Nefopam (Ajan)

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85 relevant articles (10 outcomes, 11 trials/studies) found for this Bio-Agent

Description: Non-narcotic analgesic chemically similar to ORPHENADRINE. Its mechanism of action is unclear. It is used for the relief of acute and chronic pain. (From Martindale, The Extra Pharmacopoeia, 30th ed, p26)

Also Known As:

Ajan; 3M Brand of Nefopam Hydrochloride; Acupan; Biocodex Brand of Nefopam Hydrochloride; Fenazoxine; Krewel Brand of Nefopam Hydrochloride; Nefopam Hydrochloride; Silentan Nefopam; Hydrochloride, Nefopam; Nefopam, Silentan; 1H-2,5-Benzoxazocine, 3,4,5,6-tetrahydro-5-methyl-1-phenyl-

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 23

1-Ring Heterocyclic Compounds

Experts

1.	Bilotta, F: 2 articles (11/2001 - 12/2000)
2.	Rosa, G: 2 articles (11/2001 - 12/2000)
3.	Benhamou, D: 1 article (11/2007)
4.	Geeraerts, T: 1 article (11/2007)
5.	Duranteau, J: 1 article (11/2007)
6.	Pajot, S: 1 article (11/2007)
7.	Leblanc, P-E: 1 article (11/2007)
8.	Gillardin, Jean-Marie: 1 article (04/2004)
9.	Girard, Philippe: 1 article (04/2004)
10.	Pansart, Yannick: 1 article (04/2004)

Related Diseases

1.	Pain (Aches) 01/22/1999 - "Nefopam is a clinically effective analgesic agent used to control mild to moderate pain, whose mechanism of action is unknown" 04/01/1980 - "Although a few patients with chronic pain have received nefopam for several weeks, further studies are needed to clarify its continued effectiveness and safety when used over long periods" 11/01/2007 - "METHODS: Patients with a pain intensity >3 on a 1-10 numerical pain score (NPS) received increasing or decreasing doses of nefopam (20, 30, 40, 60, 80 mg) postoperatively" 11/01/2007 - "We used the continual reassessment method (CRM) to determine the effective dose of nefopam in 80% of the patients suffering from moderate pain in the postoperative period (ED(80))" 10/01/2007 - "Nefopam is widely used for the relief of moderate acute pain" Order ALL the reference details at left...
2.	Postoperative Pain 01/01/1988 - "Evaluation of the analgesic efficacy of nefopam in postoperative pain]" 11/01/2008 - "We performed a systematic search (multiple databases, bibliographies, any language, to January 2008) for randomized, placebo-controlled trials of nefopam for the prevention of postoperative pain" 11/01/2008 - "Nefopam for the prevention of postoperative pain: quantitative systematic review." 04/01/2003 - "Nefopam hydrochloride is a non-narcotic analgesic used parenterally and orally as a racemic mixture for the relief of postoperative pain" 12/01/2001 - "In the postoperative pain model, at 30 mg x kg(-1) nefopam augmented the endpoint to thermal threshold, 60 and 90 minutes after administration compared to the threshold recorded after the incision" Order ALL the reference details at left...
3.	Neoplasms (Cancer) 03/01/1999 - "Oxadol (nefopam hydrochloride), a central analgesic, was used for postoperative pain relief in patients operated on the abdominal and pelvic organs for cancer" 12/01/1977 - "The efficacy of nefopam, a novel analgesic agent, was compared to pentazocine in a double blind study in 40 cancer patients with chronic pain" 07/01/1976 - "Open study of the analgesic effects of nefopam hydrochloride (Acupan) on cancer patients with pain." 02/01/1989 - "The analgesic efficacy and toxicity of oral diclofenac sodium 50 mg (q.i.d.) vs. nefopam 60 mg (q.i.d.) and a combination of 640 mg ASA and 40 mg codeine (q.i.d.) in cancer patients with moderate to severe chronic pain has been evaluated in a randomized double-blind study" 02/01/1989 - "Double-blind evaluation of analgesic efficacy of orally administered diclofenac, nefopam, and acetylsalicylic acid (ASA) plus codeine in chronic cancer pain." Order ALL the reference details at left...
4.	Seizures (Seizure) 10/01/2007 - "Physicians should be aware of the possible occurrence of some serious ADRs when using nefopam such as convulsions and anaphylactic shocks, especially when the drug is used in special medical conditions, like post-operative periods." 07/09/2004 - "Nefopam displaced 3H-batrachotoxinin and inhibited the uptake of 22Na in the micromolar range and it protected mice against electroshock induced seizures" 09/22/1995 - "Convulsions occurred in a stable epileptic in whom nefopam was contraindicated, and in another where the seizure threshold may have been lowered by a concomitant tricyclic antidepressant" 01/01/2007 - "Nefopam (NEF) is a known analgesic that has recently been shown to be effective in controlling both neuropathic pain and convulsions in rodents" 07/09/2004 - "On the other hand, nefopam was effective against NMDA, QA and KA induced clonic seizures in mice" Order ALL the reference details at left...
5.	Hypothermia 06/01/2001 - "Our results suggest that nefopam is effective in preventing postoperative shivering in patients undergoing neurosurgery and mild hypothermia and attenuates the haemodynamic effects of shivering during rewarming." 06/01/2001 - "We evaluated the haemodynamic and metabolic effects of prevention of shivering after prophylactic nefopam administration in neurosurgical patients undergoing craniotomy and mild systemic hypothermia (33-35 degrees C)" 04/01/1980 - "Side effects included mild dizziness and hypothermia after nefopam and mild elevation of diastolic arterial pressure after nefopam and propoxyphene" Order ALL the reference details at left...

Related Drugs and Biologics

1.	Ketoprofen (Orudis)
2.	Aspirin (Acetylsalicylic Acid)
3.	Diclofenac (SR 38)
4.	Pentazocine (Talwin)
5.	N-Methylaspartate (NMDA)
6.	Tilidine
7.	Isoniazid (Ftivazide)
8.	Codeine (Codeine Phosphate)
9.	Clonidine (ST 155)
10.	Morphine (MS Contin)

Related Therapies and Procedures

1.	Rewarming
2.	Analgesia
3.	Episiotomy
4.	Minor Surgical Procedures (Minor Surgery)
5.	Intensive Care (Surgical Intensive Care)

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