|2.||Substance-Related Disorders (Drug Abuse)
|3.||Cocaine-Related Disorders (Cocaine Addiction)
|4.||Alcoholism (Alcohol Abuse)
|5.||Eating Disorders (Eating Disorder)
|1.||Kreek, Mary Jeanne: 13 articles (02/2015 - 09/2002)|
|2.||Nunes, Edward V: 8 articles (12/2011 - 12/2002)|
|3.||Zachariou, Venetia: 7 articles (07/2014 - 06/2005)|
|4.||Reece, Albert Stuart: 6 articles (01/2013 - 10/2009)|
|5.||Lu, L: 6 articles (05/2001 - 03/2000)|
|6.||Wang, Grace Y: 5 articles (12/2015 - 09/2013)|
|7.||Lu, Lin: 5 articles (12/2014 - 10/2006)|
|8.||Peles, Einat: 5 articles (09/2014 - 02/2005)|
|9.||Adelson, Miriam: 5 articles (09/2014 - 02/2005)|
|10.||Bart, Gavin: 5 articles (10/2012 - 08/2003)|
|1.||Methadone (Dolophine)FDA LinkGeneric
10/01/2000 - "Reviews issued by the Institute of Medicine and the National Institutes of Health have defined narcotic addiction as a chronic medical disorder and have claimed that methadone maintenance coupled with social services is the most effective treatment for this condition. "
03/20/1991 - "Despite methadone treatment having been found effective in cases of opiate-dependence, and in many cases a prerequisite of rehabilitation, the queues for it are very long in Sweden--up to two years. "
01/01/2001 - "The new proposal for rule making (NPRM) will help the medical profession accept methadone treatment as beneficial for opiate addiction and realize that it should be more accessible to patients from trained physicians in the community. "
01/01/2015 - "Methadone maintenance therapy is an effective treatment for opiate dependence, but more than three-quarters of persons receiving the treatment report sleep quality disturbances. "
10/09/1976 - "Methadone was not found to be "the quick cure" for opiate addiction. "
|2.||Buprenorphine (Subutex)FDA LinkGeneric
12/01/2007 - "We examined how physicians who prescribe buprenorphine are using it in practice to determine how well buprenorphine has been adopted as a realistic and effective treatment option, with the ultimate goal of improved access to opiate addiction treatment. "
06/01/1999 - "Buprenorphine is an effective new treatment for opiate dependence. "
01/01/1997 - "Buprenorphine administered sublingually is a promising treatment for opiate dependence. "
07/01/1996 - "Sublingual buprenorphine appears useful in the treatment of opiate dependence. "
11/01/1999 - "Clinical trials have demonstrated the clinical efficacy of HD buprenorphine for narcotic addiction, but few data are published concerning the prognostic factors of treatment response in daily practice. "
|3.||Naltrexone (ReVia)FDA LinkGeneric
01/01/2014 - "Ultra-rapid opioid detoxification (UROD) and subsequently induction of naltrexone maintenance therapy can be regarded as a safe and effective detoxification method for use in patients with opiate addiction. "
06/01/2010 - "UROD and subsequently induction of naltrexone maintenance therapy can be regarded as safe and effective in patients with pure opiate addiction. "
03/01/1984 - "The results suggest that naltrexone is not a "cure" for opiate dependence, but is a medication which can be useful in protecting patients from re-addiction and is a modality patients should be encouraged to return to if they feel vulnerable to re-addiction."
01/01/1988 - "A number of studies have established the clinical efficacy of naltrexone in the treatment of opiate addiction. "
10/01/2009 - "There is increasing interest in the use of implantable naltrexone as a new treatment for opiate dependence. "
|4.||Naloxone (Narcan)FDA LinkGeneric
03/01/1995 - "5. The study has therefore shown an improvement in the previously reported false negative rate (25%) [1,2], of the conjunctival naloxone test of opiate dependence, with the use of our innovative electronic binocular pupillometer."
