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Multiple Endocrine Neoplasia (Multiple Endocrine Adenomatosis)

A group of autosomal dominant diseases characterized by the combined occurrence of tumors involving two or more ENDOCRINE GLANDS that secrete PEPTIDE HORMONES or AMINES. These neoplasias are often benign but can be malignant. They are classified by the endocrine glands involved and the degree of aggressiveness. The two major forms are MEN1 and MEN2 with gene mutations on CHROMOSOME 11 and CHROMOSOME 10, respectively.
Also Known As:
Multiple Endocrine Adenomatosis; Adenomatosis, Multiple Endocrine; Familial Endocrine Adenomatosis; Multiple Endocrine Adenopathy; Multiple Endocrine Neoplasia Syndromes; Multiple Endocrine Neoplasms; Adenomatoses, Familial Endocrine; Adenomatoses, Multiple Endocrine; Adenopathies, Multiple Endocrine; Adenopathy, Multiple Endocrine; Endocrine Adenomatoses, Familial; Endocrine Adenomatoses, Multiple; Endocrine Adenomatosis, Familial; Endocrine Adenomatosis, Multiple; Endocrine Adenopathies, Multiple; Endocrine Adenopathy, Multiple; Endocrine Neoplasms, Multiple; Familial Endocrine Adenomatoses; Multiple Endocrine Adenomatoses; Multiple Endocrine Adenopathies; Adenomatosis, Familial Endocrine; Endocrine Neoplasia, Multiple; Multiple Endocrine Neoplasia Syndrome; Neoplasia, Multiple Endocrine; Neoplasms, Multiple Endocrine
Networked: 504 relevant articles (9 outcomes, 26 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Neoplasms (Cancer)
2. Thyroid Neoplasms (Thyroid Cancer)
3. Neoplasm Metastasis (Metastasis)
4. Multiple Endocrine Neoplasia Type 2a (MEN 2)
5. Pheochromocytoma

Experts

1. Stratakis, Constantine A: 9 articles (01/2021 - 01/2006)
2. Dralle, Henning: 7 articles (02/2016 - 12/2004)
3. Pellegata, Natalia S: 5 articles (02/2016 - 07/2007)
4. Takahashi, M: 5 articles (09/2008 - 02/2000)
5. Takahashi, Masahide: 5 articles (10/2004 - 09/2002)
6. Grubbs, Elizabeth G: 4 articles (01/2022 - 01/2013)
7. Perrier, Nancy D: 4 articles (01/2022 - 06/2005)
8. Kebebew, Electron: 4 articles (06/2019 - 08/2013)
9. Nilubol, Naris: 4 articles (06/2019 - 08/2013)
10. Brandi, Maria Luisa: 4 articles (01/2018 - 07/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Multiple Endocrine Neoplasia:
1. Calcitonin (Calcitonin, Eel)FDA LinkGeneric
2. GastrinsIBA
3. Pancreatic Polypeptide (Pancreatic Polypeptide (PP))IBA
4. Glucagon (Glukagon)FDA Link
04/01/2020 - "Two rare syndromes have a high incidence of NENs: multiple endocrine neoplasia type 4 (MEN4), with a tumour spectrum similar to that of MEN1, and glucagon cell hyperplasia neoplasia (GCHN), involving only the pancreas. "
04/01/2022 - "Approximately 10% of PanNENs arise as inherited tumour syndromes which include multiple endocrine neoplasia type 1, multiple endocrine neoplasia type 4, von Hippel-Lindau syndrome, neurofibromatosis type1, tuberous sclerosis complex 1/2, Cowden syndrome, and Glucagon cell hyperplasia and neoplasia as well as familial insulinomatosis. "
01/01/1981 - "A paradoxical response of plasma gastrin level in the patients with the Zollinger-Ellison syndrome and a marked decrease of plasma gastrin level in the patients with gastric ulcer, duodenal ulcer, excluded gastric antrum, multiple endocrine adenomatosis, pernicious anemia and chronic renal failure were demonstrated by glucagon infusion. "
01/01/1986 - "He was diagnosed as suffering from multiple endocrine adenomatosis (MEA) type 1. Screening of his family members revealed that his mother had high levels of gastrin, glucagon and parathormone and his father had a high level of gastrin. "
06/01/2002 - "Ten cases of normal pancreatic tissue, two cases of nesidioblastosis, five insulin-producing tumours and one case of multiple endocrine neoplasia 1 syndrome, containing an insulin-, a somatostatin- and several glucagon-producing tumours, as well as tiny foci of endocrine dysplasia with different predominance of the secreted hormones (mainly glucagon and pancreatic polypeptide) were included in the study. "
5. Retinaldehyde (Retinal)IBA
6. Streptozocin (Streptozotocin)FDA Link
7. DNA (Deoxyribonucleic Acid)IBA
8. Hormones (Hormone)IBA
9. CatecholaminesIBA
10. Succinate Dehydrogenase (Fumarate Reductase)IBA

Therapies and Procedures

1. Parathyroidectomy
2. Therapeutics
3. Thyroidectomy
4. Pancreatectomy
5. Intravenous Administration