-Induced Cancer after Thymoma Treatments with Proton- or X-ray Beams."
9.	DNA (Deoxyribonucleic Acid)IBA 01/01/2020 - "These radiation exposures are typically anticipated, and the exposure is typically well below 1 Gy. When radiation-induced (actually ROS-induced) DNA mutation is prevented, then so too are downstream radiation-induced cancers. " 09/01/2017 - "Removal of the anti-scatter grid resulted in dose reductions of 20% (no anti-scatter grid) and 30% (15 cm air-gap), DNA double-strand break reductions of 30% (no anti-scatter grid) and 20% (15 cm air-gap) and a reduction of radiation-induced cancer mortality risk of up to 45%. " 06/01/2003 - "In order to relate the low probability of radiation-induced cancer to the relatively high incidence of non-radiation carcinogenesis, especially at low-dose irradiation, the quantitative and qualitative differences between the DNA damages from non-radiation and radiation sources need to be addressed and put into context of physiological mechanisms of cellular protection. " 01/01/2019 - "Global DNA hypomethylation is proposed as a potential biomarker for cancer risk associated with genomic instability, which is an important factor in radiation-induced cancer. "
10.	Biomarkers (Surrogate Marker)IBA 01/01/2018 - "At present, however, it is difficult or impossible to distinguish radiation-induced thyroid cancer from spontaneous/sporadic thyroid cancer because molecular radiation signatures, biomarkers of radiation exposure, or genetic factors specific to radiation-induced cancer have not yet been identified. " 01/01/2019 - "Global DNA hypomethylation is proposed as a potential biomarker for cancer risk associated with genomic instability, which is an important factor in radiation-induced cancer. " 02/01/2017 - "To elucidate potential biomarkers and possible mechanisms of radiation-induced cancer, the expression of FKTN, which encodes fukutin protein and causes Fukuyama-type congenital muscular dystrophy, was analyzed in gastric cancer (GC) tissue samples from atomic bomb survivors. "

Therapies and Procedures

1.	Therapeutics 02/01/2001 - "[A case report of radiation-induced cancer of the buccal mucosa, effectively treated with CF therapy]." 01/01/2017 - "The reduced response (cell death) exhibited by p53-mutated cells compared to p53 wild-type cells suggests a possible role of the assessed p53 mutations in radiation-induced cancer susceptibility and reduced efficacy of radiation-directed therapy." 09/01/2022 - "These findings offer compelling evidence for the potential capability of Bi2S3@BSA-Fe3O4-FA as an ideal nanoparticle for radiation-induced cancer therapy and open interesting avenues of future research in this area." 01/01/2022 - "These molecular signatures for radiation-induced cancers will inform both risk assessment and potential targeted therapies for pB-ALL." 09/01/2013 - "The biological effects of electromagnetic waves are widely studied, especially due to their harmful effects, such as radiation-induced cancer and to their application in diagnosis and therapy. "
2.	Immunotherapy 01/01/2023 - "Future research is needed to assess whether the promising results of clinical studies with pre-operative immunotherapy in locally advanced HN SCC patients may be translated into radiation-induced cancers."
3.	Radiotherapy 03/01/1996 - "The frequency of radiation-induced neoplasms was determined in dogs enrolled in the National Cancer Institute canine trials of intraoperative radiotherapy (IORT). " 01/20/2022 - "However, the overall estimated risks induced by IMRT and VMAT radiotherapy techniques were lower than the 3D-CRT techniques and can be used clinically in younger patients or patients having greater concerns about radiation induced cancers." 10/21/2021 - "As intrinsic radiosensitivity and immune status affect the initial and effective stage of the radiation-induced cancer immunity cycle, respectively, it is important to consider both of them when we select patients who can benefit from radiotherapy. " 07/02/2021 - "In parallel, the predisposition to radiation-induced adverse tissue reactions (radiosensitivity), notably observed after radiotherapy appears to be caused by different mechanisms than those linked to predisposition to radiation-induced cancer (radiosusceptibility). " 12/01/2020 - "[The risk of second radiation-induced cancer from hadrontherapy compared to traditional radiotherapy]."
4.	Aftercare (After-Treatment) 01/01/2015 - "However, exposure to radiation has the potential to cause a radiation-induced cancer (RIC) many years after treatment. " 02/01/2023 - "Radiation-induced cancer after treatment for nasopharyngeal carcinoma: a study from a high prevalence area." 01/01/2003 - "Two cases of radiation-induced cancers 20 years after treatment of first malignancies." 01/01/1994 - "[Radiation-induced cancer after treatment of mediastinal seminoma. " 01/01/1990 - "[Radiation-induced cancer after treatment of seminoma. "
5.	Bariatric Surgery 05/01/2010 - "The purpose of this study was to estimate the cumulative radiation dose from computed tomography (CT) scans and upper gastrointestinal fluoroscopic exams in the post-bariatric-surgery population and correlate these values with current concepts of potential radiation-induced cancer risk. "