|1.||Birth Weight (Birth Weights)
|2.||Opioid-Related Disorders (Opiate Addiction)
|3.||Fetal Growth Retardation (Intrauterine Growth Retardation)
|4.||Premature Birth (Birth, Premature)
|1.||Jones, Hendrée E: 17 articles (11/2015 - 05/2003)|
|2.||Jansson, Lauren M: 15 articles (01/2014 - 07/2005)|
|3.||Kaltenbach, Karol: 13 articles (01/2015 - 01/2007)|
|4.||Fischer, Gabriele: 13 articles (01/2013 - 01/2003)|
|5.||O'Grady, Kevin E: 9 articles (01/2014 - 07/2005)|
|6.||Johnson, Rolley E: 8 articles (06/2012 - 05/2003)|
|7.||Huestis, Marilyn A: 8 articles (06/2012 - 09/2004)|
|8.||Heil, Sarah H: 7 articles (11/2013 - 12/2010)|
|9.||Jagsch, Reinhold: 7 articles (01/2013 - 02/2006)|
|10.||Hayes, Marie J: 6 articles (10/2015 - 03/2012)|
03/01/2015 - "To evaluate the efficacy of a universal maternal drug testing protocol for all mothers in a community hospital setting that experienced a 3-fold increase in neonatal abstinence syndrome (NAS) over the previous 5 years. "
03/01/2016 - "This study examined the effects of prenatal alcohol exposure (PAE) on the incidence and severity of neonatal abstinence syndrome (NAS). "
05/01/2015 - "This study determined the influence of prematurity on the manifestation and treatment of neonatal abstinence syndrome (NAS). "
01/01/2015 - "To study the incidence and patient characteristics of Neonatal Abstinence Syndrome (NAS) in infants who were born to opioid addicted mothers and required NICU admission over the three year period. "
09/01/2013 - "Retrospective, uncontrolled study which evaluates different therapies of neonatal abstinence syndrome (NAS) in preterm and term neonates. "
|2.||Buprenorphine (Subutex)FDA LinkGeneric
09/01/2008 - "Sublingual buprenorphine was largely effective in controlling neonatal abstinence syndrome. "
09/01/2008 - "Buprenorphine administered via the sublingual route is feasible and apparently safe and may represent a novel treatment for neonatal abstinence syndrome."
07/01/2014 - "Buprenorphine has some evidence about its safety in newborns with neonatal abstinence syndrome, but high-powered studies on its efficacy are currently lacking. "
09/01/2008 - "The primary objective of this study was to demonstrate the feasibility and, to the extent possible in this size of study, the safety of sublingual buprenorphine in the treatment of neonatal abstinence syndrome. "
09/01/2008 - "Sublingual buprenorphine for treatment of neonatal abstinence syndrome: a randomized trial."
|3.||Morphine (MS Contin)FDA LinkGeneric
04/01/2015 - "Oral morphine weaning for neonatal abstinence syndrome at home compared with in-hospital: an observational cohort study."
02/01/2015 - "Primary neonatal outcomes included diagnosis of neonatal abstinence syndrome, neonatal abstinence syndrome peak scores, total amount of morphine used to treat neonatal abstinence syndrome (mg), and duration of treatment for neonatal abstinence syndrome (days). "
03/01/2013 - "Stability of dilute oral morphine solution for neonatal abstinence syndrome."
02/01/2013 - "The medical care also changed: greater participation on the part of mothers in neonatal care, more frequent breastfeeding, less medication for neonatal abstinence syndrome with the same severity score: i.e., 45.5% of infants with a Lipsitz score between 8 and 12 received a morphine treatment in 1999-2000 versus only 5.5% in 2005-2006 and none in 2007-2008. "
01/01/2013 - "Neonatal abstinence syndrome was treated with oral morphine solution based on standardized modified Finnegan scores. "
|4.||Clonidine (ST 155)FDA LinkGeneric
02/01/2010 - "This study suggests that a treatment of neonatal abstinence syndrome with clonidine in omission of opiates is possible without causing short-term adverse cardiovascular effects. "
04/01/2011 - "The population pharmacokinetic (PK) profile of oral clonidine was characterized in newborns with neonatal abstinence syndrome, and significant covariates affecting its PK parameters were identified. "
04/01/2011 - "Clonidine clearance matures rapidly during the early postnatal period: a population pharmacokinetic analysis in newborns with neonatal abstinence syndrome."