11/01/1995 - "Previous studies of opiate dependence in our laboratory have shown that opiate-naive (control) animals can display behaviors normally ascribed to withdrawal following naloxone challenge. "
01/01/1992 - "In clinical trials, nasally applied naloxone was used to identify opiate dependence in humans for the first time. "
01/01/1991 - "All subjects participating in an outpatient study comparing treatments for opiate dependence were given a naloxone challenge to document their level of dependence. "
01/01/2009 - "A pre-release program of overdose prevention education, including Naloxone prescription, for inmates with a history of opiate addiction would likely prevent many overdose deaths."
|5.||2-methylcyclopentadienyl manganese tricarbonyl (MMT)IBA
12/01/2014 - "Further studies are needed to explore the impact of severity of opiate addiction on long-term retention of MMT clients. "
05/01/2015 - "The present findings provide further support for MMT of opiate dependence and demonstrates potentially positive effects of substitution treatment on brain function."
11/01/2013 - "Our findings are important given the growing number of people with opiate dependence across the world and calls to increase access to MMT. "
05/20/2006 - "Analyses were based on a national sample of 200 patients presenting in MMT programs for treatment of opiate dependence. "
05/01/2006 - "There is an urgent need to implement MMT and other modern treatments for opiate dependence more widely in China."
|6.||Morphine (MS Contin)FDA LinkGeneric
02/01/2002 - "Morphine administration twice a day is more effective in inducing opiate dependence than once a day, and with the latter, the duration of morphine exposure increases the intensity of withdrawal signs. "
05/15/2009 - "The opiates 6beta-naltrexol and 6beta-naltrexamide function as neutral antagonists in in vitro and in vivo systems previously exposed to morphine, and are under investigation as improved treatments for narcotic dependence. "
01/01/2011 - "Thus, integration of proteomics, network analysis, and behavioral studies has provided a greater understanding of morphine-induced alterations in synaptic composition, and identified a potential novel therapeutic target for opiate dependence."
03/17/2009 - "These findings suggest that the acute dependence model is more suitable to study the aversive effects of morphine withdrawal on the acoustic startle response than the chronic opiate dependence model. "
02/15/1998 - "The present study provides a basis for a hypothesis that morphine may be directly compromising immune function by promoting Mphi apoptosis in patients with opiate addiction."
|7.||Cocaine (Cocaine HCl)IBA
09/01/1994 - "This study tests the reliability of lifetime DSM-IV diagnoses of alcohol, cannabis, cocaine and opiate dependence. "
07/30/2004 - "Patients with cocaine (n=32) and opiate dependence (n=32), whose diagnoses were confirmed with the Structured Clinical Interview for DSM-IV, and age- and sex-matched healthy subjects (n=32) were scanned using a 1.5 T whole body GE magnetic resonance scanner. "
07/30/2004 - "The prevalence, severity, and location of white matter signal hyperintensities (WMH) on brain magnetic resonance images were compared in patients with cocaine or opiate dependence and healthy subjects. "
07/30/2004 - "White matter hyperintensities in subjects with cocaine and opiate dependence and healthy comparison subjects."
05/01/2003 - "Because cocaine and opiate dependence in the absence of abuse were rare, it is possible that progressions in cocaine and opiate disorders occur more rapidly than cannabis and alcohol. "
01/01/2009 - "This treatment is effective for opiate addiction, reducing morbidity and mortality associated with heroin use. "
02/01/2015 - "Individual vulnerability to stress-induced relapse during abstinence from chronic heroin exposure is a key feature of opiate addiction, with limited studies on this topic. "
11/01/2014 - "In this review, we focus primarily on association studies of heroin and opiate addiction, and further describe the studies which have been replicated in this field, and are thus more likely to be useful for translational efforts. "
09/01/2002 - "This paper provides an overview of the prevalence of injection drug use and the opiate dependence problem internationally, the current opiate dependence treatment landscape in several countries, and the status of ongoing or planned heroin-assisted treatment trials in Australia, Canada and certain European countries."
02/01/1969 - "Intravenous diacetylmorphine (heroin) in studies of opiate dependence."
|9.||Methadyl Acetate (LAAM)FDA Link
09/01/2007 - "LAAM is an effective medication for the treatment of opiate dependence in community clinics with numerous behavioral and clinical advantages. "
08/01/2005 - "LAAM is an effective medication for the treatment of opiate dependence with clinical advantages due not only to the reduction of opiate use but also to the alternate-day dosing schedule. "
02/01/1981 - "A clinical, controlled study of l-alpha-acetylmethadol in the treatment of narcotic addiction."
