Narcotic Antagonists (Opioid Antagonists)

Agents inhibiting the effect of narcotics on the central nervous system.

Also Known As:

Opioid Antagonists; Competitive Opioid Antagonists; Opioid Receptor Antagonists; Opioid Reversal Agents; Agent, Opioid Reversal; Agents, Opioid Reversal; Antagonist, Competitive Opioid; Antagonist, Narcotic; Antagonist, Opioid; Antagonist, Opioid Receptor; Antagonists, Competitive Opioid; Antagonists, Narcotic; Antagonists, Opioid; Antagonists, Opioid Receptor; Opioid Antagonist, Competitive; Opioid Antagonists, Competitive; Receptor Antagonist, Opioid; Receptor Antagonists, Opioid; Reversal Agent, Opioid; Reversal Agents, Opioid; Competitive Opioid Antagonist; Narcotic Antagonist; Opioid Antagonist; Opioid Receptor Antagonist; Opioid Reversal Agent

Networked: 1627 relevant articles (127 outcomes, 221 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 160
  - Therapeutic Uses: 47080
    - Central Nervous System Agents: 51
      - Narcotic Antagonists: 1627
  - Physiological Effects of Drugs: 1
    - Narcotic Antagonists: 1627
    - Peripheral Nervous System Agents: 5
      - Sensory System Agents
        Narcotic Antagonists: 1627

Experts

1.	Zagon, Ian S: 17 articles (10/2021 - 04/2003)
2.	McLaughlin, Patricia J: 16 articles (10/2021 - 04/2003)
3.	Yuan, Chun-Su: 9 articles (02/2014 - 12/2003)
4.	Suzuki, Tsutomu: 8 articles (09/2020 - 09/2013)
5.	Sostek, Mark: 8 articles (01/2018 - 09/2013)
6.	Soyka, Michael: 8 articles (10/2016 - 01/2003)
7.	Dahan, Albert: 7 articles (11/2022 - 07/2006)
8.	Pergolizzi, Joseph V: 7 articles (10/2021 - 04/2013)
9.	Israel, Robert J: 7 articles (09/2021 - 05/2008)
10.	Kranzler, Henry R: 7 articles (10/2020 - 04/2002)

Related Diseases

1.	Alcoholism (Alcohol Abuse) 06/01/1995 - "Clinical trials suggest that opioid antagonists may be effective in the treatment of alcoholism. " 01/01/2014 - "Opioid antagonists are licensed drugs for treating alcohol use disorders; nonetheless, clinical studies have evidenced their limited effectiveness. " 11/01/2008 - "Future studies on the role of different subtypes of alcoholics according to their genetic or psychological profile to explain or even predict the effects of opioid antagonists in the treatment of alcohol dependence are needed." 01/01/2018 - "Kappa-opioid antagonists as stress resilience medications for the treatment of alcohol use disorders." 07/01/2017 - "The findings support the as-needed dosing practice, rather than the standard continual dosing, in the treatment of alcoholism with opioid receptor antagonists."
2.	Opioid-Related Disorders (Opiate Addiction) 01/01/2021 - "Background: Understanding the impact of medications for opioid use disorder on health related quality of life (QOL) may help to explain why few individuals with legal involvement remain in treatment, specifically those receiving opioid antagonists. " 08/01/2018 - "This seminal work published in Nature in the early 70's, in conjunction with many other studies, later served as the basis for the development of the narcotic antagonist (NTX) now used to treat both alcohol and opioid dependence. " 09/01/2004 - "The present study represents an effort to verify that other opioid antagonists produce this acute opioid dependence effect, and to characterize their relative pharmacological profiles. " 04/01/1993 - "The spinal rat seems to be a valuable system for a rapid quantitative pharmacological characterization of the abstinence-precipitating actions of opioid antagonists and for the study of the changes that occur during the acute development of opioid dependence." 01/01/2020 - "Rather, it suggests a novel receptor mechanism to account for the selectively high potency of 6BN to suppress opioid dependence at all developmental stages, even in adults, as compared to its well-established low potency as a classical opioid antagonist. "
3.	Pruritus (Itching) 08/01/2011 - "An early example from the series had excellent μ opioid receptor antagonist antagonist activity and was very effective in an in vivo pruritus study." 10/01/2010 - "During the past two decades, systemic μ-opioid receptor antagonists (MORA) have been used in the treatment of various forms of chronic pruritus. " 06/01/2007 - "These results clearly show potential for topically applied opioid receptor antagonist in the treatment of pruritus. " 11/01/2006 - "Opioid antagonists are useful in refractory pruritis. " 04/01/2003 - "Recently, evidence for a central mechanism for pruritus has been obtained and opioid antagonists have been tried clinically with some benefit, but their use is not widespread. "
4.	Pain (Aches) 01/01/2020 - "Our results, using pain-cue conditioning to create reduced pain responses, contrast previous studies where opioid antagonists significantly reduced the placebo effect in treatment of pain." 04/01/2013 - "Since the comprehensive review by Leavitt in 2009, few new studies on the use of opioid antagonists for pain have been published. " 04/01/2013 - "Published clinical trials, case reports and other sources were reviewed to determine the effectiveness and safety of opioid antagonists for use in relieving pain. " 10/01/2021 - "However, and in contrast to pain and pain empathy, administering an opioid antagonist did not block these effects. " 01/01/2019 - "This might be due to the activation of segmental pain inhibitory pathways during coughing indicated through the lack of pain reduction due to CT under opioid antagonist blockage."
5.	Opioid-Induced Constipation 09/15/2015 - "Peripherally acting mu-opioid antagonists are effective for opioid-induced constipation but are expensive. " 01/01/2019 - "Assessing the efficacy of peripherally acting µ-opioid receptor antagonists (PAMORAs) in the treatment of opioid-induced constipation: authors reply." 09/01/2008 - "Efficacy and safety of mu-opioid antagonists in the treatment of opioid-induced bowel dysfunction: systematic review and meta-analysis of randomized controlled trials." 01/01/2023 - "Mu-Opioid Antagonists for the Treatment of Opioid-Induced Bowel Dysfunction." 07/01/2021 - "Efficacy and Safety of Peripherally Acting μ-Opioid Receptor Antagonist (PAMORAs) for the Management of Patients With Opioid-Induced Constipation: A Systematic Review."

Related Drugs and Biologics

1.	Naltrexone (ReVia)
2.	Opioid Analgesics (Opioids)
3.	Naloxone (Narcan)
4.	methylnaltrexone
5.	Opioid Receptors (Opioid Receptor)
6.	Analgesics (Analgesic Drugs)
7.	Antipsychotic Agents (Antipsychotics)
8.	Naloxone Drug Combination Buprenorphine
9.	Morphine (MS Contin)
10.	Narcotic Antagonists (Opioid Antagonists)

Related Therapies and Procedures

1.	Therapeutics
2.	Analgesia
3.	Drug Therapy (Chemotherapy)
4.	Pain Management
5.	Estrogen Replacement Therapy