07/01/2009 - "Use of clonidine in the prevention and management of neonatal abstinence syndrome."
05/01/2009 - "To determine if oral clonidine would reduce the duration of opioid detoxification for neonatal abstinence syndrome. "
|5.||Methadone (Dolophine)FDA LinkGeneric
02/01/2014 - "In this study, neonates who received methadone for the treatment of neonatal abstinence syndrome according to a predefined clinical treatment pathway were evaluated for treatment success: defined as adherence to the methadone regimen with no residual signs of withdrawal. "
11/01/2013 - "More studies are required to explore alternatives to methadone maintenance in pregnancy and to define optimal treatment for neonatal abstinence syndrome. "
02/01/2011 - "The purpose of this study was to examine the relationship among methadone maintenance treatment, perinatal outcomes, and neonatal abstinence syndrome. "
01/01/2009 - "The purpose of this study was to examine high-dose methadone in pregnant women and its effect on the duration of neonatal abstinence syndrome. "
09/01/2007 - "The objective of this study was to determine the population prevalence and correlates of neonatal abstinence syndrome among neonates born to women on methadone, using a cross-sectional analysis of linked population health data. "
|6.||Narcotics (Narcotic Analgesics)IBA
09/01/2014 - "This paper describes design considerations for the Medication-assisted treatment for Opioid-dependent expecting Mothers (MOMs; estimated N = 370) and Investigation of Narcotics for Ameliorating Neonatal abstinence syndrome on Time in hospital (INFANTs; estimated N = 284) POCCTs, both of which are randomized, intent-to-treat, two-group trials. "
01/01/2001 - "Narcotic abuse has steadily become more prevalent in Israel and may result in an increasing number of children exposed prenatally to narcotics, with a consequent increase in the number of infants born with neonatal abstinence syndrome. "
02/01/2015 - "The incidence of neonatal abstinence syndrome fell significantly to 18.1% of pregnancies exposed to narcotics (from 29.5% in a previous 2010 study, P = .003) among patients using narcotic replacement and tapering with long-acting morphine preparations. "
09/01/1984 - "Although neonatal withdrawal syndrome is often noted in infants of narcotics addicts, ethanol withdrawal has been reported only among neonates with fetal alcohol syndrome. "
07/01/2010 - "Clonidine use for neonatal abstinence syndrome from narcotics has been shown to be effective alone or in combination with agents such as other opiates and chloral hydrate. "
|7.||Phenobarbital (Luminal)FDA Link
01/01/2015 - "Phenobarbital versus morphine in the management of neonatal abstinence syndrome, a randomized control trial."
07/01/2004 - "A randomised controlled trial of morphine versus phenobarbitone for neonatal abstinence syndrome."
12/01/2013 - "Efficacy of clonidine versus phenobarbital in reducing neonatal morphine sulfate therapy days for neonatal abstinence syndrome. "
12/01/2013 - "To compare the efficacy of clonidine versus phenobarbital in reducing morphine sulfate treatment days for neonatal abstinence syndrome (NAS). "
|8.||2-methylcyclopentadienyl manganese tricarbonyl (MMT)IBA
02/01/2014 - "MMT in pregnancy was associated with improved maternal and fetal outcomes, and rates of neonatal abstinence syndrome were similar for mothers receiving different doses. "
02/01/2014 - "Rates of neonatal abstinence syndrome were similar for mothers treated with BMT and MMT during pregnancy, but symptoms were less severe for infants whose mothers were treated with BMT. "
03/01/2012 - "Neonates with prenatal exposure to MMT spent more days in the hospital (21 vs. 14 days) for treatment of neonatal abstinence syndrome (NAS) than infants with prenatal exposure to BMT. "
|10.||Ondansetron (Zofran)FDA LinkGeneric
02/01/2015 - "Ondansetron pharmacokinetics in pregnant women and neonates: towards a new treatment for neonatal abstinence syndrome."