04/01/2009 - "LAAM was a useful and a potentially important addition to treatment options for opiate addiction, conferring greater retention and opiate suppression benefits. "
01/28/2009 - "Due to potential proarrhythmic side-effects levo-alpha-Acetylmethadol (LAAM) is currently not available in EU countries as maintenance drug in the treatment of opiate addiction. "
|10.||Clonidine (ST 155)FDA LinkGeneric
10/01/1980 - "In an open trial of clonidine in opiate withdrawal, clonidine was found to suppress opiate withdrawal signs and symptoms, allowing all of the patients to detoxify successfully from chronic opiate addiction. "
01/01/2001 - "Fourteen of fifteen treatment seeking individuals with opiate dependence knew of clonidine abuse. "
04/04/1983 - "Clonidine has been used successfully in the treatment of opiate dependence. "
08/01/1980 - "Iatrogenic opiate addiction: successful detoxification with clonidine."
03/01/1993 - "By alleviating withdrawal symptoms and by lessening the detoxification period, clonidine similarly has improved the prospect of recovery from opiate addiction. "
|1.||Drug Therapy (Chemotherapy)
05/21/2003 - "Hence, there is a need to develop new pharmacotherapies for opiate dependence that extend the range of clinical options, including new first-line treatment approaches. "
01/01/2005 - "Previous Cochrane reviews have explored the efficacy of pharmacotherapy for opiate dependence. "
12/01/2005 - "In addition, this study extends use of the CDPS to research on brief pharmacotherapy treatment of opiate addiction."
10/01/2000 - "This review was undertaken to clarify what is known about interactions between pharmacotherapies of opiate dependence and HIV-related medications, to suggest clinically useful approaches to these issues, and to outline areas which need further study. "
03/01/2013 - "Clinics licensed to provide pharmacotherapy for opiate dependence disorder are required to perform random urine drug screen (RUDS) tests. "
07/01/2014 - "In this study we use several new genetic tools that allow manipulations of Rgs9-2 activity in particular brain regions of adult mice in order to better understand the mechanism via which this protein modulates opiate addiction and analgesia. "
10/01/1976 - "The subjects used in this study demonstrated marked tolerance to narcotic analgesia, but none of them showed signs reminescent of narcotic dependence. "
01/01/2008 - "The striatal enriched RGS9 plays a prominent role in opiate and psychostimulant drug reward; RGS4 appears to modulate opiate dependence via actions in the locus coeruleus, whereas RGSz modulates analgesia via activation of the PKC pathway."
05/01/1969 - "Analgesia in narcotic addiction."
03/01/1992 - "Pharmacists do not appear to be a major obstruction to adequate analgesia for cancer patients in New Mexico but may require further education regarding lack of narcotic addiction and dosing in patients with cancer."
06/01/2008 - "Studies were reviewed that present empirical results on the long-term course of opiate addiction, progress of opiate addicts during and after treatment, variables that predict remission and abstinence, comparisons of treated and untreated samples, and recovery from opiate addiction without formal help. "
06/01/2008 - "Treatment for opiate addiction, especially maintenance treatment, reduces opiate use; however, it is unclear how long after treatment the effects last. "
01/01/1998 - "Many people treated for opiate addiction continue to use drugs during and after treatment. "
01/01/1998 - "A meta-analysis of predictors of continued drug use during and after treatment for opiate addiction."
10/25/1997 - "Craving is a significant factor in opiate addiction that is associated with drug-dependence and in relapse to drug use after treatment. "
|4.||Chinese Traditional Medicine (Traditional Chinese Medicine)
01/01/2014 - "An ultra-high-performance liquid chromatography-electrospray ionization tandem mass spectrometry (UHPLC-ESI-MS/MS) method was developed for simultaneous determination of fifteen constituents in Jitai tablet (JTT), a complex Traditional Chinese Medicine prescription (TCMP) used in treating opiate addiction. "
10/01/2006 - "Traditional Chinese medicine in treatment of opiate addiction."
06/01/2008 - "In addition, traditional Chinese medicine, including herbal therapy and acupuncture, both found to be effective in the prevention of relapse and causes few side effects, making them useful for the treatment of opiate addiction. "
01/01/2009 - "Traditional Chinese medicine (TCM) is viewed as a potential approach to the treatment of drug addiction, and especially to opiate addiction. "
|5.||Opiate Substitution Treatment