02/01/2015 - "Ondansetron is the drug of choice to prevent nausea in women undergoing cesarean surgery and can be used to prevent neonatal abstinence syndrome (NAS). "
06/01/2010 - "[Ear acupuncture points in neonates with neonatal abstinence syndrome due to maternal substitution therapy]."
04/01/2010 - "Detection of psychic ear acupuncture points in a newborn infant with neonatal abstinence syndrome."
01/01/2011 - "The aim of the study was to determine the presence of acupuncture ear points in neonates with Neonatal Abstinence Syndrome (NAS). "
06/01/2010 - "The aim of the study was to determine the presence and absence of acupuncture ear points in neonates with neonatal abstinence syndrome (NAS). "
01/01/2011 - "Active ear acupuncture points in neonates with neonatal abstinence syndrome (NAS)."
|2.||Length of Stay
07/01/2013 - "This study examined neonatal withdrawal syndrome diagnosis among Michigan infants from 2000 to 2009 and hospital length of stay (LOS) between infants with and without the syndrome for a subset of years (2006-2009). "
06/01/2015 - "Pharmacogenomic predictors of neonatal abstinence syndrome: correlation with length of stay."
06/01/2015 - "A quality improvement project to reduce length of stay for neonatal abstinence syndrome."
05/28/2015 - "From 2004 through 2013, the rate of NICU admissions for the neonatal abstinence syndrome increased from 7 cases per 1000 admissions to 27 cases per 1000 admissions; the median length of stay increased from 13 days to 19 days (P<0.001 for both trends). "
05/01/2013 - "Association of OPRM1 and COMT single-nucleotide polymorphisms with hospital length of stay and treatment of neonatal abstinence syndrome."
|3.||Drug Therapy (Chemotherapy)
01/01/2008 - "Fewer infants in the breastfed group required pharmacotherapy for neonatal abstinence syndrome, but this was not a statistically significant finding. "
07/01/1986 - "Neonatal abstinence syndrome, pharmacotherapy and developmental outcome."
06/01/2012 - "Each year in the US ∼50 000 neonates receive inpatient pharmacotherapy for the treatment of neonatal abstinence syndrome (NAS). "
11/01/2010 - "Compared to neonates who did not require medication to treat neonatal abstinence syndrome (NAS), neonates receiving pharmacotherapy for NAS showed differences over time in quality of movement, excitability, and lethargy. "
07/01/1986 - "The majority of infants born to drug-dependent women undergo neonatal abstinence syndrome (NAS) and often require pharmacotherapy for the treatment of withdrawal symptoms. "
02/01/1989 - "The results of this study show that even after treatment for the neonatal abstinence syndrome, infants of drug dependent mothers seem to differ from comparison children, which could indicate later developmental problems."
10/01/2015 - "To evaluate the generalizability of stringent protocol-driven weaning in improving total duration of opioid treatment and length of inpatient hospital stay after treatment of neonatal abstinence syndrome (NAS). "
|5.||Neonatal Intensive Care
01/01/2015 - "All newborns from January 1, 2010, to June 30, 2012, admitted to the neonatal intensive care unit for treatment of neonatal abstinence syndrome were prospectively collected. "
07/01/2014 - "Data were analyzed from 386 newborn infants with a diagnosis of neonatal abstinence syndrome undergoing treatment in a level III neonatal intensive care unit. "
05/01/2014 - "Experiences of mothers of infants with neonatal abstinence syndrome in the neonatal intensive care unit."
12/01/2013 - "All infants with a diagnosis of neonatal abstinence syndrome (171) who were admitted to a large neonatal intensive care unit in southwest Florida between September 2010 and October 2012 comprised the sample. "
01/01/1999 - "A 12 month review of infants admitted with neonatal abstinence syndrome to a neonatal intensive care unit was undertaken. "